Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q2 2017 (← Previous) (Next →)

Filing Date: Aug 14, 2017

Total Value: $2.142B (100.0% shares, 0.0% debt)

Holdings (38)

— CLOVIS ONCOLOGY INC 14.6%

Value $312M Shares 3,329,581 Share Price $93.63 Est. Cost/Share $54.10 Unrealized @ Report Date —

— ABIOMED INC 13.1%

Value $280M Shares 1,951,284 Share Price $143.30 Est. Cost/Share $32.04 Unrealized @ Report Date —

UTHR UNITED THERAPEUTICS CORP DEL 11.3%

Value $242M Shares 1,867,315 Share Price $129.73 * Est. Cost/Share $88.34 Unrealized @ Report Date +41.2%

BMRN BIOMARIN PHARMACEUTICAL INC 10.1%

Value $217M Shares 2,384,719 Share Price $90.82 Est. Cost/Share $79.29 Unrealized @ Report Date +14.7%

— ALEXION PHARMACEUTICALS INC 5.9%

Value $125M Shares 1,030,942 Share Price $121.67 Est. Cost/Share $120.21 Unrealized @ Report Date —

INSM INSMED INC 4.5%

Value $96.47M Shares 5,621,816 Share Price $17.16 Est. Cost/Share $14.61 Unrealized @ Report Date +16.9%

— EPIZYME INC 4.0%

Value $86.04M Shares 5,698,296 Share Price $15.10 Est. Cost/Share $14.85 Unrealized @ Report Date —

— SAGE THERAPEUTICS INC 3.8%

Value $82.27M Shares 1,033,025 Share Price $79.64 Est. Cost/Share $42.59 Unrealized @ Report Date —

FOLD AMICUS THERAPEUTICS INC 3.7%

Value $79.96M Shares 7,940,788 Share Price $10.07 * Est. Cost/Share $6.23 Unrealized @ Report Date +29.1%

— WRIGHT MED GROUP N V 3.4%

Value $73.57M Shares 2,676,393 Share Price $27.49 Est. Cost/Share $23.44 Unrealized @ Report Date —

VNDA VANDA PHARMACEUTICALS INC 3.2%

Value $68.51M Shares 4,203,270 Share Price $16.30 * Est. Cost/Share $8.70 Unrealized @ Report Date +65.6%

— AMAG PHARMACEUTICALS INC 2.9%

Value $61.54M Shares 3,344,620 Share Price $18.40 Est. Cost/Share $29.94 Unrealized @ Report Date —

PRTA PROTHENA CORP PLC 2.7%

Value $58.12M Shares 1,073,955 Share Price $54.12 Est. Cost/Share $32.41 Unrealized @ Report Date +64.4%

ACAD ACADIA PHARMACEUTICALS INC 2.1%

Value $45M Shares 1,613,330 Share Price $27.89 * Est. Cost/Share $29.78 Unrealized @ Report Date +0.1%

— CELGENE CORP 1.8%

Value $38.34M Shares 295,240 Share Price $129.87 Est. Cost/Share $97.51 Unrealized @ Report Date —

STAA STAAR SURGICAL CO 1.8%

Value $38.11M Shares 3,529,070 Share Price $10.80 * Est. Cost/Share $8.00 Unrealized @ Report Date +22.2%

ALGN ALIGN TECHNOLOGY INC 1.6%

Value $33.49M Shares 223,107 Share Price $150.12 * Est. Cost/Share $94.04 Unrealized @ Report Date +44.2%

— KARYOPHARM THERAPEUTICS INC 1.5%

Value $31.38M Shares 3,467,575 Share Price $9.05 Est. Cost/Share $19.70 Unrealized @ Report Date —

— MOMENTA PHARMACEUTICALS INC 1.4%

Value $30.21M Shares 1,787,576 Share Price $16.90 Est. Cost/Share $14.13 Unrealized @ Report Date —

— IMMUNOMEDICS INC 1.2%

Value $26.58M Shares 3,010,466 Share Price $8.83 Est. Cost/Share $8.83 Unrealized @ Report Date —

— AIMMUNE THERAPEUTICS INC 1.2%

Value $26.52M Shares 1,289,719 Share Price $20.56 Est. Cost/Share $22.25 Unrealized @ Report Date —

