5AM Venture Management, LLC Long-Term Concentrated

Location: San Francisco, CA

CIK: 0001799883 · Show all filings

Period: Q1 2025 (← Previous) (Next →)

Filing Date: May 15, 2025

Total Value: $264M (100.0% shares, 0.0% debt)

Holdings (31)

TRDA ENTRADA THERAPEUTICS INC 15.1%

Value $39.85M Shares 4,408,379 Est. Cost $17.12 Unrealized —

ELVN ENLIVEN THERAPEUTICS INC 9.8%

Value $26.03M Shares 1,322,477 Est. Cost $20.34 Unrealized +5.8%

DNTH DIANTHUS THERAPEUTICS INC 7.1%

Value $18.64M Shares 1,027,711 Est. Cost $12.62 Unrealized +74.7%

SKYE SKYE BIOSCIENCE INC 6.0%

Value $15.76M Shares 9,913,168 Est. Cost $11.84 Unrealized -76.9%

PHVS PHARVARIS N V 4.7%

Value $12.52M Shares 797,600 Est. Cost $19.05 Unrealized -11.5%

CNTA CENTESSA PHARMACEUTICALS PLC 4.5%

Value $11.95M Shares 830,945 Est. Cost $11.45 Unrealized —

CAMP CAMP4 THERAPEUTICS CORP 4.4%

Value $11.71M Shares 2,927,915 Est. Cost $8.22 Unrealized -41.1%

BHVN BIOHAVEN LTD 4.4%

Value $11.51M Shares 478,972 Est. Cost $33.89 Unrealized +4.1%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 4.2%

