Location: Baltimore, MD
CIK: 0001595725 · Show all filings
Period: Q1 2023 (← Previous) (Next →)
Filing Date: May 15, 2023
Total Value: $4.191B (99.8% shares, 0.2% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| HUM | HUMANA INC | 426,500 | $207M | 4.9% | $361.45 | +32.4% | COM | 444859102 |
| AGL | AGILON HEALTH INC | 7,882,500 | $187M | 4.5% | $33.92 | -34.0% | COM | 00857U107 |
| PODD | INSULET CORP | 536,750 | $171M | 4.1% | $180.60 | +64.1% | COM | 45784P101 |
| IMCR | IMMUNOCORE HLDGS PLC | 3,001,662 | $148M | 3.5% | $42.88 | — | ADS | 45258D105 |
| ARGX | ARGENX SE | 350,000 | $130M | 3.1% | $153.41 | — | SPONSORED ADR | 04016X101 |
| UNH | UNITEDHEALTH GROUP INC | 270,000 | $128M | 3.0% | $219.29 | +108.5% | COM | 91324P102 |
| EVH | EVOLENT HEALTH INC | 3,803,500 | $123M | 2.9% | $24.94 | +26.8% | CL A | 30050B101 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 1,210,100 | $122M | 2.9% | $77.07 | +35.0% | COM | 64125C109 |
| PEN | PENUMBRA INC | 433,500 | $121M | 2.9% | $138.03 | +84.9% | COM | 70975L107 |
| — | PROMETHEUS BIOSCIENCES INC | 1,031,550 | $111M | 2.6% | $53.18 | — | COM | 74349U108 |
| IDXX | IDEXX LABS INC | 207,500 | $104M | 2.5% | $335.38 | +42.7% | COM | 45168D104 |
| — | BLUEPRINT MEDICINES CORP | 2,033,048 | $91.47M | 2.2% | $63.30 | — | COM | 09627Y109 |
| — | KARUNA THERAPEUTICS INC | 493,527 | $89.64M | 2.1% | $92.95 | — | COM | 48576A100 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 348,121 | $84.34M | 2.0% | $51.77 | +426.3% | COM | 558868105 |
| ALGN | ALIGN TECHNOLOGY INC | 247,350 | $82.65M | 2.0% | $313.91 | -6.0% | COM | 016255101 |
| — | SEAGEN INC | 400,200 | $81.03M | 1.9% | $158.76 | — | COM | 81181C104 |
| — | HORIZON THERAPEUTICS PUB L | 740,100 | $80.77M | 1.9% | $83.28 | — | SHS | G46188101 |
| ISRG | INTUITIVE SURGICAL INC | 298,500 | $76.26M | 1.8% | $264.69 | -6.9% | COM NEW | 46120E602 |
| WST | WEST PHARMACEUTICAL SVSC INC | 202,000 | $69.99M | 1.7% | $294.97 | -1.7% | COM | 955306105 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 345,000 | $69.11M | 1.6% | $99.88 | +110.4% | COM | 02043Q107 |
| EXAS | EXACT SCIENCES CORP | 941,500 | $63.84M | 1.5% | $51.74 | +24.2% | COM | 30063P105 |
| ACHC | ACADIA HEALTHCARE COMPANY IN | 860,868 | $62.2M | 1.5% | $50.01 | +55.9% | COM | 00404A109 |
| — | CEREVEL THERAPEUTICS HLDNG I | 2,513,916 | $61.31M | 1.5% | $24.09 | — | COM | 15678U128 |
| AGIO | AGIOS PHARMACEUTICALS INC | 2,661,605 | $61.14M | 1.5% | $40.40 | -34.2% | COM | 00847X104 |
| SRPT | SAREPTA THERAPEUTICS INC | 442,500 | $60.99M | 1.5% | $62.74 | +106.8% | COM | 803607100 |
| DXCM | DEXCOM INC | 490,500 | $56.99M | 1.4% | $94.31 | +18.7% | COM | 252131107 |
| — | AKERO THERAPEUTICS INC | 1,454,254 | $55.64M | 1.3% | $29.34 | — | COM | 00973Y108 |
| RARE | ULTRAGENYX PHARMACEUTICAL IN | 1,336,401 | $53.59M | 1.3% | $66.17 | -35.1% | COM | 90400D108 |
