Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q1 2018 (← Previous) (Next →)

Filing Date: May 15, 2018

Total Value: $2.338B (100.0% shares, 0.0% debt)

Holdings (36)

— ABIOMED INC 16.8%

Value $392M Shares 1,346,660 Share Price $290.99 Est. Cost/Share $32.04 Unrealized @ Report Date —

— CLOVIS ONCOLOGY INC 8.9%

Value $209M Shares 3,955,660 Share Price $52.80 Est. Cost/Share $54.18 Unrealized @ Report Date —

BMRN BIOMARIN PHARMACEUTICAL INC 8.8%

Value $206M Shares 2,545,482 Share Price $81.07 * Est. Cost/Share $79.79 Unrealized @ Report Date +7.6%

UTHR UNITED THERAPEUTICS CORP DEL 7.8%

Value $182M Shares 1,622,631 Share Price $112.36 * Est. Cost/Share $88.73 Unrealized @ Report Date +43.2%

INSM INSMED INC 6.9%

Value $161M Shares 7,159,590 Share Price $22.52 * Est. Cost/Share $16.67 Unrealized @ Report Date +57.8%

— SAGE THERAPEUTICS INC 5.6%

Value $132M Shares 818,331 Share Price $161.07 Est. Cost/Share $46.14 Unrealized @ Report Date —

— ALEXION PHARMACEUTICALS INC 5.4%

Value $127M Shares 1,135,845 Share Price $111.46 Est. Cost/Share $120.92 Unrealized @ Report Date —

— EPIZYME INC 5.2%

Value $122M Shares 6,895,075 Share Price $17.75 Est. Cost/Share $15.12 Unrealized @ Report Date —

FOLD AMICUS THERAPEUTICS INC 4.0%

Value $92.46M Shares 6,147,829 Share Price $15.04 Est. Cost/Share $6.44 Unrealized @ Report Date +136.3%

— IMMUNOMEDICS INC 3.0%

Value $70.07M Shares 4,796,008 Share Price $14.61 Est. Cost/Share $11.54 Unrealized @ Report Date —

VNDA VANDA PHARMACEUTICALS INC 3.0%

Value $70.02M Shares 4,155,670 Share Price $16.85 Est. Cost/Share $8.70 Unrealized @ Report Date +92.3%

— AMAG PHARMACEUTICALS INC 2.9%

Value $67.32M Shares 3,340,806 Share Price $20.15 Est. Cost/Share $29.37 Unrealized @ Report Date —

ALGN ALIGN TECHNOLOGY INC 2.3%

Value $54.92M Shares 218,707 Share Price $251.13 * Est. Cost/Share $98.66 Unrealized @ Report Date +160.3%

— WRIGHT MED GROUP N V 2.3%

Value $54.61M Shares 2,752,294 Share Price $19.84 Est. Cost/Share $23.42 Unrealized @ Report Date —

STAA STAAR SURGICAL CO 2.2%

Value $52.03M Shares 3,515,385 Share Price $14.80 * Est. Cost/Share $8.00 Unrealized @ Report Date +95.2%

— KARYOPHARM THERAPEUTICS INC 2.1%

Value $49.38M Shares 3,679,978 Share Price $13.42 Est. Cost/Share $19.34 Unrealized @ Report Date —

— AIMMUNE THERAPEUTICS INC 1.8%

Value $43.18M Shares 1,356,514 Share Price $31.83 Est. Cost/Share $23.73 Unrealized @ Report Date —

PRTA PROTHENA CORP PLC 1.7%

Value $40.43M Shares 1,101,338 Share Price $36.71 Est. Cost/Share $32.98 Unrealized @ Report Date +10.3%

ACAD ACADIA PHARMACEUTICALS INC 1.6%

Value $37.09M Shares 1,650,780 Share Price $22.47 * Est. Cost/Share $29.82 Unrealized @ Report Date -7.2%

— CELGENE CORP 1.4%

Value $33.82M Shares 379,140 Share Price $89.21 Est. Cost/Share $96.18 Unrealized @ Report Date —

