Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q4 2016 (← Previous) (Next →)

Filing Date: Feb 15, 2017

Total Value: $1.753B (100.0% shares, 0.0% debt)

Holdings (38)

UTHR UNITED THERAPEUTICS CORP DEL 15.3%

Value $268M Shares 1,868,815 Share Price $143.43 * Est. Cost/Share $88.34 Unrealized @ Report Date +44.5%

— ABIOMED INC 12.2%

Value $214M Shares 1,903,584 Share Price $112.68 Est. Cost/Share $30.32 Unrealized @ Report Date —

— CLOVIS ONCOLOGY INC 9.6%

Value $169M Shares 3,804,088 Share Price $44.42 Est. Cost/Share $53.87 Unrealized @ Report Date —

BMRN BIOMARIN PHARMACEUTICAL INC 9.3%

Value $162M Shares 1,960,219 Share Price $82.84 * Est. Cost/Share $77.21 Unrealized @ Report Date +11.4%

— AMAG PHARMACEUTICALS INC 6.6%

Value $116M Shares 3,344,620 Share Price $34.80 Est. Cost/Share $29.94 Unrealized @ Report Date —

— ALEXION PHARMACEUTICALS INC 5.0%

Value $87.33M Shares 713,742 Share Price $122.35 Est. Cost/Share $119.75 Unrealized @ Report Date —

— ZELTIQ AESTHETICS INC 4.3%

Value $74.89M Shares 1,720,763 Share Price $43.52 Est. Cost/Share $29.98 Unrealized @ Report Date —

INSM INSMED INC 4.1%

Value $72.06M Shares 5,446,516 Share Price $13.23 * Est. Cost/Share $14.56 Unrealized @ Report Date -6.3%

VNDA VANDA PHARMACEUTICALS INC 3.8%

Value $67.04M Shares 4,203,270 Share Price $15.95 Est. Cost/Share $8.70 Unrealized @ Report Date +84.7%

— WRIGHT MED GROUP N V 3.4%

Value $59.85M Shares 2,604,593 Share Price $22.98 Est. Cost/Share $23.37 Unrealized @ Report Date —

— SAGE THERAPEUTICS INC 2.9%

Value $51.57M Shares 1,009,930 Share Price $51.06 Est. Cost/Share $40.00 Unrealized @ Report Date —

PRTA PROTHENA CORP PLC 2.8%

Value $48.89M Shares 993,855 Share Price $49.19 * Est. Cost/Share $30.77 Unrealized @ Report Date +79.3%

ACAD ACADIA PHARMACEUTICALS INC 2.5%

Value $44.18M Shares 1,532,030 Share Price $28.84 * Est. Cost/Share $29.57 Unrealized @ Report Date -10.5%

STAA STAAR SURGICAL CO 2.1%

Value $36.74M Shares 3,386,245 Share Price $10.85 * Est. Cost/Share $7.92 Unrealized @ Report Date +28.4%

— EPIZYME INC 2.1%

Value $36.73M Shares 3,035,796 Share Price $12.10 Est. Cost/Share $13.44 Unrealized @ Report Date —

— CELGENE CORP 1.9%

Value $34.17M Shares 295,240 Share Price $115.75 Est. Cost/Share $97.51 Unrealized @ Report Date —

— ARIAD PHARMACEUTICALS INC 1.9%

Value $33.36M Shares 2,682,017 Share Price $12.44 Est. Cost/Share $7.21 Unrealized @ Report Date —

FOLD AMICUS THERAPEUTICS INC 1.8%

Value $31.86M Shares 6,410,030 Share Price $4.97 * Est. Cost/Share $6.21 Unrealized @ Report Date +11.4%

— KARYOPHARM THERAPEUTICS INC 1.7%

Value $30.08M Shares 3,200,396 Share Price $9.40 Est. Cost/Share $20.34 Unrealized @ Report Date —

— MOMENTA PHARMACEUTICALS INC 1.5%

Value $26M Shares 1,727,380 Share Price $15.05 Est. Cost/Share $14.10 Unrealized @ Report Date —

GILD GILEAD SCIENCES INC 1.3%

Value $22.8M Shares 318,400 Share Price $71.61 * Est. Cost/Share $63.20 Unrealized @ Report Date -15.8%