| EW | EDWARDS LIFESCIENCES CORP | 645,900 | $53.44M | 1.3% | $62.58 | +25.6% | COM | 28176E108 |
| ASND | ASCENDIS PHARMA A/S | 425,500 | $45.62M | 1.1% | $85.24 | — | SPONSORED ADR | 04351P101 |
| FRPT | FRESHPET INC | 662,500 | $43.85M | 1.0% | $60.72 | +1.1% | COM | 358039105 |
| MIRM | MIRUM PHARMACEUTICALS INC | 1,795,733 | $43.13M | 1.0% | $14.23 | +60.1% | COM | 604749101 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 1,452,816 | $42.63M | 1.0% | $31.75 | +9.4% | COM | 03237H101 |
| XENE | XENON PHARMACEUTICALS INC | 1,178,002 | $42.16M | 1.0% | $22.63 | +63.2% | COM | 98420N105 |
| PCRX | PACIRA BIOSCIENCES INC | 1,032,600 | $42.14M | 1.0% | $48.65 | -18.2% | COM | 695127100 |
| PHR | PHREESIA INC | 1,302,500 | $42.06M | 1.0% | $28.73 | +22.5% | COM | 71944F106 |
| BMEA | BIOMEA FUSION INC | 1,297,213 | $40.23M | 1.0% | $15.37 | -19.2% | COM | 09077A106 |
| — | MIRATI THERAPEUTICS INC | 1,065,261 | $39.61M | 0.9% | $70.86 | — | COM | 60468T105 |
| — | NEVRO CORP | 1,077,900 | $38.97M | 0.9% | $81.31 | — | COM | 64157F103 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 309,450 | $38.38M | 0.9% | $65.15 | +66.5% | COM | 450056106 |
| — | OLINK HLDG AB | 1,650,000 | $37.17M | 0.9% | $22.21 | — | SPONSORED ADS | 680710100 |
| — | ACCOLADE INC | 2,545,000 | $36.6M | 0.9% | $22.71 | — | COM | 00437E102 |
| PRTA | PROTHENA CORP PLC | 753,462 | $36.52M | 0.9% | $17.26 | +206.0% | SHS | G72800108 |
| KYMR | KYMERA THERAPEUTICS INC | 1,228,379 | $36.4M | 0.9% | $31.64 | +1.9% | COM | 501575104 |
| ZLAB | ZAI LAB LTD | 1,059,700 | $35.25M | 0.8% | $61.65 | — | ADR | 98887Q104 |
| ACRS | ACLARIS THERAPEUTICS INC | 3,961,849 | $32.05M | 0.8% | $10.84 | +17.1% | COM | 00461U105 |
| — | ABCAM PLC | 2,242,500 | $30.18M | 0.7% | $18.75 | — | ADS | 000380204 |
| TVTX | TRAVERE THERAPEUTICS INC | 1,276,650 | $28.71M | 0.7% | $23.75 | -10.5% | COM | 89422G107 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 1,597,123 | $28.49M | 0.7% | $15.80 | +59.0% | COM | 76243J105 |
| XLV | SELECT SECTOR SPDR TR | 200,000 | $25.89M | 0.6% | $128.24 | — | SBI HEALTHCARE | 81369Y209 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 264,500 | $25.72M | 0.6% | $85.70 | +21.0% | COM | 09061G101 |
| — | SHOCKWAVE MED INC | 115,100 | $24.96M | 0.6% | $79.81 | — | COM | 82489T104 |
| LEGN | LEGEND BIOTECH CORP | 458,265 | $22.1M | 0.5% | $40.20 | — | SPONSORED ADS | 52490G102 |
| LFST | LIFESTANCE HEALTH GROUP INC | 2,900,000 | $21.55M | 0.5% | $17.93 | -69.1% | COM | 53228F101 |
| CNMD | CONMED CORP | 205,000 | $21.29M | 0.5% | $114.00 | -17.5% | COM | 207410101 |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 2,334,085 | $19.47M | 0.5% | $10.62 | -9.4% | COM | 09058V103 |
| — | AMRYT PHARMA PLC | 1,325,625 | $19.33M | 0.5% | $12.05 | — | SPONSORED ADS | 03217L106 |
| AZTA | AZENTA INC | 431,200 | $19.24M | 0.5% | $63.06 | -21.5% | COM | 114340102 |
