Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q4 2017 (← Previous) (Next →)

Filing Date: Feb 14, 2018

Total Value: $2.322B (100.0% shares, 0.0% debt)

Holdings (37)

— ABIOMED INC 12.8%

Value $297M Shares 1,585,413 Share Price $187.41 Est. Cost/Share $32.04 Unrealized @ Report Date —

UTHR UNITED THERAPEUTICS CORP DEL 10.2%

Value $238M Shares 1,606,250 Share Price $147.95 * Est. Cost/Share $88.34 Unrealized @ Report Date +43.9%

— CLOVIS ONCOLOGY INC 10.0%

Value $231M Shares 3,402,781 Share Price $68.00 Est. Cost/Share $54.40 Unrealized @ Report Date —

BMRN BIOMARIN PHARMACEUTICAL INC 9.6%

Value $223M Shares 2,497,806 Share Price $89.17 * Est. Cost/Share $79.67 Unrealized @ Report Date +9.1%

INSM INSMED INC 8.6%

Value $200M Shares 6,404,586 Share Price $31.18 * Est. Cost/Share $15.54 Unrealized @ Report Date +90.1%

— ALEXION PHARMACEUTICALS INC 5.8%

Value $134M Shares 1,117,642 Share Price $119.59 Est. Cost/Share $121.07 Unrealized @ Report Date —

— SAGE THERAPEUTICS INC 5.8%

Value $134M Shares 810,806 Share Price $164.71 Est. Cost/Share $46.14 Unrealized @ Report Date —

FOLD AMICUS THERAPEUTICS INC 3.7%

Value $86.43M Shares 6,006,022 Share Price $14.39 * Est. Cost/Share $6.23 Unrealized @ Report Date +120.4%

— EPIZYME INC 3.7%

Value $86.1M Shares 6,860,843 Share Price $12.55 Est. Cost/Share $15.12 Unrealized @ Report Date —

— IMMUNOMEDICS INC 3.3%

Value $77.15M Shares 4,774,261 Share Price $16.16 Est. Cost/Share $11.54 Unrealized @ Report Date —

VNDA VANDA PHARMACEUTICALS INC 2.7%

Value $63.17M Shares 4,155,670 Share Price $15.20 * Est. Cost/Share $8.70 Unrealized @ Report Date +70.5%

— WRIGHT MED GROUP N V 2.6%

Value $60.75M Shares 2,736,293 Share Price $22.20 Est. Cost/Share $23.42 Unrealized @ Report Date —

STAA STAAR SURGICAL CO 2.3%

Value $54.2M Shares 3,496,752 Share Price $15.50 * Est. Cost/Share $8.00 Unrealized @ Report Date +85.7%

ACAD ACADIA PHARMACEUTICALS INC 2.1%

Value $49.41M Shares 1,641,030 Share Price $30.11 * Est. Cost/Share $29.82 Unrealized @ Report Date +7.2%

ALGN ALIGN TECHNOLOGY INC 2.0%

Value $47.22M Shares 212,507 Share Price $222.19 * Est. Cost/Share $94.04 Unrealized @ Report Date +141.5%

— AMAG PHARMACEUTICALS INC 2.0%

Value $46.28M Shares 3,493,220 Share Price $13.25 Est. Cost/Share $29.37 Unrealized @ Report Date —

— AIMMUNE THERAPEUTICS INC 1.9%

Value $43.36M Shares 1,146,419 Share Price $37.82 Est. Cost/Share $22.25 Unrealized @ Report Date —

PRTA PROTHENA CORP PLC 1.8%

Value $41.08M Shares 1,095,655 Share Price $37.49 * Est. Cost/Share $32.98 Unrealized @ Report Date +54.4%

— KARYOPHARM THERAPEUTICS INC 1.5%

Value $34.03M Shares 3,544,439 Share Price $9.60 Est. Cost/Share $19.57 Unrealized @ Report Date —

— CELGENE CORP 1.4%

Value $32.14M Shares 307,940 Share Price $104.36 Est. Cost/Share $97.79 Unrealized @ Report Date —

