Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q1 2017 (← Previous) (Next →)

Filing Date: May 15, 2017

Total Value: $2.116B (100.0% shares, 0.0% debt)

Holdings (39)

UTHR UNITED THERAPEUTICS CORP DEL 12.1%

Value $255M Shares 1,883,315 Share Price $135.38 * Est. Cost/Share $88.34 Unrealized @ Report Date +71.5%

— CLOVIS ONCOLOGY INC 11.7%

Value $248M Shares 3,894,963 Share Price $63.67 Est. Cost/Share $54.10 Unrealized @ Report Date —

— ABIOMED INC 11.4%

Value $241M Shares 1,921,484 Share Price $125.20 Est. Cost/Share $30.32 Unrealized @ Report Date —

BMRN BIOMARIN PHARMACEUTICAL INC 9.9%

Value $209M Shares 2,382,619 Share Price $87.78 Est. Cost/Share $79.29 Unrealized @ Report Date +12.2%

— ALEXION PHARMACEUTICALS INC 5.9%

Value $125M Shares 1,027,060 Share Price $121.24 Est. Cost/Share $120.21 Unrealized @ Report Date —

— ZELTIQ AESTHETICS INC 5.3%

Value $113M Shares 2,032,692 Share Price $55.61 Est. Cost/Share $33.92 Unrealized @ Report Date —

INSM INSMED INC 4.6%

Value $96.9M Shares 5,534,150 Share Price $17.51 * Est. Cost/Share $14.57 Unrealized @ Report Date +5.8%

— EPIZYME INC 3.9%

Value $82.17M Shares 4,791,051 Share Price $17.15 Est. Cost/Share $14.80 Unrealized @ Report Date —

— WRIGHT MED GROUP N V 3.9%

Value $81.79M Shares 2,628,193 Share Price $31.12 Est. Cost/Share $23.37 Unrealized @ Report Date —

— SAGE THERAPEUTICS INC 3.7%

Value $78.32M Shares 1,101,951 Share Price $71.07 Est. Cost/Share $42.59 Unrealized @ Report Date —

— AMAG PHARMACEUTICALS INC 3.6%

Value $75.42M Shares 3,344,620 Share Price $22.55 Est. Cost/Share $29.94 Unrealized @ Report Date —

PRTA PROTHENA CORP PLC 2.8%

Value $58.91M Shares 1,055,855 Share Price $55.79 * Est. Cost/Share $32.05 Unrealized @ Report Date +63.9%

VNDA VANDA PHARMACEUTICALS INC 2.8%

Value $58.85M Shares 4,203,270 Share Price $14.00 Est. Cost/Share $8.70 Unrealized @ Report Date +63.7%

FOLD AMICUS THERAPEUTICS INC 2.7%

Value $56.21M Shares 7,882,988 Share Price $7.13 * Est. Cost/Share $6.23 Unrealized @ Report Date +1.4%

ACAD ACADIA PHARMACEUTICALS INC 2.6%

Value $54.68M Shares 1,590,430 Share Price $34.38 * Est. Cost/Share $29.78 Unrealized @ Report Date +18.5%

— KARYOPHARM THERAPEUTICS INC 2.1%

Value $43.74M Shares 3,406,475 Share Price $12.84 Est. Cost/Share $19.89 Unrealized @ Report Date —

— CELGENE CORP 1.7%

Value $36.74M Shares 295,240 Share Price $124.43 Est. Cost/Share $97.51 Unrealized @ Report Date —

STAA STAAR SURGICAL CO 1.6%

Value $34.04M Shares 3,473,170 Share Price $9.80 Est. Cost/Share $7.97 Unrealized @ Report Date +25.1%

ALGN ALIGN TECHNOLOGY INC 1.2%

Value $25.59M Shares 223,107 Share Price $114.71 * Est. Cost/Share $94.04 Unrealized @ Report Date +7.4%

— AIMMUNE THERAPEUTICS INC 1.2%

Value $25.5M Shares 1,173,498 Share Price $21.73 Est. Cost/Share $22.42 Unrealized @ Report Date —

GILD GILEAD SCIENCES INC 1.1%

Value $23.88M Shares 351,600 Share Price $67.92 * Est. Cost/Share $62.02 Unrealized @ Report Date -18.3%

