Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q3 2018 (← Previous) (Next →)

Filing Date: Nov 14, 2018

Total Value: $2.474B (100.0% shares, 0.0% debt)

Holdings (36)

— ABIOMED INC 12.9%

Value $319M Shares 708,917 Est. Cost $32.04 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 10.0%

Value $247M Shares 2,549,431 Est. Cost $79.79 Unrealized +25.1%

UTHR UNITED THERAPEUTICS CORP DEL 8.4%

Value $208M Shares 1,625,234 Est. Cost $88.73 Unrealized +39.4%

STAA STAAR SURGICAL CO 6.8%

Value $169M Shares 3,521,565 Est. Cost $8.00 Unrealized +411.6%

— ALEXION PHARMACEUTICALS INC 6.7%

Value $167M Shares 1,200,201 Est. Cost $121.26 Unrealized —

— CLOVIS ONCOLOGY INC 6.2%

Value $153M Shares 5,221,026 Est. Cost $51.30 Unrealized —

INSM INSMED INC 6.0%

Value $149M Shares 7,357,283 Est. Cost $16.87 Unrealized +34.1%

— SAGE THERAPEUTICS INC 4.8%

Value $119M Shares 840,372 Est. Cost $48.02 Unrealized —

— IMMUNOMEDICS INC 4.2%

Value $104M Shares 5,013,764 Est. Cost $11.93 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 3.9%

Value $95.37M Shares 4,155,670 Est. Cost $8.70 Unrealized +134.6%

— WRIGHT MED GROUP N V 3.2%

Value $80.03M Shares 2,757,587 Est. Cost $23.42 Unrealized —

— KARYOPHARM THERAPEUTICS INC 3.2%

Value $79.42M Shares 4,663,324 Est. Cost $18.85 Unrealized —

FOLD AMICUS THERAPEUTICS INC 3.1%

Value $76.97M Shares 6,366,147 Est. Cost $6.67 Unrealized +109.5%

— EPIZYME INC 3.0%

Value $73.2M Shares 6,906,158 Est. Cost $15.12 Unrealized —

— AMAG PHARMACEUTICALS INC 2.7%

Value $67.61M Shares 3,380,506 Est. Cost $29.26 Unrealized —

ALGN ALIGN TECHNOLOGY INC 2.3%

Value $57.83M Shares 147,807 Est. Cost $98.66 Unrealized +274.0%

— MOMENTA PHARMACEUTICALS INC 1.9%

Value $48.22M Shares 1,833,532 Est. Cost $14.12 Unrealized —

— CELGENE CORP 1.6%

Value $38.41M Shares 429,267 Est. Cost $95.03 Unrealized —

— AIMMUNE THERAPEUTICS INC 1.5%

Value $37.69M Shares 1,381,759 Est. Cost $23.79 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 1.4%

Value $34.96M Shares 1,684,180 Est. Cost $29.54 Unrealized -46.7%

— SHIRE PLC 1.4%

Value $34.94M Shares 192,738 Est. Cost $197.13 Unrealized —

— ALDER BIOPHARMACEUTICALS INC 1.2%

Value $30.85M Shares 1,853,101 Est. Cost $11.48 Unrealized —

EXAS EXACT SCIENCES CORP 1.0%

Value $24.73M Shares 313,320 Est. Cost $13.61 Unrealized +379.0%

PRTA PROTHENA CORP PLC 0.6%

Value $14.43M Shares 1,103,325 Est. Cost $32.98 Unrealized -56.2%

GILD GILEAD SCIENCES INC 0.5%

Value $13.58M Shares 175,900 Est. Cost $62.02 Unrealized -8.4%

— RIGEL PHARMACEUTICALS INC 0.5%

Value $12.73M Shares 3,966,087 Est. Cost $3.40 Unrealized —

— DICERNA PHARMACEUTICALS INC 0.3%

Value $7.644M Shares 500,913 Est. Cost $5.39 Unrealized —

— ALIMERA SCIENCES INC 0.1%

Value $2.954M Shares 3,013,793 Est. Cost $4.88 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.1%

