Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q3 2020 (← Previous) (Next →)

Filing Date: Nov 16, 2020

Total Value: $1.822B (100.0% shares, 0.0% debt)

Holdings (43)

— IMMUNOMEDICS INC 22.6%

Value $413M Shares 4,852,383 Est. Cost $13.38 Unrealized —

INSM INSMED INC 10.6%

Value $194M Shares 6,032,956 Est. Cost $17.16 Unrealized +67.5%

STAA STAAR SURGICAL CO 8.7%

Value $158M Shares 2,791,693 Est. Cost $13.06 Unrealized +312.4%

— ABIOMED INC 7.7%

Value $140M Shares 504,033 Est. Cost $43.36 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 7.2%

Value $132M Shares 1,732,550 Est. Cost $84.14 Unrealized +20.2%

FOLD AMICUS THERAPEUTICS INC 6.1%

Value $111M Shares 7,867,114 Est. Cost $8.07 Unrealized +80.7%

UTHR UNITED THERAPEUTICS CORP 4.4%

Value $79.33M Shares 785,406 Est. Cost $89.23 Unrealized +23.0%

— EPIZYME INC 4.2%

Value $76.39M Shares 6,403,600 Est. Cost $14.68 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 4.1%

Value $75.58M Shares 1,832,300 Est. Cost $29.66 Unrealized +45.6%

— KARYOPHARM THERAPEUTICS INC 4.1%

Value $74.26M Shares 5,086,152 Est. Cost $16.94 Unrealized —

— ALEXION PHARMACEUTICALS INC 2.9%

Value $52.35M Shares 457,529 Est. Cost $121.34 Unrealized —

— REVANCE THERAPEUTICS INC 2.8%

Value $50.15M Shares 1,994,905 Est. Cost $21.62 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 2.2%

Value $40.28M Shares 4,170,281 Est. Cost $11.20 Unrealized -4.6%

— SAGE THERAPEUTICS INC 2.0%

Value $36.07M Shares 590,200 Est. Cost $48.94 Unrealized —

— AMAG PHARMACEUTICALS INC 1.5%

Value $28.24M Shares 3,003,875 Est. Cost $28.78 Unrealized —

— CLOVIS ONCOLOGY INC 1.4%

Value $26.06M Shares 4,469,411 Est. Cost $47.56 Unrealized —

EHTH EHEALTH INC 1.2%

Value $22.16M Shares 280,438 Est. Cost $81.05 Unrealized 0.0%

ALGN ALIGN TECHNOLOGY INC 1.2%

Value $22.1M Shares 67,505 Est. Cost $114.31 Unrealized +167.0%

PBYI PUMA BIOTECHNOLOGY INC 0.8%

Value $13.81M Shares 1,368,317 Est. Cost $27.93 Unrealized -63.5%

GOSS GOSSAMER BIO INC 0.7%

Value $13.37M Shares 1,077,200 Est. Cost $13.13 Unrealized +1.0%

PRTA PROTHENA CORP PLC 0.7%

Value $13.27M Shares 1,328,734 Est. Cost $24.19 Unrealized -50.3%

KLDO KALEIDO BIOSCIENCES INC 0.5%

Value $8.705M Shares 786,400 Est. Cost $13.76 Unrealized -49.7%

— DICERNA PHARMACEUTICALS INC 0.3%

Value $5.969M Shares 331,813 Est. Cost $5.39 Unrealized —

ANAB ANAPTYSBIO INC 0.3%

Value $5.439M Shares 368,722 Est. Cost $18.04 Unrealized 0.0%

— ATHENEX INC 0.2%

Value $3.107M Shares 256,800 Est. Cost $13.30 Unrealized —

— ZOGENIX INC 0.2%

Value $2.933M Shares 163,600 Est. Cost $21.25 Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC 0.2%

Value $2.928M Shares 198,400 Est. Cost $13.29 Unrealized +14.7%

— RETROPHIN INC 0.2%

Value $2.915M Shares 157,900 Est. Cost $17.31 Unrealized —

— APREA THERAPEUTICS INC 0.2%

Value $2.882M Shares 119,800 Est. Cost $29.86 Unrealized —

— RIGEL PHARMACEUTICALS INC 0.2%

Value $2.842M Shares 1,184,092 Est. Cost $3.40 Unrealized —

CYTK CYTOKINETICS INC 0.1%

Value $2.678M Shares 123,686 Est. Cost $6.71 Unrealized +248.4%

— KEZAR LIFE SCIENCES INC 0.1%

Value $2.368M Shares 489,319 Est. Cost $4.98 Unrealized —

— MAGENTA THERAPEUTICS INC 0.1%

Value $2.337M Shares 343,700 Est. Cost $7.20 Unrealized —

— TRICIDA INC 0.1%

Value $1.547M Shares 170,800 Est. Cost $9.06 Unrealized —

EOLS EVOLUS INC 0.1%

Value $1.039M Shares 265,700 Est. Cost $3.65 Unrealized 0.0%

— ALIMERA SCIENCES INC 0.1%

Value $976K Shares 200,919 Est. Cost $6.30 Unrealized —

ALDX ALDEYRA THERAPEUTICS INC 0.0%

Value $874K Shares 118,000 Est. Cost $7.12 Unrealized -9.3%

— AIMMUNE THERAPEUTICS INC 0.0%

Value $682K Shares 19,800 Est. Cost $22.84 Unrealized —

URGN UROGEN PHARMA LTD 0.0%

Value $473K Shares 24,500 Est. Cost $27.01 Unrealized -16.2%

— MARINUS PHARMACEUTICALS INC 0.0%

Value $403K Shares 31,330 Est. Cost $4.17 Unrealized —

— IDERA PHARMACEUTICALS INC 0.0%

Value $165K Shares 77,044 Est. Cost $8.90 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.0%

