Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q4 2016 (← Previous) (Next →)

Filing Date: Feb 15, 2017

Total Value ($000): $1,752,860 (100.0% shares, 0.0% debt)

Holdings (38)

UTHR UNITED THERAPEUTICS CORP DEL 15.3%

Value ($000) $268,044 Shares 1,868,815 Est. Cost $88.34 Unrealized +44.5%

— ABIOMED INC 12.2%

Value ($000) $214,496 Shares 1,903,584 Est. Cost $30.32 Unrealized —

— CLOVIS ONCOLOGY INC 9.6%

Value ($000) $168,978 Shares 3,804,088 Est. Cost $53.87 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 9.3%

Value ($000) $162,385 Shares 1,960,219 Est. Cost $77.21 Unrealized +11.4%

— AMAG PHARMACEUTICALS INC 6.6%

Value ($000) $116,393 Shares 3,344,620 Est. Cost $29.94 Unrealized —

— ALEXION PHARMACEUTICALS INC 5.0%

Value ($000) $87,326 Shares 713,742 Est. Cost $119.75 Unrealized —

— ZELTIQ AESTHETICS INC 4.3%

Value ($000) $74,888 Shares 1,720,763 Est. Cost $29.98 Unrealized —

INSM INSMED INC 4.1%

Value ($000) $72,057 Shares 5,446,516 Est. Cost $14.56 Unrealized -6.3%

VNDA VANDA PHARMACEUTICALS INC 3.8%

Value ($000) $67,042 Shares 4,203,270 Est. Cost $8.70 Unrealized +84.7%

— WRIGHT MED GROUP N V 3.4%

Value ($000) $59,854 Shares 2,604,593 Est. Cost $23.37 Unrealized —

— SAGE THERAPEUTICS INC 2.9%

Value ($000) $51,567 Shares 1,009,930 Est. Cost $40.00 Unrealized —

PRTA PROTHENA CORP PLC 2.8%

Value ($000) $48,888 Shares 993,855 Est. Cost $30.77 Unrealized +79.3%

ACAD ACADIA PHARMACEUTICALS INC 2.5%

Value ($000) $44,184 Shares 1,532,030 Est. Cost $29.57 Unrealized -10.5%

STAA STAAR SURGICAL CO 2.1%

Value ($000) $36,741 Shares 3,386,245 Est. Cost $7.92 Unrealized +28.4%

— EPIZYME INC 2.1%

Value ($000) $36,733 Shares 3,035,796 Est. Cost $13.44 Unrealized —

— CELGENE CORP 1.9%

Value ($000) $34,174 Shares 295,240 Est. Cost $97.51 Unrealized —

— ARIAD PHARMACEUTICALS INC 1.9%

Value ($000) $33,364 Shares 2,682,017 Est. Cost $7.21 Unrealized —

FOLD AMICUS THERAPEUTICS INC 1.8%

Value ($000) $31,858 Shares 6,410,030 Est. Cost $6.21 Unrealized +11.4%

— KARYOPHARM THERAPEUTICS INC 1.7%

Value ($000) $30,084 Shares 3,200,396 Est. Cost $20.34 Unrealized —

— MOMENTA PHARMACEUTICALS INC 1.5%

Value ($000) $25,997 Shares 1,727,380 Est. Cost $14.10 Unrealized —

GILD GILEAD SCIENCES INC 1.3%

Value ($000) $22,801 Shares 318,400 Est. Cost $63.20 Unrealized -15.8%

— SHIRE PLC 1.2%

Value ($000) $21,144 Shares 124,100 Est. Cost $221.47 Unrealized —

— RIGEL PHARMACEUTICALS INC 0.6%

Value ($000) $9,940 Shares 4,176,623 Est. Cost $3.39 Unrealized —

— AIMMUNE THERAPEUTICS INC 0.4%

Value ($000) $7,765 Shares 379,727 Est. Cost $23.85 Unrealized —

EXAS EXACT SCIENCES CORP 0.3%

Value ($000) $5,304 Shares 396,976 Est. Cost $12.83 Unrealized +25.8%

— SUNESIS PHARMACEUTICALS INC 0.2%

Value ($000) $4,208 Shares 1,162,473 Est. Cost $4.37 Unrealized —

ALGN ALIGN TECHNOLOGY INC 0.2%

Value ($000) $3,721 Shares 38,707 Est. Cost $60.82 Unrealized +52.7%

— ALIMERA SCIENCES INC 0.2%

Value ($000) $3,255 Shares 3,013,793 Est. Cost $4.88 Unrealized —

— ACELRX PHARMACEUTICALS INC 0.2%

Value ($000) $2,685 Shares 1,032,715 Est. Cost $5.54 Unrealized —

CYTK CYTOKINETICS INC 0.1%

Value ($000) $1,503 Shares 123,686 Est. Cost $6.71 Unrealized +58.1%

— INTREXON CORP 0.1%

Value ($000) $1,018 Shares 41,900 Est. Cost $28.82 Unrealized —

— CEMPRA INC 0.1%

