Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q4 2014 (← Previous) (Next →)
Filing Date: Feb 17, 2015
Total Value: $1.192B (99.3% shares, 0.7% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| FOLD | AMICUS THERAPEUTICS INC | 14,439,444 | $120M | 10.1% | $8.32 * | $3.01 | +127.7% | COM | 03152W109 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 3,565,267 | $79.65M | 6.7% | $22.34 * | $12.74 | +48.7% | COM | 64125C109 |
| — | ACELRX PHARMACEUTICALS INC | 6,574,060 | $44.24M | 3.7% | $6.73 | $9.69 | — | COM | 00444T100 |
| SRPT | SAREPTA THERAPEUTICS INC | 2,812,352 | $40.7M | 3.4% | $14.47 * | $33.05 | -48.8% | COM | 803607100 |
| — | RELYPSA INC | 1,239,142 | $38.17M | 3.2% | $30.80 | $26.48 | — | COM | 759531106 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 1,600,000 | $35.74M | 3.0% | $22.34 * | $12.74 | +48.7% | Put | 64125C109 |
| — | RECEPTOS INC | 291,394 | $35.7M | 3.0% | $122.51 | $49.28 | — | COM | 756207106 |
| PTCT | PTC THERAPEUTICS INC | 671,736 | $34.78M | 2.9% | $51.77 * | $26.87 | +63.8% | COM | 69366J200 |
| ACAD | ACADIA PHARMACEUTICALS INC | 1,093,281 | $34.71M | 2.9% | $31.75 * | $24.52 | +15.6% | COM | 004225108 |
| — | TESARO INC | 883,359 | $32.85M | 2.8% | $37.19 | $34.85 | — | COM | 881569107 |
| XNCR | XENCOR INC | 1,927,171 | $30.91M | 2.6% | $16.04 * | $8.89 | +30.5% | COM | 98401F105 |
| — | DYAX CORP | 1,852,000 | $26.04M | 2.2% | $14.06 | $7.87 | — | COM | 26746E103 |
| — | LION BIOSCIENCES | 3,214,549 | $25.3M | 2.1% | $7.87 | $9.29 | — | COM | 53619R102 |
| — | BELLICUM PHARMACEUTICALS INC | 1,046,402 | $24.11M | 2.0% | $23.04 | $23.04 | — | COM | 079481107 |
| — | RETROPHIN INC | 1,940,725 | $23.75M | 2.0% | $12.24 | $9.19 | — | COM | 761299106 |
| — | TARO PHARMACEUTICAL INDS LTD | 154,028 | $22.82M | 1.9% | $148.19 | $130.22 | — | SHS | M8737E108 |
| — | BLUEBIRD BIO INC | 225,000 | $20.64M | 1.7% | $91.72 | $91.72 | — | COM | 09609G100 |
| — | VERSARTIS INC | 931,171 | $19.74M | 1.7% | $21.20 | $23.79 | — | COM | 92529L102 |
| — | OPHTHOTECH CORP | 429,386 | $19.27M | 1.6% | $44.87 | $37.70 | — | COM | 683745103 |
| ANIP | ANI PHARMACEUTICALS INC | 312,500 | $17.62M | 1.5% | $56.39 * | $44.09 | 0.0% | COM | 00182C103 |
| — | ALLERGAN INC | 82,583 | $17.56M | 1.5% | $212.59 | $186.33 | — | COM | 018490102 |
| ZBH | ZIMMER HLDGS INC | 154,093 | $17.48M | 1.5% | $113.42 * | $88.71 | +8.5% | COM | 98956P102 |
