Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q1 2022 (← Previous) (Next →)

Filing Date: May 16, 2022

Total Value: $1.293B (100.0% shares, 0.0% debt)

Holdings (35)

BMRN BIOMARIN PHARMACEUTICAL INC 12.8%

Value $165M Shares 2,139,614 Share Price $77.10 * Est. Cost/Share $83.16 Unrealized @ Report Date +0.6%

— ABIOMED INC 12.7%

Value $164M Shares 494,397 Share Price $331.24 Est. Cost/Share $81.43 Unrealized @ Report Date —

INSM INSMED INC 10.7%

Value $138M Shares 5,881,299 Share Price $23.50 Est. Cost/Share $17.79 Unrealized @ Report Date +30.6%

UTHR UNITED THERAPEUTICS CORP 9.1%

Value $117M Shares 653,079 Share Price $179.41 * Est. Cost/Share $89.23 Unrealized @ Report Date +113.5%

FOLD AMICUS THERAPEUTICS INC 7.3%

Value $93.79M Shares 9,903,761 Share Price $9.47 Est. Cost/Share $9.52 Unrealized @ Report Date -1.5%

STAA STAAR SURGICAL CO 7.0%

Value $90.86M Shares 1,136,968 Share Price $79.91 * Est. Cost/Share $14.28 Unrealized @ Report Date +421.6%

— REVANCE THERAPEUTICS INC 6.7%

Value $86.11M Shares 4,415,689 Share Price $19.50 Est. Cost/Share $21.99 Unrealized @ Report Date —

BIIB BIOGEN INC 5.9%

Value $76.02M Shares 360,981 Share Price $210.60 * Est. Cost/Share $264.06 Unrealized @ Report Date -17.6%

PRTA PROTHENA CORP PLC 4.8%

Value $61.49M Shares 1,681,477 Share Price $36.57 Est. Cost/Share $21.46 Unrealized @ Report Date +68.0%

ACAD ACADIA PHARMACEUTICALS INC 4.2%

Value $54.54M Shares 2,251,834 Share Price $24.22 Est. Cost/Share $33.89 Unrealized @ Report Date -28.6%

— KARYOPHARM THERAPEUTICS INC 3.2%

Value $41.43M Shares 5,621,533 Share Price $7.37 Est. Cost/Share $16.36 Unrealized @ Report Date —

— SAGE THERAPEUTICS INC 2.2%

Value $28.19M Shares 851,719 Share Price $33.10 Est. Cost/Share $46.62 Unrealized @ Report Date —

VNDA VANDA PHARMACEUTICALS INC 2.2%

Value $28.18M Shares 2,491,200 Share Price $11.31 * Est. Cost/Share $11.21 Unrealized @ Report Date +17.2%

EHTH EHEALTH INC 1.6%

Value $20.5M Shares 1,652,260 Share Price $12.41 * Est. Cost/Share $59.40 Unrealized @ Report Date -71.0%

ALGN ALIGN TECHNOLOGY INC 1.5%

Value $19.32M Shares 44,305 Share Price $436.00 * Est. Cost/Share $114.31 Unrealized @ Report Date +325.8%

ALKS ALKERMES PLC 1.4%

Value $17.72M Shares 673,571 Share Price $26.31 * Est. Cost/Share $22.36 Unrealized @ Report Date +10.8%

GOSS GOSSAMER BIO INC 1.2%

Value $15.25M Shares 1,756,757 Share Price $8.68 * Est. Cost/Share $11.85 Unrealized @ Report Date -18.6%

— KEZAR LIFE SCIENCES INC 0.8%

Value $10.91M Shares 656,200 Share Price $16.62 Est. Cost/Share $5.16 Unrealized @ Report Date —

ANAB ANAPTYSBIO INC 0.8%

Value $10.66M Shares 431,024 Share Price $24.74 * Est. Cost/Share $19.06 Unrealized @ Report Date +58.8%