— SHIRE PLC 1.2%

Value $21.14M Shares 124,100 Share Price $170.38 Est. Cost/Share $221.47 Unrealized @ Report Date —

— RIGEL PHARMACEUTICALS INC 0.6%

Value $9.94M Shares 4,176,623 Share Price $2.38 Est. Cost/Share $3.39 Unrealized @ Report Date —

— AIMMUNE THERAPEUTICS INC 0.4%

Value $7.765M Shares 379,727 Share Price $20.45 Est. Cost/Share $23.85 Unrealized @ Report Date —

EXAS EXACT SCIENCES CORP 0.3%

Value $5.304M Shares 396,976 Share Price $13.36 * Est. Cost/Share $12.83 Unrealized @ Report Date +25.8%

— SUNESIS PHARMACEUTICALS INC 0.2%

Value $4.208M Shares 1,162,473 Share Price $3.62 Est. Cost/Share $4.37 Unrealized @ Report Date —

ALGN ALIGN TECHNOLOGY INC 0.2%

Value $3.721M Shares 38,707 Share Price $96.13 * Est. Cost/Share $60.82 Unrealized @ Report Date +52.7%

— ALIMERA SCIENCES INC 0.2%

Value $3.255M Shares 3,013,793 Share Price $1.08 Est. Cost/Share $4.88 Unrealized @ Report Date —

— ACELRX PHARMACEUTICALS INC 0.2%

Value $2.685M Shares 1,032,715 Share Price $2.60 Est. Cost/Share $5.54 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.1%

Value $1.503M Shares 123,686 Share Price $12.15 * Est. Cost/Share $6.71 Unrealized @ Report Date +58.1%

— INTREXON CORP 0.1%

Value $1.018M Shares 41,900 Share Price $24.30 Est. Cost/Share $28.82 Unrealized @ Report Date —

— CEMPRA INC 0.1%

Value $953K Shares 340,320 Share Price $2.80 Est. Cost/Share $22.71 Unrealized @ Report Date —

— IDERA PHARMACEUTICALS INC 0.1%

Value $925K Shares 616,355 Share Price $1.50 Est. Cost/Share $3.70 Unrealized @ Report Date —

— SOPHIRIS BIO INC 0.0%

Value $692K Shares 247,000 Share Price $2.80 Est. Cost/Share $2.60 Unrealized @ Report Date —

— ALCOBRA LTD 0.0%

Value $573K Shares 272,788 Share Price $2.10 Est. Cost/Share $5.98 Unrealized @ Report Date —

— HISTOGENICS CORP 0.0%

Value $506K Shares 302,922 Share Price $1.67 Est. Cost/Share $11.00 Unrealized @ Report Date —

— DICERNA PHARMACEUTICALS INC 0.0%

Value $456K Shares 158,279 Share Price $2.88 Est. Cost/Share $9.72 Unrealized @ Report Date —

