Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q1 2014 (← Previous) (Next →)

Filing Date: May 16, 2014

Total Value: $1.21B (100.0% shares, 0.0% debt)

Holdings (39)

— INTERMUNE INC 12.2%

Value $148M Shares 4,418,662 Share Price $33.47 Est. Cost/Share $15.49 Unrealized @ Report Date —

— AUXILIUM PHARMACEUTICALS INC 10.9%

Value $132M Shares 4,842,031 Share Price $27.18 Est. Cost/Share $17.45 Unrealized @ Report Date —

— CYBERONICS INC 9.2%

Value $112M Shares 1,711,730 Share Price $65.26 Est. Cost/Share $52.15 Unrealized @ Report Date —

UTHR UNITED THERAPEUTICS CORP DEL 8.6%

Value $104M Shares 1,101,028 Share Price $94.03 * Est. Cost/Share $66.46 Unrealized @ Report Date +53.9%

— CUBIST PHARMACEUTICALS INC 8.3%

Value $100M Shares 1,369,211 Share Price $73.15 Est. Cost/Share $56.60 Unrealized @ Report Date —

— QUESTCOR PHARMACEUTICALS INC 5.2%

Value $62.95M Shares 969,495 Share Price $64.93 Est. Cost/Share $48.32 Unrealized @ Report Date —

— ABIOMED INC 4.7%

Value $57.35M Shares 2,202,289 Share Price $26.04 Est. Cost/Share $21.31 Unrealized @ Report Date —

VNDA VANDA PHARMACEUTICALS INC 4.3%

Value $52.25M Shares 3,215,424 Share Price $16.25 * Est. Cost/Share $7.72 Unrealized @ Report Date +84.2%

BMRN BIOMARIN PHARMACEUTICAL INC 4.2%

Value $50.86M Shares 745,687 Share Price $68.21 * Est. Cost/Share $63.65 Unrealized @ Report Date +15.8%

STAA STAAR SURGICAL CO 4.0%

Value $48.76M Shares 2,593,653 Share Price $18.80 * Est. Cost/Share $8.10 Unrealized @ Report Date +99.0%

— KYTHERA BIOPHARMACEUTICALS I 3.0%

Value $35.99M Shares 905,259 Share Price $39.76 Est. Cost/Share $38.50 Unrealized @ Report Date —

— ANACOR PHARMACEUTICALS INC 2.6%

Value $31.46M Shares 1,572,078 Share Price $20.01 Est. Cost/Share $5.59 Unrealized @ Report Date —

— AMAG PHARMACEUTICALS INC 2.6%

Value $31.24M Shares 1,614,536 Share Price $19.35 Est. Cost/Share $22.29 Unrealized @ Report Date —

— ALIMERA SCIENCES INC 2.4%

Value $28.68M Shares 3,634,984 Share Price $7.89 Est. Cost/Share $4.88 Unrealized @ Report Date —

— ARIAD PHARMACEUTICALS INC 2.3%

Value $27.88M Shares 3,458,624 Share Price $8.06 Est. Cost/Share $6.82 Unrealized @ Report Date —

— SEQUENOM INC 2.0%

Value $23.98M Shares 9,788,442 Share Price $2.45 Est. Cost/Share $3.91 Unrealized @ Report Date —

PRTA PROTHENA CORP PLC 1.7%

Value $20.42M Shares 532,918 Share Price $38.31 * Est. Cost/Share $22.48 Unrealized @ Report Date +43.4%

— RIGEL PHARMACEUTICALS INC 1.7%

Value $20.06M Shares 5,169,301 Share Price $3.88 Est. Cost/Share $3.43 Unrealized @ Report Date —

— CELLADON CORP 1.5%

Value $17.78M Shares 1,491,500 Share Price $11.92 Est. Cost/Share $11.92 Unrealized @ Report Date —

— MOMENTA PHARMACEUTICALS INC 1.3%

Value $15.32M Shares 1,314,976 Share Price $11.65 Est. Cost/Share $14.69 Unrealized @ Report Date —

— NPS PHARMACEUTICALS INC 1.1%

Value $13.03M Shares 435,200 Share Price $29.93 Est. Cost/Share $30.36 Unrealized @ Report Date —

— CLOVIS ONCOLOGY INC 1.1%

Value $12.95M Shares 186,900 Share Price $69.27 Est. Cost/Share $60.27 Unrealized @ Report Date —

