Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q1 2015 (← Previous) (Next →)
Filing Date: May 15, 2015
Total Value: $1.287B (98.8% shares, 1.2% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| FOLD | AMICUS THERAPEUTICS INC | 14,439,444 | $157M | 12.2% | $10.88 * | $3.01 | +192.4% | COM | 03152W109 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 3,741,267 | $149M | 11.5% | $39.71 * | $13.82 | +158.8% | COM | 64125C109 |
| — | RETROPHIN INC | 2,784,980 | $66.73M | 5.2% | $23.96 | $13.67 | — | COM | 761299106 |
| — | TESARO INC | 978,359 | $56.16M | 4.4% | $57.40 | $37.04 | — | COM | 881569107 |
| — | RELYPSA INC | 1,454,142 | $52.45M | 4.1% | $36.07 | $27.90 | — | COM | 759531106 |
| — | LION BIOTECHNOLOGIES INC | 2,714,549 | $32.87M | 2.6% | $12.11 | $9.29 | — | COM | 53619R102 |
| XNCR | XENCOR INC | 1,954,785 | $29.95M | 2.3% | $15.32 * | $8.98 | +75.7% | COM | 98401F105 |
| — | DYAX CORP | 1,777,000 | $29.77M | 2.3% | $16.76 | $7.87 | — | COM | 26746E103 |
| SRPT | SAREPTA THERAPEUTICS INC | 2,204,652 | $29.28M | 2.3% | $13.28 | $33.05 | -59.7% | COM | 803607100 |
| — | NEVRO CORP | 557,056 | $26.7M | 2.1% | $47.93 | $45.00 | — | COM | 64157F103 |
| — | ACELRX PHARMACEUTICALS INC | 6,574,060 | $25.38M | 2.0% | $3.86 | $9.69 | — | COM | 00444T100 |
| QURE | UNIQURE NV | 1,039,332 | $25.23M | 2.0% | $24.27 * | $20.01 | +9.0% | SHS | N90064101 |
| — | BELLICUM PHARMACEUTICALS INC | 1,046,402 | $24.25M | 1.9% | $23.17 | $23.04 | — | COM | 079481107 |
| — | VERSARTIS INC | 1,546,471 | $24.16M | 1.9% | $15.62 | $20.54 | — | COM | 92529L102 |
| ZBH | ZIMMER HLDGS INC | 180,793 | $21.25M | 1.7% | $117.52 * | $91.02 | +14.7% | COM | 98956P102 |
| — | CEMPRA INC | 572,500 | $19.64M | 1.5% | $34.31 | $29.64 | — | COM | 15130J109 |
| — | RECEPTOS INC | 118,794 | $19.59M | 1.5% | $164.89 | $49.28 | — | COM | 756207106 |
| ACAD | ACADIA PHARMACEUTICALS INC | 600,240 | $19.56M | 1.5% | $32.59 * | $24.52 | +40.2% | COM | 004225108 |
| ANIP | ANI PHARMACEUTICALS INC | 307,784 | $19.25M | 1.5% | $62.55 * | $44.09 | +38.0% | COM | 00182C103 |
| — | OTONOMY INC | 480,387 | $16.99M | 1.3% | $35.36 | $24.62 | — | COM | 68906L105 |
| — | BLUEBIRD BIO INC | 135,000 | $16.3M | 1.3% | $120.77 | $91.72 | — | COM | 09609G100 |
| — | CAPITAL SR LIVING CORP | 605,000 | $15.69M | 1.2% | $25.94 | $25.52 | — | COM | 140475104 |
| — | ACTAVIS PLC | 49,185 | $14.64M | 1.1% | $297.61 | $280.33 | — | SHS | G0083B108 |
| — | PFENEX INC | 866,423 | $13.81M | 1.1% | $15.94 | $11.93 | — | COM | 717071104 |
