Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q2 2021 (← Previous) (Next →)

Filing Date: Aug 16, 2021

Total Value: $1.815B (100.0% shares, 0.0% debt)

Holdings (42)

STAA STAAR SURGICAL CO 10.7%
Value $193M Shares 1,267,811 Share Price $152.50 * Est. Cost/Share $14.28 Unrealized @ Report Date +822.6%
BMRN BIOMARIN PHARMACEUTICAL INC 10.2%
Value $185M Shares 2,212,950 Share Price $83.44 * Est. Cost/Share $83.16 Unrealized @ Report Date -4.7%
— ABIOMED INC 10.0%
Value $182M Shares 583,933 Share Price $312.11 Est. Cost/Share $81.43 Unrealized @ Report Date —
INSM INSMED INC 9.4%
Value $171M Shares 6,019,106 Share Price $28.46 * Est. Cost/Share $17.79 Unrealized @ Report Date +66.8%
BIIB BIOGEN INC 6.9%
Value $125M Shares 361,600 Share Price $346.27 * Est. Cost/Share $264.51 Unrealized @ Report Date +14.5%
UTHR UNITED THERAPEUTICS CORP 6.8%
Value $123M Shares 687,206 Share Price $179.41 * Est. Cost/Share $89.23 Unrealized @ Report Date +113.4%
FOLD AMICUS THERAPEUTICS INC 5.3%
Value $96.42M Shares 10,002,443 Share Price $9.64 Est. Cost/Share $9.51 Unrealized @ Report Date +2.6%
— REVANCE THERAPEUTICS INC 5.2%
Value $94.9M Shares 3,201,866 Share Price $29.64 Est. Cost/Share $24.09 Unrealized @ Report Date —
PRTA PROTHENA CORP PLC 4.9%
Value $89.02M Shares 1,731,482 Share Price $51.41 * Est. Cost/Share $21.46 Unrealized @ Report Date +45.4%
VNDA VANDA PHARMACEUTICALS INC 4.5%
Value $81.56M Shares 3,791,805 Share Price $21.51 * Est. Cost/Share $11.21 Unrealized @ Report Date +59.6%
EHTH EHEALTH INC 3.7%
Value $66.92M Shares 1,145,870 Share Price $58.40 * Est. Cost/Share $71.48 Unrealized @ Report Date -8.0%
ACAD ACADIA PHARMACEUTICALS INC 3.1%
Value $57.02M Shares 2,337,877 Share Price $24.39 * Est. Cost/Share $33.89 Unrealized @ Report Date -33.4%
— EPIZYME INC 3.1%
Value $56.98M Shares 6,856,513 Share Price $8.31 Est. Cost/Share $14.39 Unrealized @ Report Date —
— KARYOPHARM THERAPEUTICS INC 3.1%
Value $55.55M Shares 5,383,052 Share Price $10.32 Est. Cost/Share $16.78 Unrealized @ Report Date —
— SAGE THERAPEUTICS INC 1.9%
Value $34.11M Shares 600,500 Share Price $56.81 Est. Cost/Share $49.38 Unrealized @ Report Date —
ALGN ALIGN TECHNOLOGY INC 1.9%
Value $33.85M Shares 55,405 Share Price $610.99 * Est. Cost/Share $114.31 Unrealized @ Report Date +417.7%
— CLOVIS ONCOLOGY INC 1.4%
Value $26.01M Shares 4,484,411 Share Price $5.80 Est. Cost/Share $47.56 Unrealized @ Report Date —
— GRITSTONE ONCOLOGY INC 1.2%
Value $21.51M Shares 2,356,282 Share Price $9.13 Est. Cost/Share $9.42 Unrealized @ Report Date —
— ALEXION PHARMACEUTICALS INC 1.0%
Value $17.43M Shares 94,850 Share Price $183.71 Est. Cost/Share $124.52 Unrealized @ Report Date —
GOSS GOSSAMER BIO INC 0.8%
Value $14.4M Shares 1,772,950 Share Price $8.12 * Est. Cost/Share $11.85 Unrealized @ Report Date -26.8%
PBYI PUMA BIOTECHNOLOGY INC 0.7%
