Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q2 2018 (← Previous) (Next →)

Filing Date: Aug 14, 2018

Total Value ($000): $2,502,471 (100.0% shares, 0.0% debt)

Holdings (36)

— ABIOMED INC 14.6%

Value ($000) $364,181 Shares 890,309 Est. Cost $32.04 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 9.6%

Value ($000) $240,156 Shares 2,549,431 Est. Cost $79.79 Unrealized +9.8%

— CLOVIS ONCOLOGY INC 9.0%

Value ($000) $226,168 Shares 4,974,007 Est. Cost $52.39 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 7.3%

Value ($000) $183,895 Shares 1,625,234 Est. Cost $88.73 Unrealized +23.9%

INSM INSMED INC 6.8%

Value ($000) $171,145 Shares 7,236,583 Est. Cost $16.77 Unrealized +53.5%

— ALEXION PHARMACEUTICALS INC 5.9%

Value ($000) $147,295 Shares 1,186,427 Est. Cost $121.06 Unrealized —

— SAGE THERAPEUTICS INC 5.2%

Value ($000) $130,317 Shares 832,536 Est. Cost $48.02 Unrealized —

— IMMUNOMEDICS INC 4.5%

Value ($000) $113,696 Shares 4,803,364 Est. Cost $11.54 Unrealized —

STAA STAAR SURGICAL CO 4.4%

Value ($000) $109,169 Shares 3,521,565 Est. Cost $8.00 Unrealized +192.4%

FOLD AMICUS THERAPEUTICS INC 3.9%

Value ($000) $96,350 Shares 6,168,347 Est. Cost $6.44 Unrealized +134.7%

— EPIZYME INC 3.7%

Value ($000) $93,578 Shares 6,906,158 Est. Cost $15.12 Unrealized —

— KARYOPHARM THERAPEUTICS INC 3.2%

Value ($000) $79,230 Shares 4,663,324 Est. Cost $18.85 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 3.2%

Value ($000) $79,166 Shares 4,155,670 Est. Cost $8.70 Unrealized +92.1%

— WRIGHT MED GROUP N V 2.9%

Value ($000) $71,587 Shares 2,757,587 Est. Cost $23.42 Unrealized —

— AMAG PHARMACEUTICALS INC 2.6%

Value ($000) $65,146 Shares 3,340,806 Est. Cost $29.37 Unrealized —

ALGN ALIGN TECHNOLOGY INC 2.5%

Value ($000) $63,161 Shares 184,607 Est. Cost $98.66 Unrealized +202.4%

— MOMENTA PHARMACEUTICALS INC 1.5%

Value ($000) $37,496 Shares 1,833,532 Est. Cost $14.12 Unrealized —

— AIMMUNE THERAPEUTICS INC 1.5%

Value ($000) $37,155 Shares 1,381,759 Est. Cost $23.79 Unrealized —

— SHIRE PLC 1.3%

Value ($000) $32,275 Shares 191,200 Est. Cost $197.13 Unrealized —

— CELGENE CORP 1.3%

Value ($000) $31,358 Shares 394,840 Est. Cost $95.51 Unrealized —

— ALDER BIOPHARMACEUTICALS INC 1.2%

Value ($000) $29,279 Shares 1,853,101 Est. Cost $11.48 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 1.0%

Value ($000) $25,207 Shares 1,650,780 Est. Cost $29.82 Unrealized -40.2%

EXAS EXACT SCIENCES CORP 0.7%

Value ($000) $18,733 Shares 313,320 Est. Cost $13.61 Unrealized +295.3%

PRTA PROTHENA CORP PLC 0.6%

Value ($000) $16,086 Shares 1,103,325 Est. Cost $32.98 Unrealized -40.1%

GILD GILEAD SCIENCES INC 0.5%

Value ($000) $12,461 Shares 175,900 Est. Cost $62.02 Unrealized -15.0%

— RIGEL PHARMACEUTICALS INC 0.4%

Value ($000) $11,224 Shares 3,966,087 Est. Cost $3.40 Unrealized —

— DICERNA PHARMACEUTICALS INC 0.2%

Value ($000) $6,136 Shares 500,913 Est. Cost $5.39 Unrealized —

— ALIMERA SCIENCES INC 0.1%

Value ($000) $2,948 Shares 3,013,793 Est. Cost $4.88 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.1%

