Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q3 2018 (← Previous) (Next →)

Filing Date: Nov 14, 2018

Total Value: $2.474B (100.0% shares, 0.0% debt)

Holdings (36)

— ABIOMED INC 12.9%

Value $319M Shares 708,917 Share Price $449.75 Est. Cost/Share $32.04 Unrealized @ Report Date —

BMRN BIOMARIN PHARMACEUTICAL INC 10.0%

Value $247M Shares 2,549,431 Share Price $96.97 * Est. Cost/Share $79.79 Unrealized @ Report Date +25.1%

UTHR UNITED THERAPEUTICS CORP DEL 8.4%

Value $208M Shares 1,625,234 Share Price $127.88 * Est. Cost/Share $88.73 Unrealized @ Report Date +39.4%

STAA STAAR SURGICAL CO 6.8%

Value $169M Shares 3,521,565 Share Price $48.00 * Est. Cost/Share $8.00 Unrealized @ Report Date +411.6%

— ALEXION PHARMACEUTICALS INC 6.7%

Value $167M Shares 1,200,201 Share Price $139.01 Est. Cost/Share $121.26 Unrealized @ Report Date —

— CLOVIS ONCOLOGY INC 6.2%

Value $153M Shares 5,221,026 Share Price $29.37 Est. Cost/Share $51.30 Unrealized @ Report Date —

INSM INSMED INC 6.0%

Value $149M Shares 7,357,283 Share Price $20.22 * Est. Cost/Share $16.87 Unrealized @ Report Date +34.1%

— SAGE THERAPEUTICS INC 4.8%

Value $119M Shares 840,372 Share Price $141.25 Est. Cost/Share $48.02 Unrealized @ Report Date —

— IMMUNOMEDICS INC 4.2%

Value $104M Shares 5,013,764 Share Price $20.83 Est. Cost/Share $11.93 Unrealized @ Report Date —

VNDA VANDA PHARMACEUTICALS INC 3.9%

Value $95.37M Shares 4,155,670 Share Price $22.95 * Est. Cost/Share $8.70 Unrealized @ Report Date +134.6%

— WRIGHT MED GROUP N V 3.2%

Value $80.03M Shares 2,757,587 Share Price $29.02 Est. Cost/Share $23.42 Unrealized @ Report Date —

— KARYOPHARM THERAPEUTICS INC 3.2%

Value $79.42M Shares 4,663,324 Share Price $17.03 Est. Cost/Share $18.85 Unrealized @ Report Date —

FOLD AMICUS THERAPEUTICS INC 3.1%

Value $76.97M Shares 6,366,147 Share Price $12.09 * Est. Cost/Share $6.67 Unrealized @ Report Date +109.5%

— EPIZYME INC 3.0%

Value $73.2M Shares 6,906,158 Share Price $10.60 Est. Cost/Share $15.12 Unrealized @ Report Date —

— AMAG PHARMACEUTICALS INC 2.7%

Value $67.61M Shares 3,380,506 Share Price $20.00 Est. Cost/Share $29.26 Unrealized @ Report Date —

ALGN ALIGN TECHNOLOGY INC 2.3%

Value $57.83M Shares 147,807 Share Price $391.22 * Est. Cost/Share $98.66 Unrealized @ Report Date +274.0%

— MOMENTA PHARMACEUTICALS INC 1.9%

Value $48.22M Shares 1,833,532 Share Price $26.30 Est. Cost/Share $14.12 Unrealized @ Report Date —

— CELGENE CORP 1.6%

Value $38.41M Shares 429,267 Share Price $89.49 Est. Cost/Share $95.03 Unrealized @ Report Date —

— AIMMUNE THERAPEUTICS INC 1.5%

Value $37.69M Shares 1,381,759 Share Price $27.28 Est. Cost/Share $23.79 Unrealized @ Report Date —

ACAD ACADIA PHARMACEUTICALS INC 1.4%

Value $34.96M Shares 1,684,180 Share Price $20.76 * Est. Cost/Share $29.54 Unrealized @ Report Date -46.7%

