Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q2 2022 (← Previous) (Next →)

Filing Date: Aug 15, 2022

Total Value: $1.147B (100.0% shares, 0.0% debt)

Holdings (33)

BMRN BIOMARIN PHARMACEUTICAL INC 14.9%

Value $171M Shares 2,061,373 Share Price $82.87 * Est. Cost/Share $83.16 Unrealized @ Report Date -4.3%

UTHR UNITED THERAPEUTICS CORP 13.0%

Value $150M Shares 634,806 Share Price $235.64 * Est. Cost/Share $89.23 Unrealized @ Report Date +127.8%

— ABIOMED INC 10.7%

Value $122M Shares 494,397 Share Price $247.51 Est. Cost/Share $81.43 Unrealized @ Report Date —

INSM INSMED INC 10.0%

Value $115M Shares 5,840,398 Share Price $19.72 * Est. Cost/Share $17.79 Unrealized @ Report Date +17.8%

FOLD AMICUS THERAPEUTICS INC 9.2%

Value $106M Shares 9,847,774 Share Price $10.74 * Est. Cost/Share $9.52 Unrealized @ Report Date -13.5%

STAA STAAR SURGICAL CO 6.8%

Value $78.49M Shares 1,106,567 Share Price $70.93 * Est. Cost/Share $14.28 Unrealized @ Report Date +351.3%

BIIB BIOGEN INC 6.4%

Value $73.62M Shares 360,981 Share Price $203.94 Est. Cost/Share $264.06 Unrealized @ Report Date -22.6%

— REVANCE THERAPEUTICS INC 5.3%

Value $60.88M Shares 4,405,039 Share Price $13.82 Est. Cost/Share $21.99 Unrealized @ Report Date —

PRTA PROTHENA CORP PLC 4.0%

Value $45.65M Shares 1,681,477 Share Price $27.15 * Est. Cost/Share $21.46 Unrealized @ Report Date +36.3%

— SAGE THERAPEUTICS INC 2.4%

Value $27.5M Shares 851,409 Share Price $32.30 Est. Cost/Share $46.62 Unrealized @ Report Date —

VNDA VANDA PHARMACEUTICALS INC 2.4%

Value $27.15M Shares 2,491,200 Share Price $10.90 * Est. Cost/Share $11.21 Unrealized @ Report Date -7.6%

— KARYOPHARM THERAPEUTICS INC 2.2%

Value $25.35M Shares 5,621,533 Share Price $4.51 Est. Cost/Share $16.36 Unrealized @ Report Date —

ACAD ACADIA PHARMACEUTICALS INC 2.1%

Value $23.65M Shares 1,678,196 Share Price $14.09 * Est. Cost/Share $33.89 Unrealized @ Report Date -44.9%

ALKS ALKERMES PLC 1.6%

Value $17.98M Shares 603,400 Share Price $29.79 * Est. Cost/Share $22.36 Unrealized @ Report Date +28.5%

EHTH EHEALTH INC 1.3%

Value $15.44M Shares 1,654,693 Share Price $9.33 * Est. Cost/Share $59.40 Unrealized @ Report Date -82.9%

GOSS GOSSAMER BIO INC 1.3%

Value $14.65M Shares 1,750,651 Share Price $8.37 * Est. Cost/Share $11.85 Unrealized @ Report Date -34.6%

SNDX SYNDAX PHARMACEUTICALS INC 1.0%

Value $11.79M Shares 612,600 Share Price $19.24 * Est. Cost/Share $16.84 Unrealized @ Report Date -1.1%

ALGN ALIGN TECHNOLOGY INC 0.9%

Value $10.49M Shares 44,305 Share Price $236.68 * Est. Cost/Share $114.31 Unrealized @ Report Date +168.8%

— EPIZYME INC 0.9%

Value $9.959M Shares 6,774,541 Share Price $1.47 Est. Cost/Share $11.87 Unrealized @ Report Date —

ANAB ANAPTYSBIO INC 0.8%

Value $8.75M Shares 431,024 Share Price $20.30 * Est. Cost/Share $19.06 Unrealized @ Report Date +16.2%

— CLOVIS ONCOLOGY INC 0.7%

Value $8.053M Shares 4,473,967 Share Price $1.80 Est. Cost/Share $42.71 Unrealized @ Report Date —

— GRITSTONE ONCOLOGY INC 0.5%

Value $5.64M Shares 2,330,504 Share Price $2.42 Est. Cost/Share $9.42 Unrealized @ Report Date —

— KEZAR LIFE SCIENCES INC 0.5%

Value $5.427M Shares 656,200 Share Price $8.27 Est. Cost/Share $5.16 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.4%

Value $4.389M Shares 111,717 Share Price $39.29 * Est. Cost/Share $6.71 Unrealized @ Report Date +499.7%

TVTX TRAVERE THERAPEUTICS INC 0.4%

Value $4.024M Shares 166,069 Share Price $24.23 * Est. Cost/Share $23.56 Unrealized @ Report Date +6.8%

MIRM MIRUM PHARMACEUTICALS INC 0.1%

Value $1.259M Shares 64,700 Share Price $19.46 * Est. Cost/Share $15.56 Unrealized @ Report Date +51.6%

— ALIMERA SCIENCES INC 0.1%

Value $1.099M Shares 200,919 Share Price $5.47 Est. Cost/Share $6.30 Unrealized @ Report Date —