| — | CELGENE CORP | 146,567 | $16.39M | 1.4% | $111.86 | $112.47 | — | COM | 151020104 |
| — | OTONOMY INC | 454,306 | $15.14M | 1.3% | $33.33 | $24.00 | — | COM | 68906L105 |
| VRTX | VERTEX PHARMACEUTICALS INC | 110,000 | $13.07M | 1.1% | $118.80 * | $73.30 | +53.7% | COM | 92532F100 |
| — | NEPTUNE TECHNOLOGIES BIORESO | 6,750,444 | $12.82M | 1.1% | $1.90 | $3.13 | — | COM | 64077P108 |
| — | THORATEC CORP | 392,465 | $12.74M | 1.1% | $32.46 | $30.31 | — | COM NEW | 885175307 |
| — | ACCELERON PHARMA INC | 317,636 | $12.38M | 1.0% | $38.96 | $32.75 | — | COM | 00434H108 |
| ESPR | ESPERION THERAPEUTICS INC NE | 302,500 | $12.23M | 1.0% | $40.44 * | $30.61 | 0.0% | COM | 29664W105 |
| SGMO | SANGAMO BIOSCIENCES INC | 800,000 | $12.17M | 1.0% | $15.21 * | $19.28 | -37.0% | COM | 800677106 |
| VRTX | VERTEX PHARMACEUTICALS INC | 100,000 | $11.88M | 1.0% | $118.80 * | $73.30 | +53.7% | Put | 92532F100 |
| BDX | BECTON DICKINSON & CO | 80,000 | $11.13M | 0.9% | $139.16 * | $107.84 | 0.0% | COM | 075887109 |
| INSM | INSMED INC | 685,812 | $10.61M | 0.9% | $15.47 * | $15.42 | -8.0% | COM PAR $.01 | 457669307 |
| VNDA | VANDA PHARMACEUTICALS INC | 600,000 | $8.592M | 0.7% | $14.32 | — | — | Call | 921659108 |
| — | ZAFGEN INC | 278,313 | $8.583M | 0.7% | $30.84 | $19.78 | — | COM | 98885E103 |
| — | QUOTIENT LTD | 453,870 | $8.169M | 0.7% | $18.00 | $12.38 | — | SHS | G73268107 |
| — | EPIZYME INC | 432,619 | $8.164M | 0.7% | $18.87 | $23.85 | — | COM | 29428V104 |
| — | ANI PHARMACEUTICALS INC | 7,500,000 | $7.885M | 0.7% | $1.05 | $1.05 | — | NOTE 3.000%12/0 | 00182CAA1 |
| MGNX | MACROGENICS INC | 215,815 | $7.569M | 0.6% | $35.07 * | $26.16 | -4.7% | COM | 556099109 |
| — | BIODELIVERY SCIENCES INTL IN | 605,407 | $7.277M | 0.6% | $12.02 | $11.55 | — | COM | 09060J106 |
| — | TOKAI PHARMACEUTICALS INC | 485,338 | $7.154M | 0.6% | $14.74 | $14.89 | — | COM | 88907J107 |
| CHRS | COHERUS BIOSCIENCES INC | 438,000 | $7.148M | 0.6% | $16.32 * | $14.11 | 0.0% | COM | 19249H103 |
| — | NEVRO CORP | 176,563 | $6.828M | 0.6% | $38.67 | $38.67 | — | COM | 64157F103 |
| HRTX | HERON THERAPEUTICS INC | 666,042 | $6.7M | 0.6% | $10.06 * | $12.60 | -35.2% | COM | 427746102 |
| SRPT | Sarepta Therapeutics Inc | 450,000 | $6.512M | 0.5% | $14.47 * | $33.05 | -48.8% | Call | 803607100 |
| — | APPLIED GENETIC TECHNOL CORP | 301,222 | $6.332M | 0.5% | $21.02 | $20.83 | — | COM | 03820J100 |
| — | AFFIMED N V | 1,005,820 | $6.236M | 0.5% | $6.20 | $63.01 | — | COM | N01045108 |