— SHIRE PLC 1.4%

Value $34.94M Shares 192,738 Share Price $181.27 Est. Cost/Share $197.13 Unrealized @ Report Date —

— ALDER BIOPHARMACEUTICALS INC 1.2%

Value $30.85M Shares 1,853,101 Share Price $16.65 Est. Cost/Share $11.48 Unrealized @ Report Date —

EXAS EXACT SCIENCES CORP 1.0%

Value $24.73M Shares 313,320 Share Price $78.92 * Est. Cost/Share $13.61 Unrealized @ Report Date +379.0%

PRTA PROTHENA CORP PLC 0.6%

Value $14.43M Shares 1,103,325 Share Price $13.08 * Est. Cost/Share $32.98 Unrealized @ Report Date -56.2%

GILD GILEAD SCIENCES INC 0.5%

Value $13.58M Shares 175,900 Share Price $77.21 * Est. Cost/Share $62.02 Unrealized @ Report Date -8.4%

— RIGEL PHARMACEUTICALS INC 0.5%

Value $12.73M Shares 3,966,087 Share Price $3.21 Est. Cost/Share $3.40 Unrealized @ Report Date —

— DICERNA PHARMACEUTICALS INC 0.3%

Value $7.644M Shares 500,913 Share Price $15.26 Est. Cost/Share $5.39 Unrealized @ Report Date —

— ALIMERA SCIENCES INC 0.1%

Value $2.954M Shares 3,013,793 Share Price $0.98 Est. Cost/Share $4.88 Unrealized @ Report Date —

— SUNESIS PHARMACEUTICALS INC 0.1%

Value $2.325M Shares 1,162,473 Share Price $2.00 Est. Cost/Share $4.37 Unrealized @ Report Date —

— ZOGENIX INC 0.1%

Value $1.463M Shares 29,500 Share Price $49.59 Est. Cost/Share $13.36 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.0%

Value $1.218M Shares 123,686 Share Price $9.85 * Est. Cost/Share $6.71 Unrealized @ Report Date +19.5%

— TREVENA INC 0.0%

Value $724K Shares 341,300 Share Price $2.12 Est. Cost/Share $2.30 Unrealized @ Report Date —

— SOPHIRIS BIO INC 0.0%

Value $689K Shares 247,000 Share Price $2.79 Est. Cost/Share $2.60 Unrealized @ Report Date —

— IDERA PHARMACEUTICALS INC 0.0%

Value $686K Shares 77,044 Share Price $8.90 Est. Cost/Share $8.90 Unrealized @ Report Date —

— MELINTA THERAPEUTICS INC 0.0%

Value $200K Shares 50,689 Share Price $3.95 Est. Cost/Share $15.80 Unrealized @ Report Date —