— MOMENTA PHARMACEUTICALS INC 1.4%

Value $33.22M Shares 1,830,435 Share Price $18.15 Est. Cost/Share $14.12 Unrealized @ Report Date —

— SHIRE PLC 1.2%

Value $28.56M Shares 191,200 Share Price $149.39 Est. Cost/Share $197.13 Unrealized @ Report Date —

— ALDER BIOPHARMACEUTICALS INC 1.0%

Value $23.49M Shares 1,849,832 Share Price $12.70 Est. Cost/Share $11.48 Unrealized @ Report Date —

— RIGEL PHARMACEUTICALS INC 0.6%

Value $14.04M Shares 3,966,087 Share Price $3.54 Est. Cost/Share $3.40 Unrealized @ Report Date —

GILD GILEAD SCIENCES INC 0.6%

Value $13.26M Shares 175,900 Share Price $75.39 * Est. Cost/Share $62.02 Unrealized @ Report Date -5.0%

EXAS EXACT SCIENCES CORP 0.5%

Value $12.61M Shares 312,719 Share Price $40.33 * Est. Cost/Share $13.61 Unrealized @ Report Date +258.3%

— DICERNA PHARMACEUTICALS INC 0.2%

Value $4.789M Shares 500,913 Share Price $9.56 Est. Cost/Share $5.39 Unrealized @ Report Date —

— SUNESIS PHARMACEUTICALS INC 0.1%

Value $3.162M Shares 1,162,473 Share Price $2.72 Est. Cost/Share $4.37 Unrealized @ Report Date —

— ALIMERA SCIENCES INC 0.1%

Value $3.104M Shares 3,013,793 Share Price $1.03 Est. Cost/Share $4.88 Unrealized @ Report Date —

— ZOGENIX INC 0.1%

Value $1.181M Shares 29,500 Share Price $40.03 Est. Cost/Share $13.36 Unrealized @ Report Date —

— IDERA PHARMACEUTICALS INC 0.0%

Value $1.134M Shares 616,355 Share Price $1.84 Est. Cost/Share $3.70 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.0%

Value $891K Shares 123,686 Share Price $7.20 * Est. Cost/Share $6.71 Unrealized @ Report Date +27.7%

— HISTOGENICS CORP 0.0%

Value $833K Shares 302,922 Share Price $2.75 Est. Cost/Share $11.00 Unrealized @ Report Date —

— TREVENA INC 0.0%

Value $560K Shares 341,300 Share Price $1.64 Est. Cost/Share $2.30 Unrealized @ Report Date —

— SOPHIRIS BIO INC 0.0%

Value $496K Shares 247,000 Share Price $2.01 Est. Cost/Share $2.60 Unrealized @ Report Date —