| — | CAPITAL SR LIVING CORP | 250,000 | $6.228M | 0.5% | $24.91 | $24.91 | — | COM | 140475104 |
| — | TRANSENTERIX INC | 2,095,708 | $6.099M | 0.5% | $2.91 | $4.24 | — | COM NEW | 89366M201 |
| — | ALLIQUA BIOMEDIC | 1,121,951 | $5.946M | 0.5% | $5.30 | $5.30 | — | COM | 19621200 |
| — | CEMPRA INC | 247,500 | $5.819M | 0.5% | $23.51 | $23.51 | — | COM | 15130J109 |
| — | LA JOLLA PHARMACEUTICAL CO | 288,955 | $5.331M | 0.4% | $18.45 | $10.80 | — | COM PAR $.0001 2 | 503459604 |
| PRTA | PROTHENA CORP PLC | 247,336 | $5.135M | 0.4% | $20.76 | $30.24 | -31.0% | SHS | G72800108 |
| — | CHINA BIOLOGIC PRODS INC | 74,023 | $4.977M | 0.4% | $67.24 | $66.50 | — | COM | 16938C106 |
| — | NEURODERM LTD | 350,000 | $4.914M | 0.4% | $14.04 | $14.04 | — | ORD SHS | M74231107 |
| ARDX | ARDELYX INC | 255,728 | $4.831M | 0.4% | $18.89 * | $17.95 | +29.0% | COM | 039697107 |
| XENE | XENON PHARMACEUTICALS INC | 225,000 | $4.444M | 0.4% | $19.75 * | $14.68 | 0.0% | COM | 98420N105 |
| — | PLASMATECH BIOPHARMACEUTICAL | 1,250,000 | $4.375M | 0.4% | $3.50 | $3.50 | — | COM | 72754H109 |
| — | MYLAN INC | 76,210 | $4.296M | 0.4% | $56.37 | $45.98 | — | COM | 628530107 |
| — | FIVE PRIME THERAPEUTICS INC | 155,256 | $4.192M | 0.4% | $27.00 | $17.46 | — | COM | 33830X104 |
| — | QUIDEL CORP | 142,500 | $4.121M | 0.3% | $28.92 | $28.92 | — | COM | 74838J101 |
| — | TETRAPHASE PHARMACEUTICALS I | 100,000 | $3.971M | 0.3% | $39.71 | $39.71 | — | COM | 88165N105 |
| — | ACTAVIS PLC | 15,088 | $3.884M | 0.3% | $257.42 | $241.27 | — | SHS | G0083B108 |
| THC | TENET HEALTHCARE CORP | 75,913 | $3.847M | 0.3% | $50.68 * | $55.41 | -5.7% | COM NEW | 88033G407 |
| — | ALERE INC | 98,000 | $3.724M | 0.3% | $38.00 | $38.00 | — | COM | 01449J105 |
| — | FLAMEL TECHNOLOGIES SA | 644,111 | $3.678M | 0.3% | $5.71 | $12.99 | — | SPONSORED ADR | 338488109 |
| HCA | HCA HOLDINGS INC | 48,639 | $3.57M | 0.3% | $73.40 * | $48.98 | +33.4% | COM | 40412C101 |
| — | THORATEC CORP | 100,000 | $3.246M | 0.3% | $32.46 | $30.31 | — | Call | 885175307 |
| — | ENDOLOGIX INC | 210,000 | $3.211M | 0.3% | $15.29 | $15.29 | — | COM | 29266S106 |
| — | DBV TECHNOLOGIES S A | 112,622 | $3.054M | 0.3% | $27.12 | $27.12 | — | SPONSORED ADR | 23306J101 |
| — | PFENEX INC | 404,665 | $2.962M | 0.2% | $7.32 | $7.36 | — | COM | 717071104 |
| — | VASCULAR BIOGENICS LTD | 500,000 | $2.955M | 0.2% | $5.91 | $5.91 | — | ORD SHS | M96885104 |