Value $12.79M Shares 1,392,997 Share Price $9.18 * Est. Cost/Share $27.70 Unrealized @ Report Date -63.4%
— DICERNA PHARMACEUTICALS INC 0.7%
Value $12.42M Shares 332,713 Share Price $37.32 Est. Cost/Share $5.39 Unrealized @ Report Date —
ALKS ALKERMES PLC 0.7%
Value $11.94M Shares 487,100 Share Price $24.52 * Est. Cost/Share $19.79 Unrealized @ Report Date +12.4%
ANAB ANAPTYSBIO INC 0.6%
Value $11.32M Shares 436,592 Share Price $25.93 * Est. Cost/Share $19.06 Unrealized @ Report Date +25.8%
SNDX SYNDAX PHARMACEUTICALS INC 0.4%
Value $6.887M Shares 401,100 Share Price $17.17 * Est. Cost/Share $16.23 Unrealized @ Report Date +12.9%
KLDO KALEIDO BIOSCIENCES INC 0.3%
Value $5.851M Shares 786,400 Share Price $7.44 * Est. Cost/Share $13.76 Unrealized @ Report Date -48.5%
— MAGENTA THERAPEUTICS INC 0.2%
Value $4.228M Shares 432,300 Share Price $9.78 Est. Cost/Share $7.38 Unrealized @ Report Date —
— ZOGENIX INC 0.2%
Value $3.71M Shares 214,700 Share Price $17.28 Est. Cost/Share $20.95 Unrealized @ Report Date —
— KEZAR LIFE SCIENCES INC 0.2%
Value $3.563M Shares 656,200 Share Price $5.43 Est. Cost/Share $5.16 Unrealized @ Report Date —
— RIGEL PHARMACEUTICALS INC 0.2%
Value $2.831M Shares 652,395 Share Price $4.34 Est. Cost/Share $3.40 Unrealized @ Report Date —
CYTK CYTOKINETICS INC 0.1%
Value $2.448M Shares 123,686 Share Price $19.79 * Est. Cost/Share $6.71 Unrealized @ Report Date +249.8%
TVTX TRAVERE THERAPEUTICS INC 0.1%
Value $2.423M Shares 166,069 Share Price $14.59 * Est. Cost/Share $23.56 Unrealized @ Report Date -16.3%
— ALIMERA SCIENCES INC 0.1%
Value $1.828M Shares 200,919 Share Price $9.10 Est. Cost/Share $6.30 Unrealized @ Report Date —
ALDX ALDEYRA THERAPEUTICS INC 0.1%
Value $1.822M Shares 160,800 Share Price $11.33 * Est. Cost/Share $7.10 Unrealized @ Report Date +69.4%
— ATHENEX INC 0.1%
Value $1.47M Shares 318,200 Share Price $4.62 Est. Cost/Share $12.86 Unrealized @ Report Date —
TCMD TACTILE SYSTEMS TECHNOLOGY I 0.1%
Value $1.409M Shares 27,100 Share Price $51.99 * Est. Cost/Share $39.74 Unrealized @ Report Date +36.0%
— MARINUS PHARMACEUTICALS INC 0.0%
Value $562K Shares 31,330 Share Price $17.94 Est. Cost/Share $15.48 Unrealized @ Report Date —
— SYROS PHARMACEUTICALS INC 0.0%
Value $439K Shares 80,600 Share Price $5.45 Est. Cost/Share $7.48 Unrealized @ Report Date —
— VIRACTA THERAPEUTICS INC 0.0%
Value $377K Shares 33,212 Share Price $11.35 Est. Cost/Share $9.24 Unrealized @ Report Date —
URGN UROGEN PHARMA LTD 0.0%
Value $374K Shares 24,500 Share Price $15.27 * Est. Cost/Share $27.01 Unrealized @ Report Date -33.1%
— IDERA PHARMACEUTICALS INC 0.0%
Value $92,000 Shares 77,044 Share Price $1.19 Est. Cost/Share $8.90 Unrealized @ Report Date —
— MINERVA NEUROSCIENCES INC 0.0%
Value $84,000 Shares 36,319 Share Price $2.31 Est. Cost/Share $5.62 Unrealized @ Report Date —