Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q4 2021 (← Previous) (Next →)

Filing Date: Feb 14, 2022

Total Value: $1.565B (100.0% shares, 0.0% debt)

Holdings (37)

BMRN BIOMARIN PHARMACEUTICAL INC 12.5%

Value $196M Shares 2,212,950 Share Price $88.35 * Est. Cost/Share $83.16 Unrealized @ Report Date -0.8%

— ABIOMED INC 11.9%

Value $186M Shares 519,033 Share Price $359.17 Est. Cost/Share $81.43 Unrealized @ Report Date —

INSM INSMED INC 10.5%

Value $164M Shares 6,025,706 Share Price $27.24 * Est. Cost/Share $17.79 Unrealized @ Report Date +60.7%

UTHR UNITED THERAPEUTICS CORP 9.5%

Value $148M Shares 687,206 Share Price $216.08 * Est. Cost/Share $89.23 Unrealized @ Report Date +120.0%

FOLD AMICUS THERAPEUTICS INC 7.5%

Value $117M Shares 10,114,043 Share Price $11.55 * Est. Cost/Share $9.52 Unrealized @ Report Date +17.1%

STAA STAAR SURGICAL CO 6.7%

Value $104M Shares 1,140,511 Share Price $91.30 * Est. Cost/Share $14.28 Unrealized @ Report Date +651.5%

BIIB BIOGEN INC 5.9%

Value $92.37M Shares 385,000 Share Price $239.92 * Est. Cost/Share $264.06 Unrealized @ Report Date -2.6%

PRTA PROTHENA CORP PLC 5.3%

Value $83.25M Shares 1,685,282 Share Price $49.40 * Est. Cost/Share $21.46 Unrealized @ Report Date +158.4%

— REVANCE THERAPEUTICS INC 4.6%

Value $71.31M Shares 4,369,366 Share Price $16.32 Est. Cost/Share $22.01 Unrealized @ Report Date —

ACAD ACADIA PHARMACEUTICALS INC 3.5%

Value $54.57M Shares 2,337,877 Share Price $23.34 * Est. Cost/Share $33.89 Unrealized @ Report Date -40.7%

VNDA VANDA PHARMACEUTICALS INC 2.8%

Value $44.47M Shares 2,834,244 Share Price $15.69 * Est. Cost/Share $11.21 Unrealized @ Report Date +55.4%

EHTH EHEALTH INC 2.6%

Value $41.2M Shares 1,615,570 Share Price $25.50 * Est. Cost/Share $60.36 Unrealized @ Report Date -45.0%

ALGN ALIGN TECHNOLOGY INC 2.3%

Value $36.41M Shares 55,405 Share Price $657.18 * Est. Cost/Share $114.31 Unrealized @ Report Date +462.4%

— KARYOPHARM THERAPEUTICS INC 2.2%

Value $35.17M Shares 5,470,452 Share Price $6.43 Est. Cost/Share $16.61 Unrealized @ Report Date —

— SAGE THERAPEUTICS INC 2.1%

Value $33.26M Shares 781,730 Share Price $42.54 Est. Cost/Share $47.83 Unrealized @ Report Date —

— GRITSTONE ONCOLOGY INC 1.9%

Value $30.3M Shares 2,356,282 Share Price $12.86 Est. Cost/Share $9.42 Unrealized @ Report Date —

GOSS GOSSAMER BIO INC 1.3%

Value $20.05M Shares 1,772,950 Share Price $11.31 * Est. Cost/Share $11.85 Unrealized @ Report Date +0.3%

ALKS ALKERMES PLC 1.1%

Value $17.54M Shares 754,200 Share Price $23.26 * Est. Cost/Share $22.36 Unrealized @ Report Date +17.6%

ANAB ANAPTYSBIO INC 1.0%

Value $15.17M Shares 436,592 Share Price $34.75 * Est. Cost/Share $19.06 Unrealized @ Report Date +66.4%

— EPIZYME INC 0.9%

Value $13.71M Shares 5,485,213 Share Price $2.50 Est. Cost/Share $14.39 Unrealized @ Report Date —