| — | DERMA SCIENCES INC | 313,583 | $2.919M | 0.2% | $9.31 | $11.63 | — | COM PAR $.01 | 249827502 |
| QURE | UNIQURE NV | 195,856 | $2.901M | 0.2% | $14.81 * | $12.24 | 0.0% | SHS | N90064101 |
| — | PROTEON THERAPEUTICS INC | 275,000 | $2.86M | 0.2% | $10.40 | $10.40 | — | COM | 74371L109 |
| — | KERYX BIOPHARMACEUTICALS | 200,000 | $2.83M | 0.2% | $14.15 | — | — | Put | 492515101 |
| — | DERMIRA INC | 152,000 | $2.753M | 0.2% | $18.11 | $18.11 | — | COM | 24983L104 |
| ARNI | ARNO THERAPEUTICS, INC | 2,034,721 | $2.746M | 0.2% | $1.35 * | $1.49 | -41.5% | COM | 042564203 |
| — | JUNO THERAPEUTICS INC | 50,000 | $2.611M | 0.2% | $52.22 | $52.22 | — | COM | 48205A109 |
| — | MEDGENICS INC | 514,224 | $2.602M | 0.2% | $5.06 | $4.93 | — | COM NEW | 58436Q203 |
| VCEL | VERICEL CORP | 850,000 | $2.584M | 0.2% | $3.04 * | $2.85 | 0.0% | COM | 92346J108 |
| — | SAGE THERAPEUTICS INC | 70,484 | $2.58M | 0.2% | $36.60 | $31.50 | — | COM | 78667J108 |
| SNN | SMITH & NEPHEW PLC | 67,407 | $2.477M | 0.2% | $36.75 | $46.85 | — | SPDN ADR NEW | 83175M205 |
| — | GENVEC INC | 1,040,344 | $2.226M | 0.2% | $2.14 | $2.54 | — | COM NEW | 37246C307 |
| PRQR | PROQR THRAPEUTICS N V | 100,000 | $2.167M | 0.2% | $21.67 * | $16.02 | -5.3% | SHS EURO | N71542109 |
| — | MGC DIAGNOSTICS CORP | 336,287 | $2.152M | 0.2% | $6.40 | $8.55 | — | COM | 552768103 |
| — | SHIRE PLC | 10,000 | $2.125M | 0.2% | $212.50 | $212.50 | — | SPONSORED ADR | 82481R106 |
| — | ALIMERA SCIENCES INC | 381,900 | $2.115M | 0.2% | $5.54 | $5.54 | — | COM | 016259103 |
| RGEN | REPLIGEN CORP | 100,000 | $1.98M | 0.2% | $19.80 | — | — | Put | 759916109 |
| — | ABIOMED INC | 50,000 | $1.903M | 0.2% | $38.06 | $24.84 | — | Call | 003654100 |
| — | CELLDEX THERAPEUTICS INC NEW | 100,000 | $1.825M | 0.2% | $18.25 | $18.25 | — | COM | 15117B103 |
| — | AGENUS INC | 402,717 | $1.599M | 0.1% | $3.97 | $3.97 | — | COM NEW | 00847G705 |
| — | UROPLASTY INC | 766,349 | $1.579M | 0.1% | $2.06 | $2.64 | — | COM NEW | 917277204 |
| — | WALGREENS BOOTS ALLIANCE INC | 20,292 | $1.546M | 0.1% | $76.19 | $76.19 | — | COM | 931427108 |
| VNDA | VANDA PHARMACEUTICALS INC | 100,000 | $1.432M | 0.1% | $14.32 | — | — | Put | 921659108 |
| — | SYNERON MEDICAL LTD | 152,609 | $1.424M | 0.1% | $9.33 | $11.84 | — | ORD SHS | M87245102 |
| — | ACHILLION PHARMACEUTICALS IN | 106,100 | $1.3M | 0.1% | $12.25 | $7.57 | — | COM | 00448Q201 |
| — | PSIVIDA CORP | 315,000 | $1.294M | 0.1% | $4.11 | $4.11 | — | COM | 74440J101 |