— QLT INC 0.9%

Value $11.35M Shares 2,041,043 Share Price $5.56 Est. Cost/Share $4.40 Unrealized @ Report Date —

EXAS EXACT SCIENCES CORP 0.9%

Value $11.02M Shares 777,676 Share Price $14.17 * Est. Cost/Share $12.83 Unrealized @ Report Date +5.3%

— OREXIGEN THERAPEUTICS INC 0.9%

Value $10.85M Shares 1,669,024 Share Price $6.50 Est. Cost/Share $6.50 Unrealized @ Report Date —

FOLD AMICUS THERAPEUTICS INC 0.7%

Value $8.221M Shares 3,971,576 Share Price $2.07 * Est. Cost/Share $3.07 Unrealized @ Report Date -18.6%

INSM INSMED INC 0.5%

Value $6.03M Shares 316,699 Share Price $19.04 Est. Cost/Share $11.32 Unrealized @ Report Date +67.9%

— SPECTRUM PHARMACEUTICALS INC 0.3%

Value $3.154M Shares 402,285 Share Price $7.84 Est. Cost/Share $7.48 Unrealized @ Report Date —

— REVANCE THERAPEUTICS INC 0.2%

Value $2.888M Shares 91,669 Share Price $31.50 Est. Cost/Share $31.50 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.2%

Value $2.348M Shares 247,186 Share Price $9.50 * Est. Cost/Share $6.71 Unrealized @ Report Date +34.7%

— AVEO PHARMACEUTICALS INC 0.2%

Value $2.137M Shares 1,429,174 Share Price $1.50 Est. Cost/Share $2.50 Unrealized @ Report Date —

— HYPERION THERAPEUTICS INC 0.1%

Value $1.618M Shares 62,700 Share Price $25.81 Est. Cost/Share $22.00 Unrealized @ Report Date —

— XOMA CORP DEL 0.1%

Value $1.334M Shares 256,100 Share Price $5.21 Est. Cost/Share $3.63 Unrealized @ Report Date —

GERN GERON CORP 0.1%

Value $1.06M Shares 507,300 Share Price $2.09 * Est. Cost/Share $3.99 Unrealized @ Report Date 0.0%

— SOPHIRIS BIO INC 0.1%

Value $975K Shares 292,900 Share Price $3.33 Est. Cost/Share $3.88 Unrealized @ Report Date —

ALGN ALIGN TECHNOLOGY INC 0.0%

Value $403K Shares 7,788 Share Price $51.75 * Est. Cost/Share $55.98 Unrealized @ Report Date 0.0%

— CELGENE CORP 0.0%

Value $362K Shares 2,590 Share Price $139.77 Est. Cost/Share $159.15 Unrealized @ Report Date —

— SHIRE PLC 0.0%

Value $267K Shares 1,800 Share Price $148.33 Est. Cost/Share $148.33 Unrealized @ Report Date —

