Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q2 2022 (← Previous) (Next →)

Filing Date: Aug 15, 2022

Total Value ($000): $1,147,302 (100.0% shares, 0.0% debt)

Holdings (33)

BMRN BIOMARIN PHARMACEUTICAL INC 14.9%

Value ($000) $170,826 Shares 2,061,373 Est. Cost $83.16 Unrealized -4.3%

UTHR UNITED THERAPEUTICS CORP 13.0%

Value ($000) $149,586 Shares 634,806 Est. Cost $89.23 Unrealized +127.8%

— ABIOMED INC 10.7%

Value ($000) $122,368 Shares 494,397 Est. Cost $81.43 Unrealized —

INSM INSMED INC 10.0%

Value ($000) $115,173 Shares 5,840,398 Est. Cost $17.79 Unrealized +17.8%

FOLD AMICUS THERAPEUTICS INC 9.2%

Value ($000) $105,765 Shares 9,847,774 Est. Cost $9.52 Unrealized -13.5%

STAA STAAR SURGICAL CO 6.8%

Value ($000) $78,489 Shares 1,106,567 Est. Cost $14.28 Unrealized +351.3%

BIIB BIOGEN INC 6.4%

Value ($000) $73,618 Shares 360,981 Est. Cost $264.06 Unrealized -22.6%

— REVANCE THERAPEUTICS INC 5.3%

Value ($000) $60,878 Shares 4,405,039 Est. Cost $21.99 Unrealized —

PRTA PROTHENA CORP PLC 4.0%

Value ($000) $45,652 Shares 1,681,477 Est. Cost $21.46 Unrealized +36.3%

— SAGE THERAPEUTICS INC 2.4%

Value ($000) $27,501 Shares 851,409 Est. Cost $46.62 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 2.4%

Value ($000) $27,154 Shares 2,491,200 Est. Cost $11.21 Unrealized -7.6%

— KARYOPHARM THERAPEUTICS INC 2.2%

Value ($000) $25,353 Shares 5,621,533 Est. Cost $16.36 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 2.1%

