Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q2 2022 (← Previous) (Next →)

Filing Date: Aug 15, 2022

Total Value: $1.147B (100.0% shares, 0.0% debt)

Holdings (33)

BMRN BIOMARIN PHARMACEUTICAL INC 14.9%

Value $171M Shares 2,061,373 Est. Cost $83.16 Unrealized -4.3%

UTHR UNITED THERAPEUTICS CORP 13.0%

Value $150M Shares 634,806 Est. Cost $89.23 Unrealized +127.8%

— ABIOMED INC 10.7%

Value $122M Shares 494,397 Est. Cost $81.43 Unrealized —

INSM INSMED INC 10.0%

Value $115M Shares 5,840,398 Est. Cost $17.79 Unrealized +17.8%

FOLD AMICUS THERAPEUTICS INC 9.2%

Value $106M Shares 9,847,774 Est. Cost $9.52 Unrealized -13.5%

STAA STAAR SURGICAL CO 6.8%

Value $78.49M Shares 1,106,567 Est. Cost $14.28 Unrealized +351.3%

BIIB BIOGEN INC 6.4%

Value $73.62M Shares 360,981 Est. Cost $264.06 Unrealized -22.6%

— REVANCE THERAPEUTICS INC 5.3%

Value $60.88M Shares 4,405,039 Est. Cost $21.99 Unrealized —

PRTA PROTHENA CORP PLC 4.0%

Value $45.65M Shares 1,681,477 Est. Cost $21.46 Unrealized +36.3%

— SAGE THERAPEUTICS INC 2.4%

Value $27.5M Shares 851,409 Est. Cost $46.62 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 2.4%

Value $27.15M Shares 2,491,200 Est. Cost $11.21 Unrealized -7.6%

— KARYOPHARM THERAPEUTICS INC 2.2%

Value $25.35M Shares 5,621,533 Est. Cost $16.36 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 2.1%

Value $23.65M Shares 1,678,196 Est. Cost $33.89 Unrealized -44.9%

ALKS ALKERMES PLC 1.6%

Value $17.98M Shares 603,400 Est. Cost $22.36 Unrealized +28.5%

EHTH EHEALTH INC 1.3%

Value $15.44M Shares 1,654,693 Est. Cost $59.40 Unrealized -82.9%

GOSS GOSSAMER BIO INC 1.3%

Value $14.65M Shares 1,750,651 Est. Cost $11.85 Unrealized -34.6%

SNDX SYNDAX PHARMACEUTICALS INC 1.0%

Value $11.79M Shares 612,600 Est. Cost $16.84 Unrealized -1.1%

ALGN ALIGN TECHNOLOGY INC 0.9%

Value $10.49M Shares 44,305 Est. Cost $114.31 Unrealized +168.8%

— EPIZYME INC 0.9%

Value $9.959M Shares 6,774,541 Est. Cost $11.87 Unrealized —

ANAB ANAPTYSBIO INC 0.8%

Value $8.75M Shares 431,024 Est. Cost $19.06 Unrealized +16.2%

— CLOVIS ONCOLOGY INC 0.7%

Value $8.053M Shares 4,473,967 Est. Cost $42.71 Unrealized —

— GRITSTONE ONCOLOGY INC 0.5%

Value $5.64M Shares 2,330,504 Est. Cost $9.42 Unrealized —

— KEZAR LIFE SCIENCES INC 0.5%

Value $5.427M Shares 656,200 Est. Cost $5.16 Unrealized —

CYTK CYTOKINETICS INC 0.4%

Value $4.389M Shares 111,717 Est. Cost $6.71 Unrealized +499.7%

TVTX TRAVERE THERAPEUTICS INC 0.4%

Value $4.024M Shares 166,069 Est. Cost $23.56 Unrealized +6.8%

MIRM MIRUM PHARMACEUTICALS INC 0.1%

Value $1.259M Shares 64,700 Est. Cost $15.56 Unrealized +51.6%

— ALIMERA SCIENCES INC 0.1%

Value $1.099M Shares 200,919 Est. Cost $6.30 Unrealized —

NVAX NOVAVAX INC 0.1%

Value $643K Shares 12,500 Est. Cost $171.82 Unrealized -69.9%

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value $642K Shares 160,800 Est. Cost $7.10 Unrealized -51.5%

