Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q4 2013 (← Previous) (Next →)

Filing Date: Feb 13, 2014

Total Value ($000): $1,072,011 (100.0% shares, 0.0% debt)

Holdings (34)

— Cyberonics, Inc. 11.9%

Value ($000) $127,676 Shares 1,951,581 Est. Cost $52.15 Unrealized —

UTHR United Therapeutics Corp 11.6%

Value ($000) $123,871 Shares 1,095,428 Est. Cost $66.46 Unrealized +35.7%

— Auxilium Pharmaceuticals, Inc. 9.4%

Value ($000) $101,243 Shares 4,883,879 Est. Cost $17.45 Unrealized —

— Cubist Pharmaceuticals, Inc. 8.6%

Value ($000) $92,020 Shares 1,336,136 Est. Cost $56.19 Unrealized —

— Abiomed Inc. 6.7%

Value ($000) $71,860 Shares 2,687,347 Est. Cost $21.31 Unrealized —

— Intermune Inc. 5.2%

Value ($000) $56,263 Shares 3,819,606 Est. Cost $12.66 Unrealized —

— Questcor Pharmaceuticals, Inc. 4.9%

Value ($000) $52,490 Shares 963,995 Est. Cost $48.32 Unrealized —

BMRN Biomarin Pharmaceuticals, Inc 4.9%

Value ($000) $52,135 Shares 741,087 Est. Cost $63.65 Unrealized +6.7%

STAA STAAR Surgical Company 4.9%

Value ($000) $52,039 Shares 3,214,253 Est. Cost $8.10 Unrealized +65.2%

— AMAG Pharmaceuticals, Inc. 4.0%

Value ($000) $42,765 Shares 1,761,332 Est. Cost $22.29 Unrealized —

VNDA Vanda Pharmaceutical Inc. 3.7%

Value ($000) $40,191 Shares 3,238,624 Est. Cost $7.72 Unrealized +30.7%

— Kythera BioPharm CMN 3.1%

Value ($000) $33,636 Shares 900,559 Est. Cost $38.50 Unrealized —

— Anacor Pharmaceuticals, Inc. 2.5%

Value ($000) $26,903 Shares 1,603,278 Est. Cost $5.59 Unrealized —

— Ariad Pharmaceuticals, Inc. 2.2%

Value ($000) $23,470 Shares 3,441,324 Est. Cost $6.82 Unrealized —

— Sequenom Inc. 2.1%

Value ($000) $21,983 Shares 9,394,627 Est. Cost $3.97 Unrealized —

— Momenta Pharmaceuticals, Inc. 1.9%

Value ($000) $20,461 Shares 1,157,276 Est. Cost $15.11 Unrealized —

— Alimera Sciences, Inc. 1.6%

Value ($000) $17,084 Shares 3,634,984 Est. Cost $4.88 Unrealized —

— Rigel Pharmaceuticals Inc. 1.4%

Value ($000) $14,868 Shares 5,217,001 Est. Cost $3.43 Unrealized —

— ViroPharma Incorporated 1.4%

Value ($000) $14,502 Shares 290,916 Est. Cost $28.65 Unrealized —

PRTA Prothena Corp PLC 1.3%

Value ($000) $14,252 Shares 537,418 Est. Cost $22.48 Unrealized +11.6%

— NPS Pharmaceuticals 1.2%

Value ($000) $13,331 Shares 439,100 Est. Cost $30.36 Unrealized —

— QLT Inc. 1.1%

Value ($000) $11,437 Shares 2,053,311 Est. Cost $4.40 Unrealized —

— Clovis Oncology Inc. 1.1%

Value ($000) $11,264 Shares 186,900 Est. Cost $60.27 Unrealized —

FOLD Amicus Therapeutics, Inc. 0.9%

Value ($000) $9,420 Shares 4,008,576 Est. Cost $3.07 Unrealized -28.6%

EXAS Exact Sciences Corp 0.9%

Value ($000) $9,233 Shares 785,776 Est. Cost $12.83 Unrealized -10.6%

INSM Insmed, Inc. 0.5%

Value ($000) $4,967 Shares 292,199 Est. Cost $10.67 Unrealized +43.5%

— Spectrum Pharmaceuticals Inc. 0.3%

Value ($000) $3,560 Shares 402,285 Est. Cost $7.48 Unrealized —

— AVEO Pharmaceuticals, Inc. 0.2%

Value ($000) $2,615 Shares 1,429,174 Est. Cost $2.50 Unrealized —

