Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q1 2021 (← Previous) (Next →)

Filing Date: May 17, 2021

Total Value: $1.755B (100.0% shares, 0.0% debt)

Holdings (42)

INSM INSMED INC 11.3%
Value $198M Shares 5,824,507 Share Price $34.06 * Est. Cost/Share $17.39 Unrealized @ Report Date +119.7%
STAA STAAR SURGICAL CO 10.9%
Value $191M Shares 1,813,911 Share Price $105.41 * Est. Cost/Share $14.28 Unrealized @ Report Date +601.3%
— ABIOMED INC 10.4%
Value $183M Shares 575,233 Share Price $318.73 Est. Cost/Share $77.94 Unrealized @ Report Date —
BMRN BIOMARIN PHARMACEUTICAL INC 9.5%
Value $167M Shares 2,205,750 Share Price $75.51 * Est. Cost/Share $83.16 Unrealized @ Report Date -1.8%
UTHR UNITED THERAPEUTICS CORP 6.5%
Value $115M Shares 687,206 Share Price $167.27 Est. Cost/Share $89.23 Unrealized @ Report Date +86.8%
FOLD AMICUS THERAPEUTICS INC 5.5%
Value $96.44M Shares 9,761,043 Share Price $9.88 * Est. Cost/Share $9.50 Unrealized @ Report Date +62.9%
BIIB BIOGEN INC 5.5%
Value $96.01M Shares 343,200 Share Price $279.75 * Est. Cost/Share $262.45 Unrealized @ Report Date +2.8%
— REVANCE THERAPEUTICS INC 5.1%
Value $89.49M Shares 3,201,866 Share Price $27.95 Est. Cost/Share $24.09 Unrealized @ Report Date —
EHTH EHEALTH INC 4.4%
Value $76.97M Shares 1,058,370 Share Price $72.73 * Est. Cost/Share $71.96 Unrealized @ Report Date -11.2%
ACAD ACADIA PHARMACEUTICALS INC 3.4%
Value $60.32M Shares 2,337,877 Share Price $25.80 * Est. Cost/Share $33.89 Unrealized @ Report Date +29.9%
— EPIZYME INC 3.4%
Value $59.72M Shares 6,856,513 Share Price $8.71 Est. Cost/Share $14.39 Unrealized @ Report Date —
VNDA VANDA PHARMACEUTICALS INC 3.2%
Value $56.95M Shares 3,791,805 Share Price $15.02 * Est. Cost/Share $11.21 Unrealized @ Report Date +44.4%
— KARYOPHARM THERAPEUTICS INC 3.2%
Value $56.43M Shares 5,363,652 Share Price $10.52 Est. Cost/Share $16.78 Unrealized @ Report Date —
— SAGE THERAPEUTICS INC 2.6%
Value $44.95M Shares 600,500 Share Price $74.85 Est. Cost/Share $49.38 Unrealized @ Report Date —
PRTA PROTHENA CORP PLC 2.5%
Value $43.77M Shares 1,742,505 Share Price $25.12 * Est. Cost/Share $21.46 Unrealized @ Report Date -12.3%
— ALEXION PHARMACEUTICALS INC 2.0%
Value $35.98M Shares 235,276 Share Price $152.91 Est. Cost/Share $124.52 Unrealized @ Report Date —
— CLOVIS ONCOLOGY INC 1.8%
Value $31.48M Shares 4,484,411 Share Price $7.02 Est. Cost/Share $47.56 Unrealized @ Report Date —
ALGN ALIGN TECHNOLOGY INC 1.7%
Value $30M Shares 55,405 Share Price $541.52 * Est. Cost/Share $114.31 Unrealized @ Report Date +383.6%
— GRITSTONE ONCOLOGY INC 1.2%
Value $21.67M Shares 2,298,382 Share Price $9.43 Est. Cost/Share $9.43 Unrealized @ Report Date —
GOSS GOSSAMER BIO INC 0.9%
Value $16.4M Shares 1,772,950 Share Price $9.25 * Est. Cost/Share $11.85 Unrealized @ Report Date -14.9%
PBYI PUMA BIOTECHNOLOGY INC 0.8%
