Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q4 2013 (← Previous) (Next →)

Filing Date: Feb 13, 2014

Total Value: $1.072B (100.0% shares, 0.0% debt)

Holdings (34)

— Cyberonics, Inc. 11.9%

Value $128M Shares 1,951,581 Share Price $65.42 Est. Cost/Share $52.15 Unrealized @ Report Date —

UTHR United Therapeutics Corp 11.6%

Value $124M Shares 1,095,428 Share Price $113.08 * Est. Cost/Share $66.46 Unrealized @ Report Date +35.7%

— Auxilium Pharmaceuticals, Inc. 9.4%

Value $101M Shares 4,883,879 Share Price $20.73 Est. Cost/Share $17.45 Unrealized @ Report Date —

— Cubist Pharmaceuticals, Inc. 8.6%

Value $92.02M Shares 1,336,136 Share Price $68.87 Est. Cost/Share $56.19 Unrealized @ Report Date —

— Abiomed Inc. 6.7%

Value $71.86M Shares 2,687,347 Share Price $26.74 Est. Cost/Share $21.31 Unrealized @ Report Date —

— Intermune Inc. 5.2%

Value $56.26M Shares 3,819,606 Share Price $14.73 Est. Cost/Share $12.66 Unrealized @ Report Date —

— Questcor Pharmaceuticals, Inc. 4.9%

Value $52.49M Shares 963,995 Share Price $54.45 Est. Cost/Share $48.32 Unrealized @ Report Date —

BMRN Biomarin Pharmaceuticals, Inc 4.9%

Value $52.13M Shares 741,087 Share Price $70.35 * Est. Cost/Share $63.65 Unrealized @ Report Date +6.7%

STAA STAAR Surgical Company 4.9%

Value $52.04M Shares 3,214,253 Share Price $16.19 * Est. Cost/Share $8.10 Unrealized @ Report Date +65.2%

— AMAG Pharmaceuticals, Inc. 4.0%

Value $42.77M Shares 1,761,332 Share Price $24.28 Est. Cost/Share $22.29 Unrealized @ Report Date —

VNDA Vanda Pharmaceutical Inc. 3.7%

Value $40.19M Shares 3,238,624 Share Price $12.41 * Est. Cost/Share $7.72 Unrealized @ Report Date +30.7%

— Kythera BioPharm CMN 3.1%

Value $33.64M Shares 900,559 Share Price $37.35 Est. Cost/Share $38.50 Unrealized @ Report Date —

— Anacor Pharmaceuticals, Inc. 2.5%

Value $26.9M Shares 1,603,278 Share Price $16.78 Est. Cost/Share $5.59 Unrealized @ Report Date —

— Ariad Pharmaceuticals, Inc. 2.2%

Value $23.47M Shares 3,441,324 Share Price $6.82 Est. Cost/Share $6.82 Unrealized @ Report Date —

— Sequenom Inc. 2.1%

Value $21.98M Shares 9,394,627 Share Price $2.34 Est. Cost/Share $3.97 Unrealized @ Report Date —

— Momenta Pharmaceuticals, Inc. 1.9%

Value $20.46M Shares 1,157,276 Share Price $17.68 Est. Cost/Share $15.11 Unrealized @ Report Date —

— Alimera Sciences, Inc. 1.6%

Value $17.08M Shares 3,634,984 Share Price $4.70 Est. Cost/Share $4.88 Unrealized @ Report Date —

— Rigel Pharmaceuticals Inc. 1.4%

Value $14.87M Shares 5,217,001 Share Price $2.85 Est. Cost/Share $3.43 Unrealized @ Report Date —

— ViroPharma Incorporated 1.4%

Value $14.5M Shares 290,916 Share Price $49.85 Est. Cost/Share $28.65 Unrealized @ Report Date —

PRTA Prothena Corp PLC 1.3%

Value $14.25M Shares 537,418 Share Price $26.52 * Est. Cost/Share $22.48 Unrealized @ Report Date +11.6%

— NPS Pharmaceuticals 1.2%

Value $13.33M Shares 439,100 Share Price $30.36 Est. Cost/Share $30.36 Unrealized @ Report Date —

— QLT Inc. 1.1%

Value $11.44M Shares 2,053,311 Share Price $5.57 Est. Cost/Share $4.40 Unrealized @ Report Date —

— Clovis Oncology Inc. 1.1%

Value $11.26M Shares 186,900 Share Price $60.27 Est. Cost/Share $60.27 Unrealized @ Report Date —

FOLD Amicus Therapeutics, Inc. 0.9%

Value $9.42M Shares 4,008,576 Share Price $2.35 * Est. Cost/Share $3.07 Unrealized @ Report Date -28.6%

EXAS Exact Sciences Corp 0.9%

Value $9.233M Shares 785,776 Share Price $11.75 * Est. Cost/Share $12.83 Unrealized @ Report Date -10.6%

INSM Insmed, Inc. 0.5%

Value $4.967M Shares 292,199 Share Price $17.00 * Est. Cost/Share $10.67 Unrealized @ Report Date +43.5%

— Spectrum Pharmaceuticals Inc. 0.3%

Value $3.56M Shares 402,285 Share Price $8.85 Est. Cost/Share $7.48 Unrealized @ Report Date —

— AVEO Pharmaceuticals, Inc. 0.2%

Value $2.615M Shares 1,429,174 Share Price $1.83 Est. Cost/Share $2.50 Unrealized @ Report Date —