| — | ACASTI PHARMA INC | 2,573,645 | $1.286M | 0.1% | $0.50 | $1.23 | — | CL A SHS | 00430K105 |
| — | SUNESIS PHARMACEUTICALS INC | 500,000 | $1.275M | 0.1% | $2.55 | $2.55 | — | COM NEW | 867328601 |
| — | MANNKIND CORP | 200,000 | $1.043M | 0.1% | $5.21 | — | — | Put | 56400P201 |
| — | PLASMATECH BIOPHARMACEUTICAL | 1,250,000 | $1M | 0.1% | $0.80 | $0.80 | — | *W EXP 10/24/201 | 72754H117 |
| — | AQUINOX PHARMACEUTICALS INC | 130,000 | $975K | 0.1% | $7.50 | $12.73 | — | COM | 03842B101 |
| PARNEUR | PARNELL PHARMACEUT HLDGS LTD | 214,100 | $888K | 0.1% | $4.15 | $5.72 | — | SHS | Q73622104 |
| — | CHAMPIONS ONCOLOGY | 1,625,744 | $812K | 0.1% | $0.50 | $0.74 | — | COM | 15870P109 |
| — | ANTHERA PHARMACEUTICALS INC | 503,156 | $795K | 0.1% | $1.58 | $1.90 | — | COM NEW | 03674U201 |
| — | ACHAOGEN INC | 60,000 | $783K | 0.1% | $13.05 | $15.47 | — | COM | 004449104 |
| — | DURECT CORP | 907,064 | $716K | 0.1% | $0.79 | $1.33 | — | COM | 266605104 |
| — | PORTOLA PHARMACEUTICALS INC | 25,000 | $708K | 0.1% | $28.32 | $28.32 | — | COM | 737010108 |
| — | HEALTH INS INNOVATIONS INC | 96,000 | $687K | 0.1% | $7.16 | $12.14 | — | COM CL A | 42225K106 |
| — | SIENTRA INC | 37,000 | $621K | 0.1% | $16.78 | $16.78 | — | COM | 82621J105 |
| — | ONCOTHYREON INC | 325,000 | $618K | 0.1% | $1.90 | $2.10 | — | COM | 682324108 |
| — | SPECTRANETICS CORP | 16,335 | $565K | 0.0% | $34.59 | $22.19 | — | COM | 84760C107 |
| — | THRESHOLD PHARMACEUTICAL INC | 160,000 | $509K | 0.0% | $3.18 | $3.61 | — | COM NEW | 885807206 |
| — | GALMED PHARMACEUTICALS LTD | 75,000 | $435K | 0.0% | $5.80 | $11.47 | — | SHS | M47238106 |
| — | RITE AID CORP | 42,385 | $318K | 0.0% | $7.50 | $7.50 | — | COM | 767754104 |
| — | GALENA BIOPHARMA INC | 200,000 | $302K | 0.0% | $1.51 | — | — | Put | 363256108 |
| — | LHC GROUP INC | 9,688 | $302K | 0.0% | $31.17 | $31.17 | — | COM | 50187A107 |
| — | MERGE HEALTHCARE INC | 82,427 | $293K | 0.0% | $3.55 | $2.88 | — | COM | 589499102 |
| — | CLOVIS ONCOLOGY INC | 5,138 | $288K | 0.0% | $56.05 | $53.54 | — | COM | 189464100 |
| — | NANOSPHERE INC | 707,566 | $277K | 0.0% | $0.39 | $0.39 | — | COM | 63009F105 |
| — | HEALTH NET INC | 5,025 | $269K | 0.0% | $53.53 | $53.53 | — | COM | 42222G108 |
| — | SKILLED HEALTHCARE GROUP INC | 31,293 | $268K | 0.0% | $8.56 | $8.56 | — | CL A | 83066R107 |
| — | SCICLONE PHARMACEUTICALS INC | 29,942 | $262K | 0.0% | $8.75 | $7.74 | — | COM | 80862K104 |