Value $11.03M Shares 282,313 Est. Cost $25.81 Unrealized +66.9%

VRDN VIRIDIAN THERAPEUTICS INC 3.8%

Value $9.929M Shares 736,595 Est. Cost $17.93 Unrealized -5.0%

TECX TECTONIC THERAPEUTIC INC 3.4%

Value $9.061M Shares 511,660 Est. Cost $15.77 Unrealized +106.6%

CLDX CELLDEX THERAPEUTICS INC NEW 3.4%

Value $9.025M Shares 497,270 Est. Cost $32.09 Unrealized -30.4%

TYRA TYRA BIOSCIENCES INC 3.3%

Value $8.735M Shares 939,298 Est. Cost $15.18 Unrealized -14.8%

ERAS ERASCA INC 2.8%

Value $7.405M Shares 5,405,404 Est. Cost $2.16 Unrealized -20.5%

ARTV ARTIVA BIOTHERAPEUTICS INC 2.7%

Value $7.06M Shares 2,353,304 Est. Cost $11.59 Unrealized -53.4%

ANAB ANAPTYSBIO INC 2.5%

Value $6.65M Shares 357,733 Est. Cost $28.24 Unrealized -40.9%

PRAX PRAXIS PRECISION MEDICINES I 2.4%

Value $6.438M Shares 170,000 Est. Cost $44.86 Unrealized +39.2%

GHRS GH RESEARCH PLC 2.4%

Value $6.316M Shares 572,665 Est. Cost $10.15 Unrealized +10.2%

EYPT EYEPOINT PHARMACEUTICALS INC 2.2%

Value $5.691M Shares 1,050,000 Est. Cost $9.03 Unrealized -22.5%

VKTX VIKING THERAPEUTICS INC 1.7%

Value $4.579M Shares 189,593 Est. Cost $14.60 Unrealized +116.5%

— VOR BIOPHARMA INC 1.7%

Value $4.565M Shares 6,361,723 Est. Cost $43.10 Unrealized —

SRZN SURROZEN INC 1.4%

Value $3.615M Shares 310,000 Est. Cost $11.62 Unrealized 0.0%

TARA PROTARA THERAPEUTICS INC 1.3%

Value $3.408M Shares 800,000 Est. Cost $3.23 Unrealized +38.3%

— SCPHARMACEUTICALS INC 1.2%

Value $3.158M Shares 1,200,647 Est. Cost $5.92 Unrealized —

— RALLYBIO CORP 0.9%

Value $2.376M Shares 3,630,724 Est. Cost $17.58 Unrealized —

— ADVERUM BIOTECHNOLOGIES INC 0.9%

Value $2.367M Shares 541,666 Est. Cost $14.14 Unrealized —

SLN SILENCE THERAPEUTICS PLC 0.5%

Value $1.343M Shares 476,200 Est. Cost $21.60 Unrealized —

ALEC ALECTOR INC 0.5%

Value $1.225M Shares 995,841 Est. Cost $3.76 Unrealized -56.7%

— CIDARA THERAPEUTICS INC 0.5%

Value $1.222M Shares 56,725 Est. Cost $11.94 Unrealized —

ZNTL ZENTALIS PHARMACEUTICALS INC 0.3%

Value $779K Shares 490,000 Est. Cost $23.99 Unrealized -91.0%

— MERSANA THERAPEUTICS INC 0.2%

Value $449K Shares 1,305,000 Est. Cost $4.03 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
TRDA	ENTRADA THERAPEUTICS INC	4,408,379	$39.85M	15.1%	$17.12	—	COM	29384C108
ELVN	ENLIVEN THERAPEUTICS INC	1,322,477	$26.03M	9.8%	$20.34	+5.8%	COM	29337E102
DNTH	DIANTHUS THERAPEUTICS INC	1,027,711	$18.64M	7.1%	$12.62	+74.7%	COM	252828108
SKYE	SKYE BIOSCIENCE INC	9,913,168	$15.76M	6.0%	$11.84	-76.9%	COM NEW	83086J200
PHVS	PHARVARIS N V	797,600	$12.52M	4.7%	$19.05	-11.5%	COM	N69605108
CNTA	CENTESSA PHARMACEUTICALS PLC	830,945	$11.95M	4.5%	$11.45	—	SPONSORED ADS	152309100
CAMP	CAMP4 THERAPEUTICS CORP	2,927,915	$11.71M	4.4%	$8.22	-41.1%	COM	13463J101
BHVN	BIOHAVEN LTD	478,972	$11.51M	4.4%	$33.89	+4.1%	COM	G1110E107
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	282,313	$11.03M	4.2%	$25.81	+66.9%	CLASS A ORD	61559X104
VRDN	VIRIDIAN THERAPEUTICS INC	736,595	$9.929M	3.8%	$17.93	-5.0%	COM	92790C104
TECX	TECTONIC THERAPEUTIC INC	511,660	$9.061M	3.4%	$15.77	+106.6%	COM	878972108
CLDX	CELLDEX THERAPEUTICS INC NEW	497,270	$9.025M	3.4%	$32.09	-30.4%	COM NEW	15117B202
TYRA	TYRA BIOSCIENCES INC	939,298	$8.735M	3.3%	$15.18	-14.8%	COM	90240B106
ERAS	ERASCA INC	5,405,404	$7.405M	2.8%	$2.16	-20.5%	COM	29479A108
ARTV	ARTIVA BIOTHERAPEUTICS INC	2,353,304	$7.06M	2.7%	$11.59	-53.4%	COM	04317A107
ANAB	ANAPTYSBIO INC	357,733	$6.65M	2.5%	$28.24	-40.9%	COM	032724106
PRAX	PRAXIS PRECISION MEDICINES I	170,000	$6.438M	2.4%	$44.86	+39.2%	COM NEW	74006W207
GHRS	GH RESEARCH PLC	572,665	$6.316M	2.4%	$10.15	+10.2%	ORDINARY SHARES	G3855L106
EYPT	EYEPOINT PHARMACEUTICALS INC	1,050,000	$5.691M	2.2%	$9.03	-22.5%	COM NEW	30233G209
VKTX	VIKING THERAPEUTICS INC	189,593	$4.579M	1.7%	$14.60	+116.5%	COM	92686J106
—	VOR BIOPHARMA INC	6,361,723	$4.565M	1.7%	$43.10	—	COM	929033108
SRZN	SURROZEN INC	310,000	$3.615M	1.4%	$11.62	0.0%	COM NEW	86889P208
TARA	PROTARA THERAPEUTICS INC	800,000	$3.408M	1.3%	$3.23	+38.3%	COM STK	74365U107
—	SCPHARMACEUTICALS INC	1,200,647	$3.158M	1.2%	$5.92	—	COM	810648105
—	RALLYBIO CORP	3,630,724	$2.376M	0.9%	$17.58	—	COM	75120L100
—	ADVERUM BIOTECHNOLOGIES INC	541,666	$2.367M	0.9%	$14.14	—	COM NEW	00773U207
SLN	SILENCE THERAPEUTICS PLC	476,200	$1.343M	0.5%	$21.60	—	ADS	82686Q101
ALEC	ALECTOR INC	995,841	$1.225M	0.5%	$3.76	-56.7%	COM	014442107
—	CIDARA THERAPEUTICS INC	56,725	$1.222M	0.5%	$11.94	—	COM NEW	171757206
ZNTL	ZENTALIS PHARMACEUTICALS INC	490,000	$779K	0.3%	$23.99	-91.0%	COM	98943L107
—	MERSANA THERAPEUTICS INC	1,305,000	$449K	0.2%	$4.03	—	COM	59045L106