Sofinnova Investments, Inc. Quant / Systematic

CIK: 0001631134 · Show all filings

Period: Q4 2021 (← Previous) (Next →)

Filing Date: Feb 14, 2022

Total Value ($000): $1,712,054 (100.0% shares, 0.0% debt)

Holdings (70)

NTRA Natera Inc 16.9%
Value ($000) $289,785 Shares 3,102,960 Est. Cost $9.81 Unrealized +958.0%
— Karuna Therapeutics, Inc. 14.9%
Value ($000) $255,853 Shares 1,953,077 Est. Cost $26.41 Unrealized —
VERA Vera Therapeutics, Inc. 4.5%
Value ($000) $77,883 Shares 2,914,776 Est. Cost $15.54 Unrealized +42.3%
RHHBY Roche Holding AG 4.1%
Value ($000) $70,764 Shares 1,369,011 Est. Cost $51.69 Unrealized —
ASND Ascendis Pharma A/S 3.9%
Value ($000) $67,241 Shares 499,824 Est. Cost $69.98 Unrealized —
SPY SPDR S&P 500 ETF Trust 2.8%
Value ($000) $47,496 Shares 100,000 Est. Cost — Unrealized —
— Aerovate Therapeutics, Inc. 2.6%
Value ($000) $44,315 Shares 3,758,686 Est. Cost $22.83 Unrealized —
ABBV Abbvie Inc 2.5%
Value ($000) $42,247 Shares 312,018 Est. Cost $97.79 Unrealized +4.0%
QQQ Invesco QQQ Trust Series 1 2.3%
Value ($000) $39,785 Shares 100,000 Est. Cost — Unrealized —
— Y-mAbs Therapeutics, Inc 2.1%
Value ($000) $35,569 Shares 2,194,278 Est. Cost $26.75 Unrealized —
IWM iShares Russell 2000 ETF 1.9%
Value ($000) $33,368 Shares 150,000 Est. Cost — Unrealized —
RGNX Regenxbio Inc 1.9%
Value ($000) $32,964 Shares 1,008,081 Est. Cost $34.35 Unrealized -0.9%
TVTX Travere Therapeutics Inc 1.9%
Value ($000) $32,308 Shares 1,040,858 Est. Cost $24.05 Unrealized +17.1%
UTHR United Therapeutics Corp 1.6%
Value ($000) $28,037 Shares 129,754 Est. Cost $97.02 Unrealized +102.3%
HRTX Heron Therapeutics Inc 1.6%
Value ($000) $26,781 Shares 2,933,351 Est. Cost $13.62 Unrealized -25.0%
— ChemoCentryx Inc 1.6%
Value ($000) $26,624 Shares 731,222 Est. Cost $29.48 Unrealized —
— Blueprint Medicines Corp 1.5%
Value ($000) $26,261 Shares 245,182 Est. Cost $103.92 Unrealized —
ALGN Align Technology Inc 1.5%
Value ($000) $25,077 Shares 38,159 Est. Cost $554.11 Unrealized +16.0%
— Horizon Therapeutics PLC 1.4%
Value ($000) $23,900 Shares 221,792 Est. Cost $109.02 Unrealized —
GH Guardant Health Inc 1.4%
Value ($000) $23,261 Shares 232,563 Est. Cost $106.07 Unrealized -2.5%
XNCR Xencor Inc 1.3%
Value ($000) $21,546 Shares 537,030 Est. Cost $37.91 Unrealized 0.0%
CYTK Cytokinetics Inc 1.2%
Value ($000) $21,166 Shares 464,366 Est. Cost $22.36 Unrealized +72.5%
BCRX BioCryst Pharmaceuticals Inc 1.2%
Value ($000) $20,920 Shares 1,510,473 Est. Cost $13.23 Unrealized 0.0%
SNDX Syndax Pharmaceuticals Inc 1.2%
Value ($000) $20,822 Shares 951,226 Est. Cost $17.69 Unrealized +4.5%
IRTC iRhythm Technologies Inc 1.2%
Value ($000) $19,876 Shares 168,882 Est. Cost $91.74 Unrealized 0.0%
DXCM Dexcom Inc 1.0%
Value ($000) $17,399 Shares 32,404 Est. Cost $97.33 Unrealized +47.6%
PTGX Protagonist Therapeutics Inc 1.0%
Value ($000) $16,493 Shares 482,257 Est. Cost $27.72 Unrealized +14.0%
— Inhibrx Inc 0.9%
Value ($000) $16,100 Shares 368,679 Est. Cost $43.67 Unrealized —
— Nextcure, Inc 0.9%
Value ($000) $16,031 Shares 2,671,856 Est. Cost $10.01 Unrealized —
GRTX Galera Therapeutics, Inc 0.8%
Value ($000) $14,154 Shares 3,083,712 Est. Cost $12.19 Unrealized -72.9%
— Inozyme Pharma, Inc. 0.8%
Value ($000) $13,833 Shares 2,028,308 Est. Cost $26.29 Unrealized —
IMTX Immatics NV 0.8%
Value ($000) $13,798 Shares 1,026,623 Est. Cost $11.81 Unrealized +5.8%
— Bolt Biotherapeutics, Inc. 0.8%
Value ($000) $13,497 Shares 2,754,437 Est. Cost $32.91 Unrealized —