— HISTOGENICS CORP 0.0%

Value $165K Shares 302,922 Share Price $0.54 Est. Cost/Share $11.00 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
—	ABIOMED INC	708,917	$319M	12.9%	$449.75	$32.04	—	COM	003654100
BMRN	BIOMARIN PHARMACEUTICAL INC	2,549,431	$247M	10.0%	$96.97 *	$79.79	+25.1%	COM	09061G101
UTHR	UNITED THERAPEUTICS CORP DEL	1,625,234	$208M	8.4%	$127.88 *	$88.73	+39.4%	COM	91307C102
STAA	STAAR SURGICAL CO	3,521,565	$169M	6.8%	$48.00 *	$8.00	+411.6%	COM PAR $0.01	852312305
—	ALEXION PHARMACEUTICALS INC	1,200,201	$167M	6.7%	$139.01	$121.26	—	COM	015351109
—	CLOVIS ONCOLOGY INC	5,221,026	$153M	6.2%	$29.37	$51.30	—	COM	189464100
INSM	INSMED INC	7,357,283	$149M	6.0%	$20.22 *	$16.87	+34.1%	COM PAR $.01	457669307
—	SAGE THERAPEUTICS INC	840,372	$119M	4.8%	$141.25	$48.02	—	COM	78667J108
—	IMMUNOMEDICS INC	5,013,764	$104M	4.2%	$20.83	$11.93	—	COM	452907108
VNDA	VANDA PHARMACEUTICALS INC	4,155,670	$95.37M	3.9%	$22.95 *	$8.70	+134.6%	COM	921659108
—	WRIGHT MED GROUP N V	2,757,587	$80.03M	3.2%	$29.02	$23.42	—	ORD SHS 0.03 PAR	N96617118
—	KARYOPHARM THERAPEUTICS INC	4,663,324	$79.42M	3.2%	$17.03	$18.85	—	COM	48576U106
FOLD	AMICUS THERAPEUTICS INC	6,366,147	$76.97M	3.1%	$12.09 *	$6.67	+109.5%	COM	03152W109
—	EPIZYME INC	6,906,158	$73.2M	3.0%	$10.60	$15.12	—	COM	29428V104
—	AMAG PHARMACEUTICALS INC	3,380,506	$67.61M	2.7%	$20.00	$29.26	—	COM	00163U106
ALGN	ALIGN TECHNOLOGY INC	147,807	$57.83M	2.3%	$391.22 *	$98.66	+274.0%	COM	016255101
—	MOMENTA PHARMACEUTICALS INC	1,833,532	$48.22M	1.9%	$26.30	$14.12	—	COM	60877T100
—	CELGENE CORP	429,267	$38.41M	1.6%	$89.49	$95.03	—	COM	151020104
—	AIMMUNE THERAPEUTICS INC	1,381,759	$37.69M	1.5%	$27.28	$23.79	—	COM	00900T107
ACAD	ACADIA PHARMACEUTICALS INC	1,684,180	$34.96M	1.4%	$20.76 *	$29.54	-46.7%	COM	004225108
—	SHIRE PLC	192,738	$34.94M	1.4%	$181.27	$197.13	—	SPONSORED ADR	82481R106
—	ALDER BIOPHARMACEUTICALS INC	1,853,101	$30.85M	1.2%	$16.65	$11.48	—	COM	014339105
EXAS	EXACT SCIENCES CORP	313,320	$24.73M	1.0%	$78.92 *	$13.61	+379.0%	COM	30063P105
PRTA	PROTHENA CORP PLC	1,103,325	$14.43M	0.6%	$13.08 *	$32.98	-56.2%	SHS	G72800108
GILD	GILEAD SCIENCES INC	175,900	$13.58M	0.5%	$77.21 *	$62.02	-8.4%	COM	375558103
—	RIGEL PHARMACEUTICALS INC	3,966,087	$12.73M	0.5%	$3.21	$3.40	—	COM NEW	766559603
—	DICERNA PHARMACEUTICALS INC	500,913	$7.644M	0.3%	$15.26	$5.39	—	COM	253031108
—	ALIMERA SCIENCES INC	3,013,793	$2.954M	0.1%	$0.98	$4.88	—	COM	016259103
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$2.325M	0.1%	$2.00	$4.37	—	COM PAR	867328700
—	ZOGENIX INC	29,500	$1.463M	0.1%	$49.59	$13.36	—	COM NEW	98978L204
CYTK	CYTOKINETICS INC	123,686	$1.218M	0.0%	$9.85 *	$6.71	+19.5%	COM NEW	23282W605
—	TREVENA INC	341,300	$724K	0.0%	$2.12	$2.30	—	COM	89532E109
—	SOPHIRIS BIO INC	247,000	$689K	0.0%	$2.79	$2.60	—	COM NEW	83578Q209
—	IDERA PHARMACEUTICALS INC	77,044	$686K	0.0%	$8.90	$8.90	—	COM PAR	45168K405
—	MELINTA THERAPEUTICS INC	50,689	$200K	0.0%	$3.95	$15.80	—	COM	58549G100
—	HISTOGENICS CORP	302,922	$165K	0.0%	$0.54	$11.00	—	COM	43358V109