| — | PORTOLA PHARMACEUTICALS INC | 355,000 | $13.48M | 1.0% | $37.96 | $37.28 | — | COM | 737010108 |
| — | ACCELERON PHARMA INC | 336,036 | $12.79M | 1.0% | $38.06 | $33.05 | — | COM | 00434H108 |
| — | THORATEC CORP | 300,000 | $12.57M | 1.0% | $41.89 | $30.31 | — | COM NEW | 885175307 |
| SGMO | SANGAMO BIOSCIENCES INC | 800,000 | $12.54M | 1.0% | $15.68 | $19.28 | -19.7% | COM | 800677106 |
| INSM | INSMED INC | 585,812 | $12.19M | 0.9% | $20.80 * | $15.42 | +14.2% | COM PAR $.01 | 457669307 |
| — | NEPTUNE TECHNOLOGIES BIORESO | 6,750,444 | $10.94M | 0.8% | $1.62 | $3.13 | — | COM | 64077P108 |
| — | QUOTIENT LTD | 550,870 | $10.7M | 0.8% | $19.43 | $13.62 | — | SHS | G73268107 |
| — | AEGERION PHARMACEUTICALS INC | 381,100 | $9.973M | 0.8% | $26.17 | $26.17 | — | COM | 00767E102 |
| SRPT | Sarepta Therapeutics Inc | 750,000 | $9.96M | 0.8% | $13.28 | $33.05 | -59.7% | Call | 803607100 |
| — | ENDOLOGIX INC | 565,000 | $9.645M | 0.7% | $17.07 | $16.41 | — | COM | 29266S106 |
| — | CELADON GROUP INC | 474,500 | $8.987M | 0.7% | $18.94 | — | — | Call | 15117E107 |
| — | ANI PHARMACEUTICALS INC | 7,500,000 | $8.621M | 0.7% | $1.15 | $1.05 | — | NOTE 3.000%12/0 | 00182CAA1 |
| — | ZS PHARMA INC | 186,777 | $7.86M | 0.6% | $42.08 | $42.08 | — | COM | 98979G105 |
| BIIB | BIOGEN INC | 18,200 | $7.685M | 0.6% | $422.25 * | $394.14 | 0.0% | COM | 09062X103 |
| — | SHIRE PLC | 30,000 | $7.179M | 0.6% | $239.30 | $230.37 | — | SPONSORED ADR | 82481R106 |
| — | ANTHERA PHARMACEUTICALS INC | 1,603,156 | $7.166M | 0.6% | $4.47 | $3.66 | — | COM NEW | 03674U201 |
| — | VBI VACCINES INC. | 2,610,356 | $6.786M | 0.5% | $2.60 | $2.60 | — | COM | 91790E102 |
| — | DYAX CORP | 400,000 | $6.702M | 0.5% | $16.75 | $7.87 | — | Put | 26746E103 |
| — | CHINA BIOLOGIC PRODS INC | 70,000 | $6.686M | 0.5% | $95.51 | $66.50 | — | COM | 16938C106 |
| — | SUPERNUS PHARMACEUTICALS | 2,915,000 | $6.65M | 0.5% | $2.28 | $2.28 | — | INC NOTE 7.500% | 868459AB4 |
| — | APPLIED GENETIC TECHNOL CO | 301,222 | $6.021M | 0.5% | $19.99 | $20.83 | — | RP COM | 03820J100 |
| — | ALLIQUA BIOMEDIC | 1,121,951 | $5.834M | 0.5% | $5.20 | $5.30 | — | COM | 19621200 |
| — | ASSEMBLY BIOSCIENCES INC | 425,000 | $5.627M | 0.4% | $13.24 | $13.24 | — | COM | 045396108 |
| — | TOKAI PHARMACEUTICALS INC | 458,338 | $5.484M | 0.4% | $11.96 | $14.89 | — | COM | 88907J107 |
| CPRX | CATALYST PHARM PARTNERS INC | 1,200,000 | $5.196M | 0.4% | $4.33 * | $3.60 | 0.0% | COM | 14888U101 |
| — | MEDGENICS INC | 639,225 | $5.146M | 0.4% | $8.05 | $5.54 | — | COM NEW | 58436Q203 |