| INFIQ | INFINITY PHARMACEUTICALS INC | 15,323 | $259K | 0.0% | $16.90 * | $14.56 | 0.0% | COM | 45665G303 |
| — | SURGICAL CARE AFFILIATES INC | 7,702 | $259K | 0.0% | $33.63 | $33.63 | — | COM | 86881L106 |
| CNC | CENTENE CORP DEL | 2,484 | $258K | 0.0% | $103.86 * | $19.96 | +16.9% | COM | 15135B101 |
| — | TRIPLE-S MGMT CORP | 10,605 | $254K | 0.0% | $23.95 | $20.57 | — | CL B | 896749108 |
| — | TRANSGENOMIC INC | 126,084 | $253K | 0.0% | $2.01 | $4.58 | — | COM NEW | 89365K305 |
| UHS | UNIVERSAL HLTH SVCS INC | 2,233 | $248K | 0.0% | $111.06 * | $91.46 | +9.7% | CL B | 913903100 |
| — | CAMBREX CORP | 11,488 | $248K | 0.0% | $21.59 | $21.59 | — | COM | 132011107 |
| — | CYBERONICS INC | 4,454 | $248K | 0.0% | $55.68 | $55.68 | — | COM | 23251P102 |
| — | EXACTECH INC | 10,374 | $245K | 0.0% | $23.62 | $24.35 | — | COM | 30064E109 |
| PAHC | PHIBRO ANIMAL HEALTH CORP | 7,526 | $237K | 0.0% | $31.49 * | $27.66 | 0.0% | CL A COM | 71742Q106 |
| — | BIOSPECIFICS TECHNOLOGIES CO | 6,065 | $234K | 0.0% | $38.58 | $38.58 | — | COM | 090931106 |
| — | PDL BIOPHARMA INC | 30,151 | $232K | 0.0% | $7.69 | $8.38 | — | COM | 69329Y104 |
| — | CIVITAS SOLUTIONS INC | 13,585 | $231K | 0.0% | $17.00 | $17.00 | — | COM | 17887R102 |
| — | AETNA INC NEW | 2,586 | $230K | 0.0% | $88.94 | $84.96 | — | COM | 00817Y108 |
| — | CIGNA CORPORATION | 2,219 | $228K | 0.0% | $102.75 | $102.75 | — | COM | 125509109 |
| — | BARD C R INC | 1,367 | $228K | 0.0% | $166.79 | $166.79 | — | COM | 067383109 |
| — | PAREXEL INTL CORP | 4,005 | $223K | 0.0% | $55.68 | $55.68 | — | COM | 699462107 |
| USPH | U S PHYSICAL THERAPY INC | 5,156 | $216K | 0.0% | $41.89 * | $39.35 | 0.0% | COM | 90337L108 |
| — | OXIGENE INC | 123,518 | $199K | 0.0% | $1.61 | $3.73 | — | COM PAR$.001 | 691828404 |
| SEM | SELECT MED HLDGS CORP | 13,365 | $192K | 0.0% | $14.37 * | $6.87 | -3.3% | COM | 81619Q105 |
| — | LANNET INC | 4,392 | $188K | 0.0% | $42.81 | $45.68 | — | COM | 516012101 |
| SUPN | SUPERNUS PHARMACEUTICALS INC | 22,285 | $185K | 0.0% | $8.30 | $8.40 | 0.0% | COM | 868459108 |
| — | OHR PHARMACEUTICAL INC | 6,000 | $50,000 | 0.0% | $8.33 | $8.33 | — | COM NEW | 67778H200 |
| — | SEATTLE GENETICS INC /WA | 900 | $29,000 | 0.0% | $32.22 | — | — | Call | 812578102 |
| — | CELLULAR DYNAMICS INTL INC | 164 | $1,000 | 0.0% | $6.10 | $6.10 | — | COM | 15117V109 |
| — | XOMA LTD | 200 | $1,000 | 0.0% | $5.00 | — | — | Call | 98419J107 |