5AM Venture Management, LLC Long-Term Concentrated

Location: San Francisco, CA

CIK: 0001799883 · Show all filings

Period: Q3 2023 (← Previous) (Next →)

Filing Date: Nov 14, 2023

Total Value: $348M (100.0% shares, 0.0% debt)

Holdings (26)

ELVN ENLIVEN THERAPEUTICS INC 20.3%

Value $70.5M Shares 5,160,975 Est. Cost $20.34 Unrealized -17.2%

TRDA ENTRADA THERAPEUTICS INC 20.0%

Value $69.65M Shares 4,408,379 Est. Cost $17.12 Unrealized —

IRON DISC MEDICINE INC 5.9%

Value $20.6M Shares 438,442 Est. Cost $49.79 Unrealized +0.5%

DNTH DIANTHUS THERAPEUTICS INC 5.8%

Value $20.13M Shares 1,472,264 Est. Cost $12.62 Unrealized 0.0%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 5.1%

Value $17.85M Shares 313,210 Est. Cost $25.81 Unrealized +113.9%

CRNX CRINETICS PHARMACEUTICALS IN 4.0%

Value $13.75M Shares 462,286 Est. Cost $19.04 Unrealized +8.2%

— VOR BIOPHARMA INC 3.9%

Value $13.49M Shares 6,361,723 Est. Cost $43.10 Unrealized —

PHVS PHARVARIS N V 3.5%

Value $12.26M Shares 587,600 Est. Cost $18.63 Unrealized -1.0%

— RALLYBIO CORP 3.5%

Value $12.24M Shares 3,630,724 Est. Cost $17.58 Unrealized —

ZNTL ZENTALIS PHARMACEUTICALS INC 2.8%

Value $9.829M Shares 490,000 Est. Cost $23.99 Unrealized +5.8%

— SCPHARMACEUTICALS INC 2.5%

Value $8.549M Shares 1,200,647 Est. Cost $5.92 Unrealized —

CLDX CELLDEX THERAPEUTICS INC NEW 2.5%

Value $8.539M Shares 310,270 Est. Cost $33.70 Unrealized -7.0%

— MIRATI THERAPEUTICS INC 2.4%

Value $8.385M Shares 192,500 Est. Cost $36.13 Unrealized —

COGT COGENT BIOSCIENCES INC 2.2%

Value $7.707M Shares 790,440 Est. Cost $6.91 Unrealized +71.6%

VKTX VIKING THERAPEUTICS INC 1.9%

Value $6.476M Shares 585,000 Est. Cost $14.60 Unrealized -2.0%

ANAB ANAPTYSBIO INC 1.8%

Value $6.425M Shares 357,733 Est. Cost $28.24 Unrealized -32.4%

VRDN VIRIDIAN THERAPEUTICS INC 1.8%

Value $6.289M Shares 410,000 Est. Cost $18.33 Unrealized +4.1%

ARVN ARVINAS INC 1.8%

Value $6.285M Shares 320,000 Est. Cost $29.28 Unrealized -16.2%

TYRA TYRA BIOSCIENCES INC 1.6%

Value $5.666M Shares 411,450 Est. Cost $14.83 Unrealized 0.0%

— SPRUCE BIOSCIENCES INC 1.5%

Value $5.343M Shares 2,364,000 Est. Cost $2.21 Unrealized —

— HOMOLOGY MEDICINES INC 1.5%

Value $5.307M Shares 4,535,919 Est. Cost $20.70 Unrealized —

RNAM AVIDITY BIOSCIENCES INC 1.2%

Value $4.246M Shares 665,555 Est. Cost $18.92 Unrealized -54.5%

GHRS GH RESEARCH PLC 1.2%

Value $4.064M Shares 404,404 Est. Cost $11.07 Unrealized +4.4%

— MERSANA THERAPEUTICS INC 0.5%

Value $1.657M Shares 1,305,000 Est. Cost $4.03 Unrealized —

— IMPEL PHARMACEUTICALS INC 0.4%

Value $1.24M Shares 2,884,791 Est. Cost $8.85 Unrealized —

— CIDARA THERAPEUTICS INC 0.3%

Value $1.069M Shares 1,134,511 Est. Cost $3.84 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ELVN	ENLIVEN THERAPEUTICS INC	5,160,975	$70.5M	20.3%	$20.34	-17.2%	COM	29337E102
TRDA	ENTRADA THERAPEUTICS INC	4,408,379	$69.65M	20.0%	$17.12	—	COM	29384C108
IRON	DISC MEDICINE INC	438,442	$20.6M	5.9%	$49.79	+0.5%	COM	254604101
DNTH	DIANTHUS THERAPEUTICS INC	1,472,264	$20.13M	5.8%	$12.62	0.0%	COM	252828108
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	313,210	$17.85M	5.1%	$25.81	+113.9%	CLASS A ORD	61559X104
CRNX	CRINETICS PHARMACEUTICALS IN	462,286	$13.75M	4.0%	$19.04	+8.2%	COM	22663K107
—	VOR BIOPHARMA INC	6,361,723	$13.49M	3.9%	$43.10	—	COM	929033108
PHVS	PHARVARIS N V	587,600	$12.26M	3.5%	$18.63	-1.0%	COM	N69605108
—	RALLYBIO CORP	3,630,724	$12.24M	3.5%	$17.58	—	COM	75120L100
ZNTL	ZENTALIS PHARMACEUTICALS INC	490,000	$9.829M	2.8%	$23.99	+5.8%	COM	98943L107
—	SCPHARMACEUTICALS INC	1,200,647	$8.549M	2.5%	$5.92	—	COM	810648105
CLDX	CELLDEX THERAPEUTICS INC NEW	310,270	$8.539M	2.5%	$33.70	-7.0%	COM NEW	15117B202
—	MIRATI THERAPEUTICS INC	192,500	$8.385M	2.4%	$36.13	—	COM	60468T105
COGT	COGENT BIOSCIENCES INC	790,440	$7.707M	2.2%	$6.91	+71.6%	COM	19240Q201
VKTX	VIKING THERAPEUTICS INC	585,000	$6.476M	1.9%	$14.60	-2.0%	COM	92686J106
ANAB	ANAPTYSBIO INC	357,733	$6.425M	1.8%	$28.24	-32.4%	COM	032724106
VRDN	VIRIDIAN THERAPEUTICS INC	410,000	$6.289M	1.8%	$18.33	+4.1%	COM	92790C104
ARVN	ARVINAS INC	320,000	$6.285M	1.8%	$29.28	-16.2%	COM	04335A105
TYRA	TYRA BIOSCIENCES INC	411,450	$5.666M	1.6%	$14.83	0.0%	COM	90240B106
—	SPRUCE BIOSCIENCES INC	2,364,000	$5.343M	1.5%	$2.21	—	COM	85209E109
—	HOMOLOGY MEDICINES INC	4,535,919	$5.307M	1.5%	$20.70	—	COM	438083107
RNAM	AVIDITY BIOSCIENCES INC	665,555	$4.246M	1.2%	$18.92	-54.5%	COM	05370A108
GHRS	GH RESEARCH PLC	404,404	$4.064M	1.2%	$11.07	+4.4%	ORDINARY SHARES	G3855L106
—	MERSANA THERAPEUTICS INC	1,305,000	$1.657M	0.5%	$4.03	—	COM	59045L106
—	IMPEL PHARMACEUTICALS INC	2,884,791	$1.24M	0.4%	$8.85	—	COM	45258K109
—	CIDARA THERAPEUTICS INC	1,134,511	$1.069M	0.3%	$3.84	—	COM	171757107