| — | FIVE PRIME THERAPEUTICS IN | 224,129 | $5.121M | 0.4% | $22.85 | $19.12 | — | C COM | 33830X104 |
| — | AFFIMED N V | 805,820 | $5.076M | 0.4% | $6.30 | $63.01 | — | COM | N01045108 |
| — | TARO PHARMACEUTICAL INDS LTD | 33,574 | $4.736M | 0.4% | $141.06 | $130.22 | — | SHS | M8737E108 |
| — | NEURODERM LTD | 350,000 | $4.697M | 0.4% | $13.42 | $14.04 | — | ORD SHS | M74231107 |
| — | LA JOLLA PHARMACEUTICAL CO | 252,915 | $4.628M | 0.4% | $18.30 | $10.80 | — | COM PAR $.0001 2 | 503459604 |
| — | ALDER BIOPHARMACEUTICALS INC | 150,000 | $4.329M | 0.3% | $28.86 | $28.86 | — | COM | 014339105 |
| — | THORATEC CORP | 100,000 | $4.189M | 0.3% | $41.89 | $30.31 | — | Call | 885175307 |
| ARDX | ARDELYX INC | 315,955 | $4.136M | 0.3% | $13.09 * | $18.10 | +3.5% | COM | 039697107 |
| — | MINERVA NEUROSCIENCES | 810,537 | $4.052M | 0.3% | $5.00 | $5.00 | — | COM | 603380106 |
| — | PLASMATECH BIOPHARMACEUTICAL | 1,250,000 | $3.925M | 0.3% | $3.14 | $3.50 | — | COM | 72754H109 |
| — | TRANSENTERIX INC | 1,328,668 | $3.893M | 0.3% | $2.93 | $4.24 | — | COM NEW | 89366M201 |
| XENE | XENON PHARMACEUTICALS INC | 225,000 | $3.795M | 0.3% | $16.87 * | $14.68 | +25.8% | COM | 98420N105 |
| HCA | HCA HOLDINGS INC | 50,000 | $3.762M | 0.3% | $75.24 * | $49.46 | +35.0% | COM | 40412C101 |
| — | TETRAPHASE PHARMACEUTICALS I | 100,000 | $3.664M | 0.3% | $36.64 | $39.71 | — | COM | 88165N105 |
| ALDX | ALDEYRA THERAPEUTICS | 357,000 | $3.634M | 0.3% | $10.18 | $10.20 | 0.0% | COM | 01438T106 |
| — | SAGE THERAPEUTICS INC | 70,484 | $3.54M | 0.3% | $50.22 | $31.50 | — | COM | 78667J108 |
| — | CELGENE CORP | 29,967 | $3.455M | 0.3% | $115.29 | $112.47 | — | COM | 151020104 |
| MGNX | MACROGENICS INC | 106,208 | $3.332M | 0.3% | $31.37 * | $26.16 | +29.6% | COM | 556099109 |
| — | PROTEON THERAPEUTICS INC | 275,000 | $3.198M | 0.2% | $11.63 | $10.40 | — | COM | 74371L109 |
| — | CHAMPIONS ONCOLOGY | 4,403,680 | $3.082M | 0.2% | $0.70 | $0.71 | — | COM | 15870P109 |
| — | PHARMACYCLICS INC | 12,000 | $3.071M | 0.2% | $255.92 | $255.92 | — | COM | 716933106 |
| — | RADIUS HEALTH INC | 74,000 | $3.046M | 0.2% | $41.16 | $41.16 | — | COM NEW | 750469207 |
| RGEN | REPLIGEN CORP | 100,000 | $3.036M | 0.2% | $30.36 | — | — | Put | 759916109 |
| — | DERMA SCIENCES INC | 343,284 | $2.908M | 0.2% | $8.47 | $11.36 | — | COM PAR $.01 | 249827502 |
| — | RAPTOR PHARMACEUTICAL CORP | 264,200 | $2.872M | 0.2% | $10.87 | $10.87 | — | COM | 75382F106 |
| — | INVITAE CORP | 165,000 | $2.765M | 0.2% | $16.76 | $16.76 | — | COM | 46185L103 |
| — | IMMUNOMEDICS INC | 600,000 | $2.625M | 0.2% | $4.38 | — | — | Put | 452907108 |
