GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q1 2024 (← Previous) (Next →)

Filing Date: May 15, 2024

Total Value ($000): $641,638 (100.0% shares, 0.0% debt)

Holdings (35)

NGNE NEUROGENE INC 8.0%

Value ($000) $51,118 Shares 1,004,291 Est. Cost $14.51 Unrealized +130.2%

— ALPINE IMMUNE SCIENCES INC 7.0%

Value ($000) $44,734 Shares 1,128,499 Est. Cost $9.38 Unrealized —

URGN UROGEN PHARMA LTD 6.1%

Value ($000) $39,308 Shares 2,620,545 Est. Cost $16.05 Unrealized +1.8%

ABVX ABIVAX SA 5.5%

Value ($000) $35,585 Shares 2,488,483 Est. Cost $12.06 Unrealized —

EOLS EVOLUS INC 5.3%

Value ($000) $34,300 Shares 2,450,000 Est. Cost $9.65 Unrealized +34.6%

PLRX PLIANT THERAPEUTICS INC 4.3%

Value ($000) $27,593 Shares 1,851,864 Est. Cost $17.57 Unrealized -6.1%

APGE APOGEE THERAPEUTICS INC 4.1%

Value ($000) $26,580 Shares 400,000 Est. Cost $22.03 Unrealized +98.2%

— AEROVATE THERAPEUTICS INC 4.1%

Value ($000) $26,249 Shares 887,690 Est. Cost $21.89 Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 3.6%