— Iveric Bio Inc 0.8%
Value ($000) $13,356 Shares 798,789 Est. Cost $16.51 Unrealized —
— Nucana Plc 0.8%
Value ($000) $13,328 Shares 5,599,999 Est. Cost $9.47 Unrealized —
— Jounce Therapeutics Inc 0.8%
Value ($000) $13,216 Shares 1,582,777 Est. Cost $7.80 Unrealized —
— ImmunoGen Inc 0.8%
Value ($000) $12,984 Shares 1,749,882 Est. Cost $7.42 Unrealized —
— Akouos, Inc. 0.8%
Value ($000) $12,878 Shares 1,515,074 Est. Cost $22.50 Unrealized —
INSM Insmed Inc 0.7%
Value ($000) $12,034 Shares 441,773 Est. Cost $31.01 Unrealized -7.8%
FULC Fulcrum Therapeutics Inc 0.6%
Value ($000) $10,927 Shares 617,670 Est. Cost $19.74 Unrealized +0.4%
SRPT Sarepta Therapeutics Inc 0.6%
Value ($000) $10,872 Shares 120,732 Est. Cost $75.81 Unrealized +12.8%
CLDX Celldex Therapeutics Inc 0.6%
Value ($000) $10,492 Shares 271,533 Est. Cost $35.60 Unrealized +22.4%
— Checkmate Pharmaceuticals Inc 0.6%
Value ($000) $10,351 Shares 3,606,707 Est. Cost $11.51 Unrealized —
PTGX Protagonist Therapeutics Inc 0.6%
Value ($000) $10,281 Shares 300,600 Est. Cost $27.72 Unrealized +14.0%
QURE Uniqure NV 0.6%
Value ($000) $10,267 Shares 495,025 Est. Cost $29.82 Unrealized -3.8%
— ObsEva SA 0.6%
Value ($000) $9,452 Shares 4,749,623 Est. Cost $13.49 Unrealized —
VIR Vir Biotechnology Inc 0.5%
Value ($000) $8,374 Shares 200,000 Est. Cost — Unrealized —
BMRN Biomarin Pharmaceutical Inc 0.5%
Value ($000) $7,715 Shares 87,322 Est. Cost $82.51 Unrealized 0.0%
— Zymeworks Inc 0.4%
Value ($000) $6,437 Shares 392,712 Est. Cost $29.04 Unrealized —
— Agenus Inc 0.4%
Value ($000) $6,315 Shares 1,961,032 Est. Cost $2.72 Unrealized —
— Nucana Plc 0.3%
Value ($000) $5,712 Shares 2,400,000 Est. Cost $4.99 Unrealized —
IFRX Inflarx NV 0.3%
Value ($000) $5,530 Shares 1,161,736 Est. Cost $4.02 Unrealized 0.0%
— Adicet Bio Inc 0.3%
Value ($000) $5,439 Shares 310,988 Est. Cost $17.49 Unrealized —
PTCT PTC Therapeutics Inc 0.3%
Value ($000) $5,275 Shares 132,448 Est. Cost $47.53 Unrealized -19.5%
KURA Kura Oncology Inc 0.3%
Value ($000) $5,168 Shares 369,173 Est. Cost $21.22 Unrealized -23.6%
— Sierra Oncology Inc 0.3%
Value ($000) $4,615 Shares 212,281 Est. Cost $21.89 Unrealized —
AXSM Axsome Therapeutics Inc 0.2%
Value ($000) $3,778 Shares 100,000 Est. Cost — Unrealized —
NVCR Novocure Ltd 0.2%
Value ($000) $3,754 Shares 50,000 Est. Cost — Unrealized —
— Intra-Cellular Therapies Inc 0.2%
Value ($000) $2,979 Shares 56,915 Est. Cost $27.53 Unrealized —
KURA Kura Oncology Inc 0.1%
Value ($000) $2,450 Shares 175,000 Est. Cost $21.22 Unrealized -23.6%
— Intercept Pharmaceuticals Inc 0.1%
Value ($000) $2,450 Shares 150,400 Est. Cost — Unrealized —
— Cyteir Therapeutics Inc 0.1%
Value ($000) $2,040 Shares 179,450 Est. Cost $21.40 Unrealized —
— Marinus Pharmaceuticals Inc 0.1%
Value ($000) $2,035 Shares 171,338 Est. Cost $13.02 Unrealized —
— Mink Therapeutics Inc 0.1%
Value ($000) $1,541 Shares 345,499 Est. Cost $4.46 Unrealized —
— Aligos Therapeutics Inc 0.1%
Value ($000) $1,517 Shares 127,791 Est. Cost $27.22 Unrealized —
— Synlogic Inc. 0.1%
Value ($000) $1,391 Shares 574,972 Est. Cost $9.38 Unrealized —
PDSB PDS Biotechnology Corporation 0.1%
Value ($000) $1,155 Shares 142,635 Est. Cost $8.36 Unrealized +28.7%
— Fusion Pharmaceuticals Inc 0.0%
Value ($000) $326 Shares 78,066 Est. Cost $7.92 Unrealized —
PODD Insulet Corp 0.0%
Value ($000) $284 Shares 1,066 Est. Cost $270.80 Unrealized +7.1%
EW Edwards Lifesciences Corp 0.0%
Value ($000) $182 Shares 1,406 Est. Cost $116.64 Unrealized 0.0%