5AM Venture Management, LLC Long-Term Concentrated

Location: San Francisco, CA

CIK: 0001799883 · Show all filings

Period: Q4 2023 (← Previous) (Next →)

Filing Date: Feb 14, 2024

Total Value: $377M (100.0% shares, 0.0% debt)

Holdings (25)

ELVN ENLIVEN THERAPEUTICS INC 18.9%

Value $71.43M Shares 5,160,975 Est. Cost $20.34 Unrealized -39.8%

TRDA ENTRADA THERAPEUTICS INC 17.6%

Value $66.52M Shares 4,408,379 Est. Cost $17.12 Unrealized —

PHVS PHARVARIS N V 5.9%

Value $22.37M Shares 797,600 Est. Cost $19.05 Unrealized +6.2%

CLDX CELLDEX THERAPEUTICS INC NEW 5.2%

Value $19.72M Shares 497,270 Est. Cost $32.09 Unrealized -8.3%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 4.8%

Value $18.28M Shares 302,630 Est. Cost $25.81 Unrealized +99.7%

BHVN BIOHAVEN LTD 4.5%

Value $17.12M Shares 399,972 Est. Cost $31.10 Unrealized 0.0%

IRON DISC MEDICINE INC 4.5%

Value $16.99M Shares 294,221 Est. Cost $49.79 Unrealized +2.8%

DNTH DIANTHUS THERAPEUTICS INC 4.1%

Value $15.31M Shares 1,472,264 Est. Cost $12.62 Unrealized -12.4%

— MERUS N V 3.8%

Value $14.34M Shares 521,531 Est. Cost $27.50 Unrealized —

— VOR BIOPHARMA INC 3.8%

Value $14.31M Shares 6,361,723 Est. Cost $43.10 Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 3.4%

Value $12.78M Shares 586,595 Est. Cost $17.56 Unrealized -10.1%

— MIRATI THERAPEUTICS INC 3.0%

Value $11.31M Shares 192,500 Est. Cost $36.13 Unrealized —

VKTX VIKING THERAPEUTICS INC 2.9%

Value $10.89M Shares 585,000 Est. Cost $14.60 Unrealized -10.4%

— RALLYBIO CORP 2.3%

Value $8.677M Shares 3,630,724 Est. Cost $17.58 Unrealized —

TYRA TYRA BIOSCIENCES INC 2.0%

Value $7.686M Shares 554,979 Est. Cost $14.34 Unrealized -9.7%

ANAB ANAPTYSBIO INC 2.0%

Value $7.663M Shares 357,733 Est. Cost $28.24 Unrealized -38.9%

— SCPHARMACEUTICALS INC 2.0%

Value $7.528M Shares 1,200,647 Est. Cost $5.92 Unrealized —

ZNTL ZENTALIS PHARMACEUTICALS INC 2.0%

Value $7.423M Shares 490,000 Est. Cost $23.99 Unrealized -39.2%

— SPRUCE BIOSCIENCES INC 1.8%

Value $6.927M Shares 2,364,000 Est. Cost $2.21 Unrealized —

RNAM AVIDITY BIOSCIENCES INC 1.6%

Value $6.023M Shares 665,555 Est. Cost $18.92 Unrealized -64.7%

COGT COGENT BIOSCIENCES INC 1.2%

Value $4.648M Shares 790,440 Est. Cost $6.91 Unrealized +10.9%

— MERSANA THERAPEUTICS INC 0.8%

Value $3.028M Shares 1,305,000 Est. Cost $4.03 Unrealized —

— HOMOLOGY MEDICINES INC 0.7%

Value $2.758M Shares 4,535,919 Est. Cost $20.70 Unrealized —

GHRS GH RESEARCH PLC 0.6%

Value $2.346M Shares 404,404 Est. Cost $11.07 Unrealized -36.2%

— CIDARA THERAPEUTICS INC 0.2%

Value $901K Shares 1,134,511 Est. Cost $3.84 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ELVN	ENLIVEN THERAPEUTICS INC	5,160,975	$71.43M	18.9%	$20.34	-39.8%	COM	29337E102
TRDA	ENTRADA THERAPEUTICS INC	4,408,379	$66.52M	17.6%	$17.12	—	COM	29384C108
PHVS	PHARVARIS N V	797,600	$22.37M	5.9%	$19.05	+6.2%	COM	N69605108
CLDX	CELLDEX THERAPEUTICS INC NEW	497,270	$19.72M	5.2%	$32.09	-8.3%	COM NEW	15117B202
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	302,630	$18.28M	4.8%	$25.81	+99.7%	CLASS A ORD	61559X104
BHVN	BIOHAVEN LTD	399,972	$17.12M	4.5%	$31.10	0.0%	COM	G1110E107
IRON	DISC MEDICINE INC	294,221	$16.99M	4.5%	$49.79	+2.8%	COM	254604101
DNTH	DIANTHUS THERAPEUTICS INC	1,472,264	$15.31M	4.1%	$12.62	-12.4%	COM	252828108
—	MERUS N V	521,531	$14.34M	3.8%	$27.50	—	COM	N5749R100
—	VOR BIOPHARMA INC	6,361,723	$14.31M	3.8%	$43.10	—	COM	929033108
VRDN	VIRIDIAN THERAPEUTICS INC	586,595	$12.78M	3.4%	$17.56	-10.1%	COM	92790C104
—	MIRATI THERAPEUTICS INC	192,500	$11.31M	3.0%	$36.13	—	COM	60468T105
VKTX	VIKING THERAPEUTICS INC	585,000	$10.89M	2.9%	$14.60	-10.4%	COM	92686J106
—	RALLYBIO CORP	3,630,724	$8.677M	2.3%	$17.58	—	COM	75120L100
TYRA	TYRA BIOSCIENCES INC	554,979	$7.686M	2.0%	$14.34	-9.7%	COM	90240B106
ANAB	ANAPTYSBIO INC	357,733	$7.663M	2.0%	$28.24	-38.9%	COM	032724106
—	SCPHARMACEUTICALS INC	1,200,647	$7.528M	2.0%	$5.92	—	COM	810648105
ZNTL	ZENTALIS PHARMACEUTICALS INC	490,000	$7.423M	2.0%	$23.99	-39.2%	COM	98943L107
—	SPRUCE BIOSCIENCES INC	2,364,000	$6.927M	1.8%	$2.21	—	COM	85209E109
RNAM	AVIDITY BIOSCIENCES INC	665,555	$6.023M	1.6%	$18.92	-64.7%	COM	05370A108
COGT	COGENT BIOSCIENCES INC	790,440	$4.648M	1.2%	$6.91	+10.9%	COM	19240Q201
—	MERSANA THERAPEUTICS INC	1,305,000	$3.028M	0.8%	$4.03	—	COM	59045L106
—	HOMOLOGY MEDICINES INC	4,535,919	$2.758M	0.7%	$20.70	—	COM	438083107
GHRS	GH RESEARCH PLC	404,404	$2.346M	0.6%	$11.07	-36.2%	ORDINARY SHARES	G3855L106
—	CIDARA THERAPEUTICS INC	1,134,511	$901K	0.2%	$3.84	—	COM	171757107