5AM Venture Management, LLC Long-Term Concentrated

Location: San Francisco, CA

CIK: 0001799883 · Show all filings

Period: Q2 2025 (← Previous) (Next →)

Filing Date: Aug 14, 2025

Total Value: $260M (100.0% shares, 0.0% debt)

Holdings (29)

SKYE SKYE BIOSCIENCE INC 15.9%

Value $41.44M Shares 9,913,168 Est. Cost $11.84 Unrealized -82.5%

TRDA ENTRADA THERAPEUTICS INC 11.1%

Value $28.95M Shares 4,308,379 Est. Cost $17.12 Unrealized —

DNTH DIANTHUS THERAPEUTICS INC 7.1%

Value $18.35M Shares 984,725 Est. Cost $12.62 Unrealized +48.7%

ELVN ENLIVEN THERAPEUTICS INC 6.0%

Value $15.5M Shares 772,477 Est. Cost $20.34 Unrealized -6.9%

PHVS PHARVARIS N V 5.4%

Value $14.04M Shares 797,600 Est. Cost $19.05 Unrealized -15.4%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 5.1%

Value $13.33M Shares 282,313 Est. Cost $25.81 Unrealized +57.8%

CNTA CENTESSA PHARMACEUTICALS PLC 4.2%

Value $10.92M Shares 830,945 Est. Cost $11.45 Unrealized —

— VOR BIOPHARMA INC 4.0%

Value $10.31M Shares 6,361,723 Est. Cost $43.10 Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 4.0%