GILD GILEAD SCIENCES INC 1.2%

Value $24.89M Shares 351,600 Share Price $70.78 * Est. Cost/Share $62.02 Unrealized @ Report Date -22.1%

— SHIRE PLC 1.0%

Value $21.52M Shares 130,200 Share Price $165.27 Est. Cost/Share $219.26 Unrealized @ Report Date —

EXAS EXACT SCIENCES CORP 0.7%

Value $15.32M Shares 433,076 Share Price $35.37 * Est. Cost/Share $13.61 Unrealized @ Report Date +126.7%

— RIGEL PHARMACEUTICALS INC 0.5%

Value $10.52M Shares 3,855,024 Share Price $2.73 Est. Cost/Share $3.39 Unrealized @ Report Date —

— ALIMERA SCIENCES INC 0.2%

Value $4.189M Shares 3,013,793 Share Price $1.39 Est. Cost/Share $4.88 Unrealized @ Report Date —

— SUNESIS PHARMACEUTICALS INC 0.1%

Value $3.139M Shares 1,162,473 Share Price $2.70 Est. Cost/Share $4.37 Unrealized @ Report Date —

— ACELRX PHARMACEUTICALS INC 0.1%

Value $2.22M Shares 1,032,715 Share Price $2.15 Est. Cost/Share $5.54 Unrealized @ Report Date —

— DICERNA PHARMACEUTICALS INC 0.1%

Value $1.588M Shares 500,913 Share Price $3.17 Est. Cost/Share $5.39 Unrealized @ Report Date —

— CEMPRA INC 0.1%

Value $1.565M Shares 340,320 Share Price $4.60 Est. Cost/Share $22.71 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.1%

Value $1.497M Shares 123,686 Share Price $12.10 * Est. Cost/Share $6.71 Unrealized @ Report Date +107.0%

— IDERA PHARMACEUTICALS INC 0.0%

Value $1.06M Shares 616,355 Share Price $1.72 Est. Cost/Share $3.70 Unrealized @ Report Date —

— TREVENA INC 0.0%

Value $785K Shares 341,300 Share Price $2.30 Est. Cost/Share $2.30 Unrealized @ Report Date —

— SOPHIRIS BIO INC 0.0%

Value $543K Shares 247,000 Share Price $2.20 Est. Cost/Share $2.60 Unrealized @ Report Date —

— HISTOGENICS CORP 0.0%

Value $542K Shares 302,922 Share Price $1.79 Est. Cost/Share $11.00 Unrealized @ Report Date —

— ZOGENIX INC 0.0%

Value $428K Shares 29,500 Share Price $14.51 Est. Cost/Share $13.36 Unrealized @ Report Date —

— ALCOBRA LTD 0.0%

Value $306K Shares 272,788 Share Price $1.12 Est. Cost/Share $5.98 Unrealized @ Report Date —

