Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q2 2021 (← Previous) (Next →)

Filing Date: Aug 16, 2021

Total Value: $1.815B (100.0% shares, 0.0% debt)

Holdings (42)

STAA STAAR SURGICAL CO 10.7%

Value $193M Shares 1,267,811 Est. Cost $14.28 Unrealized +822.6%

BMRN BIOMARIN PHARMACEUTICAL INC 10.2%

Value $185M Shares 2,212,950 Est. Cost $83.16 Unrealized -4.7%

— ABIOMED INC 10.0%

Value $182M Shares 583,933 Est. Cost $81.43 Unrealized —

INSM INSMED INC 9.4%

Value $171M Shares 6,019,106 Est. Cost $17.79 Unrealized +66.8%

BIIB BIOGEN INC 6.9%

Value $125M Shares 361,600 Est. Cost $264.51 Unrealized +14.5%

UTHR UNITED THERAPEUTICS CORP 6.8%

Value $123M Shares 687,206 Est. Cost $89.23 Unrealized +113.4%

FOLD AMICUS THERAPEUTICS INC 5.3%

Value $96.42M Shares 10,002,443 Est. Cost $9.51 Unrealized +2.6%

— REVANCE THERAPEUTICS INC 5.2%

Value $94.9M Shares 3,201,866 Est. Cost $24.09 Unrealized —

PRTA PROTHENA CORP PLC 4.9%

Value $89.02M Shares 1,731,482 Est. Cost $21.46 Unrealized +45.4%

VNDA VANDA PHARMACEUTICALS INC 4.5%

Value $81.56M Shares 3,791,805 Est. Cost $11.21 Unrealized +59.6%

EHTH EHEALTH INC 3.7%

Value $66.92M Shares 1,145,870 Est. Cost $71.48 Unrealized -8.0%

ACAD ACADIA PHARMACEUTICALS INC 3.1%

Value $57.02M Shares 2,337,877 Est. Cost $33.89 Unrealized -33.4%

— EPIZYME INC 3.1%

Value $56.98M Shares 6,856,513 Est. Cost $14.39 Unrealized —

— KARYOPHARM THERAPEUTICS INC 3.1%

Value $55.55M Shares 5,383,052 Est. Cost $16.78 Unrealized —

— SAGE THERAPEUTICS INC 1.9%

Value $34.11M Shares 600,500 Est. Cost $49.38 Unrealized —

ALGN ALIGN TECHNOLOGY INC 1.9%

Value $33.85M Shares 55,405 Est. Cost $114.31 Unrealized +417.7%

— CLOVIS ONCOLOGY INC 1.4%

Value $26.01M Shares 4,484,411 Est. Cost $47.56 Unrealized —

— GRITSTONE ONCOLOGY INC 1.2%

Value $21.51M Shares 2,356,282 Est. Cost $9.42 Unrealized —

— ALEXION PHARMACEUTICALS INC 1.0%

Value $17.43M Shares 94,850 Est. Cost $124.52 Unrealized —

GOSS GOSSAMER BIO INC 0.8%

Value $14.4M Shares 1,772,950 Est. Cost $11.85 Unrealized -26.8%

PBYI PUMA BIOTECHNOLOGY INC 0.7%

Value $12.79M Shares 1,392,997 Est. Cost $27.70 Unrealized -63.4%

— DICERNA PHARMACEUTICALS INC 0.7%

Value $12.42M Shares 332,713 Est. Cost $5.39 Unrealized —

ALKS ALKERMES PLC 0.7%

Value $11.94M Shares 487,100 Est. Cost $19.79 Unrealized +12.4%

ANAB ANAPTYSBIO INC 0.6%

Value $11.32M Shares 436,592 Est. Cost $19.06 Unrealized +25.8%

SNDX SYNDAX PHARMACEUTICALS INC 0.4%

Value $6.887M Shares 401,100 Est. Cost $16.23 Unrealized +12.9%

KLDO KALEIDO BIOSCIENCES INC 0.3%

Value $5.851M Shares 786,400 Est. Cost $13.76 Unrealized -48.5%

— MAGENTA THERAPEUTICS INC 0.2%

Value $4.228M Shares 432,300 Est. Cost $7.38 Unrealized —

— ZOGENIX INC 0.2%

Value $3.71M Shares 214,700 Est. Cost $20.95 Unrealized —

— KEZAR LIFE SCIENCES INC 0.2%

Value $3.563M Shares 656,200 Est. Cost $5.16 Unrealized —

— RIGEL PHARMACEUTICALS INC 0.2%

Value $2.831M Shares 652,395 Est. Cost $3.40 Unrealized —

CYTK CYTOKINETICS INC 0.1%

Value $2.448M Shares 123,686 Est. Cost $6.71 Unrealized +249.8%

TVTX TRAVERE THERAPEUTICS INC 0.1%

Value $2.423M Shares 166,069 Est. Cost $23.56 Unrealized -16.3%

— ALIMERA SCIENCES INC 0.1%

Value $1.828M Shares 200,919 Est. Cost $6.30 Unrealized —

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value $1.822M Shares 160,800 Est. Cost $7.10 Unrealized +69.4%