| CHRS | COHERUS BIOSCIENCES INC | 85,288 | $2.608M | 0.2% | $30.58 * | $14.11 | +83.2% | COM | 19249H103 |
| — | MGC DIAGNOSTICS CORP | 336,287 | $2.475M | 0.2% | $7.36 | $8.55 | — | COM | 552768103 |
| — | ISHARES TR | 85,000 | $2.426M | 0.2% | $28.54 | $28.54 | — | HDG MSCI GERMN | 46434V704 |
| — | DERMIRA INC | 152,000 | $2.333M | 0.2% | $15.35 | $18.11 | — | COM | 24983L104 |
| VCEL | VERICEL CORP | 589,297 | $2.18M | 0.2% | $3.70 * | $2.85 | +19.7% | COM | 92346J108 |
| — | CELADON GROUP INC | 100,000 | $1.894M | 0.1% | $18.94 | — | — | Put | 15117E107 |
| — | GENVEC INC | 615,844 | $1.811M | 0.1% | $2.94 | $2.54 | — | COM NEW | 37246C307 |
| — | BRAINSTORM CELL THERAPEUTICS | 400,000 | $1.78M | 0.1% | $4.45 | $4.45 | — | COM | 10501E201 |
| — | DURECT CORP | 907,064 | $1.732M | 0.1% | $1.91 | $1.33 | — | COM | 266605104 |
| — | WALGREENS BOOTS ALLIANCE INC | 20,292 | $1.719M | 0.1% | $84.71 | $76.19 | — | COM | 931427108 |
| — | SUNESIS PHARMACEUTICALS INC | 700,000 | $1.715M | 0.1% | $2.45 | $2.52 | — | COM NEW | 867328601 |
| — | ONCOTHYREON INC | 925,000 | $1.508M | 0.1% | $1.63 | $1.80 | — | COM | 682324108 |
| — | TRACON PHARMACEUTICALS INC | 100,000 | $1.404M | 0.1% | $14.04 | $14.04 | — | COM | 89237H100 |
| — | AVINGER INC | 112,500 | $1.248M | 0.1% | $11.09 | $11.09 | — | COM | 053734109 |
| — | PSIVIDA CORP | 315,000 | $1.244M | 0.1% | $3.95 | $4.11 | — | COM | 74440J101 |
| — | ARNO THERAPEUTICS INC | 2,034,721 | $1.179M | 0.1% | $0.58 | $0.58 | — | COM | 42564203 |
| — | UROPLASTY INC | 966,349 | $1.179M | 0.1% | $1.22 | $2.34 | — | COM NEW | 917277204 |
| — | SPARK THERAPEUTICS INC | 15,000 | $1.163M | 0.1% | $77.53 | $77.53 | — | COM | 84652J103 |
| — | PLASMATECH BIOPHARMACEUTICAL | 1,250,000 | $1.163M | 0.1% | $0.93 | $0.80 | — | *W EXP 10/24/201 | 72754H117 |
| — | ALIMERA SCIENCES INC | 231,900 | $1.161M | 0.1% | $5.01 | $5.54 | — | COM | 016259103 |
| — | STEMLINE THERAPEUTICS INC | 79,245 | $1.147M | 0.1% | $14.47 | $14.47 | — | COM | 85858C107 |
| — | ACASTI PHARMA INC | 2,365,600 | $1.134M | 0.1% | $0.48 | $1.23 | — | CL A SHS | 00430K105 |
| — | AQUINOX PHARMACEUTICALS IN | 130,000 | $1.115M | 0.1% | $8.58 | $12.73 | — | C COM | 03842B101 |
| — | KERYX BIOPHARMACEUTICALS INC | 84,380 | $1.074M | 0.1% | $12.73 | $12.73 | — | COM | 492515101 |
| GILD | GILEAD SCIENCES INC | 10,000 | $981K | 0.1% | $98.10 * | $70.55 | 0.0% | COM | 375558103 |
| PARNEUR | PARNELL PHARMACEUT HLDGS | 196,500 | $964K | 0.1% | $4.91 | $5.72 | — | LTD SHS | Q73622104 |
