Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q2 2018 (← Previous) (Next →)

Filing Date: Aug 14, 2018

Total Value: $2.502B (100.0% shares, 0.0% debt)

Holdings (36)

— ABIOMED INC 14.6%

Value $364M Shares 890,309 Share Price $409.05 Est. Cost/Share $32.04 Unrealized @ Report Date —

BMRN BIOMARIN PHARMACEUTICAL INC 9.6%

Value $240M Shares 2,549,431 Share Price $94.20 * Est. Cost/Share $79.79 Unrealized @ Report Date +9.8%

— CLOVIS ONCOLOGY INC 9.0%

Value $226M Shares 4,974,007 Share Price $45.47 Est. Cost/Share $52.39 Unrealized @ Report Date —

UTHR UNITED THERAPEUTICS CORP DEL 7.3%

Value $184M Shares 1,625,234 Share Price $113.15 * Est. Cost/Share $88.73 Unrealized @ Report Date +23.9%

INSM INSMED INC 6.8%

Value $171M Shares 7,236,583 Share Price $23.65 * Est. Cost/Share $16.77 Unrealized @ Report Date +53.5%

— ALEXION PHARMACEUTICALS INC 5.9%

Value $147M Shares 1,186,427 Share Price $124.15 Est. Cost/Share $121.06 Unrealized @ Report Date —

— SAGE THERAPEUTICS INC 5.2%

Value $130M Shares 832,536 Share Price $156.53 Est. Cost/Share $48.02 Unrealized @ Report Date —

— IMMUNOMEDICS INC 4.5%

Value $114M Shares 4,803,364 Share Price $23.67 Est. Cost/Share $11.54 Unrealized @ Report Date —

STAA STAAR SURGICAL CO 4.4%

Value $109M Shares 3,521,565 Share Price $31.00 * Est. Cost/Share $8.00 Unrealized @ Report Date +192.4%

FOLD AMICUS THERAPEUTICS INC 3.9%

Value $96.35M Shares 6,168,347 Share Price $15.62 * Est. Cost/Share $6.44 Unrealized @ Report Date +134.7%

— EPIZYME INC 3.7%

Value $93.58M Shares 6,906,158 Share Price $13.55 Est. Cost/Share $15.12 Unrealized @ Report Date —

— KARYOPHARM THERAPEUTICS INC 3.2%

Value $79.23M Shares 4,663,324 Share Price $16.99 Est. Cost/Share $18.85 Unrealized @ Report Date —

VNDA VANDA PHARMACEUTICALS INC 3.2%

Value $79.17M Shares 4,155,670 Share Price $19.05 * Est. Cost/Share $8.70 Unrealized @ Report Date +92.1%

— WRIGHT MED GROUP N V 2.9%

Value $71.59M Shares 2,757,587 Share Price $25.96 Est. Cost/Share $23.42 Unrealized @ Report Date —

— AMAG PHARMACEUTICALS INC 2.6%

Value $65.15M Shares 3,340,806 Share Price $19.50 Est. Cost/Share $29.37 Unrealized @ Report Date —

ALGN ALIGN TECHNOLOGY INC 2.5%

Value $63.16M Shares 184,607 Share Price $342.14 * Est. Cost/Share $98.66 Unrealized @ Report Date +202.4%

— MOMENTA PHARMACEUTICALS INC 1.5%

Value $37.5M Shares 1,833,532 Share Price $20.45 Est. Cost/Share $14.12 Unrealized @ Report Date —

— AIMMUNE THERAPEUTICS INC 1.5%

Value $37.16M Shares 1,381,759 Share Price $26.89 Est. Cost/Share $23.79 Unrealized @ Report Date —

— SHIRE PLC 1.3%

Value $32.27M Shares 191,200 Share Price $168.80 Est. Cost/Share $197.13 Unrealized @ Report Date —

— CELGENE CORP 1.3%

Value $31.36M Shares 394,840 Share Price $79.42 Est. Cost/Share $95.51 Unrealized @ Report Date —