— SOLENO THERAPEUTICS INC 0.0%

Value $212K Shares 423,738 Share Price $0.50 Est. Cost/Share $0.50 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
—	CLOVIS ONCOLOGY INC	3,329,581	$312M	14.6%	$93.63	$54.10	—	COM	189464100
—	ABIOMED INC	1,951,284	$280M	13.1%	$143.30	$32.04	—	COM	003654100
UTHR	UNITED THERAPEUTICS CORP DEL	1,867,315	$242M	11.3%	$129.73 *	$88.34	+41.2%	COM	91307C102
BMRN	BIOMARIN PHARMACEUTICAL INC	2,384,719	$217M	10.1%	$90.82	$79.29	+14.7%	COM	09061G101
—	ALEXION PHARMACEUTICALS INC	1,030,942	$125M	5.9%	$121.67	$120.21	—	COM	015351109
INSM	INSMED INC	5,621,816	$96.47M	4.5%	$17.16	$14.61	+16.9%	COM PAR $.01	457669307
—	EPIZYME INC	5,698,296	$86.04M	4.0%	$15.10	$14.85	—	COM	29428V104
—	SAGE THERAPEUTICS INC	1,033,025	$82.27M	3.8%	$79.64	$42.59	—	COM	78667J108
FOLD	AMICUS THERAPEUTICS INC	7,940,788	$79.96M	3.7%	$10.07 *	$6.23	+29.1%	COM	03152W109
—	WRIGHT MED GROUP N V	2,676,393	$73.57M	3.4%	$27.49	$23.44	—	ORD SHS 0.03 PAR	N96617118
VNDA	VANDA PHARMACEUTICALS INC	4,203,270	$68.51M	3.2%	$16.30 *	$8.70	+65.6%	COM	921659108
—	AMAG PHARMACEUTICALS INC	3,344,620	$61.54M	2.9%	$18.40	$29.94	—	COM	00163U106
PRTA	PROTHENA CORP PLC	1,073,955	$58.12M	2.7%	$54.12	$32.41	+64.4%	SHS	G72800108
ACAD	ACADIA PHARMACEUTICALS INC	1,613,330	$45M	2.1%	$27.89 *	$29.78	+0.1%	COM	004225108
—	CELGENE CORP	295,240	$38.34M	1.8%	$129.87	$97.51	—	COM	151020104
STAA	STAAR SURGICAL CO	3,529,070	$38.11M	1.8%	$10.80 *	$8.00	+22.2%	COM PAR $0.01	852312305
ALGN	ALIGN TECHNOLOGY INC	223,107	$33.49M	1.6%	$150.12 *	$94.04	+44.2%	COM	016255101
—	KARYOPHARM THERAPEUTICS INC	3,467,575	$31.38M	1.5%	$9.05	$19.70	—	COM	48576U106
—	MOMENTA PHARMACEUTICALS INC	1,787,576	$30.21M	1.4%	$16.90	$14.13	—	COM	60877T100
—	IMMUNOMEDICS INC	3,010,466	$26.58M	1.2%	$8.83	$8.83	—	COM	452907108
—	AIMMUNE THERAPEUTICS INC	1,289,719	$26.52M	1.2%	$20.56	$22.25	—	COM	00900T107
GILD	GILEAD SCIENCES INC	351,600	$24.89M	1.2%	$70.78 *	$62.02	-22.1%	COM	375558103
—	SHIRE PLC	130,200	$21.52M	1.0%	$165.27	$219.26	—	SPONSORED ADR	82481R106
EXAS	EXACT SCIENCES CORP	433,076	$15.32M	0.7%	$35.37 *	$13.61	+126.7%	COM	30063P105
—	RIGEL PHARMACEUTICALS INC	3,855,024	$10.52M	0.5%	$2.73	$3.39	—	COM NEW	766559603
—	ALIMERA SCIENCES INC	3,013,793	$4.189M	0.2%	$1.39	$4.88	—	COM	016259103
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$3.139M	0.1%	$2.70	$4.37	—	COM PAR	867328700
—	ACELRX PHARMACEUTICALS INC	1,032,715	$2.22M	0.1%	$2.15	$5.54	—	COM	00444T100
—	DICERNA PHARMACEUTICALS INC	500,913	$1.588M	0.1%	$3.17	$5.39	—	COM	253031108
—	CEMPRA INC	340,320	$1.565M	0.1%	$4.60	$22.71	—	COM	15130J109
CYTK	CYTOKINETICS INC	123,686	$1.497M	0.1%	$12.10 *	$6.71	+107.0%	COM NEW	23282W605
—	IDERA PHARMACEUTICALS INC	616,355	$1.06M	0.0%	$1.72	$3.70	—	COM NEW	45168K306
—	TREVENA INC	341,300	$785K	0.0%	$2.30	$2.30	—	COM	89532E109
—	SOPHIRIS BIO INC	247,000	$543K	0.0%	$2.20	$2.60	—	COM NEW	83578Q209
—	HISTOGENICS CORP	302,922	$542K	0.0%	$1.79	$11.00	—	COM	43358V109
—	ZOGENIX INC	29,500	$428K	0.0%	$14.51	$13.36	—	COM NEW	98978L204
—	ALCOBRA LTD	272,788	$306K	0.0%	$1.12	$5.98	—	SHS	M2239P109
—	SOLENO THERAPEUTICS INC	423,738	$212K	0.0%	$0.50	$0.50	—	COM	834203101