Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q3 2021 (← Previous) (Next →)

Filing Date: Nov 15, 2021

Total Value: $1.657B (100.0% shares, 0.0% debt)

Holdings (42)

— ABIOMED INC 10.8%
Value $179M Shares 549,820 Share Price $325.52 Est. Cost/Share $81.43 Unrealized @ Report Date —
BMRN BIOMARIN PHARMACEUTICAL INC 10.3%
Value $171M Shares 2,212,950 Share Price $77.29 * Est. Cost/Share $83.16 Unrealized @ Report Date -5.1%
INSM INSMED INC 10.0%
Value $166M Shares 6,019,106 Share Price $27.54 * Est. Cost/Share $17.79 Unrealized @ Report Date +47.5%
STAA STAAR SURGICAL CO 8.8%
Value $147M Shares 1,140,511 Share Price $128.53 * Est. Cost/Share $14.28 Unrealized @ Report Date +880.2%
UTHR UNITED THERAPEUTICS CORP 7.7%
Value $127M Shares 687,206 Share Price $184.58 * Est. Cost/Share $89.23 Unrealized @ Report Date +120.7%
PRTA PROTHENA CORP PLC 7.2%
Value $120M Shares 1,685,282 Share Price $71.23 * Est. Cost/Share $21.46 Unrealized @ Report Date +189.5%
BIIB BIOGEN INC 6.2%
Value $102M Shares 361,600 Share Price $282.99 * Est. Cost/Share $264.51 Unrealized @ Report Date +23.9%
FOLD AMICUS THERAPEUTICS INC 5.8%
Value $96.59M Shares 10,114,043 Share Price $9.55 * Est. Cost/Share $9.52 Unrealized @ Report Date +7.5%
— REVANCE THERAPEUTICS INC 5.4%
Value $89.2M Shares 3,201,866 Share Price $27.86 Est. Cost/Share $24.09 Unrealized @ Report Date —
VNDA VANDA PHARMACEUTICALS INC 3.9%
Value $64.99M Shares 3,791,805 Share Price $17.14 * Est. Cost/Share $11.21 Unrealized @ Report Date +56.2%
EHTH EHEALTH INC 2.8%
Value $46.41M Shares 1,145,870 Share Price $40.50 * Est. Cost/Share $71.48 Unrealized @ Report Date -34.8%
ACAD ACADIA PHARMACEUTICALS INC 2.3%
Value $38.83M Shares 2,337,877 Share Price $16.61 * Est. Cost/Share $33.89 Unrealized @ Report Date -43.1%
ALGN ALIGN TECHNOLOGY INC 2.2%
Value $36.87M Shares 55,405 Share Price $665.43 * Est. Cost/Share $114.31 Unrealized @ Report Date +494.1%
— EPIZYME INC 2.1%
Value $35.1M Shares 6,856,513 Share Price $5.12 Est. Cost/Share $14.39 Unrealized @ Report Date —
— KARYOPHARM THERAPEUTICS INC 1.9%
Value $31.33M Shares 5,383,052 Share Price $5.82 Est. Cost/Share $16.78 Unrealized @ Report Date —
— SAGE THERAPEUTICS INC 1.7%
Value $27.38M Shares 617,930 Share Price $44.31 Est. Cost/Share $49.24 Unrealized @ Report Date —
— GRITSTONE ONCOLOGY INC 1.5%
Value $25.45M Shares 2,356,282 Share Price $10.80 Est. Cost/Share $9.42 Unrealized @ Report Date —
GOSS GOSSAMER BIO INC 1.3%
Value $22.29M Shares 1,772,950 Share Price $12.57 * Est. Cost/Share $11.85 Unrealized @ Report Date -22.3%
— CLOVIS ONCOLOGY INC 1.2%
Value $20M Shares 4,484,411 Share Price $4.46 Est. Cost/Share $47.56 Unrealized @ Report Date —
ALKS ALKERMES PLC 1.1%
Value $18.19M Shares 589,900 Share Price $30.84 * Est. Cost/Share $21.27 Unrealized @ Report Date +32.9%
— DICERNA PHARMACEUTICALS INC 1.0%
