Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q1 2021 (← Previous) (Next →)

Filing Date: May 17, 2021

Total Value ($000): $1,755,095 (100.0% shares, 0.0% debt)

Holdings (42)

INSM INSMED INC 11.3%

Value ($000) $198,383 Shares 5,824,507 Est. Cost $17.39 Unrealized +119.7%

STAA STAAR SURGICAL CO 10.9%

Value ($000) $191,204 Shares 1,813,911 Est. Cost $14.28 Unrealized +601.3%

— ABIOMED INC 10.4%

Value ($000) $183,344 Shares 575,233 Est. Cost $77.94 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 9.5%

Value ($000) $166,556 Shares 2,205,750 Est. Cost $83.16 Unrealized -1.8%

UTHR UNITED THERAPEUTICS CORP 6.5%

Value ($000) $114,949 Shares 687,206 Est. Cost $89.23 Unrealized +86.8%

FOLD AMICUS THERAPEUTICS INC 5.5%

Value ($000) $96,439 Shares 9,761,043 Est. Cost $9.50 Unrealized +62.9%

BIIB BIOGEN INC 5.5%

Value ($000) $96,010 Shares 343,200 Est. Cost $262.45 Unrealized +2.8%

— REVANCE THERAPEUTICS INC 5.1%

Value ($000) $89,492 Shares 3,201,866 Est. Cost $24.09 Unrealized —

EHTH EHEALTH INC 4.4%

Value ($000) $76,975 Shares 1,058,370 Est. Cost $71.96 Unrealized -11.2%

ACAD ACADIA PHARMACEUTICALS INC 3.4%

Value ($000) $60,317 Shares 2,337,877 Est. Cost $33.89 Unrealized +29.9%

— EPIZYME INC 3.4%

Value ($000) $59,720 Shares 6,856,513 Est. Cost $14.39 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 3.2%