— Xoma Ltd. 0.2%

Value ($000) $1,724 Shares 256,100 Est. Cost $3.63 Unrealized —

CYTK Cytokinetics Inc. 0.1%

Value ($000) $1,513 Shares 232,808 Est. Cost $6.57 Unrealized 0.0%

— Hyperion Therapeutics 0.1%

Value ($000) $1,268 Shares 62,700 Est. Cost $22.00 Unrealized —

— Sophiris Bio Inc 0.1%

Value ($000) $1,084 Shares 292,900 Est. Cost $3.88 Unrealized —

— Align Technology, Inc. 0.0%

Value ($000) $445 Shares 7,788 Est. Cost $51.27 Unrealized —

— Celgene Corp. 0.0%

Value ($000) $438 Shares 2,590 Est. Cost $159.15 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	Cyberonics, Inc.	1,951,581	$127,676	11.9%	$52.15	—	COM	23251P102
UTHR	United Therapeutics Corp	1,095,428	$123,871	11.6%	$66.46	+35.7%	COM	91307C102
—	Auxilium Pharmaceuticals, Inc.	4,883,879	$101,243	9.4%	$17.45	—	COM	05334D107
—	Cubist Pharmaceuticals, Inc.	1,336,136	$92,020	8.6%	$56.19	—	COM	229678107
—	Abiomed Inc.	2,687,347	$71,860	6.7%	$21.31	—	COM	003654100
—	Intermune Inc.	3,819,606	$56,263	5.2%	$12.66	—	COM	45884X103
—	Questcor Pharmaceuticals, Inc.	963,995	$52,490	4.9%	$48.32	—	COM	74835Y101
BMRN	Biomarin Pharmaceuticals, Inc	741,087	$52,135	4.9%	$63.65	+6.7%	COM	09061G101
STAA	STAAR Surgical Company	3,214,253	$52,039	4.9%	$8.10	+65.2%	COM	852312305
—	AMAG Pharmaceuticals, Inc.	1,761,332	$42,765	4.0%	$22.29	—	COM	00163U106
VNDA	Vanda Pharmaceutical Inc.	3,238,624	$40,191	3.7%	$7.72	+30.7%	COM	921659108
—	Kythera BioPharm CMN	900,559	$33,636	3.1%	$38.50	—	COM	501570105
—	Anacor Pharmaceuticals, Inc.	1,603,278	$26,903	2.5%	$5.59	—	COM	032420101
—	Ariad Pharmaceuticals, Inc.	3,441,324	$23,470	2.2%	$6.82	—	COM	04033A100
—	Sequenom Inc.	9,394,627	$21,983	2.1%	$3.97	—	COM	817337405
—	Momenta Pharmaceuticals, Inc.	1,157,276	$20,461	1.9%	$15.11	—	COM	60877T100
—	Alimera Sciences, Inc.	3,634,984	$17,084	1.6%	$4.88	—	COM	016259103
—	Rigel Pharmaceuticals Inc.	5,217,001	$14,868	1.4%	$3.43	—	COM	766559603
—	ViroPharma Incorporated	290,916	$14,502	1.4%	$28.65	—	COM	928241108
PRTA	Prothena Corp PLC	537,418	$14,252	1.3%	$22.48	+11.6%	COM	G72800108
—	NPS Pharmaceuticals	439,100	$13,331	1.2%	$30.36	—	COM	62936P103
—	QLT Inc.	2,053,311	$11,437	1.1%	$4.40	—	COM	746927102
—	Clovis Oncology Inc.	186,900	$11,264	1.1%	$60.27	—	COM	189464100
FOLD	Amicus Therapeutics, Inc.	4,008,576	$9,420	0.9%	$3.07	-28.6%	COM	03152W109
EXAS	Exact Sciences Corp	785,776	$9,233	0.9%	$12.83	-10.6%	COM	30063P105
INSM	Insmed, Inc.	292,199	$4,967	0.5%	$10.67	+43.5%	COM	457669307
—	Spectrum Pharmaceuticals Inc.	402,285	$3,560	0.3%	$7.48	—	COM	84763A108
—	AVEO Pharmaceuticals, Inc.	1,429,174	$2,615	0.2%	$2.50	—	COM	053588109
—	Xoma Ltd.	256,100	$1,724	0.2%	$3.63	—	COM	98419J107
CYTK	Cytokinetics Inc.	232,808	$1,513	0.1%	$6.57	0.0%	COM	23282W605
—	Hyperion Therapeutics	62,700	$1,268	0.1%	$22.00	—	COM	44915N101
—	Sophiris Bio Inc	292,900	$1,084	0.1%	$3.88	—	COM	83578Q209
—	Align Technology, Inc.	7,788	$445	0.0%	$51.27	—	COM	162551014
—	Celgene Corp.	2,590	$438	0.0%	$159.15	—	COM	151020104