— ATHENEX INC 0.1%

Value $1.47M Shares 318,200 Est. Cost $12.86 Unrealized —

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.1%

Value $1.409M Shares 27,100 Est. Cost $39.74 Unrealized +36.0%

— MARINUS PHARMACEUTICALS INC 0.0%

Value $562K Shares 31,330 Est. Cost $15.48 Unrealized —

— SYROS PHARMACEUTICALS INC 0.0%

Value $439K Shares 80,600 Est. Cost $7.48 Unrealized —

— VIRACTA THERAPEUTICS INC 0.0%

Value $377K Shares 33,212 Est. Cost $9.24 Unrealized —

URGN UROGEN PHARMA LTD 0.0%

Value $374K Shares 24,500 Est. Cost $27.01 Unrealized -33.1%

— IDERA PHARMACEUTICALS INC 0.0%

Value $92,000 Shares 77,044 Est. Cost $8.90 Unrealized —

— MINERVA NEUROSCIENCES INC 0.0%

Value $84,000 Shares 36,319 Est. Cost $5.62 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
STAA	STAAR SURGICAL CO	1,267,811	$193M	10.7%	$14.28	+822.6%	COM PAR $.01	852312305
BMRN	BIOMARIN PHARMACEUTICAL INC	2,212,950	$185M	10.2%	$83.16	-4.7%	COM	09061G101
—	ABIOMED INC	583,933	$182M	10.0%	$81.43	—	COM	003654100
INSM	INSMED INC	6,019,106	$171M	9.4%	$17.79	+66.8%	COM PAR $.01	457669307
BIIB	BIOGEN INC	361,600	$125M	6.9%	$264.51	+14.5%	COM	09062X103
UTHR	UNITED THERAPEUTICS CORP	687,206	$123M	6.8%	$89.23	+113.4%	COM	91307C102
FOLD	AMICUS THERAPEUTICS INC	10,002,443	$96.42M	5.3%	$9.51	+2.6%	COM	03152W109
—	REVANCE THERAPEUTICS INC	3,201,866	$94.9M	5.2%	$24.09	—	COM	761330109
PRTA	PROTHENA CORP PLC	1,731,482	$89.02M	4.9%	$21.46	+45.4%	SHS	G72800108
VNDA	VANDA PHARMACEUTICALS INC	3,791,805	$81.56M	4.5%	$11.21	+59.6%	COM	921659108
EHTH	EHEALTH INC	1,145,870	$66.92M	3.7%	$71.48	-8.0%	COM	28238P109
ACAD	ACADIA PHARMACEUTICALS INC	2,337,877	$57.02M	3.1%	$33.89	-33.4%	COM	004225108
—	EPIZYME INC	6,856,513	$56.98M	3.1%	$14.39	—	COM	29428V104
—	KARYOPHARM THERAPEUTICS INC	5,383,052	$55.55M	3.1%	$16.78	—	COM	48576U106
—	SAGE THERAPEUTICS INC	600,500	$34.11M	1.9%	$49.38	—	COM	78667J108
ALGN	ALIGN TECHNOLOGY INC	55,405	$33.85M	1.9%	$114.31	+417.7%	COM	016255101
—	CLOVIS ONCOLOGY INC	4,484,411	$26.01M	1.4%	$47.56	—	COM	189464100
—	GRITSTONE ONCOLOGY INC	2,356,282	$21.51M	1.2%	$9.42	—	COM	39868T105
—	ALEXION PHARMACEUTICALS INC	94,850	$17.43M	1.0%	$124.52	—	COM	015351109
GOSS	GOSSAMER BIO INC	1,772,950	$14.4M	0.8%	$11.85	-26.8%	COM	38341P102
PBYI	PUMA BIOTECHNOLOGY INC	1,392,997	$12.79M	0.7%	$27.70	-63.4%	COM	74587V107
—	DICERNA PHARMACEUTICALS INC	332,713	$12.42M	0.7%	$5.39	—	COM	253031108
ALKS	ALKERMES PLC	487,100	$11.94M	0.7%	$19.79	+12.4%	SHS	G01767105
ANAB	ANAPTYSBIO INC	436,592	$11.32M	0.6%	$19.06	+25.8%	COM	032724106
SNDX	SYNDAX PHARMACEUTICALS INC	401,100	$6.887M	0.4%	$16.23	+12.9%	COM	87164F105
KLDO	KALEIDO BIOSCIENCES INC	786,400	$5.851M	0.3%	$13.76	-48.5%	COM	483347100
—	MAGENTA THERAPEUTICS INC	432,300	$4.228M	0.2%	$7.38	—	COM	55910K108
—	ZOGENIX INC	214,700	$3.71M	0.2%	$20.95	—	COM NEW	98978L204
—	KEZAR LIFE SCIENCES INC	656,200	$3.563M	0.2%	$5.16	—	COM	49372L100
—	RIGEL PHARMACEUTICALS INC	652,395	$2.831M	0.2%	$3.40	—	COM NEW	766559603
CYTK	CYTOKINETICS INC	123,686	$2.448M	0.1%	$6.71	+249.8%	COM NEW	23282W605
TVTX	TRAVERE THERAPEUTICS INC	166,069	$2.423M	0.1%	$23.56	-16.3%	COM	89422G107
—	ALIMERA SCIENCES INC	200,919	$1.828M	0.1%	$6.30	—	COM NEW	016259202
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$1.822M	0.1%	$7.10	+69.4%	COM	01438T106
—	ATHENEX INC	318,200	$1.47M	0.1%	$12.86	—	COM	04685N103
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$1.409M	0.1%	$39.74	+36.0%	COM	87357P100
—	MARINUS PHARMACEUTICALS INC	31,330	$562K	0.0%	$15.48	—	COM NEW	56854Q200
—	SYROS PHARMACEUTICALS INC	80,600	$439K	0.0%	$7.48	—	COM	87184Q107
—	VIRACTA THERAPEUTICS INC	33,212	$377K	0.0%	$9.24	—	COM	92765F108
URGN	UROGEN PHARMA LTD	24,500	$374K	0.0%	$27.01	-33.1%	COM	M96088105
—	IDERA PHARMACEUTICALS INC	77,044	$92,000	0.0%	$8.90	—	COM PAR	45168K405
—	MINERVA NEUROSCIENCES INC	36,319	$84,000	0.0%	$5.62	—	COM	603380106