Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q3 2017 (← Previous) (Next →)

Filing Date: Nov 14, 2017

Total Value: $2.374B (100.0% shares, 0.0% debt)

Holdings (40)

— ABIOMED INC 13.7%

Value $326M Shares 1,935,300 Share Price $168.60 Est. Cost/Share $32.04 Unrealized @ Report Date —

— CLOVIS ONCOLOGY INC 11.6%

Value $274M Shares 3,329,581 Share Price $82.40 Est. Cost/Share $54.10 Unrealized @ Report Date —

BMRN BIOMARIN PHARMACEUTICAL INC 9.6%

Value $227M Shares 2,438,519 Share Price $93.07 * Est. Cost/Share $79.50 Unrealized @ Report Date +11.2%

UTHR UNITED THERAPEUTICS CORP DEL 8.7%

Value $207M Shares 1,762,650 Share Price $117.19 * Est. Cost/Share $88.34 Unrealized @ Report Date +44.6%

INSM INSMED INC 8.1%

Value $193M Shares 6,171,816 Share Price $31.21 * Est. Cost/Share $15.01 Unrealized @ Report Date +26.9%

— ALEXION PHARMACEUTICALS INC 6.4%

Value $152M Shares 1,080,342 Share Price $140.29 Est. Cost/Share $121.12 Unrealized @ Report Date —

— EPIZYME INC 5.1%

Value $122M Shares 6,398,296 Share Price $19.05 Est. Cost/Share $15.31 Unrealized @ Report Date —

FOLD AMICUS THERAPEUTICS INC 4.7%

Value $112M Shares 7,420,288 Share Price $15.08 * Est. Cost/Share $6.23 Unrealized @ Report Date +112.3%

VNDA VANDA PHARMACEUTICALS INC 3.1%

Value $74.39M Shares 4,155,670 Share Price $17.90 * Est. Cost/Share $8.70 Unrealized @ Report Date +92.3%

PRTA PROTHENA CORP PLC 3.0%

Value $70.97M Shares 1,095,655 Share Price $64.77 * Est. Cost/Share $32.98 Unrealized @ Report Date +85.7%

— WRIGHT MED GROUP N V 2.9%

Value $69.24M Shares 2,676,393 Share Price $25.87 Est. Cost/Share $23.44 Unrealized @ Report Date —

— AMAG PHARMACEUTICALS INC 2.7%

Value $63.49M Shares 3,441,233 Share Price $18.45 Est. Cost/Share $29.62 Unrealized @ Report Date —

ACAD ACADIA PHARMACEUTICALS INC 2.6%

Value $61.82M Shares 1,641,030 Share Price $37.67 * Est. Cost/Share $29.82 Unrealized @ Report Date +9.1%

— SAGE THERAPEUTICS INC 2.1%

Value $49.05M Shares 787,251 Share Price $62.30 Est. Cost/Share $42.59 Unrealized @ Report Date —

STAA STAAR SURGICAL CO 1.8%

Value $43.66M Shares 3,507,052 Share Price $12.45 * Est. Cost/Share $8.00 Unrealized @ Report Date +39.3%

— CELGENE CORP 1.8%

Value $43.05M Shares 295,240 Share Price $145.82 Est. Cost/Share $97.51 Unrealized @ Report Date —

— IMMUNOMEDICS INC 1.8%

Value $42.09M Shares 3,010,466 Share Price $13.98 Est. Cost/Share $8.83 Unrealized @ Report Date —

ALGN ALIGN TECHNOLOGY INC 1.8%

Value $41.56M Shares 223,107 Share Price $186.27 * Est. Cost/Share $94.04 Unrealized @ Report Date +82.0%

— KARYOPHARM THERAPEUTICS INC 1.6%

Value $38.41M Shares 3,498,585 Share Price $10.98 Est. Cost/Share $19.70 Unrealized @ Report Date —

— MOMENTA PHARMACEUTICALS INC 1.4%

Value $33.21M Shares 1,794,998 Share Price $18.50 Est. Cost/Share $14.13 Unrealized @ Report Date —

— AIMMUNE THERAPEUTICS INC 1.4%

Value $32.07M Shares 1,293,764 Share Price $24.79 Est. Cost/Share $22.25 Unrealized @ Report Date —

EXAS EXACT SCIENCES CORP 0.9%

Value $20.41M Shares 433,076 Share Price $47.12 * Est. Cost/Share $13.61 Unrealized @ Report Date +195.7%