— MAGENTA THERAPEUTICS INC 0.0%

Value $519K Shares 432,300 Est. Cost $7.38 Unrealized —

URGN UROGEN PHARMA LTD 0.0%

Value $201K Shares 24,500 Est. Cost $27.01 Unrealized -74.6%

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.0%

Value $198K Shares 27,100 Est. Cost $39.74 Unrealized -68.1%

— MARINUS PHARMACEUTICALS INC 0.0%

Value $152K Shares 31,330 Est. Cost $15.48 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	2,061,373	$171M	14.9%	$83.16	-4.3%	COM	09061G101
UTHR	UNITED THERAPEUTICS CORP	634,806	$150M	13.0%	$89.23	+127.8%	COM	91307C102
—	ABIOMED INC	494,397	$122M	10.7%	$81.43	—	COM	003654100
INSM	INSMED INC	5,840,398	$115M	10.0%	$17.79	+17.8%	COM	457669307
FOLD	AMICUS THERAPEUTICS INC	9,847,774	$106M	9.2%	$9.52	-13.5%	COM	03152W109
STAA	STAAR SURGICAL CO	1,106,567	$78.49M	6.8%	$14.28	+351.3%	COM	852312305
BIIB	BIOGEN INC	360,981	$73.62M	6.4%	$264.06	-22.6%	COM	09062X103
—	REVANCE THERAPEUTICS INC	4,405,039	$60.88M	5.3%	$21.99	—	COM	761330109
PRTA	PROTHENA CORP PLC	1,681,477	$45.65M	4.0%	$21.46	+36.3%	COM	G72800108
—	SAGE THERAPEUTICS INC	851,409	$27.5M	2.4%	$46.62	—	COM	78667J108
VNDA	VANDA PHARMACEUTICALS INC	2,491,200	$27.15M	2.4%	$11.21	-7.6%	COM	921659108
—	KARYOPHARM THERAPEUTICS INC	5,621,533	$25.35M	2.2%	$16.36	—	COM	48576U106
ACAD	ACADIA PHARMACEUTICALS INC	1,678,196	$23.65M	2.1%	$33.89	-44.9%	COM	004225108
ALKS	ALKERMES PLC	603,400	$17.98M	1.6%	$22.36	+28.5%	COM	G01767105
EHTH	EHEALTH INC	1,654,693	$15.44M	1.3%	$59.40	-82.9%	COM	28238P109
GOSS	GOSSAMER BIO INC	1,750,651	$14.65M	1.3%	$11.85	-34.6%	COM	38341P102
SNDX	SYNDAX PHARMACEUTICALS INC	612,600	$11.79M	1.0%	$16.84	-1.1%	COM	87164F105
ALGN	ALIGN TECHNOLOGY INC	44,305	$10.49M	0.9%	$114.31	+168.8%	COM	016255101
—	EPIZYME INC	6,774,541	$9.959M	0.9%	$11.87	—	COM	29428V104
ANAB	ANAPTYSBIO INC	431,024	$8.75M	0.8%	$19.06	+16.2%	COM	032724106
—	CLOVIS ONCOLOGY INC	4,473,967	$8.053M	0.7%	$42.71	—	COM	189464100
—	GRITSTONE ONCOLOGY INC	2,330,504	$5.64M	0.5%	$9.42	—	COM	39868T105
—	KEZAR LIFE SCIENCES INC	656,200	$5.427M	0.5%	$5.16	—	COM	49372L100
CYTK	CYTOKINETICS INC	111,717	$4.389M	0.4%	$6.71	+499.7%	COM	23282W605
TVTX	TRAVERE THERAPEUTICS INC	166,069	$4.024M	0.4%	$23.56	+6.8%	COM	89422G107
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$1.259M	0.1%	$15.56	+51.6%	COM	604749101
—	ALIMERA SCIENCES INC	200,919	$1.099M	0.1%	$6.30	—	COM	016259202
NVAX	NOVAVAX INC	12,500	$643K	0.1%	$171.82	-69.9%	COM	670002401
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$642K	0.1%	$7.10	-51.5%	COM	01438T106
—	MAGENTA THERAPEUTICS INC	432,300	$519K	0.0%	$7.38	—	COM	55910K108
URGN	UROGEN PHARMA LTD	24,500	$201K	0.0%	$27.01	-74.6%	COM	M96088105
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$198K	0.0%	$39.74	-68.1%	COM	87357P100
—	MARINUS PHARMACEUTICALS INC	31,330	$152K	0.0%	$15.48	—	COM	56854Q200