— MOMENTA PHARMACEUTICALS INC 1.1%

Value $23.49M Shares 1,759,376 Share Price $13.35 Est. Cost/Share $14.08 Unrealized @ Report Date —

— SHIRE PLC 1.1%

Value $22.68M Shares 130,200 Share Price $174.23 Est. Cost/Share $219.26 Unrealized @ Report Date —

— RIGEL PHARMACEUTICALS INC 0.7%

Value $14.08M Shares 4,254,623 Share Price $3.31 Est. Cost/Share $3.39 Unrealized @ Report Date —

EXAS EXACT SCIENCES CORP 0.5%

Value $10.04M Shares 425,276 Share Price $23.62 * Est. Cost/Share $13.30 Unrealized @ Report Date +49.0%

— SUNESIS PHARMACEUTICALS INC 0.2%

Value $4.766M Shares 1,162,473 Share Price $4.10 Est. Cost/Share $4.37 Unrealized @ Report Date —

— ALIMERA SCIENCES INC 0.2%

Value $4.219M Shares 3,013,793 Share Price $1.40 Est. Cost/Share $4.88 Unrealized @ Report Date —

— ACELRX PHARMACEUTICALS INC 0.2%

Value $3.253M Shares 1,032,715 Share Price $3.15 Est. Cost/Share $5.54 Unrealized @ Report Date —

— DICERNA PHARMACEUTICALS INC 0.1%

Value $1.637M Shares 481,519 Share Price $3.40 Est. Cost/Share $5.48 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.1%

Value $1.589M Shares 123,686 Share Price $12.85 * Est. Cost/Share $6.71 Unrealized @ Report Date +74.1%

— IDERA PHARMACEUTICALS INC 0.1%

Value $1.522M Shares 616,355 Share Price $2.47 Est. Cost/Share $3.70 Unrealized @ Report Date —

— CEMPRA INC 0.1%

Value $1.276M Shares 340,320 Share Price $3.75 Est. Cost/Share $22.71 Unrealized @ Report Date —

— Trevena Inc 0.1%

Value $1.253M Shares 341,300 Share Price $3.67 Est. Cost/Share $3.67 Unrealized @ Report Date —

— INTREXON CORP 0.0%

Value $830K Shares 41,900 Share Price $19.81 Est. Cost/Share $28.82 Unrealized @ Report Date —

— SOPHIRIS BIO INC 0.0%

Value $699K Shares 247,000 Share Price $2.83 Est. Cost/Share $2.60 Unrealized @ Report Date —

— HISTOGENICS CORP 0.0%

Value $524K Shares 302,922 Share Price $1.73 Est. Cost/Share $11.00 Unrealized @ Report Date —

— ZOGENIX INC 0.0%

Value $320K Shares 29,500 Share Price $10.85 Est. Cost/Share $13.36 Unrealized @ Report Date —

— ALCOBRA LTD 0.0%

Value $311K Shares 272,788 Share Price $1.14 Est. Cost/Share $5.98 Unrealized @ Report Date —