| VNDA | VANDA PHARMACEUTICALS INC | 100,000 | $930K | 0.1% | $9.30 | — | — | Call | 921659108 |
| VNDA | VANDA PHARMACEUTICALS INC | 100,000 | $930K | 0.1% | $9.30 | — | — | Put | 921659108 |
| — | AGENUS INC | 181,117 | $929K | 0.1% | $5.13 | $3.97 | — | COM NEW | 00847G705 |
| INCY | INCYTE CORP | 10,000 | $917K | 0.1% | $91.70 * | $82.67 | 0.0% | COM | 45337C102 |
| INFIQ | INFINITY PHARMACEUTICALS INC | 61,000 | $853K | 0.1% | $13.98 * | $15.11 | +1.2% | COM | 45665G303 |
| — | ABIOMED INC | 10,000 | $716K | 0.1% | $71.60 | $71.60 | — | COM | 003654100 |
| — | GALMED PHARMACEUTICALS LTD | 75,000 | $706K | 0.1% | $9.41 | $11.47 | — | SHS | M47238106 |
| — | IMPRIVATA INC | 50,000 | $700K | 0.1% | $14.00 | $14.00 | — | COM | 45323J103 |
| — | AUSPEX PHARMACEUTICALS INC | 6,000 | $602K | 0.0% | $100.33 | $100.33 | — | COM | 05211J102 |
| — | ACHAOGEN INC | 60,000 | $586K | 0.0% | $9.77 | $15.47 | — | COM | 004449104 |
| ILMN | ILLUMINA INC | 2,859 | $531K | 0.0% | $185.73 | $188.35 | 0.0% | COM | 452327109 |
| EGRX | EAGLE PHARMACEUTICALS INC | 12,088 | $506K | 0.0% | $41.86 * | $28.37 | 0.0% | COM | 269796108 |
| — | BOVIE MEDICAL CORP | 200,000 | $478K | 0.0% | $2.39 | $2.39 | — | COM | 10211F100 |
| THC | TENET HEALTHCARE CORP | 8,500 | $449K | 0.0% | $52.82 * | $55.41 | -15.6% | COM NEW | 88033G407 |
| MDT | MEDTRONIC PLC | 5,000 | $390K | 0.0% | $78.00 * | $58.10 | 0.0% | SHS | G5960L103 |
| — | MERGE HEALTHCARE INC | 82,427 | $368K | 0.0% | $4.46 | $2.88 | — | COM | 589499102 |
| — | ARIAD PHARMACEUTICALS INC | 41,949 | $346K | 0.0% | $8.25 | $8.25 | — | COM | 04033A100 |
| — | HYPERION THERAPEUTICS INC | 6,913 | $317K | 0.0% | $45.86 | $45.86 | — | COM | 44915N101 |
| — | MYLAN N V | 5,133 | $305K | 0.0% | $59.42 | $59.42 | — | SHS EURO | N59465109 |
| — | LANNET INC | 4,392 | $297K | 0.0% | $67.62 | $45.68 | — | COM | 516012101 |
| — | CAMBREX CORP | 7,331 | $291K | 0.0% | $39.69 | $21.59 | — | COM | 132011107 |
| — | AETNA INC NEW | 2,586 | $275K | 0.0% | $106.34 | $84.96 | — | COM | 00817Y108 |
| UHS | UNIVERSAL HLTH SVCS INC | 2,233 | $263K | 0.0% | $117.78 * | $91.46 | +15.6% | CL B | 913903100 |
| UTHR | UNITED THERAPEUTICS CORP DEL | 1,481 | $255K | 0.0% | $172.18 * | $152.45 | 0.0% | COM | 91307C102 |
| — | CIGNA CORPORATION | 1,970 | $255K | 0.0% | $129.44 | $102.75 | — | COM | 125509109 |
| — | GREATBATCH INC | 4,391 | $254K | 0.0% | $57.85 | $57.85 | — | COM | 39153L106 |
| — | HEALTH NET INC | 4,109 | $249K | 0.0% | $60.60 | $53.53 | — | COM | 42222G108 |
| — | LABORATORY CORP AMER HLDGS | 1,956 | $247K | 0.0% | $126.28 | $126.28 | — | COM NEW | 50540R409 |