— ALDER BIOPHARMACEUTICALS INC 1.2%

Value $29.28M Shares 1,853,101 Share Price $15.80 Est. Cost/Share $11.48 Unrealized @ Report Date —

ACAD ACADIA PHARMACEUTICALS INC 1.0%

Value $25.21M Shares 1,650,780 Share Price $15.27 * Est. Cost/Share $29.82 Unrealized @ Report Date -40.2%

EXAS EXACT SCIENCES CORP 0.7%

Value $18.73M Shares 313,320 Share Price $59.79 * Est. Cost/Share $13.61 Unrealized @ Report Date +295.3%

PRTA PROTHENA CORP PLC 0.6%

Value $16.09M Shares 1,103,325 Share Price $14.58 * Est. Cost/Share $32.98 Unrealized @ Report Date -40.1%

GILD GILEAD SCIENCES INC 0.5%

Value $12.46M Shares 175,900 Share Price $70.84 * Est. Cost/Share $62.02 Unrealized @ Report Date -15.0%

— RIGEL PHARMACEUTICALS INC 0.4%

Value $11.22M Shares 3,966,087 Share Price $2.83 Est. Cost/Share $3.40 Unrealized @ Report Date —

— DICERNA PHARMACEUTICALS INC 0.2%

Value $6.136M Shares 500,913 Share Price $12.25 Est. Cost/Share $5.39 Unrealized @ Report Date —

— ALIMERA SCIENCES INC 0.1%

Value $2.948M Shares 3,013,793 Share Price $0.98 Est. Cost/Share $4.88 Unrealized @ Report Date —

— SUNESIS PHARMACEUTICALS INC 0.1%

Value $2.464M Shares 1,162,473 Share Price $2.12 Est. Cost/Share $4.37 Unrealized @ Report Date —

— ZOGENIX INC 0.1%

Value $1.304M Shares 29,500 Share Price $44.20 Est. Cost/Share $13.36 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.0%

Value $1.027M Shares 123,686 Share Price $8.30 Est. Cost/Share $6.71 Unrealized @ Report Date +24.0%

— IDERA PHARMACEUTICALS INC 0.0%

Value $814K Shares 616,355 Share Price $1.32 Est. Cost/Share $3.70 Unrealized @ Report Date —

— HISTOGENICS CORP 0.0%

Value $757K Shares 302,922 Share Price $2.50 Est. Cost/Share $11.00 Unrealized @ Report Date —

— SOPHIRIS BIO INC 0.0%

Value $694K Shares 247,000 Share Price $2.81 Est. Cost/Share $2.60 Unrealized @ Report Date —

— TREVENA INC 0.0%

Value $491K Shares 341,300 Share Price $1.44 Est. Cost/Share $2.30 Unrealized @ Report Date —

