Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q3 2021 (← Previous) (Next →)

Filing Date: Nov 15, 2021

Total Value ($000): $1,656,829 (100.0% shares, 0.0% debt)

Holdings (42)

— ABIOMED INC 10.8%

Value ($000) $178,977 Shares 549,820 Est. Cost $81.43 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 10.3%

Value ($000) $171,039 Shares 2,212,950 Est. Cost $83.16 Unrealized -5.1%

INSM INSMED INC 10.0%

Value ($000) $165,766 Shares 6,019,106 Est. Cost $17.79 Unrealized +47.5%

STAA STAAR SURGICAL CO 8.8%

Value ($000) $146,590 Shares 1,140,511 Est. Cost $14.28 Unrealized +880.2%

UTHR UNITED THERAPEUTICS CORP 7.7%

Value ($000) $126,844 Shares 687,206 Est. Cost $89.23 Unrealized +120.7%

PRTA PROTHENA CORP PLC 7.2%

Value ($000) $120,043 Shares 1,685,282 Est. Cost $21.46 Unrealized +189.5%

BIIB BIOGEN INC 6.2%

Value ($000) $102,329 Shares 361,600 Est. Cost $264.51 Unrealized +23.9%

FOLD AMICUS THERAPEUTICS INC 5.8%

Value ($000) $96,589 Shares 10,114,043 Est. Cost $9.52 Unrealized +7.5%

— REVANCE THERAPEUTICS INC 5.4%

Value ($000) $89,204 Shares 3,201,866 Est. Cost $24.09 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 3.9%