Value ($000) $56,953 Shares 3,791,805 Est. Cost $11.21 Unrealized +44.4%

— KARYOPHARM THERAPEUTICS INC 3.2%

Value ($000) $56,426 Shares 5,363,652 Est. Cost $16.78 Unrealized —

— SAGE THERAPEUTICS INC 2.6%

Value ($000) $44,947 Shares 600,500 Est. Cost $49.38 Unrealized —

PRTA PROTHENA CORP PLC 2.5%

Value ($000) $43,772 Shares 1,742,505 Est. Cost $21.46 Unrealized -12.3%

— ALEXION PHARMACEUTICALS INC 2.0%

Value ($000) $35,976 Shares 235,276 Est. Cost $124.52 Unrealized —

— CLOVIS ONCOLOGY INC 1.8%

Value ($000) $31,481 Shares 4,484,411 Est. Cost $47.56 Unrealized —

ALGN ALIGN TECHNOLOGY INC 1.7%

Value ($000) $30,003 Shares 55,405 Est. Cost $114.31 Unrealized +383.6%

— GRITSTONE ONCOLOGY INC 1.2%

Value ($000) $21,674 Shares 2,298,382 Est. Cost $9.43 Unrealized —

GOSS GOSSAMER BIO INC 0.9%

Value ($000) $16,400 Shares 1,772,950 Est. Cost $11.85 Unrealized -14.9%

PBYI PUMA BIOTECHNOLOGY INC 0.8%

Value ($000) $13,540 Shares 1,392,997 Est. Cost $27.70 Unrealized -59.7%

ANAB ANAPTYSBIO INC 0.5%

Value ($000) $9,409 Shares 436,592 Est. Cost $19.06 Unrealized +32.4%

ALKS ALKERMES PLC 0.5%

Value ($000) $9,099 Shares 487,100 Est. Cost $19.79 Unrealized +3.4%

— DICERNA PHARMACEUTICALS INC 0.5%

Value ($000) $8,507 Shares 332,713 Est. Cost $5.39 Unrealized —

KLDO KALEIDO BIOSCIENCES INC 0.4%

Value ($000) $6,370 Shares 786,400 Est. Cost $13.76 Unrealized -20.9%

SNDX SYNDAX PHARMACEUTICALS INC 0.3%

Value ($000) $5,908 Shares 264,200 Est. Cost $15.14 Unrealized +49.2%

— MAGENTA THERAPEUTICS INC 0.3%

Value ($000) $5,118 Shares 432,300 Est. Cost $7.38 Unrealized —

— ZOGENIX INC 0.2%

Value ($000) $4,191 Shares 214,700 Est. Cost $20.95 Unrealized —

TVTX TRAVERE THERAPEUTICS INC 0.2%

Value ($000) $4,147 Shares 166,069 Est. Cost $23.56 Unrealized +17.3%

— KEZAR LIFE SCIENCES INC 0.2%

Value ($000) $3,911 Shares 656,200 Est. Cost $5.16 Unrealized —

CYTK CYTOKINETICS INC 0.2%

Value ($000) $2,877 Shares 123,686 Est. Cost $6.71 Unrealized +218.1%

— RIGEL PHARMACEUTICALS INC 0.1%

Value ($000) $2,231 Shares 652,395 Est. Cost $3.40 Unrealized —

— ALIMERA SCIENCES INC 0.1%

Value ($000) $1,933 Shares 200,919 Est. Cost $6.30 Unrealized —

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value ($000) $1,910 Shares 160,800 Est. Cost $7.10 Unrealized +62.3%

