Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q1 2014 (← Previous) (Next →)

Filing Date: May 16, 2014

Total Value ($000): $1,210,103

Holdings (39)

— INTERMUNE INC 12.2%

Value ($000) $147,893 Shares 4,418,662 Est. Cost $15.49 Unrealized —

— AUXILIUM PHARMACEUTICALS INC 10.9%

Value ($000) $131,606 Shares 4,842,031 Est. Cost $17.45 Unrealized —

— CYBERONICS INC 9.2%

Value ($000) $111,701 Shares 1,711,730 Est. Cost $52.15 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 8.6%

Value ($000) $103,530 Shares 1,101,028 Est. Cost $66.46 Unrealized +53.9%

— CUBIST PHARMACEUTICALS INC 8.3%

Value ($000) $100,158 Shares 1,369,211 Est. Cost $56.60 Unrealized —

— QUESTCOR PHARMACEUTICALS INC 5.2%

Value ($000) $62,949 Shares 969,495 Est. Cost $48.32 Unrealized —

— ABIOMED INC 4.7%

Value ($000) $57,348 Shares 2,202,289 Est. Cost $21.31 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 4.3%

Value ($000) $52,251 Shares 3,215,424 Est. Cost $7.72 Unrealized +84.2%

BMRN BIOMARIN PHARMACEUTICAL INC 4.2%

Value ($000) $50,863 Shares 745,687 Est. Cost $63.65 Unrealized +15.8%

STAA STAAR SURGICAL CO 4.0%

Value ($000) $48,761 Shares 2,593,653 Est. Cost $8.10 Unrealized +99.0%

— KYTHERA BIOPHARMACEUTICALS I 3.0%

Value ($000) $35,993 Shares 905,259 Est. Cost $38.50 Unrealized —

— ANACOR PHARMACEUTICALS INC 2.6%

Value ($000) $31,457 Shares 1,572,078 Est. Cost $5.59 Unrealized —

— AMAG PHARMACEUTICALS INC 2.6%

Value ($000) $31,241 Shares 1,614,536 Est. Cost $22.29 Unrealized —

— ALIMERA SCIENCES INC 2.4%

Value ($000) $28,680 Shares 3,634,984 Est. Cost $4.88 Unrealized —

— ARIAD PHARMACEUTICALS INC 2.3%

Value ($000) $27,877 Shares 3,458,624 Est. Cost $6.82 Unrealized —

— SEQUENOM INC 2.0%

Value ($000) $23,982 Shares 9,788,442 Est. Cost $3.91 Unrealized —

PRTA PROTHENA CORP PLC 1.7%

Value ($000) $20,416 Shares 532,918 Est. Cost $22.48 Unrealized +43.4%

— RIGEL PHARMACEUTICALS INC 1.7%

Value ($000) $20,057 Shares 5,169,301 Est. Cost $3.43 Unrealized —

— CELLADON CORP 1.5%

Value ($000) $17,779 Shares 1,491,500 Est. Cost $11.92 Unrealized —

— MOMENTA PHARMACEUTICALS INC 1.3%

Value ($000) $15,319 Shares 1,314,976 Est. Cost $14.69 Unrealized —

— NPS PHARMACEUTICALS INC 1.1%

Value ($000) $13,026 Shares 435,200 Est. Cost $30.36 Unrealized —

— CLOVIS ONCOLOGY INC 1.1%

Value ($000) $12,947 Shares 186,900 Est. Cost $60.27 Unrealized —

— QLT INC 0.9%

Value ($000) $11,348 Shares 2,041,043 Est. Cost $4.40 Unrealized —

EXAS EXACT SCIENCES CORP 0.9%

Value ($000) $11,020 Shares 777,676 Est. Cost $12.83 Unrealized +5.3%

— OREXIGEN THERAPEUTICS INC 0.9%

Value ($000) $10,849 Shares 1,669,024 Est. Cost $6.50 Unrealized —

FOLD AMICUS THERAPEUTICS INC 0.7%

Value ($000) $8,221 Shares 3,971,576 Est. Cost $3.07 Unrealized -18.6%

INSM INSMED INC 0.5%

Value ($000) $6,030 Shares 316,699 Est. Cost $11.32 Unrealized +67.9%

— SPECTRUM PHARMACEUTICALS INC 0.3%

Value ($000) $3,154 Shares 402,285 Est. Cost $7.48 Unrealized —

— REVANCE THERAPEUTICS INC 0.2%

Value ($000) $2,888 Shares 91,669 Est. Cost $31.50 Unrealized —

CYTK CYTOKINETICS INC 0.2%

Value ($000) $2,348 Shares 247,186 Est. Cost $6.71 Unrealized +34.7%

— AVEO PHARMACEUTICALS INC 0.2%

Value ($000) $2,137 Shares 1,429,174 Est. Cost $2.50 Unrealized —

— HYPERION THERAPEUTICS INC 0.1%