— SHIRE PLC 0.8%

Value $19.94M Shares 130,200 Share Price $153.14 Est. Cost/Share $219.26 Unrealized @ Report Date —

GILD GILEAD SCIENCES INC 0.6%

Value $14.25M Shares 175,900 Share Price $81.02 * Est. Cost/Share $62.02 Unrealized @ Report Date -9.8%

— BIOVERATIV INC 0.5%

Value $12.06M Shares 211,300 Share Price $57.07 Est. Cost/Share $57.07 Unrealized @ Report Date —

— RIGEL PHARMACEUTICALS INC 0.4%

Value $9.792M Shares 3,855,024 Share Price $2.54 Est. Cost/Share $3.39 Unrealized @ Report Date —

— ACELRX PHARMACEUTICALS INC 0.2%

Value $4.75M Shares 1,032,715 Share Price $4.60 Est. Cost/Share $5.54 Unrealized @ Report Date —

— ALIMERA SCIENCES INC 0.2%

Value $4.069M Shares 3,013,793 Share Price $1.35 Est. Cost/Share $4.88 Unrealized @ Report Date —

— DICERNA PHARMACEUTICALS INC 0.1%

Value $2.88M Shares 500,913 Share Price $5.75 Est. Cost/Share $5.39 Unrealized @ Report Date —

— SUNESIS PHARMACEUTICALS INC 0.1%

Value $2.255M Shares 1,162,473 Share Price $1.94 Est. Cost/Share $4.37 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.1%

Value $1.793M Shares 123,686 Share Price $14.50 * Est. Cost/Share $6.71 Unrealized @ Report Date +103.5%

— IDERA PHARMACEUTICALS INC 0.1%

Value $1.374M Shares 616,355 Share Price $2.23 Est. Cost/Share $3.70 Unrealized @ Report Date —

— CEMPRA INC 0.0%

Value $1.106M Shares 340,320 Share Price $3.25 Est. Cost/Share $22.71 Unrealized @ Report Date —

— ZOGENIX INC 0.0%

Value $1.034M Shares 29,500 Share Price $35.05 Est. Cost/Share $13.36 Unrealized @ Report Date —

— TREVENA INC 0.0%

Value $870K Shares 341,300 Share Price $2.55 Est. Cost/Share $2.30 Unrealized @ Report Date —

— ALDER BIOPHARMACEUTICALS INC 0.0%

Value $789K Shares 64,400 Share Price $12.25 Est. Cost/Share $12.25 Unrealized @ Report Date —

— HISTOGENICS CORP 0.0%

Value $600K Shares 302,922 Share Price $1.98 Est. Cost/Share $11.00 Unrealized @ Report Date —

— SOPHIRIS BIO INC 0.0%

Value $530K Shares 247,000 Share Price $2.15 Est. Cost/Share $2.60 Unrealized @ Report Date —

— ALCOBRA LTD 0.0%

Value $276K Shares 272,788 Share Price $1.01 Est. Cost/Share $5.98 Unrealized @ Report Date —