| — | INOZYME PHARMA INC | 3,214,900 | $18.42M | 0.4% | $9.93 | — | COM | 45790W108 |
| MLYS | MINERALYS THERAPEUTICS INC | 1,167,492 | $18.28M | 0.4% | $16.83 | 0.0% | COM | 603170101 |
| CMPX | COMPASS THERAPEUTICS INC | 5,513,788 | $18.03M | 0.4% | $3.31 | +18.6% | COM | 20454B104 |
| — | DYNAVAX TECHNOLOGIES CORP | 1,813,758 | $17.79M | 0.4% | $7.97 | — | COM NEW | 268158201 |
| IMTX | IMMATICS N.V | 2,513,923 | $17.35M | 0.4% | $9.14 | -10.5% | SHS | N44445109 |
| — | MERSANA THERAPEUTICS INC | 4,103,803 | $16.87M | 0.4% | $13.04 | — | COM | 59045L106 |
| CYTK | CYTOKINETICS INC | 447,600 | $15.75M | 0.4% | $41.02 | -0.6% | COM NEW | 23282W605 |
| COLL | COLLEGIUM PHARMACEUTICAL INC | 650,000 | $15.59M | 0.4% | $15.97 | +66.0% | COM | 19459J104 |
| RVMD | REVOLUTION MEDICINES INC | 702,712 | $15.22M | 0.4% | $24.62 | 0.0% | COM | 76155X100 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 421,504 | $15.17M | 0.4% | $30.05 | +43.6% | COM NEW | 15117B202 |
| WRBY | WARBY PARKER INC | 1,300,000 | $13.77M | 0.3% | $39.64 | -65.4% | CL A COM | 93403J106 |
| PLRX | PLIANT THERAPEUTICS INC | 491,221 | $13.07M | 0.3% | $28.47 | 0.0% | COM | 729139105 |
| ANAB | ANAPTYSBIO INC | 576,600 | $12.55M | 0.3% | $28.23 | -13.9% | COM | 032724106 |
| FOLD | AMICUS THERAPEUTICS INC | 1,063,806 | $11.8M | 0.3% | $11.48 | +7.4% | COM | 03152W109 |
| — | CHINOOK THERAPEUTICS INC | 507,512 | $11.75M | 0.3% | $15.86 | — | COM | 16961L106 |
| EDAP | EDAP TMS S A | 1,030,000 | $11.4M | 0.3% | $7.54 | — | SPONSORED ADR | 268311107 |
| RLAY | RELAY THERAPEUTICS INC | 673,966 | $11.1M | 0.3% | $33.24 | -46.1% | COM | 75943R102 |
| HCAT | HEALTH CATALYST INC | 929,900 | $10.85M | 0.3% | $33.08 | -61.5% | COM | 42225T107 |
| AURA | AURA BIOSCIENCES INC | 1,019,757 | $9.463M | 0.2% | $17.87 | -41.9% | COM | 05153U107 |
| BHVN | BIOHAVEN LTD | 685,623 | $9.366M | 0.2% | $12.49 | +27.5% | COM | G1110E107 |
| — | VERVE THERAPEUTICS INC | 558,837 | $8.058M | 0.2% | $57.71 | — | COM | 92539P101 |
| MGNX | MACROGENICS INC | 1,123,096 | $8.053M | 0.2% | $17.45 | -65.5% | COM | 556099109 |
| NVCR | NOVOCURE LTD | 125,000 | $7.518M | 0.2% | $37.58 | +112.6% | ORD SHS | G6674U108 |
| LUNG | PULMONX CORP | 652,400 | $7.294M | 0.2% | $45.31 | -78.2% | COM | 745848101 |
| — | RENEO PHARMACEUTICALS INC | 1,143,185 | $6.836M | 0.2% | $9.31 | — | COM | 75974E103 |
| IRON | DISC MEDICINE INC | 313,468 | $6.642M | 0.2% | $49.79 | -55.3% | COM | 254604101 |
| — | SPRUCE BIOSCIENCES INC | 2,728,125 | $6.029M | 0.1% | $15.23 | — | COM | 85209E109 |
| AUPH | AURINIA PHARMACEUTICALS INC | 479,540 | $5.256M | 0.1% | $13.26 | -33.6% | COM | 05156V102 |
| — | ICOSAVAX INC | 864,510 | $5.014M | 0.1% | $26.02 | — | COM | 45114M109 |
| GH | GUARDANT HEALTH INC | 200,000 | $4.688M | 0.1% | $42.73 | -33.2% | COM | 40131M109 |
| — | KINNATE BIOPHARMA INC | 746,973 | $4.669M | 0.1% | $24.53 | — | COM | 49705R105 |
