Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q3 2016 (← Previous) (Next →)

Filing Date: Nov 14, 2016

Total Value: $1.722B (100.0% shares, 0.0% debt)

Holdings (42)

— ABIOMED INC 14.1%

Value $242M Shares 1,884,384 Est. Cost $29.48 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 12.1%

Value $208M Shares 1,763,458 Est. Cost $85.99 Unrealized +39.7%

BMRN BIOMARIN PHARMACEUTICAL INC 9.6%

Value $166M Shares 1,790,899 Est. Cost $76.38 Unrealized +23.3%

— CLOVIS ONCOLOGY INC 8.0%

Value $137M Shares 3,804,088 Est. Cost $53.87 Unrealized —

— AMAG PHARMACEUTICALS INC 4.7%

Value $81.54M Shares 3,326,720 Est. Cost $29.94 Unrealized —

INSM INSMED INC 4.3%

Value $73.93M Shares 5,091,298 Est. Cost $14.63 Unrealized -14.4%

— CEMPRA INC 4.0%

Value $68.84M Shares 2,844,483 Est. Cost $22.71 Unrealized —

— ALEXION PHARMACEUTICALS INC 4.0%

Value $68.83M Shares 561,700 Est. Cost $119.05 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 4.0%

Value $68.4M Shares 4,110,708 Est. Cost $8.54 Unrealized +57.7%

— WRIGHT MED GROUP N V 3.5%

Value $59.87M Shares 2,440,493 Est. Cost $23.40 Unrealized —

PRTA PROTHENA CORP PLC 3.3%

Value $56.04M Shares 934,455 Est. Cost $29.22 Unrealized +83.6%

— ZELTIQ AESTHETICS INC 3.2%

Value $55.48M Shares 1,414,563 Est. Cost $27.05 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 2.7%

Value $47.14M Shares 1,481,930 Est. Cost $29.67 Unrealized +14.3%

FOLD AMICUS THERAPEUTICS INC 2.4%

Value $42.07M Shares 5,685,388 Est. Cost $6.12 Unrealized +10.3%

— SAGE THERAPEUTICS INC 2.4%

Value $41.54M Shares 902,051 Est. Cost $38.68 Unrealized —

— ARIAD PHARMACEUTICALS INC 2.1%

Value $35.42M Shares 2,587,617 Est. Cost $7.02 Unrealized —

— CELGENE CORP 1.8%

Value $30.6M Shares 292,700 Est. Cost $97.51 Unrealized —

STAA STAAR SURGICAL CO 1.8%

Value $30.5M Shares 3,244,610 Est. Cost $7.82 Unrealized +2.7%

— KARYOPHARM THERAPEUTICS INC 1.7%

Value $30.02M Shares 3,085,849 Est. Cost $20.75 Unrealized —

— EPIZYME INC 1.6%

Value $27.7M Shares 2,814,540 Est. Cost $13.55 Unrealized —

GILD GILEAD SCIENCES INC 1.5%

Value $25.19M Shares 318,400 Est. Cost $63.20 Unrealized -8.6%

— SHIRE PLC 1.4%

Value $23.88M Shares 123,200 Est. Cost $221.47 Unrealized —

— MOMENTA PHARMACEUTICALS INC 1.1%

Value $19.3M Shares 1,650,876 Est. Cost $14.05 Unrealized —

— ENDO INTL PLC 1.1%

Value $19.05M Shares 945,330 Est. Cost $78.87 Unrealized —

— RIGEL PHARMACEUTICALS INC 1.1%

Value $19.03M Shares 5,186,088 Est. Cost $3.39 Unrealized —

EXAS EXACT SCIENCES CORP 0.4%

Value $7.372M Shares 396,976 Est. Cost $12.83 Unrealized +37.3%

— ACELRX PHARMACEUTICALS INC 0.4%

Value $6.359M Shares 1,634,608 Est. Cost $5.54 Unrealized —

— AIMMUNE THERAPEUTICS INC 0.3%

Value $5.696M Shares 379,727 Est. Cost $23.85 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.3%