Value $17.25M Shares 855,713 Share Price $20.16 Est. Cost/Share $14.42 Unrealized @ Report Date —
AZN ASTRAZENECA PLC-SPONS ADR 0.7%
Value $12.1M Shares 201,489 Share Price $60.06 Est. Cost/Share $60.06 Unrealized @ Report Date —
ANAB ANAPTYSBIO INC 0.7%
Value $11.84M Shares 436,592 Share Price $27.12 * Est. Cost/Share $19.06 Unrealized @ Report Date +33.2%
PBYI PUMA BIOTECHNOLOGY INC 0.6%
Value $9.765M Shares 1,392,997 Share Price $7.01 * Est. Cost/Share $27.70 Unrealized @ Report Date -73.0%
SNDX SYNDAX PHARMACEUTICALS INC 0.5%
Value $8.502M Shares 444,900 Share Price $19.11 * Est. Cost/Share $16.27 Unrealized @ Report Date +2.4%
— KEZAR LIFE SCIENCES INC 0.3%
Value $5.67M Shares 656,200 Share Price $8.64 Est. Cost/Share $5.16 Unrealized @ Report Date —
CYTK CYTOKINETICS INC 0.3%
Value $4.421M Shares 123,686 Share Price $35.74 * Est. Cost/Share $6.71 Unrealized @ Report Date +338.5%
KLDO KALEIDO BIOSCIENCES INC 0.3%
Value $4.294M Shares 786,400 Share Price $5.46 * Est. Cost/Share $13.76 Unrealized @ Report Date -54.9%
TVTX TRAVERE THERAPEUTICS INC 0.2%
Value $4.027M Shares 166,069 Share Price $24.25 * Est. Cost/Share $23.56 Unrealized @ Report Date -22.0%
— ZOGENIX INC 0.2%
Value $3.261M Shares 214,700 Share Price $15.19 Est. Cost/Share $20.95 Unrealized @ Report Date —
— MAGENTA THERAPEUTICS INC 0.2%
Value $3.147M Shares 432,300 Share Price $7.28 Est. Cost/Share $7.38 Unrealized @ Report Date —
— RIGEL PHARMACEUTICALS INC 0.1%
Value $2.368M Shares 652,395 Share Price $3.63 Est. Cost/Share $3.40 Unrealized @ Report Date —
ALDX ALDEYRA THERAPEUTICS INC 0.1%
Value $1.412M Shares 160,800 Share Price $8.78 * Est. Cost/Share $7.10 Unrealized @ Report Date +29.3%
TCMD TACTILE SYSTEMS TECHNOLOGY I 0.1%
Value $1.205M Shares 27,100 Share Price $44.46 Est. Cost/Share $39.74 Unrealized @ Report Date +13.2%
— ATHENEX INC 0.1%
Value $958K Shares 318,200 Share Price $3.01 Est. Cost/Share $12.86 Unrealized @ Report Date —
— ALIMERA SCIENCES INC 0.1%
Value $848K Shares 200,919 Share Price $4.22 Est. Cost/Share $6.30 Unrealized @ Report Date —
URGN UROGEN PHARMA LTD 0.0%
Value $412K Shares 24,500 Share Price $16.82 * Est. Cost/Share $27.01 Unrealized @ Report Date -41.3%
— SYROS PHARMACEUTICALS INC 0.0%
Value $360K Shares 80,600 Share Price $4.47 Est. Cost/Share $7.48 Unrealized @ Report Date —
— MARINUS PHARMACEUTICALS INC 0.0%
Value $357K Shares 31,330 Share Price $11.39 Est. Cost/Share $15.48 Unrealized @ Report Date —
— VIRACTA THERAPEUTICS INC 0.0%
Value $266K Shares 33,212 Share Price $8.01 Est. Cost/Share $9.24 Unrealized @ Report Date —
— IDERA PHARMACEUTICALS INC 0.0%
Value $79,000 Shares 77,044 Share Price $1.03 Est. Cost/Share $8.90 Unrealized @ Report Date —
— MINERVA NEUROSCIENCES INC 0.0%
Value $63,000 Shares 36,319 Share Price $1.73 Est. Cost/Share $5.62 Unrealized @ Report Date —