| — | VIGIL NEUROSCIENCE INC | 471,958 | $4.62M | 0.1% | $7.03 | — | COM | 92673K108 |
| XLO | XILIO THERAPEUTICS INC | 1,440,759 | $4.567M | 0.1% | $14.70 | -78.7% | COM | 98422T100 |
| MREO | MEREO BIOPHARMA GROUP PLC | 6,244,897 | $4.415M | 0.1% | $2.88 | — | SPON ADS | 589492107 |
| — | PARATEK PHARMACEUTICALS INC | 1,734,037 | $4.404M | 0.1% | $6.08 | — | COM | 699374302 |
| — | INVITAE CORP | 3,241,425 | $4.376M | 0.1% | $19.23 | — | COM | 46185L103 |
| — | THESEUS PHARMACEUTICALS INC | 437,329 | $3.883M | 0.1% | $12.68 | — | COM | 88369M101 |
| NVAX | NOVAVAX INC | 535,400 | $3.71M | 0.1% | $43.41 | -78.8% | COM NEW | 670002401 |
| FATE | FATE THERAPEUTICS INC | 612,215 | $3.49M | 0.1% | $21.03 | -71.3% | COM | 31189P102 |
| BEAM | BEAM THERAPEUTICS INC | 111,430 | $3.412M | 0.1% | $39.75 | -0.7% | COM | 07373V105 |
| — | TRAVERE THERAPEUTICS INC | 3,250,000 | $3.126M | 0.1% | $0.79 | — | NOTE 2.500% 9/1 | 761299AB2 |
| ADAPY | ADAPTIMMUNE THERAPEUTICS PLC | 2,787,845 | $3.039M | 0.1% | $7.10 | — | SPONDS ADR | 00653A107 |
| DSGN | DESIGN THERAPEUTICS INC | 460,391 | $2.656M | 0.1% | $26.33 | -71.6% | COM | 25056L103 |
| — | GOSSAMER BIO INC | 9,573,000 | $2.641M | 0.1% | $1.01 | — | NOTE 5.000% 6/0 | 38341PAA0 |
| — | 89BIO INC | 164,500 | $2.505M | 0.1% | — | — | Call | 282559103 |
| FULC | FULCRUM THERAPEUTICS INC | 727,673 | $2.074M | 0.0% | $14.24 | -37.1% | COM | 359616109 |
| — | TEMPEST THERAPEUTICS INC | 823,654 | $1.911M | 0.0% | $7.50 | — | COM | 87978U108 |
| — | GAMIDA CELL LTD | 2,344,649 | $1.899M | 0.0% | $3.36 | — | SHS | M47364100 |
| — | LEAP THERAPEUTICS INC | 4,655,186 | $1.583M | 0.0% | $3.15 | — | COM | 52187K101 |
| — | ESSA PHARMA INC | 524,944 | $1.559M | 0.0% | $28.44 | — | COM NEW | 29668H708 |
| NKTX | NKARTA INC | 393,389 | $1.397M | 0.0% | $26.66 | -82.2% | COM | 65487U108 |
| GOSS | GOSSAMER BIO INC | 1,100,274 | $1.386M | 0.0% | $5.50 | -65.2% | COM | 38341P102 |
| — | NEUROCRINE BIOSCIENCES INC | 1,000,000 | $1.351M | 0.0% | $1.45 | — | NOTE 2.250% 5/1 | 64125CAD1 |
| — | AEGLEA BIOTHERAPEUTICS INC | 3,413,906 | $990K | 0.0% | $4.00 | — | COM | 00773J103 |
| SPRO | SPERO THERAPEUTICS INC | 669,533 | $971K | 0.0% | $11.75 | -85.7% | COM | 84833T103 |
| ALT | ALTIMMUNE INC | 223,255 | $942K | 0.0% | $14.76 | -19.5% | COM NEW | 02155H200 |
| — | VINCERX PHARMA INC | 891,719 | $927K | 0.0% | $12.19 | — | COM NEW | 92731L106 |
| CGEN | COMPUGEN LTD | 1,289,990 | $906K | 0.0% | $6.12 | -86.6% | ORD | M25722105 |
| — | APPLIED THERAPEUTICS INC | 780,791 | $633K | 0.0% | $24.45 | — | COM | 03828A101 |
| — | NEVRO CORP | 500,000 | $470K | 0.0% | $1.37 | — | NOTE 2.750% 4/0 | 64157FAC7 |
| — | ATRECA INC | 362,530 | $413K | 0.0% | $13.90 | — | CL A COM | 04965G109 |
| TLPH | ACELRX PHARMACEUTICALS INC | 316,460 | $208K | 0.0% | $2.81 | -43.8% | COM NEW | 00444T209 |
| — | NUVATION BIO INC | 134,028 | $16,083 | 0.0% | $2.67 | — | *W EXP 07/07/202 | 67080N119 |