Value ($000) $64,992 Shares 3,791,805 Est. Cost $11.21 Unrealized +56.2%

EHTH EHEALTH INC 2.8%

Value ($000) $46,408 Shares 1,145,870 Est. Cost $71.48 Unrealized -34.8%

ACAD ACADIA PHARMACEUTICALS INC 2.3%

Value ($000) $38,832 Shares 2,337,877 Est. Cost $33.89 Unrealized -43.1%

ALGN ALIGN TECHNOLOGY INC 2.2%

Value ($000) $36,868 Shares 55,405 Est. Cost $114.31 Unrealized +494.1%

— EPIZYME INC 2.1%

Value ($000) $35,105 Shares 6,856,513 Est. Cost $14.39 Unrealized —

— KARYOPHARM THERAPEUTICS INC 1.9%

Value ($000) $31,329 Shares 5,383,052 Est. Cost $16.78 Unrealized —

— SAGE THERAPEUTICS INC 1.7%

Value ($000) $27,380 Shares 617,930 Est. Cost $49.24 Unrealized —

— GRITSTONE ONCOLOGY INC 1.5%

Value ($000) $25,448 Shares 2,356,282 Est. Cost $9.42 Unrealized —

GOSS GOSSAMER BIO INC 1.3%

Value ($000) $22,286 Shares 1,772,950 Est. Cost $11.85 Unrealized -22.3%

— CLOVIS ONCOLOGY INC 1.2%

Value ($000) $20,000 Shares 4,484,411 Est. Cost $47.56 Unrealized —

ALKS ALKERMES PLC 1.1%

Value ($000) $18,193 Shares 589,900 Est. Cost $21.27 Unrealized +32.9%

— DICERNA PHARMACEUTICALS INC 1.0%

Value ($000) $17,251 Shares 855,713 Est. Cost $14.42 Unrealized —

AZN ASTRAZENECA PLC-SPONS ADR 0.7%

Value ($000) $12,101 Shares 201,489 Est. Cost $60.06 Unrealized —

ANAB ANAPTYSBIO INC 0.7%

Value ($000) $11,840 Shares 436,592 Est. Cost $19.06 Unrealized +33.2%

PBYI PUMA BIOTECHNOLOGY INC 0.6%

Value ($000) $9,765 Shares 1,392,997 Est. Cost $27.70 Unrealized -73.0%

SNDX SYNDAX PHARMACEUTICALS INC 0.5%

Value ($000) $8,502 Shares 444,900 Est. Cost $16.27 Unrealized +2.4%

— KEZAR LIFE SCIENCES INC 0.3%

Value ($000) $5,670 Shares 656,200 Est. Cost $5.16 Unrealized —

CYTK CYTOKINETICS INC 0.3%

Value ($000) $4,421 Shares 123,686 Est. Cost $6.71 Unrealized +338.5%

KLDO KALEIDO BIOSCIENCES INC 0.3%

Value ($000) $4,294 Shares 786,400 Est. Cost $13.76 Unrealized -54.9%

TVTX TRAVERE THERAPEUTICS INC 0.2%

Value ($000) $4,027 Shares 166,069 Est. Cost $23.56 Unrealized -22.0%

— ZOGENIX INC 0.2%

Value ($000) $3,261 Shares 214,700 Est. Cost $20.95 Unrealized —

— MAGENTA THERAPEUTICS INC 0.2%

Value ($000) $3,147 Shares 432,300 Est. Cost $7.38 Unrealized —

— RIGEL PHARMACEUTICALS INC 0.1%

Value ($000) $2,368 Shares 652,395 Est. Cost $3.40 Unrealized —

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value ($000) $1,412 Shares 160,800 Est. Cost $7.10 Unrealized +29.3%