Value $10.3M Shares 736,595 Est. Cost $17.93 Unrealized -24.3%

TECX TECTONIC THERAPEUTIC INC 3.9%

Value $10.17M Shares 511,660 Est. Cost $15.77 Unrealized +28.5%

CLDX CELLDEX THERAPEUTICS INC NEW 3.9%

Value $10.12M Shares 497,270 Est. Cost $32.09 Unrealized -39.3%

EYPT EYEPOINT PHARMACEUTICALS INC 3.8%

Value $9.88M Shares 1,050,000 Est. Cost $9.03 Unrealized -23.5%

TYRA TYRA BIOSCIENCES INC 3.5%

Value $8.989M Shares 939,298 Est. Cost $15.18 Unrealized -37.4%

PRAX PRAXIS PRECISION MEDICINES I 2.7%

Value $7.149M Shares 170,000 Est. Cost $44.86 Unrealized -15.1%

GHRS GH RESEARCH PLC 2.7%

Value $6.981M Shares 572,665 Est. Cost $10.15 Unrealized +8.0%

ERAS ERASCA INC 2.6%

Value $6.865M Shares 5,405,404 Est. Cost $2.16 Unrealized -38.0%

BHVN BIOHAVEN LTD 2.6%

Value $6.758M Shares 478,972 Est. Cost $33.89 Unrealized -47.4%

VKTX VIKING THERAPEUTICS INC 1.9%

Value $5.024M Shares 189,593 Est. Cost $14.60 Unrealized +80.4%

— SCPHARMACEUTICALS INC 1.8%

Value $4.574M Shares 1,200,647 Est. Cost $5.92 Unrealized —

CAMP CAMP4 THERAPEUTICS CORP 1.6%

Value $4.245M Shares 2,927,915 Est. Cost $8.22 Unrealized -75.8%

ARTV ARTIVA BIOTHERAPEUTICS INC 1.4%

Value $3.553M Shares 2,353,304 Est. Cost $11.59 Unrealized -81.9%

SRZN SURROZEN INC 1.1%

Value $2.771M Shares 310,000 Est. Cost $11.62 Unrealized -21.4%

SLN SILENCE THERAPEUTICS PLC 1.1%

Value $2.762M Shares 476,200 Est. Cost $21.60 Unrealized —

TARA PROTARA THERAPEUTICS INC 0.9%

Value $2.424M Shares 800,000 Est. Cost $3.23 Unrealized +6.8%

ALEC ALECTOR INC 0.5%

Value $1.394M Shares 995,841 Est. Cost $3.76 Unrealized -66.7%

— RALLYBIO CORP 0.5%

Value $1.227M Shares 3,630,724 Est. Cost $17.58 Unrealized —

— ADVERUM BIOTECHNOLOGIES INC 0.4%

Value $1.165M Shares 541,666 Est. Cost $14.14 Unrealized —

ZNTL ZENTALIS PHARMACEUTICALS INC 0.2%

Value $568K Shares 490,000 Est. Cost $23.99 Unrealized -94.5%

— MERSANA THERAPEUTICS INC 0.1%

Value $386K Shares 1,305,000 Est. Cost $4.03 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
SKYE	SKYE BIOSCIENCE INC	9,913,168	$41.44M	15.9%	$11.84	-82.5%	COM NEW	83086J200
TRDA	ENTRADA THERAPEUTICS INC	4,308,379	$28.95M	11.1%	$17.12	—	COM	29384C108
DNTH	DIANTHUS THERAPEUTICS INC	984,725	$18.35M	7.1%	$12.62	+48.7%	COM	252828108
ELVN	ENLIVEN THERAPEUTICS INC	772,477	$15.5M	6.0%	$20.34	-6.9%	COM	29337E102
PHVS	PHARVARIS N V	797,600	$14.04M	5.4%	$19.05	-15.4%	COM	N69605108
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	282,313	$13.33M	5.1%	$25.81	+57.8%	CLASS A ORD	61559X104
CNTA	CENTESSA PHARMACEUTICALS PLC	830,945	$10.92M	4.2%	$11.45	—	SPONSORED ADS	152309100
—	VOR BIOPHARMA INC	6,361,723	$10.31M	4.0%	$43.10	—	COM	929033108
VRDN	VIRIDIAN THERAPEUTICS INC	736,595	$10.3M	4.0%	$17.93	-24.3%	COM	92790C104
TECX	TECTONIC THERAPEUTIC INC	511,660	$10.17M	3.9%	$15.77	+28.5%	COM	878972108
CLDX	CELLDEX THERAPEUTICS INC NEW	497,270	$10.12M	3.9%	$32.09	-39.3%	COM NEW	15117B202
EYPT	EYEPOINT PHARMACEUTICALS INC	1,050,000	$9.88M	3.8%	$9.03	-23.5%	COM NEW	30233G209
TYRA	TYRA BIOSCIENCES INC	939,298	$8.989M	3.5%	$15.18	-37.4%	COM	90240B106
PRAX	PRAXIS PRECISION MEDICINES I	170,000	$7.149M	2.7%	$44.86	-15.1%	COM NEW	74006W207
GHRS	GH RESEARCH PLC	572,665	$6.981M	2.7%	$10.15	+8.0%	ORDINARY SHARES	G3855L106
ERAS	ERASCA INC	5,405,404	$6.865M	2.6%	$2.16	-38.0%	COM	29479A108
BHVN	BIOHAVEN LTD	478,972	$6.758M	2.6%	$33.89	-47.4%	COM	G1110E107
VKTX	VIKING THERAPEUTICS INC	189,593	$5.024M	1.9%	$14.60	+80.4%	COM	92686J106
—	SCPHARMACEUTICALS INC	1,200,647	$4.574M	1.8%	$5.92	—	COM	810648105
CAMP	CAMP4 THERAPEUTICS CORP	2,927,915	$4.245M	1.6%	$8.22	-75.8%	COM	13463J101
ARTV	ARTIVA BIOTHERAPEUTICS INC	2,353,304	$3.553M	1.4%	$11.59	-81.9%	COM	04317A107
SRZN	SURROZEN INC	310,000	$2.771M	1.1%	$11.62	-21.4%	COM NEW	86889P208
SLN	SILENCE THERAPEUTICS PLC	476,200	$2.762M	1.1%	$21.60	—	ADS	82686Q101
TARA	PROTARA THERAPEUTICS INC	800,000	$2.424M	0.9%	$3.23	+6.8%	COM STK	74365U107
ALEC	ALECTOR INC	995,841	$1.394M	0.5%	$3.76	-66.7%	COM	014442107
—	RALLYBIO CORP	3,630,724	$1.227M	0.5%	$17.58	—	COM	75120L100
—	ADVERUM BIOTECHNOLOGIES INC	541,666	$1.165M	0.4%	$14.14	—	COM NEW	00773U207
ZNTL	ZENTALIS PHARMACEUTICALS INC	490,000	$568K	0.2%	$23.99	-94.5%	COM	98943L107
—	MERSANA THERAPEUTICS INC	1,305,000	$386K	0.1%	$4.03	—	COM	59045L106