Location: Baltimore, MD
CIK: 0001595725 · Show all filings
Period: Q3 2022 (← Previous) (Next →)
Filing Date: Nov 14, 2022
Total Value: $3.872B (99.6% shares, 0.4% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| HUM | HUMANA INC | 426,500 | $207M | 5.3% | $361.45 | +29.8% | COM | 444859102 |
| AGL | AGILON HEALTH INC | 7,747,500 | $181M | 4.7% | $34.17 | -29.9% | COM | 00857U107 |
| IMCR | IMMUNOCORE HLDGS PLC | 3,493,743 | $164M | 4.2% | $42.88 | — | ADS | 45258D105 |
| UNH | UNITEDHEALTH GROUP INC | 269,500 | $136M | 3.5% | $219.29 | +125.8% | COM | 91324P102 |
| ARGX | ARGENX SE | 350,000 | $124M | 3.2% | $153.41 | — | SPONSORED ADR | 04016X101 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 1,122,500 | $119M | 3.1% | $74.96 | +35.4% | COM | 64125C109 |
| PODD | INSULET CORP | 518,500 | $119M | 3.1% | $176.76 | +41.7% | COM | 45784P101 |
| EVH | EVOLENT HEALTH INC | 3,262,500 | $117M | 3.0% | $24.32 | +44.9% | CL A | 30050B101 |
| — | BLUEPRINT MEDICINES CORP | 1,538,195 | $101M | 2.6% | $69.46 | — | COM | 09627Y109 |
| — | KARUNA THERAPEUTICS INC | 413,762 | $93.07M | 2.4% | $75.86 | — | COM | 48576A100 |
| PEN | PENUMBRA INC | 476,000 | $90.25M | 2.3% | $134.13 | +19.6% | COM | 70975L107 |
| AGIO | AGIOS PHARMACEUTICALS INC | 3,057,869 | $86.48M | 2.2% | $40.40 | -33.6% | COM | 00847X104 |
| IDXX | IDEXX LABS INC | 224,315 | $73.08M | 1.9% | $335.38 | +9.5% | COM | 45168D104 |
| ALGN | ALIGN TECHNOLOGY INC | 344,000 | $71.25M | 1.8% | $313.91 | -18.0% | COM | 016255101 |
| — | CEREVEL THERAPEUTICS HLDNG I | 2,499,148 | $70.63M | 1.8% | $24.09 | — | COM | 15678U128 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 332,500 | $66.55M | 1.7% | $95.74 | +99.2% | COM | 02043Q107 |
| ACHC | ACADIA HEALTHCARE COMPANY IN | 845,000 | $66.06M | 1.7% | $49.50 | +61.5% | COM | 00404A109 |
| ACRS | ACLARIS THERAPEUTICS INC | 3,961,249 | $62.35M | 1.6% | $10.84 | +45.4% | COM | 00461U105 |
| — | MIRATI THERAPEUTICS INC | 866,776 | $60.54M | 1.6% | $81.75 | — | COM | 60468T105 |
| ISRG | INTUITIVE SURGICAL INC | 298,500 | $55.95M | 1.4% | $264.69 | -18.9% | COM NEW | 46120E602 |
| PCRX | PACIRA BIOSCIENCES INC | 1,017,500 | $54.12M | 1.4% | $48.65 | +14.3% | COM | 695127100 |
| EW | EDWARDS LIFESCIENCES CORP | 631,000 | $52.14M | 1.3% | $62.24 | +54.6% | COM | 28176E108 |
| — | SHOCKWAVE MED INC | 180,100 | $50.08M | 1.3% | $79.81 | — | COM | 82489T104 |
| RARE | ULTRAGENYX PHARMACEUTICAL IN | 1,187,992 | $49.2M | 1.3% | $69.38 | -25.9% | COM | 90400D108 |
| SRPT | SAREPTA THERAPEUTICS INC | 430,000 | $47.53M | 1.2% | $60.98 | +65.3% | COM | 803607100 |
| — | AKERO THERAPEUTICS INC | 1,369,973 | $46.65M | 1.2% | $28.42 | — | COM | 00973Y108 |
| — | HORIZON THERAPEUTICS PUB L | 727,000 | $44.99M | 1.2% | $82.74 | — | SHS | G46188101 |
| WST | WEST PHARMACEUTICAL SVSC INC | 180,500 | $44.42M | 1.1% | $297.09 | +1.6% | COM | 955306105 |
| ASND | ASCENDIS PHARMA A/S | 425,500 | $43.94M | 1.1% | $85.24 | — | SPONSORED ADR | 04351P101 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 1,760,865 | $43.14M | 1.1% | $15.80 | +17.7% | COM | 76243J105 |