NVAX NOVAVAX INC 0.1%

Value $643K Shares 12,500 Share Price $51.44 Est. Cost/Share $171.82 Unrealized @ Report Date -69.9%

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value $642K Shares 160,800 Share Price $3.99 * Est. Cost/Share $7.10 Unrealized @ Report Date -51.5%

— MAGENTA THERAPEUTICS INC 0.0%

Value $519K Shares 432,300 Share Price $1.20 Est. Cost/Share $7.38 Unrealized @ Report Date —

URGN UROGEN PHARMA LTD 0.0%

Value $201K Shares 24,500 Share Price $8.20 * Est. Cost/Share $27.01 Unrealized @ Report Date -74.6%

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.0%

Value $198K Shares 27,100 Share Price $7.31 * Est. Cost/Share $39.74 Unrealized @ Report Date -68.1%

— MARINUS PHARMACEUTICALS INC 0.0%

Value $152K Shares 31,330 Share Price $4.85 Est. Cost/Share $15.48 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	2,061,373	$171M	14.9%	$82.87 *	$83.16	-4.3%	COM	09061G101
UTHR	UNITED THERAPEUTICS CORP	634,806	$150M	13.0%	$235.64 *	$89.23	+127.8%	COM	91307C102
—	ABIOMED INC	494,397	$122M	10.7%	$247.51	$81.43	—	COM	003654100
INSM	INSMED INC	5,840,398	$115M	10.0%	$19.72 *	$17.79	+17.8%	COM	457669307
FOLD	AMICUS THERAPEUTICS INC	9,847,774	$106M	9.2%	$10.74 *	$9.52	-13.5%	COM	03152W109
STAA	STAAR SURGICAL CO	1,106,567	$78.49M	6.8%	$70.93 *	$14.28	+351.3%	COM	852312305
BIIB	BIOGEN INC	360,981	$73.62M	6.4%	$203.94	$264.06	-22.6%	COM	09062X103
—	REVANCE THERAPEUTICS INC	4,405,039	$60.88M	5.3%	$13.82	$21.99	—	COM	761330109
PRTA	PROTHENA CORP PLC	1,681,477	$45.65M	4.0%	$27.15 *	$21.46	+36.3%	COM	G72800108
—	SAGE THERAPEUTICS INC	851,409	$27.5M	2.4%	$32.30	$46.62	—	COM	78667J108
VNDA	VANDA PHARMACEUTICALS INC	2,491,200	$27.15M	2.4%	$10.90 *	$11.21	-7.6%	COM	921659108
—	KARYOPHARM THERAPEUTICS INC	5,621,533	$25.35M	2.2%	$4.51	$16.36	—	COM	48576U106
ACAD	ACADIA PHARMACEUTICALS INC	1,678,196	$23.65M	2.1%	$14.09 *	$33.89	-44.9%	COM	004225108
ALKS	ALKERMES PLC	603,400	$17.98M	1.6%	$29.79 *	$22.36	+28.5%	COM	G01767105
EHTH	EHEALTH INC	1,654,693	$15.44M	1.3%	$9.33 *	$59.40	-82.9%	COM	28238P109
GOSS	GOSSAMER BIO INC	1,750,651	$14.65M	1.3%	$8.37 *	$11.85	-34.6%	COM	38341P102
SNDX	SYNDAX PHARMACEUTICALS INC	612,600	$11.79M	1.0%	$19.24 *	$16.84	-1.1%	COM	87164F105
ALGN	ALIGN TECHNOLOGY INC	44,305	$10.49M	0.9%	$236.68 *	$114.31	+168.8%	COM	016255101
—	EPIZYME INC	6,774,541	$9.959M	0.9%	$1.47	$11.87	—	COM	29428V104
ANAB	ANAPTYSBIO INC	431,024	$8.75M	0.8%	$20.30 *	$19.06	+16.2%	COM	032724106
—	CLOVIS ONCOLOGY INC	4,473,967	$8.053M	0.7%	$1.80	$42.71	—	COM	189464100
—	GRITSTONE ONCOLOGY INC	2,330,504	$5.64M	0.5%	$2.42	$9.42	—	COM	39868T105
—	KEZAR LIFE SCIENCES INC	656,200	$5.427M	0.5%	$8.27	$5.16	—	COM	49372L100
CYTK	CYTOKINETICS INC	111,717	$4.389M	0.4%	$39.29 *	$6.71	+499.7%	COM	23282W605
TVTX	TRAVERE THERAPEUTICS INC	166,069	$4.024M	0.4%	$24.23 *	$23.56	+6.8%	COM	89422G107
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$1.259M	0.1%	$19.46 *	$15.56	+51.6%	COM	604749101
—	ALIMERA SCIENCES INC	200,919	$1.099M	0.1%	$5.47	$6.30	—	COM	016259202
NVAX	NOVAVAX INC	12,500	$643K	0.1%	$51.44	$171.82	-69.9%	COM	670002401
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$642K	0.1%	$3.99 *	$7.10	-51.5%	COM	01438T106
—	MAGENTA THERAPEUTICS INC	432,300	$519K	0.0%	$1.20	$7.38	—	COM	55910K108
URGN	UROGEN PHARMA LTD	24,500	$201K	0.0%	$8.20 *	$27.01	-74.6%	COM	M96088105
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$198K	0.0%	$7.31 *	$39.74	-68.1%	COM	87357P100
—	MARINUS PHARMACEUTICALS INC	31,330	$152K	0.0%	$4.85	$15.48	—	COM	56854Q200