— MELINTA THERAPEUTICS INC 0.0%

Value $375K Shares 50,689 Share Price $7.40 Est. Cost/Share $15.80 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
—	ABIOMED INC	1,346,660	$392M	16.8%	$290.99	$32.04	—	COM	003654100
—	CLOVIS ONCOLOGY INC	3,955,660	$209M	8.9%	$52.80	$54.18	—	COM	189464100
BMRN	BIOMARIN PHARMACEUTICAL INC	2,545,482	$206M	8.8%	$81.07 *	$79.79	+7.6%	COM	09061G101
UTHR	UNITED THERAPEUTICS CORP DEL	1,622,631	$182M	7.8%	$112.36 *	$88.73	+43.2%	COM	91307C102
INSM	INSMED INC	7,159,590	$161M	6.9%	$22.52 *	$16.67	+57.8%	COM PAR $.01	457669307
—	SAGE THERAPEUTICS INC	818,331	$132M	5.6%	$161.07	$46.14	—	COM	78667J108
—	ALEXION PHARMACEUTICALS INC	1,135,845	$127M	5.4%	$111.46	$120.92	—	COM	015351109
—	EPIZYME INC	6,895,075	$122M	5.2%	$17.75	$15.12	—	COM	29428V104
FOLD	AMICUS THERAPEUTICS INC	6,147,829	$92.46M	4.0%	$15.04	$6.44	+136.3%	COM	03152W109
—	IMMUNOMEDICS INC	4,796,008	$70.07M	3.0%	$14.61	$11.54	—	COM	452907108
VNDA	VANDA PHARMACEUTICALS INC	4,155,670	$70.02M	3.0%	$16.85	$8.70	+92.3%	COM	921659108
—	AMAG PHARMACEUTICALS INC	3,340,806	$67.32M	2.9%	$20.15	$29.37	—	COM	00163U106
ALGN	ALIGN TECHNOLOGY INC	218,707	$54.92M	2.3%	$251.13 *	$98.66	+160.3%	COM	016255101
—	WRIGHT MED GROUP N V	2,752,294	$54.61M	2.3%	$19.84	$23.42	—	ORD SHS 0.03 PAR	N96617118
STAA	STAAR SURGICAL CO	3,515,385	$52.03M	2.2%	$14.80 *	$8.00	+95.2%	COM PAR $0.01	852312305
—	KARYOPHARM THERAPEUTICS INC	3,679,978	$49.38M	2.1%	$13.42	$19.34	—	COM	48576U106
—	AIMMUNE THERAPEUTICS INC	1,356,514	$43.18M	1.8%	$31.83	$23.73	—	COM	00900T107
PRTA	PROTHENA CORP PLC	1,101,338	$40.43M	1.7%	$36.71	$32.98	+10.3%	SHS	G72800108
ACAD	ACADIA PHARMACEUTICALS INC	1,650,780	$37.09M	1.6%	$22.47 *	$29.82	-7.2%	COM	004225108
—	CELGENE CORP	379,140	$33.82M	1.4%	$89.21	$96.18	—	COM	151020104
—	MOMENTA PHARMACEUTICALS INC	1,830,435	$33.22M	1.4%	$18.15	$14.12	—	COM	60877T100
—	SHIRE PLC	191,200	$28.56M	1.2%	$149.39	$197.13	—	SPONSORED ADR	82481R106
—	ALDER BIOPHARMACEUTICALS INC	1,849,832	$23.49M	1.0%	$12.70	$11.48	—	COM	014339105
—	RIGEL PHARMACEUTICALS INC	3,966,087	$14.04M	0.6%	$3.54	$3.40	—	COM NEW	766559603
GILD	GILEAD SCIENCES INC	175,900	$13.26M	0.6%	$75.39 *	$62.02	-5.0%	COM	375558103
EXAS	EXACT SCIENCES CORP	312,719	$12.61M	0.5%	$40.33 *	$13.61	+258.3%	COM	30063P105
—	DICERNA PHARMACEUTICALS INC	500,913	$4.789M	0.2%	$9.56	$5.39	—	COM	253031108
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$3.162M	0.1%	$2.72	$4.37	—	COM PAR	867328700
—	ALIMERA SCIENCES INC	3,013,793	$3.104M	0.1%	$1.03	$4.88	—	COM	016259103
—	ZOGENIX INC	29,500	$1.181M	0.1%	$40.03	$13.36	—	COM NEW	98978L204
—	IDERA PHARMACEUTICALS INC	616,355	$1.134M	0.0%	$1.84	$3.70	—	COM NEW	45168K306
CYTK	CYTOKINETICS INC	123,686	$891K	0.0%	$7.20 *	$6.71	+27.7%	COM NEW	23282W605
—	HISTOGENICS CORP	302,922	$833K	0.0%	$2.75	$11.00	—	COM	43358V109
—	TREVENA INC	341,300	$560K	0.0%	$1.64	$2.30	—	COM	89532E109
—	SOPHIRIS BIO INC	247,000	$496K	0.0%	$2.01	$2.60	—	COM NEW	83578Q209
—	MELINTA THERAPEUTICS INC	50,689	$375K	0.0%	$7.40	$15.80	—	COM	58549G100