Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q4 2020 (← Previous) (Next →)

Filing Date: Feb 16, 2021

Total Value: $1.908B (100.0% shares, 0.0% debt)

Holdings (41)

STAA STAAR SURGICAL CO 11.8%

Value $226M Shares 2,849,348 Est. Cost $14.28 Unrealized +412.6%

INSM INSMED INC 10.7%

Value $203M Shares 6,105,980 Est. Cost $17.39 Unrealized +110.0%

BMRN BIOMARIN PHARMACEUTICAL INC 9.9%

Value $189M Shares 2,155,050 Est. Cost $83.19 Unrealized -4.7%

FOLD AMICUS THERAPEUTICS INC 9.5%

Value $182M Shares 7,867,114 Est. Cost $8.07 Unrealized +153.5%

— ABIOMED INC 9.5%

Value $180M Shares 556,633 Est. Cost $69.89 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 6.4%

Value $123M Shares 2,301,477 Est. Cost $33.73 Unrealized +47.2%

UTHR UNITED THERAPEUTICS CORP 6.2%

Value $119M Shares 785,406 Est. Cost $89.23 Unrealized +47.1%

— KARYOPHARM THERAPEUTICS INC 4.3%

Value $81.54M Shares 5,267,652 Est. Cost $16.89 Unrealized —

— ALEXION PHARMACEUTICALS INC 4.1%

Value $78.66M Shares 503,429 Est. Cost $124.52 Unrealized —

— REVANCE THERAPEUTICS INC 4.0%

Value $75.76M Shares 2,673,313 Est. Cost $23.32 Unrealized —

— EPIZYME INC 3.8%

Value $73.19M Shares 6,738,913 Est. Cost $14.49 Unrealized —

BIIB BIOGEN INC 3.0%

Value $57.37M Shares 234,300 Est. Cost $259.08 Unrealized 0.0%

VNDA VANDA PHARMACEUTICALS INC 2.9%

Value $55.59M Shares 4,230,548 Est. Cost $11.21 Unrealized +7.3%

— SAGE THERAPEUTICS INC 2.7%

Value $51.06M Shares 590,200 Est. Cost $48.94 Unrealized —

EHTH EHEALTH INC 2.2%

Value $41.45M Shares 586,999 Est. Cost $78.41 Unrealized -3.1%

ALGN ALIGN TECHNOLOGY INC 1.9%

Value $36.07M Shares 67,505 Est. Cost $114.31 Unrealized +293.3%

— CLOVIS ONCOLOGY INC 1.1%

Value $21.45M Shares 4,469,411 Est. Cost $47.56 Unrealized —

PRTA PROTHENA CORP PLC 1.1%

Value $20.32M Shares 1,691,805 Est. Cost $21.54 Unrealized -45.1%

GOSS GOSSAMER BIO INC 0.9%

Value $16.82M Shares 1,739,050 Est. Cost $11.88 Unrealized -17.1%

PBYI PUMA BIOTECHNOLOGY INC 0.7%

Value $14.1M Shares 1,373,897 Est. Cost $27.93 Unrealized -63.8%

ANAB ANAPTYSBIO INC 0.5%

Value $8.95M Shares 416,292 Est. Cost $18.75 Unrealized +29.5%

— DICERNA PHARMACEUTICALS INC 0.4%

Value $7.31M Shares 331,813 Est. Cost $5.39 Unrealized —

KLDO KALEIDO BIOSCIENCES INC 0.4%

Value $7.156M Shares 786,400 Est. Cost $13.76 Unrealized -40.4%

SNDX SYNDAX PHARMACEUTICALS INC 0.3%

Value $5.876M Shares 264,200 Est. Cost $15.14 Unrealized +37.0%

TVTX TRAVERE THERAPEUTICS INC 0.2%

Value $4.304M Shares 157,900 Est. Cost $23.35 Unrealized 0.0%

— ZOGENIX INC 0.2%

Value $4.292M Shares 214,700 Est. Cost $20.95 Unrealized —

— ATHENEX INC 0.2%

Value $3.519M Shares 318,200 Est. Cost $12.86 Unrealized —

— RIGEL PHARMACEUTICALS INC 0.2%

Value $3.494M Shares 998,156 Est. Cost $3.40 Unrealized —

— MAGENTA THERAPEUTICS INC 0.2%

Value $3.349M Shares 427,108 Est. Cost $7.33 Unrealized —

ALKS ALKERMES PLC 0.2%

Value $3.004M Shares 150,598 Est. Cost $18.28 Unrealized 0.0%

— KEZAR LIFE SCIENCES INC 0.2%

Value $2.862M Shares 548,206 Est. Cost $5.01 Unrealized —

CYTK CYTOKINETICS INC 0.1%

Value $2.57M Shares 123,686 Est. Cost $6.71 Unrealized +172.2%

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.1%

Value $1.218M Shares 27,100 Est. Cost $39.74 Unrealized 0.0%

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value $1.103M Shares 160,800 Est. Cost $7.10 Unrealized -1.1%

— ALIMERA SCIENCES INC 0.0%

Value $848K Shares 200,919 Est. Cost $6.30 Unrealized —

— APREA THERAPEUTICS INC 0.0%

Value $634K Shares 128,770 Est. Cost $28.13 Unrealized —

URGN UROGEN PHARMA LTD 0.0%

Value $441K Shares 24,500 Est. Cost $27.01 Unrealized -22.4%

— MARINUS PHARMACEUTICALS INC 0.0%

Value $382K Shares 31,330 Est. Cost $4.17 Unrealized —

— IDERA PHARMACEUTICALS INC 0.0%

Value $283K Shares 77,044 Est. Cost $8.90 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.0%