— Xoma Ltd. 0.2%

Value $1.724M Shares 256,100 Share Price $6.73 Est. Cost/Share $3.63 Unrealized @ Report Date —

CYTK Cytokinetics Inc. 0.1%

Value $1.513M Shares 232,808 Share Price $6.50 Est. Cost/Share $6.57 Unrealized @ Report Date 0.0%

— Hyperion Therapeutics 0.1%

Value $1.268M Shares 62,700 Share Price $20.22 Est. Cost/Share $22.00 Unrealized @ Report Date —

— Sophiris Bio Inc 0.1%

Value $1.084M Shares 292,900 Share Price $3.70 Est. Cost/Share $3.88 Unrealized @ Report Date —

— Align Technology, Inc. 0.0%

Value $445K Shares 7,788 Share Price $57.14 Est. Cost/Share $51.27 Unrealized @ Report Date —

— Celgene Corp. 0.0%

Value $438K Shares 2,590 Share Price $169.11 Est. Cost/Share $159.15 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
—	Cyberonics, Inc.	1,951,581	$128M	11.9%	$65.42	$52.15	—	COM	23251P102
UTHR	United Therapeutics Corp	1,095,428	$124M	11.6%	$113.08 *	$66.46	+35.7%	COM	91307C102
—	Auxilium Pharmaceuticals, Inc.	4,883,879	$101M	9.4%	$20.73	$17.45	—	COM	05334D107
—	Cubist Pharmaceuticals, Inc.	1,336,136	$92.02M	8.6%	$68.87	$56.19	—	COM	229678107
—	Abiomed Inc.	2,687,347	$71.86M	6.7%	$26.74	$21.31	—	COM	003654100
—	Intermune Inc.	3,819,606	$56.26M	5.2%	$14.73	$12.66	—	COM	45884X103
—	Questcor Pharmaceuticals, Inc.	963,995	$52.49M	4.9%	$54.45	$48.32	—	COM	74835Y101
BMRN	Biomarin Pharmaceuticals, Inc	741,087	$52.13M	4.9%	$70.35 *	$63.65	+6.7%	COM	09061G101
STAA	STAAR Surgical Company	3,214,253	$52.04M	4.9%	$16.19 *	$8.10	+65.2%	COM	852312305
—	AMAG Pharmaceuticals, Inc.	1,761,332	$42.77M	4.0%	$24.28	$22.29	—	COM	00163U106
VNDA	Vanda Pharmaceutical Inc.	3,238,624	$40.19M	3.7%	$12.41 *	$7.72	+30.7%	COM	921659108
—	Kythera BioPharm CMN	900,559	$33.64M	3.1%	$37.35	$38.50	—	COM	501570105
—	Anacor Pharmaceuticals, Inc.	1,603,278	$26.9M	2.5%	$16.78	$5.59	—	COM	032420101
—	Ariad Pharmaceuticals, Inc.	3,441,324	$23.47M	2.2%	$6.82	$6.82	—	COM	04033A100
—	Sequenom Inc.	9,394,627	$21.98M	2.1%	$2.34	$3.97	—	COM	817337405
—	Momenta Pharmaceuticals, Inc.	1,157,276	$20.46M	1.9%	$17.68	$15.11	—	COM	60877T100
—	Alimera Sciences, Inc.	3,634,984	$17.08M	1.6%	$4.70	$4.88	—	COM	016259103
—	Rigel Pharmaceuticals Inc.	5,217,001	$14.87M	1.4%	$2.85	$3.43	—	COM	766559603
—	ViroPharma Incorporated	290,916	$14.5M	1.4%	$49.85	$28.65	—	COM	928241108
PRTA	Prothena Corp PLC	537,418	$14.25M	1.3%	$26.52 *	$22.48	+11.6%	COM	G72800108
—	NPS Pharmaceuticals	439,100	$13.33M	1.2%	$30.36	$30.36	—	COM	62936P103
—	QLT Inc.	2,053,311	$11.44M	1.1%	$5.57	$4.40	—	COM	746927102
—	Clovis Oncology Inc.	186,900	$11.26M	1.1%	$60.27	$60.27	—	COM	189464100
FOLD	Amicus Therapeutics, Inc.	4,008,576	$9.42M	0.9%	$2.35 *	$3.07	-28.6%	COM	03152W109
EXAS	Exact Sciences Corp	785,776	$9.233M	0.9%	$11.75 *	$12.83	-10.6%	COM	30063P105
INSM	Insmed, Inc.	292,199	$4.967M	0.5%	$17.00 *	$10.67	+43.5%	COM	457669307
—	Spectrum Pharmaceuticals Inc.	402,285	$3.56M	0.3%	$8.85	$7.48	—	COM	84763A108
—	AVEO Pharmaceuticals, Inc.	1,429,174	$2.615M	0.2%	$1.83	$2.50	—	COM	053588109
—	Xoma Ltd.	256,100	$1.724M	0.2%	$6.73	$3.63	—	COM	98419J107
CYTK	Cytokinetics Inc.	232,808	$1.513M	0.1%	$6.50	$6.57	0.0%	COM	23282W605
—	Hyperion Therapeutics	62,700	$1.268M	0.1%	$20.22	$22.00	—	COM	44915N101
—	Sophiris Bio Inc	292,900	$1.084M	0.1%	$3.70	$3.88	—	COM	83578Q209
—	Align Technology, Inc.	7,788	$445K	0.0%	$57.14	$51.27	—	COM	162551014
—	Celgene Corp.	2,590	$438K	0.0%	$169.11	$159.15	—	COM	151020104