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.1%

Value ($000) $1,205 Shares 27,100 Est. Cost $39.74 Unrealized +13.2%

— ATHENEX INC 0.1%

Value ($000) $958 Shares 318,200 Est. Cost $12.86 Unrealized —

— ALIMERA SCIENCES INC 0.1%

Value ($000) $848 Shares 200,919 Est. Cost $6.30 Unrealized —

URGN UROGEN PHARMA LTD 0.0%

Value ($000) $412 Shares 24,500 Est. Cost $27.01 Unrealized -41.3%

— SYROS PHARMACEUTICALS INC 0.0%

Value ($000) $360 Shares 80,600 Est. Cost $7.48 Unrealized —

— MARINUS PHARMACEUTICALS INC 0.0%

Value ($000) $357 Shares 31,330 Est. Cost $15.48 Unrealized —

— VIRACTA THERAPEUTICS INC 0.0%

Value ($000) $266 Shares 33,212 Est. Cost $9.24 Unrealized —

— IDERA PHARMACEUTICALS INC 0.0%

Value ($000) $79 Shares 77,044 Est. Cost $8.90 Unrealized —

— MINERVA NEUROSCIENCES INC 0.0%

Value ($000) $63 Shares 36,319 Est. Cost $5.62 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	ABIOMED INC	549,820	$178,977	10.8%	$81.43	—	COM	003654100
BMRN	BIOMARIN PHARMACEUTICAL INC	2,212,950	$171,039	10.3%	$83.16	-5.1%	COM	09061G101
INSM	INSMED INC	6,019,106	$165,766	10.0%	$17.79	+47.5%	COM PAR $.01	457669307
STAA	STAAR SURGICAL CO	1,140,511	$146,590	8.8%	$14.28	+880.2%	COM PAR $.01	852312305
UTHR	UNITED THERAPEUTICS CORP	687,206	$126,844	7.7%	$89.23	+120.7%	COM	91307C102
PRTA	PROTHENA CORP PLC	1,685,282	$120,043	7.2%	$21.46	+189.5%	SHS	G72800108
BIIB	BIOGEN INC	361,600	$102,329	6.2%	$264.51	+23.9%	COM	09062X103
FOLD	AMICUS THERAPEUTICS INC	10,114,043	$96,589	5.8%	$9.52	+7.5%	COM	03152W109
—	REVANCE THERAPEUTICS INC	3,201,866	$89,204	5.4%	$24.09	—	COM	761330109
VNDA	VANDA PHARMACEUTICALS INC	3,791,805	$64,992	3.9%	$11.21	+56.2%	COM	921659108
EHTH	EHEALTH INC	1,145,870	$46,408	2.8%	$71.48	-34.8%	COM	28238P109
ACAD	ACADIA PHARMACEUTICALS INC	2,337,877	$38,832	2.3%	$33.89	-43.1%	COM	004225108
ALGN	ALIGN TECHNOLOGY INC	55,405	$36,868	2.2%	$114.31	+494.1%	COM	016255101
—	EPIZYME INC	6,856,513	$35,105	2.1%	$14.39	—	COM	29428V104
—	KARYOPHARM THERAPEUTICS INC	5,383,052	$31,329	1.9%	$16.78	—	COM	48576U106
—	SAGE THERAPEUTICS INC	617,930	$27,380	1.7%	$49.24	—	COM	78667J108
—	GRITSTONE ONCOLOGY INC	2,356,282	$25,448	1.5%	$9.42	—	COM	39868T105
GOSS	GOSSAMER BIO INC	1,772,950	$22,286	1.3%	$11.85	-22.3%	COM	38341P102
—	CLOVIS ONCOLOGY INC	4,484,411	$20,000	1.2%	$47.56	—	COM	189464100
ALKS	ALKERMES PLC	589,900	$18,193	1.1%	$21.27	+32.9%	SHS	G01767105
—	DICERNA PHARMACEUTICALS INC	855,713	$17,251	1.0%	$14.42	—	COM	253031108
AZN	ASTRAZENECA PLC-SPONS ADR	201,489	$12,101	0.7%	$60.06	—	SPONSORED ADR	046353108
ANAB	ANAPTYSBIO INC	436,592	$11,840	0.7%	$19.06	+33.2%	COM	032724106
PBYI	PUMA BIOTECHNOLOGY INC	1,392,997	$9,765	0.6%	$27.70	-73.0%	COM	74587V107
SNDX	SYNDAX PHARMACEUTICALS INC	444,900	$8,502	0.5%	$16.27	+2.4%	COM	87164F105
—	KEZAR LIFE SCIENCES INC	656,200	$5,670	0.3%	$5.16	—	COM	49372L100
CYTK	CYTOKINETICS INC	123,686	$4,421	0.3%	$6.71	+338.5%	COM NEW	23282W605
KLDO	KALEIDO BIOSCIENCES INC	786,400	$4,294	0.3%	$13.76	-54.9%	COM	483347100
TVTX	TRAVERE THERAPEUTICS INC	166,069	$4,027	0.2%	$23.56	-22.0%	COM	89422G107
—	ZOGENIX INC	214,700	$3,261	0.2%	$20.95	—	COM NEW	98978L204
—	MAGENTA THERAPEUTICS INC	432,300	$3,147	0.2%	$7.38	—	COM	55910K108
—	RIGEL PHARMACEUTICALS INC	652,395	$2,368	0.1%	$3.40	—	COM NEW	766559603
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$1,412	0.1%	$7.10	+29.3%	COM	01438T106
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$1,205	0.1%	$39.74	+13.2%	COM	87357P100
—	ATHENEX INC	318,200	$958	0.1%	$12.86	—	COM	04685N103
—	ALIMERA SCIENCES INC	200,919	$848	0.1%	$6.30	—	COM NEW	016259202
URGN	UROGEN PHARMA LTD	24,500	$412	0.0%	$27.01	-41.3%	COM	M96088105
—	SYROS PHARMACEUTICALS INC	80,600	$360	0.0%	$7.48	—	COM	87184Q107
—	MARINUS PHARMACEUTICALS INC	31,330	$357	0.0%	$15.48	—	COM NEW	56854Q200
—	VIRACTA THERAPEUTICS INC	33,212	$266	0.0%	$9.24	—	COM	92765F108
—	IDERA PHARMACEUTICALS INC	77,044	$79	0.0%	$8.90	—	COM PAR	45168K405
—	MINERVA NEUROSCIENCES INC	36,319	$63	0.0%	$5.62	—	COM	603380106