| XENE | XENON PHARMACEUTICALS INC | 1,155,961 | $41.73M | 1.1% | $22.40 | +60.5% | COM | 98420N105 |
| PRTA | PROTHENA CORP PLC | 678,462 | $41.13M | 1.1% | $12.70 | +148.9% | SHS | G72800108 |
| ZLAB | ZAI LAB LTD | 1,192,400 | $40.78M | 1.1% | $61.65 | — | ADR | 98887Q104 |
| BAX | BAXTER INTL INC | 755,500 | $40.69M | 1.1% | $71.07 | -22.2% | COM | 071813109 |
| — | CINCOR PHARMA INC | 1,205,856 | $39.58M | 1.0% | $19.88 | — | COM | 17240Y109 |
| DXCM | DEXCOM INC | 490,500 | $39.51M | 1.0% | $94.31 | -10.2% | COM | 252131107 |
| — | PROMETHEUS BIOSCIENCES INC | 645,407 | $38.09M | 1.0% | $19.18 | — | COM | 74349U108 |
| MIRM | MIRUM PHARMACEUTICALS INC | 1,795,733 | $37.73M | 1.0% | $14.23 | +69.2% | COM | 604749101 |
| — | SEAGEN INC | 272,000 | $37.22M | 1.0% | $173.02 | — | COM | 81181C104 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 293,250 | $36.74M | 0.9% | $62.74 | +130.2% | COM | 450056106 |
| — | NEVRO CORP | 787,000 | $36.67M | 0.9% | $96.73 | — | COM | 64157F103 |
| FRPT | FRESHPET INC | 700,000 | $35.06M | 0.9% | $60.72 | -22.3% | COM | 358039105 |
| — | COVETRUS INC | 1,678,800 | $35.05M | 0.9% | $21.18 | — | COM | 22304C100 |
| PHR | PHREESIA INC | 1,302,500 | $33.19M | 0.9% | $28.73 | -13.1% | COM | 71944F106 |
| — | ABCAM PLC | 2,032,500 | $30.47M | 0.8% | $19.15 | — | ADS | 000380204 |
| — | MERSANA THERAPEUTICS INC | 4,075,958 | $27.55M | 0.7% | $13.04 | — | COM | 59045L106 |
| — | ACCOLADE INC | 2,274,000 | $25.97M | 0.7% | $25.32 | — | COM | 00437E102 |
| XLV | SELECT SECTOR SPDR TR | 200,000 | $24.22M | 0.6% | $128.24 | — | SBI HEALTHCARE | 81369Y209 |
| TVTX | TRAVERE THERAPEUTICS INC | 951,650 | $23.45M | 0.6% | $24.60 | +5.0% | COM | 89422G107 |
| KYMR | KYMERA THERAPEUTICS INC | 1,046,743 | $22.79M | 0.6% | $32.50 | -18.9% | COM | 501575104 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 264,500 | $22.42M | 0.6% | $85.70 | +3.9% | COM | 09061G101 |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 1,712,507 | $21.58M | 0.6% | $10.69 | +20.4% | COM | 09058V103 |
| CYTK | CYTOKINETICS INC | 443,000 | $21.46M | 0.6% | $41.02 | +17.3% | COM NEW | 23282W605 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 317,485 | $20.63M | 0.5% | $47.33 | +46.8% | COM | 558868105 |
| — | VERVE THERAPEUTICS INC | 558,837 | $19.2M | 0.5% | $57.71 | — | COM | 92539P101 |
| GOSS | GOSSAMER BIO INC | 1,586,962 | $19.01M | 0.5% | $12.41 | 0.0% | COM | 38341P102 |
| EXAS | EXACT SCIENCES CORP | 578,600 | $18.8M | 0.5% | $56.38 | -26.9% | COM | 30063P105 |
| CNMD | CONMED CORP | 233,000 | $18.68M | 0.5% | $114.00 | -19.9% | COM | 207410101 |
| AURA | AURA BIOSCIENCES INC | 1,015,757 | $18.41M | 0.5% | $17.87 | -15.3% | COM | 05153U107 |
| LEGN | LEGEND BIOTECH CORP | 450,466 | $18.38M | 0.5% | $40.06 | — | SPONSORED ADS | 52490G102 |
| — | DYNAVAX TECHNOLOGIES CORP | 1,683,358 | $17.57M | 0.5% | $7.76 | — | COM NEW | 268158201 |
| — | OLINK HLDG AB | 1,445,000 | $17.54M | 0.5% | $22.16 | — | SPONSORED ADS | 680710100 |