Value ($000) $23,376 Shares 1,335,000 Est. Cost $19.39 Unrealized 0.0%

ANAB ANAPTYSBIO INC 3.4%

Value ($000) $22,002 Shares 976,981 Est. Cost $23.39 Unrealized +1.2%

ESPR ESPERION THERAPEUTICS INC NE 3.3%

Value ($000) $21,440 Shares 8,000,000 Est. Cost $2.43 Unrealized 0.0%

INSM INSMED INC 3.3%

Value ($000) $21,042 Shares 775,585 Est. Cost $26.50 Unrealized +5.6%

ACLX ARCELLX INC 3.3%

Value ($000) $20,865 Shares 300,000 Est. Cost $58.67 Unrealized +8.1%

XENE XENON PHARMACEUTICALS INC 3.1%

Value ($000) $19,637 Shares 456,148 Est. Cost $24.44 Unrealized +88.2%

— MIND MEDICINE MINDMED INC 2.9%

Value ($000) $18,800 Shares 2,000,000 Est. Cost $9.40 Unrealized —

DNTH DIANTHUS THERAPEUTICS INC 2.9%

Value ($000) $18,750 Shares 625,000 Est. Cost $21.73 Unrealized 0.0%

OTLK OUTLOOK THERAPEUTICS INC 2.8%

Value ($000) $17,671 Shares 1,480,000 Est. Cost $8.09 Unrealized 0.0%

FOLD AMICUS THERAPEUTICS INC 2.7%

Value ($000) $17,617 Shares 1,495,500 Est. Cost $12.08 Unrealized +5.9%

OCUL OCULAR THERAPEUTIX INC 2.5%

Value ($000) $15,731 Shares 1,728,723 Est. Cost $5.42 Unrealized +30.9%

— DYNAVAX TECHNOLOGIES CORP 2.4%

Value ($000) $15,698 Shares 1,264,920 Est. Cost $12.41 Unrealized —

CYTK CYTOKINETICS INC 2.2%

Value ($000) $14,176 Shares 202,202 Est. Cost $40.16 Unrealized +92.6%

— OPTINOSE INC 2.0%

Value ($000) $12,828 Shares 8,786,318 Est. Cost $1.78 Unrealized —

JSPR JASPER THERAPEUTICS INC 1.9%

Value ($000) $11,966 Shares 407,550 Est. Cost $17.76 Unrealized 0.0%

— INTRA-CELLULAR THERAPIES INC 1.6%

Value ($000) $10,380 Shares 150,000 Est. Cost $56.58 Unrealized —

— MERUS N V 1.6%

Value ($000) $10,055 Shares 223,288 Est. Cost $43.46 Unrealized —

VTGN VISTAGEN THERAPEUTICS INC 1.5%

Value ($000) $9,814 Shares 1,858,735 Est. Cost $3.78 Unrealized +27.1%

TERN TERNS PHARMACEUTICALS INC 1.3%

Value ($000) $8,593 Shares 1,309,975 Est. Cost $5.81 Unrealized +12.4%

IMCR IMMUNOCORE HLDGS PLC 1.2%

Value ($000) $7,475 Shares 115,000 Est. Cost $50.92 Unrealized —

AUTL AUTOLUS THERAPEUTICS PLC 1.2%

Value ($000) $7,443 Shares 1,166,667 Est. Cost $6.38 Unrealized —

PBYI PUMA BIOTECHNOLOGY INC 1.1%

Value ($000) $7,121 Shares 1,343,628 Est. Cost $3.70 Unrealized +45.6%

ZURA ZURA BIO LTD 1.1%

Value ($000) $7,087 Shares 2,757,740 Est. Cost $8.03 Unrealized -55.9%

BBOT HELIX ACQUISITION CORP II 0.8%

Value ($000) $5,200 Shares 500,000 Est. Cost $10.35 Unrealized 0.0%

SYRE SPYRE THERAPEUTICS INC 0.7%

Value ($000) $4,741 Shares 125,000 Est. Cost $13.78 Unrealized +110.3%

KYTX KYVERNA THERAPEUTICS INC 0.6%

Value ($000) $3,726 Shares 150,000 Est. Cost $27.84 Unrealized 0.0%

ARVN ARVINAS INC 0.5%

Value ($000) $2,936 Shares 71,113 Est. Cost $23.38 Unrealized +86.9%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
NGNE	NEUROGENE INC	1,004,291	$51,118	8.0%	$14.51	+130.2%	COM	64135M105
—	ALPINE IMMUNE SCIENCES INC	1,128,499	$44,734	7.0%	$9.38	—	COM	02083G100
URGN	UROGEN PHARMA LTD	2,620,545	$39,308	6.1%	$16.05	+1.8%	COM	M96088105
ABVX	ABIVAX SA	2,488,483	$35,585	5.5%	$12.06	—	SPONSORED ADS	00370M103
EOLS	EVOLUS INC	2,450,000	$34,300	5.3%	$9.65	+34.6%	COM	30052C107
PLRX	PLIANT THERAPEUTICS INC	1,851,864	$27,593	4.3%	$17.57	-6.1%	COM	729139105
APGE	APOGEE THERAPEUTICS INC	400,000	$26,580	4.1%	$22.03	+98.2%	COM	03770N101
—	AEROVATE THERAPEUTICS INC	887,690	$26,249	4.1%	$21.89	—	COM	008064107
VRDN	VIRIDIAN THERAPEUTICS INC	1,335,000	$23,376	3.6%	$19.39	0.0%	COM	92790C104
ANAB	ANAPTYSBIO INC	976,981	$22,002	3.4%	$23.39	+1.2%	COM	032724106
ESPR	ESPERION THERAPEUTICS INC NE	8,000,000	$21,440	3.3%	$2.43	0.0%	COM	29664W105
INSM	INSMED INC	775,585	$21,042	3.3%	$26.50	+5.6%	COM PAR $.01	457669307
ACLX	ARCELLX INC	300,000	$20,865	3.3%	$58.67	+8.1%	COMMON STOCK	03940C100
XENE	XENON PHARMACEUTICALS INC	456,148	$19,637	3.1%	$24.44	+88.2%	COM	98420N105
—	MIND MEDICINE MINDMED INC	2,000,000	$18,800	2.9%	$9.40	—	COM NEW	60255C885
DNTH	DIANTHUS THERAPEUTICS INC	625,000	$18,750	2.9%	$21.73	0.0%	COM	252828108
OTLK	OUTLOOK THERAPEUTICS INC	1,480,000	$17,671	2.8%	$8.09	0.0%	COM	69012T305
FOLD	AMICUS THERAPEUTICS INC	1,495,500	$17,617	2.7%	$12.08	+5.9%	COM	03152W109
OCUL	OCULAR THERAPEUTIX INC	1,728,723	$15,731	2.5%	$5.42	+30.9%	COM	67576A100
—	DYNAVAX TECHNOLOGIES CORP	1,264,920	$15,698	2.4%	$12.41	—	COM NEW	268158201
CYTK	CYTOKINETICS INC	202,202	$14,176	2.2%	$40.16	+92.6%	COM NEW	23282W605
—	OPTINOSE INC	8,786,318	$12,828	2.0%	$1.78	—	COM	68404V100
JSPR	JASPER THERAPEUTICS INC	407,550	$11,966	1.9%	$17.76	0.0%	COM NEW	471871202
—	INTRA-CELLULAR THERAPIES INC	150,000	$10,380	1.6%	$56.58	—	COM	46116X101
—	MERUS N V	223,288	$10,055	1.6%	$43.46	—	COM	N5749R100
VTGN	VISTAGEN THERAPEUTICS INC	1,858,735	$9,814	1.5%	$3.78	+27.1%	COM	92840H400
TERN	TERNS PHARMACEUTICALS INC	1,309,975	$8,593	1.3%	$5.81	+12.4%	COM	880881107
IMCR	IMMUNOCORE HLDGS PLC	115,000	$7,475	1.2%	$50.92	—	ADS	45258D105
AUTL	AUTOLUS THERAPEUTICS PLC	1,166,667	$7,443	1.2%	$6.38	—	SPON ADS	05280R100
PBYI	PUMA BIOTECHNOLOGY INC	1,343,628	$7,121	1.1%	$3.70	+45.6%	COM	74587V107
ZURA	ZURA BIO LTD	2,757,740	$7,087	1.1%	$8.03	-55.9%	CLASS A ORD SHS	G9TY5A101
BBOT	HELIX ACQUISITION CORP II	500,000	$5,200	0.8%	$10.35	0.0%	CL A ORD SHS	G4444H101
SYRE	SPYRE THERAPEUTICS INC	125,000	$4,741	0.7%	$13.78	+110.3%	COM NEW	00773J202
KYTX	KYVERNA THERAPEUTICS INC	150,000	$3,726	0.6%	$27.84	0.0%	COM	501976104
ARVN	ARVINAS INC	71,113	$2,936	0.5%	$23.38	+86.9%	COM	04335A105