— SOLENO THERAPEUTICS INC 0.0%

Value $220K Shares 84,748 Share Price $2.60 Est. Cost/Share $0.50 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
—	ABIOMED INC	1,935,300	$326M	13.7%	$168.60	$32.04	—	COM	003654100
—	CLOVIS ONCOLOGY INC	3,329,581	$274M	11.6%	$82.40	$54.10	—	COM	189464100
BMRN	BIOMARIN PHARMACEUTICAL INC	2,438,519	$227M	9.6%	$93.07 *	$79.50	+11.2%	COM	09061G101
UTHR	UNITED THERAPEUTICS CORP DEL	1,762,650	$207M	8.7%	$117.19 *	$88.34	+44.6%	COM	91307C102
INSM	INSMED INC	6,171,816	$193M	8.1%	$31.21 *	$15.01	+26.9%	COM PAR $.01	457669307
—	ALEXION PHARMACEUTICALS INC	1,080,342	$152M	6.4%	$140.29	$121.12	—	COM	015351109
—	EPIZYME INC	6,398,296	$122M	5.1%	$19.05	$15.31	—	COM	29428V104
FOLD	AMICUS THERAPEUTICS INC	7,420,288	$112M	4.7%	$15.08 *	$6.23	+112.3%	COM	03152W109
VNDA	VANDA PHARMACEUTICALS INC	4,155,670	$74.39M	3.1%	$17.90 *	$8.70	+92.3%	COM	921659108
PRTA	PROTHENA CORP PLC	1,095,655	$70.97M	3.0%	$64.77 *	$32.98	+85.7%	SHS	G72800108
—	WRIGHT MED GROUP N V	2,676,393	$69.24M	2.9%	$25.87	$23.44	—	ORD SHS 0.03 PAR	N96617118
—	AMAG PHARMACEUTICALS INC	3,441,233	$63.49M	2.7%	$18.45	$29.62	—	COM	00163U106
ACAD	ACADIA PHARMACEUTICALS INC	1,641,030	$61.82M	2.6%	$37.67 *	$29.82	+9.1%	COM	004225108
—	SAGE THERAPEUTICS INC	787,251	$49.05M	2.1%	$62.30	$42.59	—	COM	78667J108
STAA	STAAR SURGICAL CO	3,507,052	$43.66M	1.8%	$12.45 *	$8.00	+39.3%	COM PAR $0.01	852312305
—	CELGENE CORP	295,240	$43.05M	1.8%	$145.82	$97.51	—	COM	151020104
—	IMMUNOMEDICS INC	3,010,466	$42.09M	1.8%	$13.98	$8.83	—	COM	452907108
ALGN	ALIGN TECHNOLOGY INC	223,107	$41.56M	1.8%	$186.27 *	$94.04	+82.0%	COM	016255101
—	KARYOPHARM THERAPEUTICS INC	3,498,585	$38.41M	1.6%	$10.98	$19.70	—	COM	48576U106
—	MOMENTA PHARMACEUTICALS INC	1,794,998	$33.21M	1.4%	$18.50	$14.13	—	COM	60877T100
—	AIMMUNE THERAPEUTICS INC	1,293,764	$32.07M	1.4%	$24.79	$22.25	—	COM	00900T107
EXAS	EXACT SCIENCES CORP	433,076	$20.41M	0.9%	$47.12 *	$13.61	+195.7%	COM	30063P105
—	SHIRE PLC	130,200	$19.94M	0.8%	$153.14	$219.26	—	SPONSORED ADR	82481R106
GILD	GILEAD SCIENCES INC	175,900	$14.25M	0.6%	$81.02 *	$62.02	-9.8%	COM	375558103
—	BIOVERATIV INC	211,300	$12.06M	0.5%	$57.07	$57.07	—	COM	09075E100
—	RIGEL PHARMACEUTICALS INC	3,855,024	$9.792M	0.4%	$2.54	$3.39	—	COM NEW	766559603
—	ACELRX PHARMACEUTICALS INC	1,032,715	$4.75M	0.2%	$4.60	$5.54	—	COM	00444T100
—	ALIMERA SCIENCES INC	3,013,793	$4.069M	0.2%	$1.35	$4.88	—	COM	016259103
—	DICERNA PHARMACEUTICALS INC	500,913	$2.88M	0.1%	$5.75	$5.39	—	COM	253031108
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$2.255M	0.1%	$1.94	$4.37	—	COM PAR	867328700
CYTK	CYTOKINETICS INC	123,686	$1.793M	0.1%	$14.50 *	$6.71	+103.5%	COM NEW	23282W605
—	IDERA PHARMACEUTICALS INC	616,355	$1.374M	0.1%	$2.23	$3.70	—	COM NEW	45168K306
—	CEMPRA INC	340,320	$1.106M	0.0%	$3.25	$22.71	—	COM	15130J109
—	ZOGENIX INC	29,500	$1.034M	0.0%	$35.05	$13.36	—	COM NEW	98978L204
—	TREVENA INC	341,300	$870K	0.0%	$2.55	$2.30	—	COM	89532E109
—	ALDER BIOPHARMACEUTICALS INC	64,400	$789K	0.0%	$12.25	$12.25	—	COM	014339105
—	HISTOGENICS CORP	302,922	$600K	0.0%	$1.98	$11.00	—	COM	43358V109
—	SOPHIRIS BIO INC	247,000	$530K	0.0%	$2.15	$2.60	—	COM NEW	83578Q209
—	ALCOBRA LTD	272,788	$276K	0.0%	$1.01	$5.98	—	SHS	M2239P109
—	SOLENO THERAPEUTICS INC	84,748	$220K	0.0%	$2.60	$0.50	—	COM	834203101