SNDX SYNDAX PHARMACEUTICALS INC 0.8%

Value $13.11M Shares 598,900 Share Price $21.89 * Est. Cost/Share $16.84 Unrealized @ Report Date +9.7%

— KEZAR LIFE SCIENCES INC 0.7%

Value $10.97M Shares 656,200 Share Price $16.72 Est. Cost/Share $5.16 Unrealized @ Report Date —

— CLOVIS ONCOLOGY INC 0.7%

Value $10.83M Shares 3,997,826 Share Price $2.71 Est. Cost/Share $47.56 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.4%

Value $5.638M Shares 123,686 Share Price $45.58 * Est. Cost/Share $6.71 Unrealized @ Report Date +474.8%

TVTX TRAVERE THERAPEUTICS INC 0.3%

Value $5.155M Shares 166,069 Share Price $31.04 * Est. Cost/Share $23.56 Unrealized @ Report Date +19.6%

— ZOGENIX INC 0.2%

Value $2.987M Shares 183,800 Share Price $16.25 Est. Cost/Share $20.95 Unrealized @ Report Date —

— MAGENTA THERAPEUTICS INC 0.1%

Value $1.915M Shares 432,300 Share Price $4.43 Est. Cost/Share $7.38 Unrealized @ Report Date —

NVAX NOVAVAX INC 0.1%

Value $1.788M Shares 12,500 Share Price $143.04 * Est. Cost/Share $171.82 Unrealized @ Report Date 0.0%

— RIGEL PHARMACEUTICALS INC 0.1%

Value $1.729M Shares 652,395 Share Price $2.65 Est. Cost/Share $3.40 Unrealized @ Report Date —

AZN ASTRAZENECA PLC-SPONS ADR 0.1%

Value $1.704M Shares 29,260 Share Price $58.24 Est. Cost/Share $60.06 Unrealized @ Report Date —

MIRM MIRUM PHARMACEUTICALS INC 0.1%

Value $1.032M Shares 64,700 Share Price $15.95 * Est. Cost/Share $15.56 Unrealized @ Report Date 0.0%

— ALIMERA SCIENCES INC 0.1%

Value $1.031M Shares 200,919 Share Price $5.13 Est. Cost/Share $6.30 Unrealized @ Report Date —

KLDO KALEIDO BIOSCIENCES INC 0.1%

Value $815K Shares 341,030 Share Price $2.39 * Est. Cost/Share $13.76 Unrealized @ Report Date -70.4%

ALDX ALDEYRA THERAPEUTICS INC 0.0%

Value $643K Shares 160,800 Share Price $4.00 * Est. Cost/Share $7.10 Unrealized @ Report Date +7.5%

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.0%

Value $516K Shares 27,100 Share Price $19.04 * Est. Cost/Share $39.74 Unrealized @ Report Date -28.6%

— MARINUS PHARMACEUTICALS INC 0.0%

Value $372K Shares 31,330 Share Price $11.87 Est. Cost/Share $15.48 Unrealized @ Report Date —