Value ($000) $1,618 Shares 62,700 Est. Cost $22.00 Unrealized —

— XOMA CORP DEL 0.1%

Value ($000) $1,334 Shares 256,100 Est. Cost $3.63 Unrealized —

GERN GERON CORP 0.1%

Value ($000) $1,060 Shares 507,300 Est. Cost $3.99 Unrealized 0.0%

— SOPHIRIS BIO INC 0.1%

Value ($000) $975 Shares 292,900 Est. Cost $3.88 Unrealized —

ALGN ALIGN TECHNOLOGY INC 0.0%

Value ($000) $403 Shares 7,788 Est. Cost $55.98 Unrealized 0.0%

— CELGENE CORP 0.0%

Value ($000) $362 Shares 2,590 Est. Cost $159.15 Unrealized —

— SHIRE PLC 0.0%

Value ($000) $267 Shares 1,800 Est. Cost $148.33 Unrealized —

GILD GILEAD SCIENCES INC 0.0%

Value ($000) $255 Shares 3,600 Est. Cost $54.49 Unrealized 0.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	INTERMUNE INC	4,418,662	$147,893	12.2%	$15.49	—	—	45884X103
—	AUXILIUM PHARMACEUTICALS INC	4,842,031	$131,606	10.9%	$17.45	—	—	05334D107
—	CYBERONICS INC	1,711,730	$111,701	9.2%	$52.15	—	—	23251P102
UTHR	UNITED THERAPEUTICS CORP DEL	1,101,028	$103,530	8.6%	$66.46	+53.9%	—	91307C102
—	CUBIST PHARMACEUTICALS INC	1,369,211	$100,158	8.3%	$56.60	—	—	229678107
—	QUESTCOR PHARMACEUTICALS INC	969,495	$62,949	5.2%	$48.32	—	—	74835Y101
—	ABIOMED INC	2,202,289	$57,348	4.7%	$21.31	—	—	003654100
VNDA	VANDA PHARMACEUTICALS INC	3,215,424	$52,251	4.3%	$7.72	+84.2%	—	921659108
BMRN	BIOMARIN PHARMACEUTICAL INC	745,687	$50,863	4.2%	$63.65	+15.8%	—	09061G101
STAA	STAAR SURGICAL CO	2,593,653	$48,761	4.0%	$8.10	+99.0%	—	852312305
—	KYTHERA BIOPHARMACEUTICALS I	905,259	$35,993	3.0%	$38.50	—	—	501570105
—	ANACOR PHARMACEUTICALS INC	1,572,078	$31,457	2.6%	$5.59	—	—	032420101
—	AMAG PHARMACEUTICALS INC	1,614,536	$31,241	2.6%	$22.29	—	—	00163U106
—	ALIMERA SCIENCES INC	3,634,984	$28,680	2.4%	$4.88	—	—	016259103
—	ARIAD PHARMACEUTICALS INC	3,458,624	$27,877	2.3%	$6.82	—	—	04033A100
—	SEQUENOM INC	9,788,442	$23,982	2.0%	$3.91	—	—	817337405
PRTA	PROTHENA CORP PLC	532,918	$20,416	1.7%	$22.48	+43.4%	—	G72800108
—	RIGEL PHARMACEUTICALS INC	5,169,301	$20,057	1.7%	$3.43	—	—	766559603
—	CELLADON CORP	1,491,500	$17,779	1.5%	$11.92	—	—	15117E107
—	MOMENTA PHARMACEUTICALS INC	1,314,976	$15,319	1.3%	$14.69	—	—	60877T100
—	NPS PHARMACEUTICALS INC	435,200	$13,026	1.1%	$30.36	—	—	62936P103
—	CLOVIS ONCOLOGY INC	186,900	$12,947	1.1%	$60.27	—	—	189464100
—	QLT INC	2,041,043	$11,348	0.9%	$4.40	—	—	746927102
EXAS	EXACT SCIENCES CORP	777,676	$11,020	0.9%	$12.83	+5.3%	—	30063P105
—	OREXIGEN THERAPEUTICS INC	1,669,024	$10,849	0.9%	$6.50	—	—	686164104
FOLD	AMICUS THERAPEUTICS INC	3,971,576	$8,221	0.7%	$3.07	-18.6%	—	03152W109
INSM	INSMED INC	316,699	$6,030	0.5%	$11.32	+67.9%	—	457669307
—	SPECTRUM PHARMACEUTICALS INC	402,285	$3,154	0.3%	$7.48	—	—	84763A108
—	REVANCE THERAPEUTICS INC	91,669	$2,888	0.2%	$31.50	—	—	761330109
CYTK	CYTOKINETICS INC	247,186	$2,348	0.2%	$6.71	+34.7%	—	23282W605
—	AVEO PHARMACEUTICALS INC	1,429,174	$2,137	0.2%	$2.50	—	—	053588109
—	HYPERION THERAPEUTICS INC	62,700	$1,618	0.1%	$22.00	—	—	44915N101
—	XOMA CORP DEL	256,100	$1,334	0.1%	$3.63	—	—	98419J107
GERN	GERON CORP	507,300	$1,060	0.1%	$3.99	0.0%	—	374163103
—	SOPHIRIS BIO INC	292,900	$975	0.1%	$3.88	—	—	83578Q209
ALGN	ALIGN TECHNOLOGY INC	7,788	$403	0.0%	$55.98	0.0%	—	016255101
—	CELGENE CORP	2,590	$362	0.0%	$159.15	—	—	151020104
—	SHIRE PLC	1,800	$267	0.0%	$148.33	—	—	82481R106
GILD	GILEAD SCIENCES INC	3,600	$255	0.0%	$54.49	0.0%	—	375558103