Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q1 2017 (← Previous) (Next →)

Filing Date: May 15, 2017

Total Value: $2.116B (100.0% shares, 0.0% debt)

Holdings (39)

UTHR UNITED THERAPEUTICS CORP DEL 12.1%

Value $255M Shares 1,883,315 Est. Cost $88.34 Unrealized +71.5%

— CLOVIS ONCOLOGY INC 11.7%

Value $248M Shares 3,894,963 Est. Cost $54.10 Unrealized —

— ABIOMED INC 11.4%

Value $241M Shares 1,921,484 Est. Cost $30.32 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 9.9%

Value $209M Shares 2,382,619 Est. Cost $79.29 Unrealized +12.2%

— ALEXION PHARMACEUTICALS INC 5.9%

Value $125M Shares 1,027,060 Est. Cost $120.21 Unrealized —

— ZELTIQ AESTHETICS INC 5.3%

Value $113M Shares 2,032,692 Est. Cost $33.92 Unrealized —

INSM INSMED INC 4.6%

Value $96.9M Shares 5,534,150 Est. Cost $14.57 Unrealized +5.8%

— EPIZYME INC 3.9%

Value $82.17M Shares 4,791,051 Est. Cost $14.80 Unrealized —

— WRIGHT MED GROUP N V 3.9%

Value $81.79M Shares 2,628,193 Est. Cost $23.37 Unrealized —

— SAGE THERAPEUTICS INC 3.7%

Value $78.32M Shares 1,101,951 Est. Cost $42.59 Unrealized —

— AMAG PHARMACEUTICALS INC 3.6%

Value $75.42M Shares 3,344,620 Est. Cost $29.94 Unrealized —

PRTA PROTHENA CORP PLC 2.8%

Value $58.91M Shares 1,055,855 Est. Cost $32.05 Unrealized +63.9%

VNDA VANDA PHARMACEUTICALS INC 2.8%

Value $58.85M Shares 4,203,270 Est. Cost $8.70 Unrealized +63.7%

FOLD AMICUS THERAPEUTICS INC 2.7%

Value $56.21M Shares 7,882,988 Est. Cost $6.23 Unrealized +1.4%

ACAD ACADIA PHARMACEUTICALS INC 2.6%

Value $54.68M Shares 1,590,430 Est. Cost $29.78 Unrealized +18.5%

— KARYOPHARM THERAPEUTICS INC 2.1%

Value $43.74M Shares 3,406,475 Est. Cost $19.89 Unrealized —

— CELGENE CORP 1.7%

Value $36.74M Shares 295,240 Est. Cost $97.51 Unrealized —

STAA STAAR SURGICAL CO 1.6%

Value $34.04M Shares 3,473,170 Est. Cost $7.97 Unrealized +25.1%

ALGN ALIGN TECHNOLOGY INC 1.2%

Value $25.59M Shares 223,107 Est. Cost $94.04 Unrealized +7.4%

— AIMMUNE THERAPEUTICS INC 1.2%

Value $25.5M Shares 1,173,498 Est. Cost $22.42 Unrealized —

GILD GILEAD SCIENCES INC 1.1%

Value $23.88M Shares 351,600 Est. Cost $62.02 Unrealized -18.3%

— MOMENTA PHARMACEUTICALS INC 1.1%

Value $23.49M Shares 1,759,376 Est. Cost $14.08 Unrealized —

— SHIRE PLC 1.1%

Value $22.68M Shares 130,200 Est. Cost $219.26 Unrealized —

— RIGEL PHARMACEUTICALS INC 0.7%

Value $14.08M Shares 4,254,623 Est. Cost $3.39 Unrealized —

EXAS EXACT SCIENCES CORP 0.5%

Value $10.04M Shares 425,276 Est. Cost $13.30 Unrealized +49.0%

— SUNESIS PHARMACEUTICALS INC 0.2%

Value $4.766M Shares 1,162,473 Est. Cost $4.37 Unrealized —

— ALIMERA SCIENCES INC 0.2%

Value $4.219M Shares 3,013,793 Est. Cost $4.88 Unrealized —

— ACELRX PHARMACEUTICALS INC 0.2%

Value $3.253M Shares 1,032,715 Est. Cost $5.54 Unrealized —

— DICERNA PHARMACEUTICALS INC 0.1%

Value $1.637M Shares 481,519 Est. Cost $5.48 Unrealized —

CYTK CYTOKINETICS INC 0.1%

Value $1.589M Shares 123,686 Est. Cost $6.71 Unrealized +74.1%

— IDERA PHARMACEUTICALS INC 0.1%

Value $1.522M Shares 616,355 Est. Cost $3.70 Unrealized —

— CEMPRA INC 0.1%

Value $1.276M Shares 340,320 Est. Cost $22.71 Unrealized —

— Trevena Inc 0.1%

Value $1.253M Shares 341,300 Est. Cost $3.67 Unrealized —

— INTREXON CORP 0.0%