Value $5.08M Shares 1,162,473 Est. Cost $4.37 Unrealized —

— ALIMERA SCIENCES INC 0.3%

Value $4.491M Shares 3,013,793 Est. Cost $4.88 Unrealized —

ALGN ALIGN TECHNOLOGY INC 0.2%

Value $3.512M Shares 37,457 Est. Cost $59.75 Unrealized +51.4%

— IDERA PHARMACEUTICALS INC 0.2%

Value $3.22M Shares 1,257,748 Est. Cost $3.70 Unrealized —

— DICERNA PHARMACEUTICALS INC 0.1%

Value $1.575M Shares 267,890 Est. Cost $9.72 Unrealized —

— HISTOGENICS CORP 0.1%

Value $1.459M Shares 454,545 Est. Cost $11.00 Unrealized —

— INTREXON CORP 0.1%

Value $1.32M Shares 47,100 Est. Cost $28.82 Unrealized —

CYTK CYTOKINETICS INC 0.1%

Value $1.135M Shares 123,686 Est. Cost $6.71 Unrealized +55.5%

— SOPHIRIS BIO INC 0.0%

Value $768K Shares 247,000 Est. Cost $2.60 Unrealized —

— ALCOBRA LTD 0.0%

Value $674K Shares 272,788 Est. Cost $5.98 Unrealized —

— OREXIGEN THERAPEUTICS INC 0.0%

Value $555K Shares 167,302 Est. Cost $3.32 Unrealized —

— ZOGENIX INC 0.0%

Value $337K Shares 29,500 Est. Cost $13.36 Unrealized —

QURE UNIQURE NV 0.0%

Value $156K Shares 20,453 Est. Cost $26.34 Unrealized -69.9%

— MARINUS PHARMACEUTICALS INC 0.0%

Value $116K Shares 63,517 Est. Cost $7.84 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	ABIOMED INC	1,884,384	$242M	14.1%	$29.48	—	COM	003654100
UTHR	UNITED THERAPEUTICS CORP DEL	1,763,458	$208M	12.1%	$85.99	+39.7%	COM	91307C102
BMRN	BIOMARIN PHARMACEUTICAL INC	1,790,899	$166M	9.6%	$76.38	+23.3%	COM	09061G101
—	CLOVIS ONCOLOGY INC	3,804,088	$137M	8.0%	$53.87	—	COM	189464100
—	AMAG PHARMACEUTICALS INC	3,326,720	$81.54M	4.7%	$29.94	—	COM	00163U106
INSM	INSMED INC	5,091,298	$73.93M	4.3%	$14.63	-14.4%	COM PAR $.01	457669307
—	CEMPRA INC	2,844,483	$68.84M	4.0%	$22.71	—	COM	15130J109
—	ALEXION PHARMACEUTICALS INC	561,700	$68.83M	4.0%	$119.05	—	COM	015351109
VNDA	VANDA PHARMACEUTICALS INC	4,110,708	$68.4M	4.0%	$8.54	+57.7%	COM	921659108
—	WRIGHT MED GROUP N V	2,440,493	$59.87M	3.5%	$23.40	—	ORD SHS 0.03 PAR	N96617118
PRTA	PROTHENA CORP PLC	934,455	$56.04M	3.3%	$29.22	+83.6%	SHS	G72800108
—	ZELTIQ AESTHETICS INC	1,414,563	$55.48M	3.2%	$27.05	—	COM	98933Q108
ACAD	ACADIA PHARMACEUTICALS INC	1,481,930	$47.14M	2.7%	$29.67	+14.3%	COM	004225108
FOLD	AMICUS THERAPEUTICS INC	5,685,388	$42.07M	2.4%	$6.12	+10.3%	COM	03152W109
—	SAGE THERAPEUTICS INC	902,051	$41.54M	2.4%	$38.68	—	COM	78667J108
—	ARIAD PHARMACEUTICALS INC	2,587,617	$35.42M	2.1%	$7.02	—	COM	04033A100
—	CELGENE CORP	292,700	$30.6M	1.8%	$97.51	—	COM	151020104
STAA	STAAR SURGICAL CO	3,244,610	$30.5M	1.8%	$7.82	+2.7%	COM PAR $0.01	852312305
—	KARYOPHARM THERAPEUTICS INC	3,085,849	$30.02M	1.7%	$20.75	—	COM	48576U106
—	EPIZYME INC	2,814,540	$27.7M	1.6%	$13.55	—	COM	29428V104
GILD	GILEAD SCIENCES INC	318,400	$25.19M	1.5%	$63.20	-8.6%	COM	375558103
—	SHIRE PLC	123,200	$23.88M	1.4%	$221.47	—	SPONSORED ADR	82481R106
—	MOMENTA PHARMACEUTICALS INC	1,650,876	$19.3M	1.1%	$14.05	—	COM	60877T100
—	ENDO INTL PLC	945,330	$19.05M	1.1%	$78.87	—	SHS	G30401106
—	RIGEL PHARMACEUTICALS INC	5,186,088	$19.03M	1.1%	$3.39	—	COM NEW	766559603
EXAS	EXACT SCIENCES CORP	396,976	$7.372M	0.4%	$12.83	+37.3%	COM	30063P105
—	ACELRX PHARMACEUTICALS INC	1,634,608	$6.359M	0.4%	$5.54	—	COM	00444T100
—	AIMMUNE THERAPEUTICS INC	379,727	$5.696M	0.3%	$23.85	—	COM	00900T107
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$5.08M	0.3%	$4.37	—	COM PAR	867328700
—	ALIMERA SCIENCES INC	3,013,793	$4.491M	0.3%	$4.88	—	COM	016259103
ALGN	ALIGN TECHNOLOGY INC	37,457	$3.512M	0.2%	$59.75	+51.4%	COM	016255101
—	IDERA PHARMACEUTICALS INC	1,257,748	$3.22M	0.2%	$3.70	—	COM NEW	45168K306
—	DICERNA PHARMACEUTICALS INC	267,890	$1.575M	0.1%	$9.72	—	COM	253031108
—	HISTOGENICS CORP	454,545	$1.459M	0.1%	$11.00	—	COM	43358V109
—	INTREXON CORP	47,100	$1.32M	0.1%	$28.82	—	COM	46122T102
CYTK	CYTOKINETICS INC	123,686	$1.135M	0.1%	$6.71	+55.5%	COM NEW	23282W605
—	SOPHIRIS BIO INC	247,000	$768K	0.0%	$2.60	—	COM NEW	83578Q209
—	ALCOBRA LTD	272,788	$674K	0.0%	$5.98	—	SHS	M2239P109
—	OREXIGEN THERAPEUTICS INC	167,302	$555K	0.0%	$3.32	—	COM NEW	686164302
—	ZOGENIX INC	29,500	$337K	0.0%	$13.36	—	COM NEW	98978L204
QURE	UNIQURE NV	20,453	$156K	0.0%	$26.34	-69.9%	SHS	N90064101
—	MARINUS PHARMACEUTICALS INC	63,517	$116K	0.0%	$7.84	—	COM	56854Q101