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.1%

Value ($000) $1,477 Shares 27,100 Est. Cost $39.74 Unrealized +34.9%

— ATHENEX INC 0.1%

Value ($000) $1,368 Shares 318,200 Est. Cost $12.86 Unrealized —

— SYROS PHARMACEUTICALS INC 0.0%

Value ($000) $603 Shares 80,600 Est. Cost $7.48 Unrealized —

— MARINUS PHARMACEUTICALS INC 0.0%

Value ($000) $485 Shares 31,330 Est. Cost $15.48 Unrealized —

URGN UROGEN PHARMA LTD 0.0%

Value ($000) $477 Shares 24,500 Est. Cost $27.01 Unrealized -21.4%

— VIRACTA THERAPEUTICS INC 0.0%

Value ($000) $307 Shares 33,212 Est. Cost $9.24 Unrealized —

— MINERVA NEUROSCIENCES INC 0.0%

Value ($000) $106 Shares 36,319 Est. Cost $5.62 Unrealized —

— IDERA PHARMACEUTICALS INC 0.0%

Value ($000) $100 Shares 77,044 Est. Cost $8.90 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
INSM	INSMED INC	5,824,507	$198,383	11.3%	$17.39	+119.7%	COM PAR $.01	457669307
STAA	STAAR SURGICAL CO	1,813,911	$191,204	10.9%	$14.28	+601.3%	COM PAR $0.01	852312305
—	ABIOMED INC	575,233	$183,344	10.4%	$77.94	—	COM	003654100
BMRN	BIOMARIN PHARMACEUTICAL INC	2,205,750	$166,556	9.5%	$83.16	-1.8%	COM	09061G101
UTHR	UNITED THERAPEUTICS CORP	687,206	$114,949	6.5%	$89.23	+86.8%	COM	91307C102
FOLD	AMICUS THERAPEUTICS INC	9,761,043	$96,439	5.5%	$9.50	+62.9%	COM	03152W109
BIIB	BIOGEN INC	343,200	$96,010	5.5%	$262.45	+2.8%	COM	09062X103
—	REVANCE THERAPEUTICS INC	3,201,866	$89,492	5.1%	$24.09	—	COM	761330109
EHTH	EHEALTH INC	1,058,370	$76,975	4.4%	$71.96	-11.2%	COM	28238P109
ACAD	ACADIA PHARMACEUTICALS INC	2,337,877	$60,317	3.4%	$33.89	+29.9%	COM	004225108
—	EPIZYME INC	6,856,513	$59,720	3.4%	$14.39	—	COM	29428V104
VNDA	VANDA PHARMACEUTICALS INC	3,791,805	$56,953	3.2%	$11.21	+44.4%	COM	921659108
—	KARYOPHARM THERAPEUTICS INC	5,363,652	$56,426	3.2%	$16.78	—	COM	48576U106
—	SAGE THERAPEUTICS INC	600,500	$44,947	2.6%	$49.38	—	COM	78667J108
PRTA	PROTHENA CORP PLC	1,742,505	$43,772	2.5%	$21.46	-12.3%	SHS	G72800108
—	ALEXION PHARMACEUTICALS INC	235,276	$35,976	2.0%	$124.52	—	COM	015351109
—	CLOVIS ONCOLOGY INC	4,484,411	$31,481	1.8%	$47.56	—	COM	189464100
ALGN	ALIGN TECHNOLOGY INC	55,405	$30,003	1.7%	$114.31	+383.6%	COM	016255101
—	GRITSTONE ONCOLOGY INC	2,298,382	$21,674	1.2%	$9.43	—	COM	39868T105
GOSS	GOSSAMER BIO INC	1,772,950	$16,400	0.9%	$11.85	-14.9%	COM	38341P102
PBYI	PUMA BIOTECHNOLOGY INC	1,392,997	$13,540	0.8%	$27.70	-59.7%	COM	74587V107
ANAB	ANAPTYSBIO INC	436,592	$9,409	0.5%	$19.06	+32.4%	COM	032724106
ALKS	ALKERMES PLC	487,100	$9,099	0.5%	$19.79	+3.4%	SHS	G01767105
—	DICERNA PHARMACEUTICALS INC	332,713	$8,507	0.5%	$5.39	—	COM	253031108
KLDO	KALEIDO BIOSCIENCES INC	786,400	$6,370	0.4%	$13.76	-20.9%	COM	483347100
SNDX	SYNDAX PHARMACEUTICALS INC	264,200	$5,908	0.3%	$15.14	+49.2%	COM	87164F105
—	MAGENTA THERAPEUTICS INC	432,300	$5,118	0.3%	$7.38	—	COM	55910K108
—	ZOGENIX INC	214,700	$4,191	0.2%	$20.95	—	COM	98978L204
TVTX	TRAVERE THERAPEUTICS INC	166,069	$4,147	0.2%	$23.56	+17.3%	COM	89422G107
—	KEZAR LIFE SCIENCES INC	656,200	$3,911	0.2%	$5.16	—	COM	49372L100
CYTK	CYTOKINETICS INC	123,686	$2,877	0.2%	$6.71	+218.1%	COM NEW	23282W605
—	RIGEL PHARMACEUTICALS INC	652,395	$2,231	0.1%	$3.40	—	COM NEW	766559603
—	ALIMERA SCIENCES INC	200,919	$1,933	0.1%	$6.30	—	COM NEW	016259202
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$1,910	0.1%	$7.10	+62.3%	COM	01438T106
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$1,477	0.1%	$39.74	+34.9%	COM	87357P100
—	ATHENEX INC	318,200	$1,368	0.1%	$12.86	—	COM	04685N103
—	SYROS PHARMACEUTICALS INC	80,600	$603	0.0%	$7.48	—	COM	87184Q107
—	MARINUS PHARMACEUTICALS INC	31,330	$485	0.0%	$15.48	—	COM NEW	56854Q200
URGN	UROGEN PHARMA LTD	24,500	$477	0.0%	$27.01	-21.4%	COM	M96088105
—	VIRACTA THERAPEUTICS INC	33,212	$307	0.0%	$9.24	—	COM	92765F108
—	MINERVA NEUROSCIENCES INC	36,319	$106	0.0%	$5.62	—	COM	603380106
—	IDERA PHARMACEUTICALS INC	77,044	$100	0.0%	$8.90	—	COM PAR	45168K405