— CAPNIA INC 0.0%

Value $301K Shares 423,738 Share Price $0.71 Est. Cost/Share $0.71 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
UTHR	UNITED THERAPEUTICS CORP DEL	1,883,315	$255M	12.1%	$135.38 *	$88.34	+71.5%	COM	91307C102
—	CLOVIS ONCOLOGY INC	3,894,963	$248M	11.7%	$63.67	$54.10	—	COM	189464100
—	ABIOMED INC	1,921,484	$241M	11.4%	$125.20	$30.32	—	COM	003654100
BMRN	BIOMARIN PHARMACEUTICAL INC	2,382,619	$209M	9.9%	$87.78	$79.29	+12.2%	COM	09061G101
—	ALEXION PHARMACEUTICALS INC	1,027,060	$125M	5.9%	$121.24	$120.21	—	COM	015351109
—	ZELTIQ AESTHETICS INC	2,032,692	$113M	5.3%	$55.61	$33.92	—	COM	98933Q108
INSM	INSMED INC	5,534,150	$96.9M	4.6%	$17.51 *	$14.57	+5.8%	COM PAR $.01	457669307
—	EPIZYME INC	4,791,051	$82.17M	3.9%	$17.15	$14.80	—	COM	29428V104
—	WRIGHT MED GROUP N V	2,628,193	$81.79M	3.9%	$31.12	$23.37	—	ORD SHS 0.03 PAR	N96617118
—	SAGE THERAPEUTICS INC	1,101,951	$78.32M	3.7%	$71.07	$42.59	—	COM	78667J108
—	AMAG PHARMACEUTICALS INC	3,344,620	$75.42M	3.6%	$22.55	$29.94	—	COM	00163U106
PRTA	PROTHENA CORP PLC	1,055,855	$58.91M	2.8%	$55.79 *	$32.05	+63.9%	SHS	G72800108
VNDA	VANDA PHARMACEUTICALS INC	4,203,270	$58.85M	2.8%	$14.00	$8.70	+63.7%	COM	921659108
FOLD	AMICUS THERAPEUTICS INC	7,882,988	$56.21M	2.7%	$7.13 *	$6.23	+1.4%	COM	03152W109
ACAD	ACADIA PHARMACEUTICALS INC	1,590,430	$54.68M	2.6%	$34.38 *	$29.78	+18.5%	COM	004225108
—	KARYOPHARM THERAPEUTICS INC	3,406,475	$43.74M	2.1%	$12.84	$19.89	—	COM	48576U106
—	CELGENE CORP	295,240	$36.74M	1.7%	$124.43	$97.51	—	COM	151020104
STAA	STAAR SURGICAL CO	3,473,170	$34.04M	1.6%	$9.80	$7.97	+25.1%	COM PAR $0.01	852312305
ALGN	ALIGN TECHNOLOGY INC	223,107	$25.59M	1.2%	$114.71 *	$94.04	+7.4%	COM	016255101
—	AIMMUNE THERAPEUTICS INC	1,173,498	$25.5M	1.2%	$21.73	$22.42	—	COM	00900T107
GILD	GILEAD SCIENCES INC	351,600	$23.88M	1.1%	$67.92 *	$62.02	-18.3%	COM	375558103
—	MOMENTA PHARMACEUTICALS INC	1,759,376	$23.49M	1.1%	$13.35	$14.08	—	COM	60877T100
—	SHIRE PLC	130,200	$22.68M	1.1%	$174.23	$219.26	—	SPONSORED ADR	82481R106
—	RIGEL PHARMACEUTICALS INC	4,254,623	$14.08M	0.7%	$3.31	$3.39	—	COM NEW	766559603
EXAS	EXACT SCIENCES CORP	425,276	$10.04M	0.5%	$23.62 *	$13.30	+49.0%	COM	30063P105
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$4.766M	0.2%	$4.10	$4.37	—	COM PAR	867328700
—	ALIMERA SCIENCES INC	3,013,793	$4.219M	0.2%	$1.40	$4.88	—	COM	016259103
—	ACELRX PHARMACEUTICALS INC	1,032,715	$3.253M	0.2%	$3.15	$5.54	—	COM	00444T100
—	DICERNA PHARMACEUTICALS INC	481,519	$1.637M	0.1%	$3.40	$5.48	—	COM	253031108
CYTK	CYTOKINETICS INC	123,686	$1.589M	0.1%	$12.85 *	$6.71	+74.1%	COM NEW	23282W605
—	IDERA PHARMACEUTICALS INC	616,355	$1.522M	0.1%	$2.47	$3.70	—	COM NEW	45168K306
—	CEMPRA INC	340,320	$1.276M	0.1%	$3.75	$22.71	—	COM	15130J109
—	Trevena Inc	341,300	$1.253M	0.1%	$3.67	$3.67	—	COM	89532e109
—	INTREXON CORP	41,900	$830K	0.0%	$19.81	$28.82	—	COM	46122T102
—	SOPHIRIS BIO INC	247,000	$699K	0.0%	$2.83	$2.60	—	COM NEW	83578Q209
—	HISTOGENICS CORP	302,922	$524K	0.0%	$1.73	$11.00	—	COM	43358V109
—	ZOGENIX INC	29,500	$320K	0.0%	$10.85	$13.36	—	COM NEW	98978L204
—	ALCOBRA LTD	272,788	$311K	0.0%	$1.14	$5.98	—	SHS	M2239P109
—	CAPNIA INC	423,738	$301K	0.0%	$0.71	$0.71	—	COM	14066L105