5AM Venture Management, LLC Long-Term Concentrated

Location: San Francisco, CA

CIK: 0001799883 · Show all filings

Period: Q1 2024 (← Previous) (Next →)

Filing Date: May 15, 2024

Total Value: $447M (100.0% shares, 0.0% debt)

Holdings (26)

ELVN ENLIVEN THERAPEUTICS INC 15.1%

Value $67.47M Shares 3,835,975 Est. Cost $20.34 Unrealized -24.6%

TRDA ENTRADA THERAPEUTICS INC 14.0%

Value $62.47M Shares 4,408,379 Est. Cost $17.12 Unrealized —

DNTH DIANTHUS THERAPEUTICS INC 8.3%

Value $37.26M Shares 1,242,029 Est. Cost $12.62 Unrealized +72.3%

— MERUS N V 5.5%

Value $24.71M Shares 548,825 Est. Cost $28.37 Unrealized —

CLDX CELLDEX THERAPEUTICS INC NEW 4.7%

Value $20.87M Shares 497,270 Est. Cost $32.09 Unrealized +28.0%

PRAX PRAXIS PRECISION MEDICINES I 4.6%

Value $20.75M Shares 340,000 Est. Cost $44.86 Unrealized 0.0%

VKTX VIKING THERAPEUTICS INC 4.4%

Value $19.48M Shares 237,560 Est. Cost $14.60 Unrealized +204.9%

PHVS PHARVARIS N V 4.1%

Value $18.43M Shares 797,600 Est. Cost $19.05 Unrealized +39.4%

BHVN BIOHAVEN LTD 3.9%

Value $17.5M Shares 319,972 Est. Cost $31.10 Unrealized +59.2%

RNAM AVIDITY BIOSCIENCES INC 3.8%

Value $16.98M Shares 665,555 Est. Cost $18.92 Unrealized -17.1%

TYRA TYRA BIOSCIENCES INC 3.4%

Value $15.4M Shares 939,298 Est. Cost $15.18 Unrealized +8.0%

— VOR BIOPHARMA INC 3.4%

Value $15.08M Shares 6,361,723 Est. Cost $43.10 Unrealized —

MLTX MOONLAKE IMMUNOTHERAPEUTICS 3.2%

Value $14.18M Shares 282,313 Est. Cost $25.81 Unrealized +110.2%

CNTA CENTESSA PHARMACEUTICALS PLC 3.1%

Value $14.07M Shares 1,245,000 Est. Cost $11.30 Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 2.9%

Value $12.9M Shares 736,595 Est. Cost $17.93 Unrealized +8.1%

SLN SILENCE THERAPEUTICS PLC 2.3%

Value $10.29M Shares 476,200 Est. Cost $21.60 Unrealized —

ANAB ANAPTYSBIO INC 1.8%

Value $8.056M Shares 357,733 Est. Cost $28.24 Unrealized -16.2%

ZNTL ZENTALIS PHARMACEUTICALS INC 1.7%

Value $7.722M Shares 490,000 Est. Cost $23.99 Unrealized -42.7%

— ADVERUM BIOTECHNOLOGIES INC 1.7%

Value $7.659M Shares 541,666 Est. Cost $14.14 Unrealized —

— RALLYBIO CORP 1.5%

Value $6.717M Shares 3,630,724 Est. Cost $17.58 Unrealized —

GHRS GH RESEARCH PLC 1.4%

Value $6.105M Shares 572,665 Est. Cost $10.15 Unrealized -21.7%

— SCPHARMACEUTICALS INC 1.3%

Value $6.027M Shares 1,200,647 Est. Cost $5.92 Unrealized —

— MERSANA THERAPEUTICS INC 1.3%

Value $5.846M Shares 1,305,000 Est. Cost $4.03 Unrealized —

COGT COGENT BIOSCIENCES INC 1.2%

Value $5.312M Shares 790,440 Est. Cost $6.91 Unrealized -10.6%

QTTB Q32 BIO INC 1.0%

Value $4.294M Shares 251,994 Est. Cost $13.78 Unrealized 0.0%

— CIDARA THERAPEUTICS INC 0.2%

Value $1.044M Shares 1,134,511 Est. Cost $3.84 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ELVN	ENLIVEN THERAPEUTICS INC	3,835,975	$67.47M	15.1%	$20.34	-24.6%	COM	29337E102
TRDA	ENTRADA THERAPEUTICS INC	4,408,379	$62.47M	14.0%	$17.12	—	COM	29384C108
DNTH	DIANTHUS THERAPEUTICS INC	1,242,029	$37.26M	8.3%	$12.62	+72.3%	COM	252828108
—	MERUS N V	548,825	$24.71M	5.5%	$28.37	—	COM	N5749R100
CLDX	CELLDEX THERAPEUTICS INC NEW	497,270	$20.87M	4.7%	$32.09	+28.0%	COM NEW	15117B202
PRAX	PRAXIS PRECISION MEDICINES I	340,000	$20.75M	4.6%	$44.86	0.0%	COM NEW	74006W207
VKTX	VIKING THERAPEUTICS INC	237,560	$19.48M	4.4%	$14.60	+204.9%	COM	92686J106
PHVS	PHARVARIS N V	797,600	$18.43M	4.1%	$19.05	+39.4%	COM	N69605108
BHVN	BIOHAVEN LTD	319,972	$17.5M	3.9%	$31.10	+59.2%	COM	G1110E107
RNAM	AVIDITY BIOSCIENCES INC	665,555	$16.98M	3.8%	$18.92	-17.1%	COM	05370A108
TYRA	TYRA BIOSCIENCES INC	939,298	$15.4M	3.4%	$15.18	+8.0%	COM	90240B106
—	VOR BIOPHARMA INC	6,361,723	$15.08M	3.4%	$43.10	—	COM	929033108
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	282,313	$14.18M	3.2%	$25.81	+110.2%	CLASS A ORD	61559X104
CNTA	CENTESSA PHARMACEUTICALS PLC	1,245,000	$14.07M	3.1%	$11.30	—	SPONSORED ADS	152309100
VRDN	VIRIDIAN THERAPEUTICS INC	736,595	$12.9M	2.9%	$17.93	+8.1%	COM	92790C104
SLN	SILENCE THERAPEUTICS PLC	476,200	$10.29M	2.3%	$21.60	—	ADS	82686Q101
ANAB	ANAPTYSBIO INC	357,733	$8.056M	1.8%	$28.24	-16.2%	COM	032724106
ZNTL	ZENTALIS PHARMACEUTICALS INC	490,000	$7.722M	1.7%	$23.99	-42.7%	COM	98943L107
—	ADVERUM BIOTECHNOLOGIES INC	541,666	$7.659M	1.7%	$14.14	—	COM NEW	00773U207
—	RALLYBIO CORP	3,630,724	$6.717M	1.5%	$17.58	—	COM	75120L100
GHRS	GH RESEARCH PLC	572,665	$6.105M	1.4%	$10.15	-21.7%	ORDINARY SHARES	G3855L106
—	SCPHARMACEUTICALS INC	1,200,647	$6.027M	1.3%	$5.92	—	COM	810648105
—	MERSANA THERAPEUTICS INC	1,305,000	$5.846M	1.3%	$4.03	—	COM	59045L106
COGT	COGENT BIOSCIENCES INC	790,440	$5.312M	1.2%	$6.91	-10.6%	COM	19240Q201
QTTB	Q32 BIO INC	251,994	$4.294M	1.0%	$13.78	0.0%	COM	746964105
—	CIDARA THERAPEUTICS INC	1,134,511	$1.044M	0.2%	$3.84	—	COM	171757107