GILD GILEAD SCIENCES INC 0.0%

Value $255K Shares 3,600 Share Price $70.83 * Est. Cost/Share $54.49 Unrealized @ Report Date 0.0%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
—	INTERMUNE INC	4,418,662	$148M	12.2%	$33.47	$15.49	—	COM	45884X103
—	AUXILIUM PHARMACEUTICALS INC	4,842,031	$132M	10.9%	$27.18	$17.45	—	COM	05334D107
—	CYBERONICS INC	1,711,730	$112M	9.2%	$65.26	$52.15	—	COM	23251P102
UTHR	UNITED THERAPEUTICS CORP DEL	1,101,028	$104M	8.6%	$94.03 *	$66.46	+53.9%	COM	91307C102
—	CUBIST PHARMACEUTICALS INC	1,369,211	$100M	8.3%	$73.15	$56.60	—	COM	229678107
—	QUESTCOR PHARMACEUTICALS INC	969,495	$62.95M	5.2%	$64.93	$48.32	—	COM	74835Y101
—	ABIOMED INC	2,202,289	$57.35M	4.7%	$26.04	$21.31	—	COM	003654100
VNDA	VANDA PHARMACEUTICALS INC	3,215,424	$52.25M	4.3%	$16.25 *	$7.72	+84.2%	COM	921659108
BMRN	BIOMARIN PHARMACEUTICAL INC	745,687	$50.86M	4.2%	$68.21 *	$63.65	+15.8%	COM	09061G101
STAA	STAAR SURGICAL CO	2,593,653	$48.76M	4.0%	$18.80 *	$8.10	+99.0%	COM PAR $0.01	852312305
—	KYTHERA BIOPHARMACEUTICALS I	905,259	$35.99M	3.0%	$39.76	$38.50	—	COM	501570105
—	ANACOR PHARMACEUTICALS INC	1,572,078	$31.46M	2.6%	$20.01	$5.59	—	COM	032420101
—	AMAG PHARMACEUTICALS INC	1,614,536	$31.24M	2.6%	$19.35	$22.29	—	COM	00163U106
—	ALIMERA SCIENCES INC	3,634,984	$28.68M	2.4%	$7.89	$4.88	—	COM	016259103
—	ARIAD PHARMACEUTICALS INC	3,458,624	$27.88M	2.3%	$8.06	$6.82	—	COM	04033A100
—	SEQUENOM INC	9,788,442	$23.98M	2.0%	$2.45	$3.91	—	COM NEW	817337405
PRTA	PROTHENA CORP PLC	532,918	$20.42M	1.7%	$38.31 *	$22.48	+43.4%	SHS	G72800108
—	RIGEL PHARMACEUTICALS INC	5,169,301	$20.06M	1.7%	$3.88	$3.43	—	COM NEW	766559603
—	CELLADON CORP	1,491,500	$17.78M	1.5%	$11.92	$11.92	—	COM	15117E107
—	MOMENTA PHARMACEUTICALS INC	1,314,976	$15.32M	1.3%	$11.65	$14.69	—	COM	60877T100
—	NPS PHARMACEUTICALS INC	435,200	$13.03M	1.1%	$29.93	$30.36	—	COM	62936P103
—	CLOVIS ONCOLOGY INC	186,900	$12.95M	1.1%	$69.27	$60.27	—	COM	189464100
—	QLT INC	2,041,043	$11.35M	0.9%	$5.56	$4.40	—	COM	746927102
EXAS	EXACT SCIENCES CORP	777,676	$11.02M	0.9%	$14.17 *	$12.83	+5.3%	COM	30063P105
—	OREXIGEN THERAPEUTICS INC	1,669,024	$10.85M	0.9%	$6.50	$6.50	—	COM	686164104
FOLD	AMICUS THERAPEUTICS INC	3,971,576	$8.221M	0.7%	$2.07 *	$3.07	-18.6%	COM	03152W109
INSM	INSMED INC	316,699	$6.03M	0.5%	$19.04	$11.32	+67.9%	COM PAR $.01	457669307
—	SPECTRUM PHARMACEUTICALS INC	402,285	$3.154M	0.3%	$7.84	$7.48	—	COM	84763A108
—	REVANCE THERAPEUTICS INC	91,669	$2.888M	0.2%	$31.50	$31.50	—	COM	761330109
CYTK	CYTOKINETICS INC	247,186	$2.348M	0.2%	$9.50 *	$6.71	+34.7%	COM NEW	23282W605
—	AVEO PHARMACEUTICALS INC	1,429,174	$2.137M	0.2%	$1.50	$2.50	—	COM	053588109
—	HYPERION THERAPEUTICS INC	62,700	$1.618M	0.1%	$25.81	$22.00	—	COM	44915N101
—	XOMA CORP DEL	256,100	$1.334M	0.1%	$5.21	$3.63	—	COM	98419J107
GERN	GERON CORP	507,300	$1.06M	0.1%	$2.09 *	$3.99	0.0%	COM	374163103
—	SOPHIRIS BIO INC	292,900	$975K	0.1%	$3.33	$3.88	—	COM NEW	83578Q209
ALGN	ALIGN TECHNOLOGY INC	7,788	$403K	0.0%	$51.75 *	$55.98	0.0%	COM	016255101
—	CELGENE CORP	2,590	$362K	0.0%	$139.77	$159.15	—	COM	151020104
—	SHIRE PLC	1,800	$267K	0.0%	$148.33	$148.33	—	SPONSORED ADR	82481R106
GILD	GILEAD SCIENCES INC	3,600	$255K	0.0%	$70.83 *	$54.49	0.0%	COM	375558103