— MELINTA THERAPEUTICS INC 0.0%

Value $322K Shares 50,689 Share Price $6.35 Est. Cost/Share $15.80 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
—	ABIOMED INC	890,309	$364M	14.6%	$409.05	$32.04	—	COM	003654100
BMRN	BIOMARIN PHARMACEUTICAL INC	2,549,431	$240M	9.6%	$94.20 *	$79.79	+9.8%	COM	09061G101
—	CLOVIS ONCOLOGY INC	4,974,007	$226M	9.0%	$45.47	$52.39	—	COM	189464100
UTHR	UNITED THERAPEUTICS CORP DEL	1,625,234	$184M	7.3%	$113.15 *	$88.73	+23.9%	COM	91307C102
INSM	INSMED INC	7,236,583	$171M	6.8%	$23.65 *	$16.77	+53.5%	COM PAR $.01	457669307
—	ALEXION PHARMACEUTICALS INC	1,186,427	$147M	5.9%	$124.15	$121.06	—	COM	015351109
—	SAGE THERAPEUTICS INC	832,536	$130M	5.2%	$156.53	$48.02	—	COM	78667J108
—	IMMUNOMEDICS INC	4,803,364	$114M	4.5%	$23.67	$11.54	—	COM	452907108
STAA	STAAR SURGICAL CO	3,521,565	$109M	4.4%	$31.00 *	$8.00	+192.4%	COM PAR $0.01	852312305
FOLD	AMICUS THERAPEUTICS INC	6,168,347	$96.35M	3.9%	$15.62 *	$6.44	+134.7%	COM	03152W109
—	EPIZYME INC	6,906,158	$93.58M	3.7%	$13.55	$15.12	—	COM	29428V104
—	KARYOPHARM THERAPEUTICS INC	4,663,324	$79.23M	3.2%	$16.99	$18.85	—	COM	48576U106
VNDA	VANDA PHARMACEUTICALS INC	4,155,670	$79.17M	3.2%	$19.05 *	$8.70	+92.1%	COM	921659108
—	WRIGHT MED GROUP N V	2,757,587	$71.59M	2.9%	$25.96	$23.42	—	ORD SHS 0.03 PAR	N96617118
—	AMAG PHARMACEUTICALS INC	3,340,806	$65.15M	2.6%	$19.50	$29.37	—	COM	00163U106
ALGN	ALIGN TECHNOLOGY INC	184,607	$63.16M	2.5%	$342.14 *	$98.66	+202.4%	COM	016255101
—	MOMENTA PHARMACEUTICALS INC	1,833,532	$37.5M	1.5%	$20.45	$14.12	—	COM	60877T100
—	AIMMUNE THERAPEUTICS INC	1,381,759	$37.16M	1.5%	$26.89	$23.79	—	COM	00900T107
—	SHIRE PLC	191,200	$32.27M	1.3%	$168.80	$197.13	—	SPONSORED ADR	82481R106
—	CELGENE CORP	394,840	$31.36M	1.3%	$79.42	$95.51	—	COM	151020104
—	ALDER BIOPHARMACEUTICALS INC	1,853,101	$29.28M	1.2%	$15.80	$11.48	—	COM	014339105
ACAD	ACADIA PHARMACEUTICALS INC	1,650,780	$25.21M	1.0%	$15.27 *	$29.82	-40.2%	COM	004225108
EXAS	EXACT SCIENCES CORP	313,320	$18.73M	0.7%	$59.79 *	$13.61	+295.3%	COM	30063P105
PRTA	PROTHENA CORP PLC	1,103,325	$16.09M	0.6%	$14.58 *	$32.98	-40.1%	SHS	G72800108
GILD	GILEAD SCIENCES INC	175,900	$12.46M	0.5%	$70.84 *	$62.02	-15.0%	COM	375558103
—	RIGEL PHARMACEUTICALS INC	3,966,087	$11.22M	0.4%	$2.83	$3.40	—	COM NEW	766559603
—	DICERNA PHARMACEUTICALS INC	500,913	$6.136M	0.2%	$12.25	$5.39	—	COM	253031108
—	ALIMERA SCIENCES INC	3,013,793	$2.948M	0.1%	$0.98	$4.88	—	COM	016259103
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$2.464M	0.1%	$2.12	$4.37	—	COM PAR	867328700
—	ZOGENIX INC	29,500	$1.304M	0.1%	$44.20	$13.36	—	COM NEW	98978L204
CYTK	CYTOKINETICS INC	123,686	$1.027M	0.0%	$8.30	$6.71	+24.0%	COM NEW	23282W605
—	IDERA PHARMACEUTICALS INC	616,355	$814K	0.0%	$1.32	$3.70	—	COM NEW	45168K306
—	HISTOGENICS CORP	302,922	$757K	0.0%	$2.50	$11.00	—	COM	43358V109
—	SOPHIRIS BIO INC	247,000	$694K	0.0%	$2.81	$2.60	—	COM NEW	83578Q209
—	TREVENA INC	341,300	$491K	0.0%	$1.44	$2.30	—	COM	89532E109
—	MELINTA THERAPEUTICS INC	50,689	$322K	0.0%	$6.35	$15.80	—	COM	58549G100