Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q1 2022 (← Previous) (Next →)

Filing Date: May 16, 2022

Total Value ($000): $1,293,496 (100.0% shares, 0.0% debt)

Holdings (35)

BMRN BIOMARIN PHARMACEUTICAL INC 12.8%

Value ($000) $164,964 Shares 2,139,614 Est. Cost $83.16 Unrealized +0.6%

— ABIOMED INC 12.7%

Value ($000) $163,764 Shares 494,397 Est. Cost $81.43 Unrealized —

INSM INSMED INC 10.7%

Value ($000) $138,211 Shares 5,881,299 Est. Cost $17.79 Unrealized +30.6%

UTHR UNITED THERAPEUTICS CORP 9.1%

Value ($000) $117,169 Shares 653,079 Est. Cost $89.23 Unrealized +113.5%

FOLD AMICUS THERAPEUTICS INC 7.3%

Value ($000) $93,789 Shares 9,903,761 Est. Cost $9.52 Unrealized -1.5%

STAA STAAR SURGICAL CO 7.0%

Value ($000) $90,855 Shares 1,136,968 Est. Cost $14.28 Unrealized +421.6%

— REVANCE THERAPEUTICS INC 6.7%

Value ($000) $86,106 Shares 4,415,689 Est. Cost $21.99 Unrealized —

BIIB BIOGEN INC 5.9%

Value ($000) $76,023 Shares 360,981 Est. Cost $264.06 Unrealized -17.6%

PRTA PROTHENA CORP PLC 4.8%

Value ($000) $61,492 Shares 1,681,477 Est. Cost $21.46 Unrealized +68.0%

ACAD ACADIA PHARMACEUTICALS INC 4.2%

Value ($000) $54,539 Shares 2,251,834 Est. Cost $33.89 Unrealized -28.6%

— KARYOPHARM THERAPEUTICS INC 3.2%

Value ($000) $41,431 Shares 5,621,533 Est. Cost $16.36 Unrealized —

— SAGE THERAPEUTICS INC 2.2%

Value ($000) $28,192 Shares 851,719 Est. Cost $46.62 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 2.2%

Value ($000) $28,175 Shares 2,491,200 Est. Cost $11.21 Unrealized +17.2%

EHTH EHEALTH INC 1.6%

Value ($000) $20,505 Shares 1,652,260 Est. Cost $59.40 Unrealized -71.0%

ALGN ALIGN TECHNOLOGY INC 1.5%

Value ($000) $19,317 Shares 44,305 Est. Cost $114.31 Unrealized +325.8%

ALKS ALKERMES PLC 1.4%

Value ($000) $17,722 Shares 673,571 Est. Cost $22.36 Unrealized +10.8%

GOSS GOSSAMER BIO INC 1.2%

Value ($000) $15,249 Shares 1,756,757 Est. Cost $11.85 Unrealized -18.6%

— KEZAR LIFE SCIENCES INC 0.8%

Value ($000) $10,906 Shares 656,200 Est. Cost $5.16 Unrealized —

ANAB ANAPTYSBIO INC 0.8%

Value ($000) $10,664 Shares 431,024 Est. Cost $19.06 Unrealized +58.8%

SNDX SYNDAX PHARMACEUTICALS INC 0.8%

Value ($000) $10,647 Shares 612,600 Est. Cost $16.84 Unrealized +0.0%

— GRITSTONE ONCOLOGY INC 0.7%

Value ($000) $9,602 Shares 2,330,504 Est. Cost $9.42 Unrealized —

— CLOVIS ONCOLOGY INC 0.7%

Value ($000) $9,037 Shares 4,473,967 Est. Cost $42.71 Unrealized —

— EPIZYME INC 0.6%

Value ($000) $7,791 Shares 6,774,541 Est. Cost $11.87 Unrealized —

TVTX TRAVERE THERAPEUTICS INC 0.3%

Value ($000) $4,280 Shares 166,069 Est. Cost $23.56 Unrealized +12.7%

CYTK CYTOKINETICS INC 0.3%

Value ($000) $4,112 Shares 111,717 Est. Cost $6.71 Unrealized +429.3%

— RIGEL PHARMACEUTICALS INC 0.2%

Value ($000) $1,951 Shares 652,395 Est. Cost $3.40 Unrealized —

MIRM MIRUM PHARMACEUTICALS INC 0.1%

Value ($000) $1,425 Shares 64,700 Est. Cost $15.56 Unrealized +31.1%

— MAGENTA THERAPEUTICS INC 0.1%

Value ($000) $1,254 Shares 432,300 Est. Cost $7.38 Unrealized —

— ALIMERA SCIENCES INC 0.1%

Value ($000) $1,125 Shares 200,919 Est. Cost $6.30 Unrealized —

NVAX NOVAVAX INC 0.1%

Value ($000) $921 Shares 12,500 Est. Cost $171.82 Unrealized -48.1%

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value ($000) $715 Shares 160,800 Est. Cost $7.10 Unrealized -43.9%