| WRBY | WARBY PARKER INC | 1,309,475 | $17.47M | 0.5% | $41.37 | -67.8% | CL A COM | 93403J106 |
| IMTX | IMMATICS N.V | 1,681,224 | $16.81M | 0.4% | $8.86 | +21.8% | SHS | N44445109 |
| ANAB | ANAPTYSBIO INC | 576,600 | $14.71M | 0.4% | $28.23 | -17.0% | COM | 032724106 |
| AZTA | AZENTA INC | 330,200 | $14.15M | 0.4% | $67.09 | -11.0% | COM | 114340102 |
| RLAY | RELAY THERAPEUTICS INC | 618,267 | $13.83M | 0.4% | $34.51 | -36.4% | COM | 75943R102 |
| NVCR | NOVOCURE LTD | 175,000 | $13.3M | 0.3% | $37.58 | +107.6% | ORD SHS | G6674U108 |
| LFST | LIFESTANCE HEALTH GROUP INC | 2,000,000 | $13.24M | 0.3% | $23.27 | -70.0% | COM | 53228F101 |
| ARVN | ARVINAS INC | 280,100 | $12.46M | 0.3% | $32.84 | +47.8% | COM | 04335A105 |
| CMPX | COMPASS THERAPEUTICS INC | 5,333,188 | $12.16M | 0.3% | $3.29 | -15.8% | COM | 20454B104 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 421,604 | $11.85M | 0.3% | $30.05 | +2.0% | COM NEW | 15117B202 |
| COLL | COLLEGIUM PHARMACEUTICAL INC | 725,000 | $11.62M | 0.3% | $15.97 | +10.4% | COM | 19459J104 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 403,737 | $11.37M | 0.3% | $22.45 | +11.1% | COM | 03237H101 |
| NVAX | NOVAVAX INC | 599,300 | $10.91M | 0.3% | $43.41 | -0.2% | COM NEW | 670002401 |
| GH | GUARDANT HEALTH INC | 200,000 | $10.77M | 0.3% | $42.73 | +20.2% | COM | 40131M109 |
| FOLD | AMICUS THERAPEUTICS INC | 1,012,506 | $10.57M | 0.3% | $11.49 | -3.0% | COM | 03152W109 |
| — | CHINOOK THERAPEUTICS INC | 507,512 | $9.978M | 0.3% | $15.86 | — | COM | 16961L106 |
| LUNG | PULMONX CORP | 597,400 | $9.953M | 0.3% | $48.60 | -62.1% | COM | 745848101 |
| — | GOSSAMER BIO INC | 9,573,000 | $9.884M | 0.3% | $1.01 | — | NOTE 5.000% 6/0 | 38341PAA0 |
| — | ORION ACQUISITION CORP | 1,000,000 | $9.87M | 0.3% | $10.00 | — | UNIT 02/19/2026 | 68626A207 |
| — | AMRYT PHARMA PLC | 1,325,625 | $9.173M | 0.2% | $12.05 | — | SPONSORED ADS | 03217L106 |
| — | KINNATE BIOPHARMA INC | 746,973 | $8.926M | 0.2% | $24.53 | — | COM | 49705R105 |
| HCAT | HEALTH CATALYST INC | 880,000 | $8.536M | 0.2% | $34.41 | -61.5% | COM | 42225T107 |
| — | INVITAE CORP | 3,386,855 | $8.332M | 0.2% | $20.06 | — | COM | 46185L103 |
| NKTX | NKARTA INC | 616,277 | $8.11M | 0.2% | $26.66 | -46.4% | COM | 65487U108 |
| AUPH | AURINIA PHARMACEUTICALS INC | 1,066,408 | $8.019M | 0.2% | $13.26 | -34.7% | COM | 05156V102 |
| DSGN | DESIGN THERAPEUTICS INC | 460,391 | $7.698M | 0.2% | $26.33 | -24.4% | COM | 25056L103 |
| — | INOZYME PHARMA INC | 2,807,618 | $7.524M | 0.2% | $11.00 | — | COM | 45790W108 |
| EDAP | EDAP TMS S A | 910,000 | $7.508M | 0.2% | $7.07 | — | SPONSORED ADR | 268311107 |
| BMEA | BIOMEA FUSION INC | 730,846 | $7.148M | 0.2% | $17.65 | -35.0% | COM | 09077A106 |
| — | GAMIDA CELL LTD | 4,119,883 | $6.551M | 0.2% | $3.36 | — | SHS | M47364100 |
| MREO | MEREO BIOPHARMA GROUP PLC | 6,244,897 | $5.377M | 0.1% | $2.88 | — | SPON ADS | 589492107 |
| BEAM | BEAM THERAPEUTICS INC | 111,430 | $5.309M | 0.1% | $39.75 | +43.5% | COM | 07373V105 |