| — | WELLCARE HEALTH PLANS INC | 2,690 | $246K | 0.0% | $91.45 | $91.45 | — | COM | 94946T106 |
| — | SURGICAL CARE AFFILIATES | 7,020 | $241K | 0.0% | $34.33 | $33.63 | — | INC COM | 86881L106 |
| PAHC | PHIBRO ANIMAL HEALTH CORP | 6,809 | $241K | 0.0% | $35.39 * | $27.66 | +16.4% | CL A COM | 71742Q106 |
| CAH | CARDINAL HEALTH INC | 2,574 | $232K | 0.0% | $90.13 * | $63.64 | 0.0% | COM | 14149Y108 |
| MCK | MCKESSON CORP | 1,015 | $230K | 0.0% | $226.60 * | $204.26 | 0.0% | COM | 58155Q103 |
| RDNT | RADNET INC | 26,525 | $223K | 0.0% | $8.41 | $8.37 | 0.0% | COM | 750491102 |
| — | LIFEPOINT HOSPITALS INC | 3,025 | $222K | 0.0% | $73.39 | $73.39 | — | COM | 53219L109 |
| — | RITE AID CORP | 25,063 | $218K | 0.0% | $8.70 | $7.50 | — | COM | 767754104 |
| — | TRIPLE-S MGMT CORP | 10,605 | $211K | 0.0% | $19.90 | $20.57 | — | CL B | 896749108 |
| CYTK | CYTOKINETICS INC | 30,227 | $205K | 0.0% | $6.78 * | $7.47 | 0.0% | COM NEW | 23282W605 |
| — | AMSURG CORP | 3,328 | $205K | 0.0% | $61.60 | $61.60 | — | COM | 03232P405 |
| — | MAGELLAN HEALTH INC | 2,900 | $205K | 0.0% | $70.69 | $70.69 | — | COM NEW | 559079207 |
| ICLR | ICON PLC | 2,898 | $204K | 0.0% | $70.39 * | $61.98 | 0.0% | SHS | G4705A100 |
| — | EXACTECH INC | 7,905 | $203K | 0.0% | $25.68 | $24.35 | — | COM | 30064E109 |
| — | CATALENT INC | 6,429 | $200K | 0.0% | $31.11 | $31.11 | — | COM | 148806102 |
| — | LHC GROUP INC | 5,917 | $195K | 0.0% | $32.96 | $31.17 | — | COM | 50187A107 |
| BKD | BROOKDALE SR LIVING INC | 5,000 | $189K | 0.0% | $37.80 * | $36.62 | 0.0% | COM | 112463104 |
| — | OXIGENE INC | 123,518 | $180K | 0.0% | $1.46 | $3.73 | — | COM PAR$.001 | 691828404 |
| ASND | ASCENDIS PHARMA A S | 10,000 | $174K | 0.0% | $17.40 | $17.40 | — | SPONSORED ADR | 04351P101 |
| — | SYNERGETICS USA INC | 21,786 | $117K | 0.0% | $5.37 | $5.37 | — | COM | 87160G107 |
| CLLS | CELLECTIS S A | 1,500 | $52,000 | 0.0% | $34.67 | $34.67 | — | SPONSORED ADS | 15117K103 |
| — | CAPRICOR THERAPEUTICS INC | 4,000 | $35,000 | 0.0% | $8.75 | $8.75 | — | COM | 14070B101 |
| ESPR | ESPERION THERAPEUTICS INC NE | 102 | $9,000 | 0.0% | $88.24 * | $30.61 | +110.8% | COM | 29664W105 |
| — | CELLULAR DYNAMICS INTL INC | 164 | $3,000 | 0.0% | $18.29 | $6.10 | — | COM | 15117V109 |
| — | TRANSGENOMIC INC | 357 | $1,000 | 0.0% | $2.80 | $4.58 | — | COM NEW | 89365K305 |
| — | MANNKIND CORP | 100 | $1,000 | 0.0% | $10.00 | — | — | Call | 56400P201 |
| — | DBV TECHNOLOGIES S A | 2 | $0 | 0.0% | $0.00 | $27.12 | — | SPONSORED ADR | 23306J101 |