SNDX SYNDAX PHARMACEUTICALS INC 0.8%

Value $10.65M Shares 612,600 Share Price $17.38 * Est. Cost/Share $16.84 Unrealized @ Report Date +0.0%

— GRITSTONE ONCOLOGY INC 0.7%

Value $9.602M Shares 2,330,504 Share Price $4.12 Est. Cost/Share $9.42 Unrealized @ Report Date —

— CLOVIS ONCOLOGY INC 0.7%

Value $9.037M Shares 4,473,967 Share Price $2.02 Est. Cost/Share $42.71 Unrealized @ Report Date —

— EPIZYME INC 0.6%

Value $7.791M Shares 6,774,541 Share Price $1.15 Est. Cost/Share $11.87 Unrealized @ Report Date —

TVTX TRAVERE THERAPEUTICS INC 0.3%

Value $4.28M Shares 166,069 Share Price $25.77 * Est. Cost/Share $23.56 Unrealized @ Report Date +12.7%

CYTK CYTOKINETICS INC 0.3%

Value $4.112M Shares 111,717 Share Price $36.81 * Est. Cost/Share $6.71 Unrealized @ Report Date +429.3%

— RIGEL PHARMACEUTICALS INC 0.2%

Value $1.951M Shares 652,395 Share Price $2.99 Est. Cost/Share $3.40 Unrealized @ Report Date —

MIRM MIRUM PHARMACEUTICALS INC 0.1%

Value $1.425M Shares 64,700 Share Price $22.02 * Est. Cost/Share $15.56 Unrealized @ Report Date +31.1%

— MAGENTA THERAPEUTICS INC 0.1%

Value $1.254M Shares 432,300 Share Price $2.90 Est. Cost/Share $7.38 Unrealized @ Report Date —

— ALIMERA SCIENCES INC 0.1%

Value $1.125M Shares 200,919 Share Price $5.60 Est. Cost/Share $6.30 Unrealized @ Report Date —

NVAX NOVAVAX INC 0.1%

Value $921K Shares 12,500 Share Price $73.68 * Est. Cost/Share $171.82 Unrealized @ Report Date -48.1%

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value $715K Shares 160,800 Share Price $4.45 * Est. Cost/Share $7.10 Unrealized @ Report Date -43.9%

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.0%

Value $546K Shares 27,100 Share Price $20.15 * Est. Cost/Share $39.74 Unrealized @ Report Date -56.0%

KLDO KALEIDO BIOSCIENCES INC 0.0%

Value $511K Shares 309,692 Share Price $1.65 * Est. Cost/Share $13.76 Unrealized @ Report Date -87.0%

— MARINUS PHARMACEUTICALS INC 0.0%

Value $293K Shares 31,330 Share Price $9.35 Est. Cost/Share $15.48 Unrealized @ Report Date —