— MOMENTA PHARMACEUTICALS INC 1.1%

Value $25.41M Shares 1,821,576 Share Price $13.95 Est. Cost/Share $14.12 Unrealized @ Report Date —

— ALDER BIOPHARMACEUTICALS INC 0.9%

Value $21.07M Shares 1,840,246 Share Price $11.45 Est. Cost/Share $11.48 Unrealized @ Report Date —

— SHIRE PLC 0.9%

Value $21.07M Shares 135,800 Share Price $155.12 Est. Cost/Share $216.61 Unrealized @ Report Date —

EXAS EXACT SCIENCES CORP 0.7%

Value $16.33M Shares 310,876 Share Price $52.54 Est. Cost/Share $13.61 Unrealized @ Report Date +292.2%

— RIGEL PHARMACEUTICALS INC 0.7%

Value $15.27M Shares 3,935,584 Share Price $3.88 Est. Cost/Share $3.40 Unrealized @ Report Date —

— BIOVERATIV INC 0.6%

Value $14.26M Shares 264,400 Share Price $53.92 Est. Cost/Share $56.44 Unrealized @ Report Date —

GILD GILEAD SCIENCES INC 0.5%

Value $12.6M Shares 175,900 Share Price $71.64 * Est. Cost/Share $62.02 Unrealized @ Report Date -9.9%

— DICERNA PHARMACEUTICALS INC 0.2%

Value $4.523M Shares 500,913 Share Price $9.03 Est. Cost/Share $5.39 Unrealized @ Report Date —

— SUNESIS PHARMACEUTICALS INC 0.2%

Value $4.29M Shares 1,162,473 Share Price $3.69 Est. Cost/Share $4.37 Unrealized @ Report Date —

— ALIMERA SCIENCES INC 0.2%

Value $4.008M Shares 3,013,793 Share Price $1.33 Est. Cost/Share $4.88 Unrealized @ Report Date —

— IDERA PHARMACEUTICALS INC 0.1%

Value $1.301M Shares 616,355 Share Price $2.11 Est. Cost/Share $3.70 Unrealized @ Report Date —

— ZOGENIX INC 0.1%

Value $1.181M Shares 29,500 Share Price $40.03 Est. Cost/Share $13.36 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.0%

Value $1.008M Shares 123,686 Share Price $8.15 * Est. Cost/Share $6.71 Unrealized @ Report Date +69.1%

— MELINTA THERAPEUTICS INC 0.0%

Value $801K Shares 50,689 Share Price $15.80 Est. Cost/Share $15.80 Unrealized @ Report Date —

— HISTOGENICS CORP 0.0%

Value $621K Shares 302,922 Share Price $2.05 Est. Cost/Share $11.00 Unrealized @ Report Date —

— SOPHIRIS BIO INC 0.0%

Value $561K Shares 247,000 Share Price $2.27 Est. Cost/Share $2.60 Unrealized @ Report Date —