| — | EQRX INC | 1,000,000 | $4.95M | 0.1% | $4.13 | — | COM | 26886C107 |
| — | PARATEK PHARMACEUTICALS INC | 1,734,037 | $4.456M | 0.1% | $6.08 | — | COM | 699374302 |
| — | VIGIL NEUROSCIENCE INC | 471,958 | $4.295M | 0.1% | $7.03 | — | COM | 92673K108 |
| MGNX | MACROGENICS INC | 1,206,642 | $4.175M | 0.1% | $17.45 | -78.1% | COM | 556099109 |
| XLO | XILIO THERAPEUTICS INC | 1,362,878 | $3.966M | 0.1% | $15.36 | -81.9% | COM | 98422T100 |
| — | F-STAR THERAPEUTICS INC | 751,889 | $3.85M | 0.1% | $8.59 | — | COM | 30315R107 |
| — | RENEO PHARMACEUTICALS INC | 1,143,185 | $3.83M | 0.1% | $9.31 | — | COM | 75974E103 |
| — | TRAVERE THERAPEUTICS INC | 3,250,000 | $3.289M | 0.1% | $0.79 | — | NOTE 2.500% 9/1 | 761299AB2 |
| — | LEAP THERAPEUTICS INC | 3,659,847 | $3.221M | 0.1% | $3.92 | — | COM | 52187K101 |
| FULC | FULCRUM THERAPEUTICS INC | 384,590 | $3.111M | 0.1% | $18.95 | -62.2% | COM | 359616109 |
| — | BCLS ACQUISITION CORP | 309,000 | $3.096M | 0.1% | $11.14 | — | COM CL A | G0904B105 |
| ALT | ALTIMMUNE INC | 223,255 | $2.851M | 0.1% | $14.76 | 0.0% | COM NEW | 02155H200 |
| — | THESEUS PHARMACEUTICALS INC | 437,329 | $2.537M | 0.1% | $12.68 | — | COM | 88369M101 |
| ADAPY | ADAPTIMMUNE THERAPEUTICS PLC | 2,357,544 | $2.534M | 0.1% | $8.15 | — | SPONDS ADR | 00653A107 |
| — | ICOSAVAX INC | 781,000 | $2.468M | 0.1% | $28.18 | — | COM | 45114M109 |
| FATE | FATE THERAPEUTICS INC | 110,000 | $2.465M | 0.1% | $89.50 | -67.7% | COM | 31189P102 |
| — | SPRUCE BIOSCIENCES INC | 1,622,689 | $2.223M | 0.1% | $24.10 | — | COM | 85209E109 |
| — | JIYA ACQUISITION CORP | 206,200 | $2.056M | 0.1% | $10.30 | — | COM CL A | 47760M102 |
| — | IMARA INC | 842,402 | $1.921M | 0.0% | $4.05 | — | COM | 45249V107 |
| — | AEGLEA BIOTHERAPEUTICS INC | 3,413,906 | $1.796M | 0.0% | $4.00 | — | COM | 00773J103 |
| SPRO | SPERO THERAPEUTICS INC | 770,710 | $1.541M | 0.0% | $11.75 | -91.5% | COM | 84833T103 |
| — | VINCERX PHARMA INC | 1,108,570 | $1.53M | 0.0% | $12.19 | — | COM NEW | 92731L106 |
| — | TEMPEST THERAPEUTICS INC | 823,654 | $1.433M | 0.0% | $7.50 | — | COM | 87978U108 |
| — | NEUROCRINE BIOSCIENCES INC | 1,000,000 | $1.413M | 0.0% | $1.45 | — | NOTE 2.250% 5/1 | 64125CAD1 |
| — | ACELRX PHARMACEUTICALS INC | 6,329,202 | $1.323M | 0.0% | $1.08 | — | COM | 00444T100 |
| BHVN | BIOHAVEN LTD | 167,421 | $1.055M | 0.0% | $7.25 | 0.0% | COM | G1110E107 |
| — | ESSA PHARMA INC | 524,944 | $955K | 0.0% | $28.44 | — | COM NEW | 29668H708 |
| CGEN | COMPUGEN LTD | 1,289,990 | $848K | 0.0% | $6.12 | -76.9% | ORD | M25722105 |
| — | ATRECA INC | 462,530 | $726K | 0.0% | $13.90 | — | CL A COM | 04965G109 |
| — | APPLIED THERAPEUTICS INC | 701,680 | $653K | 0.0% | $31.74 | — | COM | 03828A101 |
| — | PHASEBIO PHARMACEUTICALS INC | 2,719,074 | $479K | 0.0% | $4.30 | — | COM | 717224109 |
| — | NEVRO CORP | 500,000 | $473K | 0.0% | $1.37 | — | NOTE 2.750% 4/0 | 64157FAC7 |
| ALT | ALTIMMUNE INC | 33,500 | $428K | 0.0% | $14.76 | 0.0% | Call | 02155H200 |
| — | NUVATION BIO INC | 134,028 | $27,000 | 0.0% | $2.67 | — | *W EXP 07/07/202 | 67080N119 |