— ZOGENIX INC 0.0%

Value $358K Shares 29,500 Share Price $12.14 Est. Cost/Share $13.36 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
UTHR	UNITED THERAPEUTICS CORP DEL	1,868,815	$268M	15.3%	$143.43 *	$88.34	+44.5%	COM	91307C102
—	ABIOMED INC	1,903,584	$214M	12.2%	$112.68	$30.32	—	COM	003654100
—	CLOVIS ONCOLOGY INC	3,804,088	$169M	9.6%	$44.42	$53.87	—	COM	189464100
BMRN	BIOMARIN PHARMACEUTICAL INC	1,960,219	$162M	9.3%	$82.84 *	$77.21	+11.4%	COM	09061G101
—	AMAG PHARMACEUTICALS INC	3,344,620	$116M	6.6%	$34.80	$29.94	—	COM	00163U106
—	ALEXION PHARMACEUTICALS INC	713,742	$87.33M	5.0%	$122.35	$119.75	—	COM	015351109
—	ZELTIQ AESTHETICS INC	1,720,763	$74.89M	4.3%	$43.52	$29.98	—	COM	98933Q108
INSM	INSMED INC	5,446,516	$72.06M	4.1%	$13.23 *	$14.56	-6.3%	COM PAR $.01	457669307
VNDA	VANDA PHARMACEUTICALS INC	4,203,270	$67.04M	3.8%	$15.95	$8.70	+84.7%	COM	921659108
—	WRIGHT MED GROUP N V	2,604,593	$59.85M	3.4%	$22.98	$23.37	—	ORD SHS 0.03 PAR	N96617118
—	SAGE THERAPEUTICS INC	1,009,930	$51.57M	2.9%	$51.06	$40.00	—	COM	78667J108
PRTA	PROTHENA CORP PLC	993,855	$48.89M	2.8%	$49.19 *	$30.77	+79.3%	SHS	G72800108
ACAD	ACADIA PHARMACEUTICALS INC	1,532,030	$44.18M	2.5%	$28.84 *	$29.57	-10.5%	COM	004225108
STAA	STAAR SURGICAL CO	3,386,245	$36.74M	2.1%	$10.85 *	$7.92	+28.4%	COM PAR $0.01	852312305
—	EPIZYME INC	3,035,796	$36.73M	2.1%	$12.10	$13.44	—	COM	29428V104
—	CELGENE CORP	295,240	$34.17M	1.9%	$115.75	$97.51	—	COM	151020104
—	ARIAD PHARMACEUTICALS INC	2,682,017	$33.36M	1.9%	$12.44	$7.21	—	COM	04033A100
FOLD	AMICUS THERAPEUTICS INC	6,410,030	$31.86M	1.8%	$4.97 *	$6.21	+11.4%	COM	03152W109
—	KARYOPHARM THERAPEUTICS INC	3,200,396	$30.08M	1.7%	$9.40	$20.34	—	COM	48576U106
—	MOMENTA PHARMACEUTICALS INC	1,727,380	$26M	1.5%	$15.05	$14.10	—	COM	60877T100
GILD	GILEAD SCIENCES INC	318,400	$22.8M	1.3%	$71.61 *	$63.20	-15.8%	COM	375558103
—	SHIRE PLC	124,100	$21.14M	1.2%	$170.38	$221.47	—	SPONSORED ADR	82481R106
—	RIGEL PHARMACEUTICALS INC	4,176,623	$9.94M	0.6%	$2.38	$3.39	—	COM NEW	766559603
—	AIMMUNE THERAPEUTICS INC	379,727	$7.765M	0.4%	$20.45	$23.85	—	COM	00900T107
EXAS	EXACT SCIENCES CORP	396,976	$5.304M	0.3%	$13.36 *	$12.83	+25.8%	COM	30063P105
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$4.208M	0.2%	$3.62	$4.37	—	COM PAR	867328700
ALGN	ALIGN TECHNOLOGY INC	38,707	$3.721M	0.2%	$96.13 *	$60.82	+52.7%	COM	016255101
—	ALIMERA SCIENCES INC	3,013,793	$3.255M	0.2%	$1.08	$4.88	—	COM	016259103
—	ACELRX PHARMACEUTICALS INC	1,032,715	$2.685M	0.2%	$2.60	$5.54	—	COM	00444T100
CYTK	CYTOKINETICS INC	123,686	$1.503M	0.1%	$12.15 *	$6.71	+58.1%	COM NEW	23282W605
—	INTREXON CORP	41,900	$1.018M	0.1%	$24.30	$28.82	—	COM	46122T102
—	CEMPRA INC	340,320	$953K	0.1%	$2.80	$22.71	—	COM	15130J109
—	IDERA PHARMACEUTICALS INC	616,355	$925K	0.1%	$1.50	$3.70	—	COM NEW	45168K306
—	SOPHIRIS BIO INC	247,000	$692K	0.0%	$2.80	$2.60	—	COM NEW	83578Q209
—	ALCOBRA LTD	272,788	$573K	0.0%	$2.10	$5.98	—	SHS	M2239P109
—	HISTOGENICS CORP	302,922	$506K	0.0%	$1.67	$11.00	—	COM	43358V109
—	DICERNA PHARMACEUTICALS INC	158,279	$456K	0.0%	$2.88	$9.72	—	COM	253031108
—	ZOGENIX INC	29,500	$358K	0.0%	$12.14	$13.36	—	COM NEW	98978L204