Value $13.54M Shares 1,392,997 Share Price $9.72 * Est. Cost/Share $27.70 Unrealized @ Report Date -59.7%
ANAB ANAPTYSBIO INC 0.5%
Value $9.409M Shares 436,592 Share Price $21.55 * Est. Cost/Share $19.06 Unrealized @ Report Date +32.4%
ALKS ALKERMES PLC 0.5%
Value $9.099M Shares 487,100 Share Price $18.68 * Est. Cost/Share $19.79 Unrealized @ Report Date +3.4%
— DICERNA PHARMACEUTICALS INC 0.5%
Value $8.507M Shares 332,713 Share Price $25.57 Est. Cost/Share $5.39 Unrealized @ Report Date —
KLDO KALEIDO BIOSCIENCES INC 0.4%
Value $6.37M Shares 786,400 Share Price $8.10 * Est. Cost/Share $13.76 Unrealized @ Report Date -20.9%
SNDX SYNDAX PHARMACEUTICALS INC 0.3%
Value $5.908M Shares 264,200 Share Price $22.36 Est. Cost/Share $15.14 Unrealized @ Report Date +49.2%
— MAGENTA THERAPEUTICS INC 0.3%
Value $5.118M Shares 432,300 Share Price $11.84 Est. Cost/Share $7.38 Unrealized @ Report Date —
— ZOGENIX INC 0.2%
Value $4.191M Shares 214,700 Share Price $19.52 Est. Cost/Share $20.95 Unrealized @ Report Date —
TVTX TRAVERE THERAPEUTICS INC 0.2%
Value $4.147M Shares 166,069 Share Price $24.97 * Est. Cost/Share $23.56 Unrealized @ Report Date +17.3%
— KEZAR LIFE SCIENCES INC 0.2%
Value $3.911M Shares 656,200 Share Price $5.96 Est. Cost/Share $5.16 Unrealized @ Report Date —
CYTK CYTOKINETICS INC 0.2%
Value $2.877M Shares 123,686 Share Price $23.26 * Est. Cost/Share $6.71 Unrealized @ Report Date +218.1%
— RIGEL PHARMACEUTICALS INC 0.1%
Value $2.231M Shares 652,395 Share Price $3.42 Est. Cost/Share $3.40 Unrealized @ Report Date —
— ALIMERA SCIENCES INC 0.1%
Value $1.933M Shares 200,919 Share Price $9.62 Est. Cost/Share $6.30 Unrealized @ Report Date —
ALDX ALDEYRA THERAPEUTICS INC 0.1%
Value $1.91M Shares 160,800 Share Price $11.88 * Est. Cost/Share $7.10 Unrealized @ Report Date +62.3%
TCMD TACTILE SYSTEMS TECHNOLOGY I 0.1%
Value $1.477M Shares 27,100 Share Price $54.50 Est. Cost/Share $39.74 Unrealized @ Report Date +34.9%
— ATHENEX INC 0.1%
Value $1.368M Shares 318,200 Share Price $4.30 Est. Cost/Share $12.86 Unrealized @ Report Date —
— SYROS PHARMACEUTICALS INC 0.0%
Value $603K Shares 80,600 Share Price $7.48 Est. Cost/Share $7.48 Unrealized @ Report Date —
— MARINUS PHARMACEUTICALS INC 0.0%
Value $485K Shares 31,330 Share Price $15.48 Est. Cost/Share $15.48 Unrealized @ Report Date —
URGN UROGEN PHARMA LTD 0.0%
Value $477K Shares 24,500 Share Price $19.47 * Est. Cost/Share $27.01 Unrealized @ Report Date -21.4%
— VIRACTA THERAPEUTICS INC 0.0%
Value $307K Shares 33,212 Share Price $9.24 Est. Cost/Share $9.24 Unrealized @ Report Date —
— MINERVA NEUROSCIENCES INC 0.0%
Value $106K Shares 36,319 Share Price $2.92 Est. Cost/Share $5.62 Unrealized @ Report Date —
— IDERA PHARMACEUTICALS INC 0.0%
Value $100K Shares 77,044 Share Price $1.30 Est. Cost/Share $8.90 Unrealized @ Report Date —