Value $231K Shares 116,246 Est. Cost $4.37 Unrealized —

— MINERVA NEUROSCIENCES INC 0.0%

Value $85,000 Shares 36,319 Est. Cost $5.62 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
STAA	STAAR SURGICAL CO	2,849,348	$226M	11.8%	$14.28	+412.6%	COM PAR $0.01	852312305
INSM	INSMED INC	6,105,980	$203M	10.7%	$17.39	+110.0%	COM PAR $.01	457669307
BMRN	BIOMARIN PHARMACEUTICAL INC	2,155,050	$189M	9.9%	$83.19	-4.7%	COM	09061G101
FOLD	AMICUS THERAPEUTICS INC	7,867,114	$182M	9.5%	$8.07	+153.5%	COM	03152W109
—	ABIOMED INC	556,633	$180M	9.5%	$69.89	—	COM	003654100
ACAD	ACADIA PHARMACEUTICALS INC	2,301,477	$123M	6.4%	$33.73	+47.2%	COM	004225108
UTHR	UNITED THERAPEUTICS CORP	785,406	$119M	6.2%	$89.23	+47.1%	COM	91307C102
—	KARYOPHARM THERAPEUTICS INC	5,267,652	$81.54M	4.3%	$16.89	—	COM	48576U106
—	ALEXION PHARMACEUTICALS INC	503,429	$78.66M	4.1%	$124.52	—	COM	015351109
—	REVANCE THERAPEUTICS INC	2,673,313	$75.76M	4.0%	$23.32	—	COM	761330109
—	EPIZYME INC	6,738,913	$73.19M	3.8%	$14.49	—	COM	29428V104
BIIB	BIOGEN INC	234,300	$57.37M	3.0%	$259.08	0.0%	COM	09062X103
VNDA	VANDA PHARMACEUTICALS INC	4,230,548	$55.59M	2.9%	$11.21	+7.3%	COM	921659108
—	SAGE THERAPEUTICS INC	590,200	$51.06M	2.7%	$48.94	—	COM	78667J108
EHTH	EHEALTH INC	586,999	$41.45M	2.2%	$78.41	-3.1%	COM	28238P109
ALGN	ALIGN TECHNOLOGY INC	67,505	$36.07M	1.9%	$114.31	+293.3%	COM	016255101
—	CLOVIS ONCOLOGY INC	4,469,411	$21.45M	1.1%	$47.56	—	COM	189464100
PRTA	PROTHENA CORP PLC	1,691,805	$20.32M	1.1%	$21.54	-45.1%	SHS	G72800108
GOSS	GOSSAMER BIO INC	1,739,050	$16.82M	0.9%	$11.88	-17.1%	COM	38341P102
PBYI	PUMA BIOTECHNOLOGY INC	1,373,897	$14.1M	0.7%	$27.93	-63.8%	COM	74587V107
ANAB	ANAPTYSBIO INC	416,292	$8.95M	0.5%	$18.75	+29.5%	COM	032724106
—	DICERNA PHARMACEUTICALS INC	331,813	$7.31M	0.4%	$5.39	—	COM	253031108
KLDO	KALEIDO BIOSCIENCES INC	786,400	$7.156M	0.4%	$13.76	-40.4%	COM	483347100
SNDX	SYNDAX PHARMACEUTICALS INC	264,200	$5.876M	0.3%	$15.14	+37.0%	COM	87164F105
TVTX	TRAVERE THERAPEUTICS INC	157,900	$4.304M	0.2%	$23.35	0.0%	COM	89422G107
—	ZOGENIX INC	214,700	$4.292M	0.2%	$20.95	—	COM NEW	98978L204
—	ATHENEX INC	318,200	$3.519M	0.2%	$12.86	—	COM	04685N103
—	RIGEL PHARMACEUTICALS INC	998,156	$3.494M	0.2%	$3.40	—	COM NEW	766559603
—	MAGENTA THERAPEUTICS INC	427,108	$3.349M	0.2%	$7.33	—	COM	55910K108
ALKS	ALKERMES PLC	150,598	$3.004M	0.2%	$18.28	0.0%	SHS	G01767105
—	KEZAR LIFE SCIENCES INC	548,206	$2.862M	0.2%	$5.01	—	COM	49372L100
CYTK	CYTOKINETICS INC	123,686	$2.57M	0.1%	$6.71	+172.2%	COM NEW	23282W605
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$1.218M	0.1%	$39.74	0.0%	COM	87357P100
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$1.103M	0.1%	$7.10	-1.1%	COM	01438T106
—	ALIMERA SCIENCES INC	200,919	$848K	0.0%	$6.30	—	COM NEW	016259202
—	APREA THERAPEUTICS INC	128,770	$634K	0.0%	$28.13	—	COM	03836J102
URGN	UROGEN PHARMA LTD	24,500	$441K	0.0%	$27.01	-22.4%	COM	M96088105
—	MARINUS PHARMACEUTICALS INC	31,330	$382K	0.0%	$4.17	—	COM	56854Q101
—	IDERA PHARMACEUTICALS INC	77,044	$283K	0.0%	$8.90	—	COM PAR	45168K405
—	SUNESIS PHARMACEUTICALS INC	116,246	$231K	0.0%	$4.37	—	COM	867328700
—	MINERVA NEUROSCIENCES INC	36,319	$85,000	0.0%	$5.62	—	COM	603380106