Value $830K Shares 41,900 Est. Cost $28.82 Unrealized —

— SOPHIRIS BIO INC 0.0%

Value $699K Shares 247,000 Est. Cost $2.60 Unrealized —

— HISTOGENICS CORP 0.0%

Value $524K Shares 302,922 Est. Cost $11.00 Unrealized —

— ZOGENIX INC 0.0%

Value $320K Shares 29,500 Est. Cost $13.36 Unrealized —

— ALCOBRA LTD 0.0%

Value $311K Shares 272,788 Est. Cost $5.98 Unrealized —

— CAPNIA INC 0.0%

Value $301K Shares 423,738 Est. Cost $0.71 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
UTHR	UNITED THERAPEUTICS CORP DEL	1,883,315	$255M	12.1%	$88.34	+71.5%	COM	91307C102
—	CLOVIS ONCOLOGY INC	3,894,963	$248M	11.7%	$54.10	—	COM	189464100
—	ABIOMED INC	1,921,484	$241M	11.4%	$30.32	—	COM	003654100
BMRN	BIOMARIN PHARMACEUTICAL INC	2,382,619	$209M	9.9%	$79.29	+12.2%	COM	09061G101
—	ALEXION PHARMACEUTICALS INC	1,027,060	$125M	5.9%	$120.21	—	COM	015351109
—	ZELTIQ AESTHETICS INC	2,032,692	$113M	5.3%	$33.92	—	COM	98933Q108
INSM	INSMED INC	5,534,150	$96.9M	4.6%	$14.57	+5.8%	COM PAR $.01	457669307
—	EPIZYME INC	4,791,051	$82.17M	3.9%	$14.80	—	COM	29428V104
—	WRIGHT MED GROUP N V	2,628,193	$81.79M	3.9%	$23.37	—	ORD SHS 0.03 PAR	N96617118
—	SAGE THERAPEUTICS INC	1,101,951	$78.32M	3.7%	$42.59	—	COM	78667J108
—	AMAG PHARMACEUTICALS INC	3,344,620	$75.42M	3.6%	$29.94	—	COM	00163U106
PRTA	PROTHENA CORP PLC	1,055,855	$58.91M	2.8%	$32.05	+63.9%	SHS	G72800108
VNDA	VANDA PHARMACEUTICALS INC	4,203,270	$58.85M	2.8%	$8.70	+63.7%	COM	921659108
FOLD	AMICUS THERAPEUTICS INC	7,882,988	$56.21M	2.7%	$6.23	+1.4%	COM	03152W109
ACAD	ACADIA PHARMACEUTICALS INC	1,590,430	$54.68M	2.6%	$29.78	+18.5%	COM	004225108
—	KARYOPHARM THERAPEUTICS INC	3,406,475	$43.74M	2.1%	$19.89	—	COM	48576U106
—	CELGENE CORP	295,240	$36.74M	1.7%	$97.51	—	COM	151020104
STAA	STAAR SURGICAL CO	3,473,170	$34.04M	1.6%	$7.97	+25.1%	COM PAR $0.01	852312305
ALGN	ALIGN TECHNOLOGY INC	223,107	$25.59M	1.2%	$94.04	+7.4%	COM	016255101
—	AIMMUNE THERAPEUTICS INC	1,173,498	$25.5M	1.2%	$22.42	—	COM	00900T107
GILD	GILEAD SCIENCES INC	351,600	$23.88M	1.1%	$62.02	-18.3%	COM	375558103
—	MOMENTA PHARMACEUTICALS INC	1,759,376	$23.49M	1.1%	$14.08	—	COM	60877T100
—	SHIRE PLC	130,200	$22.68M	1.1%	$219.26	—	SPONSORED ADR	82481R106
—	RIGEL PHARMACEUTICALS INC	4,254,623	$14.08M	0.7%	$3.39	—	COM NEW	766559603
EXAS	EXACT SCIENCES CORP	425,276	$10.04M	0.5%	$13.30	+49.0%	COM	30063P105
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$4.766M	0.2%	$4.37	—	COM PAR	867328700
—	ALIMERA SCIENCES INC	3,013,793	$4.219M	0.2%	$4.88	—	COM	016259103
—	ACELRX PHARMACEUTICALS INC	1,032,715	$3.253M	0.2%	$5.54	—	COM	00444T100
—	DICERNA PHARMACEUTICALS INC	481,519	$1.637M	0.1%	$5.48	—	COM	253031108
CYTK	CYTOKINETICS INC	123,686	$1.589M	0.1%	$6.71	+74.1%	COM NEW	23282W605
—	IDERA PHARMACEUTICALS INC	616,355	$1.522M	0.1%	$3.70	—	COM NEW	45168K306
—	CEMPRA INC	340,320	$1.276M	0.1%	$22.71	—	COM	15130J109
—	Trevena Inc	341,300	$1.253M	0.1%	$3.67	—	COM	89532e109
—	INTREXON CORP	41,900	$830K	0.0%	$28.82	—	COM	46122T102
—	SOPHIRIS BIO INC	247,000	$699K	0.0%	$2.60	—	COM NEW	83578Q209
—	HISTOGENICS CORP	302,922	$524K	0.0%	$11.00	—	COM	43358V109
—	ZOGENIX INC	29,500	$320K	0.0%	$13.36	—	COM NEW	98978L204
—	ALCOBRA LTD	272,788	$311K	0.0%	$5.98	—	SHS	M2239P109
—	CAPNIA INC	423,738	$301K	0.0%	$0.71	—	COM	14066L105