Value $145K Shares 116,246 Est. Cost $4.37 Unrealized —

— MINERVA NEUROSCIENCES INC 0.0%

Value $115K Shares 36,319 Est. Cost $5.62 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	IMMUNOMEDICS INC	4,852,383	$413M	22.6%	$13.38	—	COM	452907108
INSM	INSMED INC	6,032,956	$194M	10.6%	$17.16	+67.5%	COM PAR $.01	457669307
STAA	STAAR SURGICAL CO	2,791,693	$158M	8.7%	$13.06	+312.4%	COM PAR $0.01	852312305
—	ABIOMED INC	504,033	$140M	7.7%	$43.36	—	COM	003654100
BMRN	BIOMARIN PHARMACEUTICAL INC	1,732,550	$132M	7.2%	$84.14	+20.2%	COM	09061G101
FOLD	AMICUS THERAPEUTICS INC	7,867,114	$111M	6.1%	$8.07	+80.7%	COM	03152W109
UTHR	UNITED THERAPEUTICS CORP	785,406	$79.33M	4.4%	$89.23	+23.0%	COM	91307C102
—	EPIZYME INC	6,403,600	$76.39M	4.2%	$14.68	—	COM	29428V104
ACAD	ACADIA PHARMACEUTICALS INC	1,832,300	$75.58M	4.1%	$29.66	+45.6%	COM	004225108
—	KARYOPHARM THERAPEUTICS INC	5,086,152	$74.26M	4.1%	$16.94	—	COM	48576U106
—	ALEXION PHARMACEUTICALS INC	457,529	$52.35M	2.9%	$121.34	—	COM	015351109
—	REVANCE THERAPEUTICS INC	1,994,905	$50.15M	2.8%	$21.62	—	COM	761330109
VNDA	VANDA PHARMACEUTICALS INC	4,170,281	$40.28M	2.2%	$11.20	-4.6%	COM	921659108
—	SAGE THERAPEUTICS INC	590,200	$36.07M	2.0%	$48.94	—	COM	78667J108
—	AMAG PHARMACEUTICALS INC	3,003,875	$28.24M	1.5%	$28.78	—	COM	00163U106
—	CLOVIS ONCOLOGY INC	4,469,411	$26.06M	1.4%	$47.56	—	COM	189464100
EHTH	EHEALTH INC	280,438	$22.16M	1.2%	$81.05	0.0%	COM	28238P109
ALGN	ALIGN TECHNOLOGY INC	67,505	$22.1M	1.2%	$114.31	+167.0%	COM	016255101
PBYI	PUMA BIOTECHNOLOGY INC	1,368,317	$13.81M	0.8%	$27.93	-63.5%	COM	74587V107
GOSS	GOSSAMER BIO INC	1,077,200	$13.37M	0.7%	$13.13	+1.0%	COM	38341P102
PRTA	PROTHENA CORP PLC	1,328,734	$13.27M	0.7%	$24.19	-50.3%	SHS	G72800108
KLDO	KALEIDO BIOSCIENCES INC	786,400	$8.705M	0.5%	$13.76	-49.7%	COM	483347100
—	DICERNA PHARMACEUTICALS INC	331,813	$5.969M	0.3%	$5.39	—	COM	253031108
ANAB	ANAPTYSBIO INC	368,722	$5.439M	0.3%	$18.04	0.0%	COM	032724106
—	ATHENEX INC	256,800	$3.107M	0.2%	$13.30	—	COM	04685N103
—	ZOGENIX INC	163,600	$2.933M	0.2%	$21.25	—	COM NEW	98978L204
SNDX	SYNDAX PHARMACEUTICALS INC	198,400	$2.928M	0.2%	$13.29	+14.7%	COM	87164F105
—	RETROPHIN INC	157,900	$2.915M	0.2%	$17.31	—	COM	761299106
—	APREA THERAPEUTICS INC	119,800	$2.882M	0.2%	$29.86	—	COM	03836J102
—	RIGEL PHARMACEUTICALS INC	1,184,092	$2.842M	0.2%	$3.40	—	COM NEW	766559603
CYTK	CYTOKINETICS INC	123,686	$2.678M	0.1%	$6.71	+248.4%	COM NEW	23282W605
—	KEZAR LIFE SCIENCES INC	489,319	$2.368M	0.1%	$4.98	—	COM	49372L100
—	MAGENTA THERAPEUTICS INC	343,700	$2.337M	0.1%	$7.20	—	COM	55910K108
—	TRICIDA INC	170,800	$1.547M	0.1%	$9.06	—	COM	89610F101
EOLS	EVOLUS INC	265,700	$1.039M	0.1%	$3.65	0.0%	COM	30052C107
—	ALIMERA SCIENCES INC	200,919	$976K	0.1%	$6.30	—	COM NEW	016259202
ALDX	ALDEYRA THERAPEUTICS INC	118,000	$874K	0.0%	$7.12	-9.3%	COM	01438T106
—	AIMMUNE THERAPEUTICS INC	19,800	$682K	0.0%	$22.84	—	COM	00900T107
URGN	UROGEN PHARMA LTD	24,500	$473K	0.0%	$27.01	-16.2%	COM	M96088105
—	MARINUS PHARMACEUTICALS INC	31,330	$403K	0.0%	$4.17	—	COM	56854Q101
—	IDERA PHARMACEUTICALS INC	77,044	$165K	0.0%	$8.90	—	COM PAR	45168K405
—	SUNESIS PHARMACEUTICALS INC	116,246	$145K	0.0%	$4.37	—	COM	867328700
—	MINERVA NEUROSCIENCES INC	36,319	$115K	0.0%	$5.62	—	COM	603380106