Value ($000) $953 Shares 340,320 Est. Cost $22.71 Unrealized —

— IDERA PHARMACEUTICALS INC 0.1%

Value ($000) $925 Shares 616,355 Est. Cost $3.70 Unrealized —

— SOPHIRIS BIO INC 0.0%

Value ($000) $692 Shares 247,000 Est. Cost $2.60 Unrealized —

— ALCOBRA LTD 0.0%

Value ($000) $573 Shares 272,788 Est. Cost $5.98 Unrealized —

— HISTOGENICS CORP 0.0%

Value ($000) $506 Shares 302,922 Est. Cost $11.00 Unrealized —

— DICERNA PHARMACEUTICALS INC 0.0%

Value ($000) $456 Shares 158,279 Est. Cost $9.72 Unrealized —

— ZOGENIX INC 0.0%

Value ($000) $358 Shares 29,500 Est. Cost $13.36 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
UTHR	UNITED THERAPEUTICS CORP DEL	1,868,815	$268,044	15.3%	$88.34	+44.5%	COM	91307C102
—	ABIOMED INC	1,903,584	$214,496	12.2%	$30.32	—	COM	003654100
—	CLOVIS ONCOLOGY INC	3,804,088	$168,978	9.6%	$53.87	—	COM	189464100
BMRN	BIOMARIN PHARMACEUTICAL INC	1,960,219	$162,385	9.3%	$77.21	+11.4%	COM	09061G101
—	AMAG PHARMACEUTICALS INC	3,344,620	$116,393	6.6%	$29.94	—	COM	00163U106
—	ALEXION PHARMACEUTICALS INC	713,742	$87,326	5.0%	$119.75	—	COM	015351109
—	ZELTIQ AESTHETICS INC	1,720,763	$74,888	4.3%	$29.98	—	COM	98933Q108
INSM	INSMED INC	5,446,516	$72,057	4.1%	$14.56	-6.3%	COM PAR $.01	457669307
VNDA	VANDA PHARMACEUTICALS INC	4,203,270	$67,042	3.8%	$8.70	+84.7%	COM	921659108
—	WRIGHT MED GROUP N V	2,604,593	$59,854	3.4%	$23.37	—	ORD SHS 0.03 PAR	N96617118
—	SAGE THERAPEUTICS INC	1,009,930	$51,567	2.9%	$40.00	—	COM	78667J108
PRTA	PROTHENA CORP PLC	993,855	$48,888	2.8%	$30.77	+79.3%	SHS	G72800108
ACAD	ACADIA PHARMACEUTICALS INC	1,532,030	$44,184	2.5%	$29.57	-10.5%	COM	004225108
STAA	STAAR SURGICAL CO	3,386,245	$36,741	2.1%	$7.92	+28.4%	COM PAR $0.01	852312305
—	EPIZYME INC	3,035,796	$36,733	2.1%	$13.44	—	COM	29428V104
—	CELGENE CORP	295,240	$34,174	1.9%	$97.51	—	COM	151020104
—	ARIAD PHARMACEUTICALS INC	2,682,017	$33,364	1.9%	$7.21	—	COM	04033A100
FOLD	AMICUS THERAPEUTICS INC	6,410,030	$31,858	1.8%	$6.21	+11.4%	COM	03152W109
—	KARYOPHARM THERAPEUTICS INC	3,200,396	$30,084	1.7%	$20.34	—	COM	48576U106
—	MOMENTA PHARMACEUTICALS INC	1,727,380	$25,997	1.5%	$14.10	—	COM	60877T100
GILD	GILEAD SCIENCES INC	318,400	$22,801	1.3%	$63.20	-15.8%	COM	375558103
—	SHIRE PLC	124,100	$21,144	1.2%	$221.47	—	SPONSORED ADR	82481R106
—	RIGEL PHARMACEUTICALS INC	4,176,623	$9,940	0.6%	$3.39	—	COM NEW	766559603
—	AIMMUNE THERAPEUTICS INC	379,727	$7,765	0.4%	$23.85	—	COM	00900T107
EXAS	EXACT SCIENCES CORP	396,976	$5,304	0.3%	$12.83	+25.8%	COM	30063P105
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$4,208	0.2%	$4.37	—	COM PAR	867328700
ALGN	ALIGN TECHNOLOGY INC	38,707	$3,721	0.2%	$60.82	+52.7%	COM	016255101
—	ALIMERA SCIENCES INC	3,013,793	$3,255	0.2%	$4.88	—	COM	016259103
—	ACELRX PHARMACEUTICALS INC	1,032,715	$2,685	0.2%	$5.54	—	COM	00444T100
CYTK	CYTOKINETICS INC	123,686	$1,503	0.1%	$6.71	+58.1%	COM NEW	23282W605
—	INTREXON CORP	41,900	$1,018	0.1%	$28.82	—	COM	46122T102
—	CEMPRA INC	340,320	$953	0.1%	$22.71	—	COM	15130J109
—	IDERA PHARMACEUTICALS INC	616,355	$925	0.1%	$3.70	—	COM NEW	45168K306
—	SOPHIRIS BIO INC	247,000	$692	0.0%	$2.60	—	COM NEW	83578Q209
—	ALCOBRA LTD	272,788	$573	0.0%	$5.98	—	SHS	M2239P109
—	HISTOGENICS CORP	302,922	$506	0.0%	$11.00	—	COM	43358V109
—	DICERNA PHARMACEUTICALS INC	158,279	$456	0.0%	$9.72	—	COM	253031108
—	ZOGENIX INC	29,500	$358	0.0%	$13.36	—	COM NEW	98978L204