— TREVENA INC 0.0%

Value $546K Shares 341,300 Share Price $1.60 Est. Cost/Share $2.30 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
—	ABIOMED INC	1,585,413	$297M	12.8%	$187.41	$32.04	—	COM	003654100
UTHR	UNITED THERAPEUTICS CORP DEL	1,606,250	$238M	10.2%	$147.95 *	$88.34	+43.9%	COM	91307C102
—	CLOVIS ONCOLOGY INC	3,402,781	$231M	10.0%	$68.00	$54.40	—	COM	189464100
BMRN	BIOMARIN PHARMACEUTICAL INC	2,497,806	$223M	9.6%	$89.17 *	$79.67	+9.1%	COM	09061G101
INSM	INSMED INC	6,404,586	$200M	8.6%	$31.18 *	$15.54	+90.1%	COM PAR $.01	457669307
—	ALEXION PHARMACEUTICALS INC	1,117,642	$134M	5.8%	$119.59	$121.07	—	COM	015351109
—	SAGE THERAPEUTICS INC	810,806	$134M	5.8%	$164.71	$46.14	—	COM	78667J108
FOLD	AMICUS THERAPEUTICS INC	6,006,022	$86.43M	3.7%	$14.39 *	$6.23	+120.4%	COM	03152W109
—	EPIZYME INC	6,860,843	$86.1M	3.7%	$12.55	$15.12	—	COM	29428V104
—	IMMUNOMEDICS INC	4,774,261	$77.15M	3.3%	$16.16	$11.54	—	COM	452907108
VNDA	VANDA PHARMACEUTICALS INC	4,155,670	$63.17M	2.7%	$15.20 *	$8.70	+70.5%	COM	921659108
—	WRIGHT MED GROUP N V	2,736,293	$60.75M	2.6%	$22.20	$23.42	—	ORD SHS 0.03 PAR	N96617118
STAA	STAAR SURGICAL CO	3,496,752	$54.2M	2.3%	$15.50 *	$8.00	+85.7%	COM PAR $0.01	852312305
ACAD	ACADIA PHARMACEUTICALS INC	1,641,030	$49.41M	2.1%	$30.11 *	$29.82	+7.2%	COM	004225108
ALGN	ALIGN TECHNOLOGY INC	212,507	$47.22M	2.0%	$222.19 *	$94.04	+141.5%	COM	016255101
—	AMAG PHARMACEUTICALS INC	3,493,220	$46.28M	2.0%	$13.25	$29.37	—	COM	00163U106
—	AIMMUNE THERAPEUTICS INC	1,146,419	$43.36M	1.9%	$37.82	$22.25	—	COM	00900T107
PRTA	PROTHENA CORP PLC	1,095,655	$41.08M	1.8%	$37.49 *	$32.98	+54.4%	SHS	G72800108
—	KARYOPHARM THERAPEUTICS INC	3,544,439	$34.03M	1.5%	$9.60	$19.57	—	COM	48576U106
—	CELGENE CORP	307,940	$32.14M	1.4%	$104.36	$97.79	—	COM	151020104
—	MOMENTA PHARMACEUTICALS INC	1,821,576	$25.41M	1.1%	$13.95	$14.12	—	COM	60877T100
—	ALDER BIOPHARMACEUTICALS INC	1,840,246	$21.07M	0.9%	$11.45	$11.48	—	COM	014339105
—	SHIRE PLC	135,800	$21.07M	0.9%	$155.12	$216.61	—	SPONSORED ADR	82481R106
EXAS	EXACT SCIENCES CORP	310,876	$16.33M	0.7%	$52.54	$13.61	+292.2%	COM	30063P105
—	RIGEL PHARMACEUTICALS INC	3,935,584	$15.27M	0.7%	$3.88	$3.40	—	COM NEW	766559603
—	BIOVERATIV INC	264,400	$14.26M	0.6%	$53.92	$56.44	—	COM	09075E100
GILD	GILEAD SCIENCES INC	175,900	$12.6M	0.5%	$71.64 *	$62.02	-9.9%	COM	375558103
—	DICERNA PHARMACEUTICALS INC	500,913	$4.523M	0.2%	$9.03	$5.39	—	COM	253031108
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$4.29M	0.2%	$3.69	$4.37	—	COM PAR	867328700
—	ALIMERA SCIENCES INC	3,013,793	$4.008M	0.2%	$1.33	$4.88	—	COM	016259103
—	IDERA PHARMACEUTICALS INC	616,355	$1.301M	0.1%	$2.11	$3.70	—	COM NEW	45168K306
—	ZOGENIX INC	29,500	$1.181M	0.1%	$40.03	$13.36	—	COM NEW	98978L204
CYTK	CYTOKINETICS INC	123,686	$1.008M	0.0%	$8.15 *	$6.71	+69.1%	COM NEW	23282W605
—	MELINTA THERAPEUTICS INC	50,689	$801K	0.0%	$15.80	$15.80	—	COM	58549G100
—	HISTOGENICS CORP	302,922	$621K	0.0%	$2.05	$11.00	—	COM	43358V109
—	SOPHIRIS BIO INC	247,000	$561K	0.0%	$2.27	$2.60	—	COM NEW	83578Q209
—	TREVENA INC	341,300	$546K	0.0%	$1.60	$2.30	—	COM	89532E109