URGN UROGEN PHARMA LTD 0.0%

Value $213K Shares 24,500 Share Price $8.69 * Est. Cost/Share $27.01 Unrealized @ Report Date -71.1%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	2,139,614	$165M	12.8%	$77.10 *	$83.16	+0.6%	COM	09061G101
—	ABIOMED INC	494,397	$164M	12.7%	$331.24	$81.43	—	COM	003654100
INSM	INSMED INC	5,881,299	$138M	10.7%	$23.50	$17.79	+30.6%	COM	457669307
UTHR	UNITED THERAPEUTICS CORP	653,079	$117M	9.1%	$179.41 *	$89.23	+113.5%	COM	91307C102
FOLD	AMICUS THERAPEUTICS INC	9,903,761	$93.79M	7.3%	$9.47	$9.52	-1.5%	COM	03152W109
STAA	STAAR SURGICAL CO	1,136,968	$90.86M	7.0%	$79.91 *	$14.28	+421.6%	COM	852312305
—	REVANCE THERAPEUTICS INC	4,415,689	$86.11M	6.7%	$19.50	$21.99	—	COM	761330109
BIIB	BIOGEN INC	360,981	$76.02M	5.9%	$210.60 *	$264.06	-17.6%	COM	09062X103
PRTA	PROTHENA CORP PLC	1,681,477	$61.49M	4.8%	$36.57	$21.46	+68.0%	COM	G72800108
ACAD	ACADIA PHARMACEUTICALS INC	2,251,834	$54.54M	4.2%	$24.22	$33.89	-28.6%	COM	004225108
—	KARYOPHARM THERAPEUTICS INC	5,621,533	$41.43M	3.2%	$7.37	$16.36	—	COM	48576U106
—	SAGE THERAPEUTICS INC	851,719	$28.19M	2.2%	$33.10	$46.62	—	COM	78667J108
VNDA	VANDA PHARMACEUTICALS INC	2,491,200	$28.18M	2.2%	$11.31 *	$11.21	+17.2%	COM	921659108
EHTH	EHEALTH INC	1,652,260	$20.5M	1.6%	$12.41 *	$59.40	-71.0%	COM	28238P109
ALGN	ALIGN TECHNOLOGY INC	44,305	$19.32M	1.5%	$436.00 *	$114.31	+325.8%	COM	016255101
ALKS	ALKERMES PLC	673,571	$17.72M	1.4%	$26.31 *	$22.36	+10.8%	COM	G01767105
GOSS	GOSSAMER BIO INC	1,756,757	$15.25M	1.2%	$8.68 *	$11.85	-18.6%	COM	38341P102
—	KEZAR LIFE SCIENCES INC	656,200	$10.91M	0.8%	$16.62	$5.16	—	COM	49372L100
ANAB	ANAPTYSBIO INC	431,024	$10.66M	0.8%	$24.74 *	$19.06	+58.8%	COM	032724106
SNDX	SYNDAX PHARMACEUTICALS INC	612,600	$10.65M	0.8%	$17.38 *	$16.84	+0.0%	COM	87164F105
—	GRITSTONE ONCOLOGY INC	2,330,504	$9.602M	0.7%	$4.12	$9.42	—	COM	39868T105
—	CLOVIS ONCOLOGY INC	4,473,967	$9.037M	0.7%	$2.02	$42.71	—	COM	189464100
—	EPIZYME INC	6,774,541	$7.791M	0.6%	$1.15	$11.87	—	COM	29428V104
TVTX	TRAVERE THERAPEUTICS INC	166,069	$4.28M	0.3%	$25.77 *	$23.56	+12.7%	COM	89422G107
CYTK	CYTOKINETICS INC	111,717	$4.112M	0.3%	$36.81 *	$6.71	+429.3%	COM	23282W605
—	RIGEL PHARMACEUTICALS INC	652,395	$1.951M	0.2%	$2.99	$3.40	—	COM	766559603
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$1.425M	0.1%	$22.02 *	$15.56	+31.1%	COM	604749101
—	MAGENTA THERAPEUTICS INC	432,300	$1.254M	0.1%	$2.90	$7.38	—	COM	55910K108
—	ALIMERA SCIENCES INC	200,919	$1.125M	0.1%	$5.60	$6.30	—	COM	016259202
NVAX	NOVAVAX INC	12,500	$921K	0.1%	$73.68 *	$171.82	-48.1%	COM	670002401
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$715K	0.1%	$4.45 *	$7.10	-43.9%	COM	01438T106
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$546K	0.0%	$20.15 *	$39.74	-56.0%	COM	87357P100
KLDO	KALEIDO BIOSCIENCES INC	309,692	$511K	0.0%	$1.65 *	$13.76	-87.0%	COM	483347100
—	MARINUS PHARMACEUTICALS INC	31,330	$293K	0.0%	$9.35	$15.48	—	COM	56854Q200
URGN	UROGEN PHARMA LTD	24,500	$213K	0.0%	$8.69 *	$27.01	-71.1%	COM	M96088105