Value ($000) $2,464 Shares 1,162,473 Est. Cost $4.37 Unrealized —

— ZOGENIX INC 0.1%

Value ($000) $1,304 Shares 29,500 Est. Cost $13.36 Unrealized —

CYTK CYTOKINETICS INC 0.0%

Value ($000) $1,027 Shares 123,686 Est. Cost $6.71 Unrealized +24.0%

— IDERA PHARMACEUTICALS INC 0.0%

Value ($000) $814 Shares 616,355 Est. Cost $3.70 Unrealized —

— HISTOGENICS CORP 0.0%

Value ($000) $757 Shares 302,922 Est. Cost $11.00 Unrealized —

— SOPHIRIS BIO INC 0.0%

Value ($000) $694 Shares 247,000 Est. Cost $2.60 Unrealized —

— TREVENA INC 0.0%

Value ($000) $491 Shares 341,300 Est. Cost $2.30 Unrealized —

— MELINTA THERAPEUTICS INC 0.0%

Value ($000) $322 Shares 50,689 Est. Cost $15.80 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	ABIOMED INC	890,309	$364,181	14.6%	$32.04	—	COM	003654100
BMRN	BIOMARIN PHARMACEUTICAL INC	2,549,431	$240,156	9.6%	$79.79	+9.8%	COM	09061G101
—	CLOVIS ONCOLOGY INC	4,974,007	$226,168	9.0%	$52.39	—	COM	189464100
UTHR	UNITED THERAPEUTICS CORP DEL	1,625,234	$183,895	7.3%	$88.73	+23.9%	COM	91307C102
INSM	INSMED INC	7,236,583	$171,145	6.8%	$16.77	+53.5%	COM PAR $.01	457669307
—	ALEXION PHARMACEUTICALS INC	1,186,427	$147,295	5.9%	$121.06	—	COM	015351109
—	SAGE THERAPEUTICS INC	832,536	$130,317	5.2%	$48.02	—	COM	78667J108
—	IMMUNOMEDICS INC	4,803,364	$113,696	4.5%	$11.54	—	COM	452907108
STAA	STAAR SURGICAL CO	3,521,565	$109,169	4.4%	$8.00	+192.4%	COM PAR $0.01	852312305
FOLD	AMICUS THERAPEUTICS INC	6,168,347	$96,350	3.9%	$6.44	+134.7%	COM	03152W109
—	EPIZYME INC	6,906,158	$93,578	3.7%	$15.12	—	COM	29428V104
—	KARYOPHARM THERAPEUTICS INC	4,663,324	$79,230	3.2%	$18.85	—	COM	48576U106
VNDA	VANDA PHARMACEUTICALS INC	4,155,670	$79,166	3.2%	$8.70	+92.1%	COM	921659108
—	WRIGHT MED GROUP N V	2,757,587	$71,587	2.9%	$23.42	—	ORD SHS 0.03 PAR	N96617118
—	AMAG PHARMACEUTICALS INC	3,340,806	$65,146	2.6%	$29.37	—	COM	00163U106
ALGN	ALIGN TECHNOLOGY INC	184,607	$63,161	2.5%	$98.66	+202.4%	COM	016255101
—	MOMENTA PHARMACEUTICALS INC	1,833,532	$37,496	1.5%	$14.12	—	COM	60877T100
—	AIMMUNE THERAPEUTICS INC	1,381,759	$37,155	1.5%	$23.79	—	COM	00900T107
—	SHIRE PLC	191,200	$32,275	1.3%	$197.13	—	SPONSORED ADR	82481R106
—	CELGENE CORP	394,840	$31,358	1.3%	$95.51	—	COM	151020104
—	ALDER BIOPHARMACEUTICALS INC	1,853,101	$29,279	1.2%	$11.48	—	COM	014339105
ACAD	ACADIA PHARMACEUTICALS INC	1,650,780	$25,207	1.0%	$29.82	-40.2%	COM	004225108
EXAS	EXACT SCIENCES CORP	313,320	$18,733	0.7%	$13.61	+295.3%	COM	30063P105
PRTA	PROTHENA CORP PLC	1,103,325	$16,086	0.6%	$32.98	-40.1%	SHS	G72800108
GILD	GILEAD SCIENCES INC	175,900	$12,461	0.5%	$62.02	-15.0%	COM	375558103
—	RIGEL PHARMACEUTICALS INC	3,966,087	$11,224	0.4%	$3.40	—	COM NEW	766559603
—	DICERNA PHARMACEUTICALS INC	500,913	$6,136	0.2%	$5.39	—	COM	253031108
—	ALIMERA SCIENCES INC	3,013,793	$2,948	0.1%	$4.88	—	COM	016259103
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$2,464	0.1%	$4.37	—	COM PAR	867328700
—	ZOGENIX INC	29,500	$1,304	0.1%	$13.36	—	COM NEW	98978L204
CYTK	CYTOKINETICS INC	123,686	$1,027	0.0%	$6.71	+24.0%	COM NEW	23282W605
—	IDERA PHARMACEUTICALS INC	616,355	$814	0.0%	$3.70	—	COM NEW	45168K306
—	HISTOGENICS CORP	302,922	$757	0.0%	$11.00	—	COM	43358V109
—	SOPHIRIS BIO INC	247,000	$694	0.0%	$2.60	—	COM NEW	83578Q209
—	TREVENA INC	341,300	$491	0.0%	$2.30	—	COM	89532E109
—	MELINTA THERAPEUTICS INC	50,689	$322	0.0%	$15.80	—	COM	58549G100