Value $2.325M Shares 1,162,473 Est. Cost $4.37 Unrealized —

— ZOGENIX INC 0.1%

Value $1.463M Shares 29,500 Est. Cost $13.36 Unrealized —

CYTK CYTOKINETICS INC 0.0%

Value $1.218M Shares 123,686 Est. Cost $6.71 Unrealized +19.5%

— TREVENA INC 0.0%

Value $724K Shares 341,300 Est. Cost $2.30 Unrealized —

— SOPHIRIS BIO INC 0.0%

Value $689K Shares 247,000 Est. Cost $2.60 Unrealized —

— IDERA PHARMACEUTICALS INC 0.0%

Value $686K Shares 77,044 Est. Cost $8.90 Unrealized —

— MELINTA THERAPEUTICS INC 0.0%

Value $200K Shares 50,689 Est. Cost $15.80 Unrealized —

— HISTOGENICS CORP 0.0%

Value $165K Shares 302,922 Est. Cost $11.00 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	ABIOMED INC	708,917	$319M	12.9%	$32.04	—	COM	003654100
BMRN	BIOMARIN PHARMACEUTICAL INC	2,549,431	$247M	10.0%	$79.79	+25.1%	COM	09061G101
UTHR	UNITED THERAPEUTICS CORP DEL	1,625,234	$208M	8.4%	$88.73	+39.4%	COM	91307C102
STAA	STAAR SURGICAL CO	3,521,565	$169M	6.8%	$8.00	+411.6%	COM PAR $0.01	852312305
—	ALEXION PHARMACEUTICALS INC	1,200,201	$167M	6.7%	$121.26	—	COM	015351109
—	CLOVIS ONCOLOGY INC	5,221,026	$153M	6.2%	$51.30	—	COM	189464100
INSM	INSMED INC	7,357,283	$149M	6.0%	$16.87	+34.1%	COM PAR $.01	457669307
—	SAGE THERAPEUTICS INC	840,372	$119M	4.8%	$48.02	—	COM	78667J108
—	IMMUNOMEDICS INC	5,013,764	$104M	4.2%	$11.93	—	COM	452907108
VNDA	VANDA PHARMACEUTICALS INC	4,155,670	$95.37M	3.9%	$8.70	+134.6%	COM	921659108
—	WRIGHT MED GROUP N V	2,757,587	$80.03M	3.2%	$23.42	—	ORD SHS 0.03 PAR	N96617118
—	KARYOPHARM THERAPEUTICS INC	4,663,324	$79.42M	3.2%	$18.85	—	COM	48576U106
FOLD	AMICUS THERAPEUTICS INC	6,366,147	$76.97M	3.1%	$6.67	+109.5%	COM	03152W109
—	EPIZYME INC	6,906,158	$73.2M	3.0%	$15.12	—	COM	29428V104
—	AMAG PHARMACEUTICALS INC	3,380,506	$67.61M	2.7%	$29.26	—	COM	00163U106
ALGN	ALIGN TECHNOLOGY INC	147,807	$57.83M	2.3%	$98.66	+274.0%	COM	016255101
—	MOMENTA PHARMACEUTICALS INC	1,833,532	$48.22M	1.9%	$14.12	—	COM	60877T100
—	CELGENE CORP	429,267	$38.41M	1.6%	$95.03	—	COM	151020104
—	AIMMUNE THERAPEUTICS INC	1,381,759	$37.69M	1.5%	$23.79	—	COM	00900T107
ACAD	ACADIA PHARMACEUTICALS INC	1,684,180	$34.96M	1.4%	$29.54	-46.7%	COM	004225108
—	SHIRE PLC	192,738	$34.94M	1.4%	$197.13	—	SPONSORED ADR	82481R106
—	ALDER BIOPHARMACEUTICALS INC	1,853,101	$30.85M	1.2%	$11.48	—	COM	014339105
EXAS	EXACT SCIENCES CORP	313,320	$24.73M	1.0%	$13.61	+379.0%	COM	30063P105
PRTA	PROTHENA CORP PLC	1,103,325	$14.43M	0.6%	$32.98	-56.2%	SHS	G72800108
GILD	GILEAD SCIENCES INC	175,900	$13.58M	0.5%	$62.02	-8.4%	COM	375558103
—	RIGEL PHARMACEUTICALS INC	3,966,087	$12.73M	0.5%	$3.40	—	COM NEW	766559603
—	DICERNA PHARMACEUTICALS INC	500,913	$7.644M	0.3%	$5.39	—	COM	253031108
—	ALIMERA SCIENCES INC	3,013,793	$2.954M	0.1%	$4.88	—	COM	016259103
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$2.325M	0.1%	$4.37	—	COM PAR	867328700
—	ZOGENIX INC	29,500	$1.463M	0.1%	$13.36	—	COM NEW	98978L204
CYTK	CYTOKINETICS INC	123,686	$1.218M	0.0%	$6.71	+19.5%	COM NEW	23282W605
—	TREVENA INC	341,300	$724K	0.0%	$2.30	—	COM	89532E109
—	SOPHIRIS BIO INC	247,000	$689K	0.0%	$2.60	—	COM NEW	83578Q209
—	IDERA PHARMACEUTICALS INC	77,044	$686K	0.0%	$8.90	—	COM PAR	45168K405
—	MELINTA THERAPEUTICS INC	50,689	$200K	0.0%	$15.80	—	COM	58549G100
—	HISTOGENICS CORP	302,922	$165K	0.0%	$11.00	—	COM	43358V109