URGN UROGEN PHARMA LTD 0.0%

Value $233K Shares 24,500 Share Price $9.51 * Est. Cost/Share $27.01 Unrealized @ Report Date -47.8%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	2,212,950	$196M	12.5%	$88.35 *	$83.16	-0.8%	COM	09061G101
—	ABIOMED INC	519,033	$186M	11.9%	$359.17	$81.43	—	COM	003654100
INSM	INSMED INC	6,025,706	$164M	10.5%	$27.24 *	$17.79	+60.7%	COM	457669307
UTHR	UNITED THERAPEUTICS CORP	687,206	$148M	9.5%	$216.08 *	$89.23	+120.0%	COM	91307C102
FOLD	AMICUS THERAPEUTICS INC	10,114,043	$117M	7.5%	$11.55 *	$9.52	+17.1%	COM	03152W109
STAA	STAAR SURGICAL CO	1,140,511	$104M	6.7%	$91.30 *	$14.28	+651.5%	COM	852312305
BIIB	BIOGEN INC	385,000	$92.37M	5.9%	$239.92 *	$264.06	-2.6%	COM	09062X103
PRTA	PROTHENA CORP PLC	1,685,282	$83.25M	5.3%	$49.40 *	$21.46	+158.4%	COM	G72800108
—	REVANCE THERAPEUTICS INC	4,369,366	$71.31M	4.6%	$16.32	$22.01	—	COM	761330109
ACAD	ACADIA PHARMACEUTICALS INC	2,337,877	$54.57M	3.5%	$23.34 *	$33.89	-40.7%	COM	004225108
VNDA	VANDA PHARMACEUTICALS INC	2,834,244	$44.47M	2.8%	$15.69 *	$11.21	+55.4%	COM	921659108
EHTH	EHEALTH INC	1,615,570	$41.2M	2.6%	$25.50 *	$60.36	-45.0%	COM	28238P109
ALGN	ALIGN TECHNOLOGY INC	55,405	$36.41M	2.3%	$657.18 *	$114.31	+462.4%	COM	016255101
—	KARYOPHARM THERAPEUTICS INC	5,470,452	$35.17M	2.2%	$6.43	$16.61	—	COM	48576U106
—	SAGE THERAPEUTICS INC	781,730	$33.26M	2.1%	$42.54	$47.83	—	COM	78667J108
—	GRITSTONE ONCOLOGY INC	2,356,282	$30.3M	1.9%	$12.86	$9.42	—	COM	39868T105
GOSS	GOSSAMER BIO INC	1,772,950	$20.05M	1.3%	$11.31 *	$11.85	+0.3%	COM	38341P102
ALKS	ALKERMES PLC	754,200	$17.54M	1.1%	$23.26 *	$22.36	+17.6%	COM	G01767105
ANAB	ANAPTYSBIO INC	436,592	$15.17M	1.0%	$34.75 *	$19.06	+66.4%	COM	032724106
—	EPIZYME INC	5,485,213	$13.71M	0.9%	$2.50	$14.39	—	COM	29428V104
SNDX	SYNDAX PHARMACEUTICALS INC	598,900	$13.11M	0.8%	$21.89 *	$16.84	+9.7%	COM	87164F105
—	KEZAR LIFE SCIENCES INC	656,200	$10.97M	0.7%	$16.72	$5.16	—	COM	49372L100
—	CLOVIS ONCOLOGY INC	3,997,826	$10.83M	0.7%	$2.71	$47.56	—	COM	189464100
CYTK	CYTOKINETICS INC	123,686	$5.638M	0.4%	$45.58 *	$6.71	+474.8%	COM	23282W605
TVTX	TRAVERE THERAPEUTICS INC	166,069	$5.155M	0.3%	$31.04 *	$23.56	+19.6%	COM	89422G107
—	ZOGENIX INC	183,800	$2.987M	0.2%	$16.25	$20.95	—	COM	98978L204
—	MAGENTA THERAPEUTICS INC	432,300	$1.915M	0.1%	$4.43	$7.38	—	COM	55910K108
NVAX	NOVAVAX INC	12,500	$1.788M	0.1%	$143.04 *	$171.82	0.0%	COM	670002401
—	RIGEL PHARMACEUTICALS INC	652,395	$1.729M	0.1%	$2.65	$3.40	—	COM	766559603
AZN	ASTRAZENECA PLC-SPONS ADR	29,260	$1.704M	0.1%	$58.24	$60.06	—	COM	046353108
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$1.032M	0.1%	$15.95 *	$15.56	0.0%	COM	604749101
—	ALIMERA SCIENCES INC	200,919	$1.031M	0.1%	$5.13	$6.30	—	COM	016259202
KLDO	KALEIDO BIOSCIENCES INC	341,030	$815K	0.1%	$2.39 *	$13.76	-70.4%	COM	483347100
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$643K	0.0%	$4.00 *	$7.10	+7.5%	COM	01438T106
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$516K	0.0%	$19.04 *	$39.74	-28.6%	COM	87357P100
—	MARINUS PHARMACEUTICALS INC	31,330	$372K	0.0%	$11.87	$15.48	—	COM	56854Q200
URGN	UROGEN PHARMA LTD	24,500	$233K	0.0%	$9.51 *	$27.01	-47.8%	COM	M96088105