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.0%

Value ($000) $546 Shares 27,100 Est. Cost $39.74 Unrealized -56.0%

KLDO KALEIDO BIOSCIENCES INC 0.0%

Value ($000) $511 Shares 309,692 Est. Cost $13.76 Unrealized -87.0%

— MARINUS PHARMACEUTICALS INC 0.0%

Value ($000) $293 Shares 31,330 Est. Cost $15.48 Unrealized —

URGN UROGEN PHARMA LTD 0.0%

Value ($000) $213 Shares 24,500 Est. Cost $27.01 Unrealized -71.1%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	2,139,614	$164,964	12.8%	$83.16	+0.6%	COM	09061G101
—	ABIOMED INC	494,397	$163,764	12.7%	$81.43	—	COM	003654100
INSM	INSMED INC	5,881,299	$138,211	10.7%	$17.79	+30.6%	COM	457669307
UTHR	UNITED THERAPEUTICS CORP	653,079	$117,169	9.1%	$89.23	+113.5%	COM	91307C102
FOLD	AMICUS THERAPEUTICS INC	9,903,761	$93,789	7.3%	$9.52	-1.5%	COM	03152W109
STAA	STAAR SURGICAL CO	1,136,968	$90,855	7.0%	$14.28	+421.6%	COM	852312305
—	REVANCE THERAPEUTICS INC	4,415,689	$86,106	6.7%	$21.99	—	COM	761330109
BIIB	BIOGEN INC	360,981	$76,023	5.9%	$264.06	-17.6%	COM	09062X103
PRTA	PROTHENA CORP PLC	1,681,477	$61,492	4.8%	$21.46	+68.0%	COM	G72800108
ACAD	ACADIA PHARMACEUTICALS INC	2,251,834	$54,539	4.2%	$33.89	-28.6%	COM	004225108
—	KARYOPHARM THERAPEUTICS INC	5,621,533	$41,431	3.2%	$16.36	—	COM	48576U106
—	SAGE THERAPEUTICS INC	851,719	$28,192	2.2%	$46.62	—	COM	78667J108
VNDA	VANDA PHARMACEUTICALS INC	2,491,200	$28,175	2.2%	$11.21	+17.2%	COM	921659108
EHTH	EHEALTH INC	1,652,260	$20,505	1.6%	$59.40	-71.0%	COM	28238P109
ALGN	ALIGN TECHNOLOGY INC	44,305	$19,317	1.5%	$114.31	+325.8%	COM	016255101
ALKS	ALKERMES PLC	673,571	$17,722	1.4%	$22.36	+10.8%	COM	G01767105
GOSS	GOSSAMER BIO INC	1,756,757	$15,249	1.2%	$11.85	-18.6%	COM	38341P102
—	KEZAR LIFE SCIENCES INC	656,200	$10,906	0.8%	$5.16	—	COM	49372L100
ANAB	ANAPTYSBIO INC	431,024	$10,664	0.8%	$19.06	+58.8%	COM	032724106
SNDX	SYNDAX PHARMACEUTICALS INC	612,600	$10,647	0.8%	$16.84	+0.0%	COM	87164F105
—	GRITSTONE ONCOLOGY INC	2,330,504	$9,602	0.7%	$9.42	—	COM	39868T105
—	CLOVIS ONCOLOGY INC	4,473,967	$9,037	0.7%	$42.71	—	COM	189464100
—	EPIZYME INC	6,774,541	$7,791	0.6%	$11.87	—	COM	29428V104
TVTX	TRAVERE THERAPEUTICS INC	166,069	$4,280	0.3%	$23.56	+12.7%	COM	89422G107
CYTK	CYTOKINETICS INC	111,717	$4,112	0.3%	$6.71	+429.3%	COM	23282W605
—	RIGEL PHARMACEUTICALS INC	652,395	$1,951	0.2%	$3.40	—	COM	766559603
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$1,425	0.1%	$15.56	+31.1%	COM	604749101
—	MAGENTA THERAPEUTICS INC	432,300	$1,254	0.1%	$7.38	—	COM	55910K108
—	ALIMERA SCIENCES INC	200,919	$1,125	0.1%	$6.30	—	COM	016259202
NVAX	NOVAVAX INC	12,500	$921	0.1%	$171.82	-48.1%	COM	670002401
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$715	0.1%	$7.10	-43.9%	COM	01438T106
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$546	0.0%	$39.74	-56.0%	COM	87357P100
KLDO	KALEIDO BIOSCIENCES INC	309,692	$511	0.0%	$13.76	-87.0%	COM	483347100
—	MARINUS PHARMACEUTICALS INC	31,330	$293	0.0%	$15.48	—	COM	56854Q200
URGN	UROGEN PHARMA LTD	24,500	$213	0.0%	$27.01	-71.1%	COM	M96088105