Value ($000) $23,646 Shares 1,678,196 Est. Cost $33.89 Unrealized -44.9%

ALKS ALKERMES PLC 1.6%

Value ($000) $17,975 Shares 603,400 Est. Cost $22.36 Unrealized +28.5%

EHTH EHEALTH INC 1.3%

Value ($000) $15,438 Shares 1,654,693 Est. Cost $59.40 Unrealized -82.9%

GOSS GOSSAMER BIO INC 1.3%

Value ($000) $14,653 Shares 1,750,651 Est. Cost $11.85 Unrealized -34.6%

SNDX SYNDAX PHARMACEUTICALS INC 1.0%

Value ($000) $11,786 Shares 612,600 Est. Cost $16.84 Unrealized -1.1%

ALGN ALIGN TECHNOLOGY INC 0.9%

Value ($000) $10,486 Shares 44,305 Est. Cost $114.31 Unrealized +168.8%

— EPIZYME INC 0.9%

Value ($000) $9,959 Shares 6,774,541 Est. Cost $11.87 Unrealized —

ANAB ANAPTYSBIO INC 0.8%

Value ($000) $8,750 Shares 431,024 Est. Cost $19.06 Unrealized +16.2%

— CLOVIS ONCOLOGY INC 0.7%

Value ($000) $8,053 Shares 4,473,967 Est. Cost $42.71 Unrealized —

— GRITSTONE ONCOLOGY INC 0.5%

Value ($000) $5,640 Shares 2,330,504 Est. Cost $9.42 Unrealized —

— KEZAR LIFE SCIENCES INC 0.5%

Value ($000) $5,427 Shares 656,200 Est. Cost $5.16 Unrealized —

CYTK CYTOKINETICS INC 0.4%

Value ($000) $4,389 Shares 111,717 Est. Cost $6.71 Unrealized +499.7%

TVTX TRAVERE THERAPEUTICS INC 0.4%

Value ($000) $4,024 Shares 166,069 Est. Cost $23.56 Unrealized +6.8%

MIRM MIRUM PHARMACEUTICALS INC 0.1%

Value ($000) $1,259 Shares 64,700 Est. Cost $15.56 Unrealized +51.6%

— ALIMERA SCIENCES INC 0.1%

Value ($000) $1,099 Shares 200,919 Est. Cost $6.30 Unrealized —

NVAX NOVAVAX INC 0.1%

Value ($000) $643 Shares 12,500 Est. Cost $171.82 Unrealized -69.9%

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value ($000) $642 Shares 160,800 Est. Cost $7.10 Unrealized -51.5%

— MAGENTA THERAPEUTICS INC 0.0%

Value ($000) $519 Shares 432,300 Est. Cost $7.38 Unrealized —

URGN UROGEN PHARMA LTD 0.0%

Value ($000) $201 Shares 24,500 Est. Cost $27.01 Unrealized -74.6%

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.0%

Value ($000) $198 Shares 27,100 Est. Cost $39.74 Unrealized -68.1%

— MARINUS PHARMACEUTICALS INC 0.0%

Value ($000) $152 Shares 31,330 Est. Cost $15.48 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	2,061,373	$170,826	14.9%	$83.16	-4.3%	COM	09061G101
UTHR	UNITED THERAPEUTICS CORP	634,806	$149,586	13.0%	$89.23	+127.8%	COM	91307C102
—	ABIOMED INC	494,397	$122,368	10.7%	$81.43	—	COM	003654100
INSM	INSMED INC	5,840,398	$115,173	10.0%	$17.79	+17.8%	COM	457669307
FOLD	AMICUS THERAPEUTICS INC	9,847,774	$105,765	9.2%	$9.52	-13.5%	COM	03152W109
STAA	STAAR SURGICAL CO	1,106,567	$78,489	6.8%	$14.28	+351.3%	COM	852312305
BIIB	BIOGEN INC	360,981	$73,618	6.4%	$264.06	-22.6%	COM	09062X103
—	REVANCE THERAPEUTICS INC	4,405,039	$60,878	5.3%	$21.99	—	COM	761330109
PRTA	PROTHENA CORP PLC	1,681,477	$45,652	4.0%	$21.46	+36.3%	COM	G72800108
—	SAGE THERAPEUTICS INC	851,409	$27,501	2.4%	$46.62	—	COM	78667J108
VNDA	VANDA PHARMACEUTICALS INC	2,491,200	$27,154	2.4%	$11.21	-7.6%	COM	921659108
—	KARYOPHARM THERAPEUTICS INC	5,621,533	$25,353	2.2%	$16.36	—	COM	48576U106
ACAD	ACADIA PHARMACEUTICALS INC	1,678,196	$23,646	2.1%	$33.89	-44.9%	COM	004225108
ALKS	ALKERMES PLC	603,400	$17,975	1.6%	$22.36	+28.5%	COM	G01767105
EHTH	EHEALTH INC	1,654,693	$15,438	1.3%	$59.40	-82.9%	COM	28238P109
GOSS	GOSSAMER BIO INC	1,750,651	$14,653	1.3%	$11.85	-34.6%	COM	38341P102
SNDX	SYNDAX PHARMACEUTICALS INC	612,600	$11,786	1.0%	$16.84	-1.1%	COM	87164F105
ALGN	ALIGN TECHNOLOGY INC	44,305	$10,486	0.9%	$114.31	+168.8%	COM	016255101
—	EPIZYME INC	6,774,541	$9,959	0.9%	$11.87	—	COM	29428V104
ANAB	ANAPTYSBIO INC	431,024	$8,750	0.8%	$19.06	+16.2%	COM	032724106
—	CLOVIS ONCOLOGY INC	4,473,967	$8,053	0.7%	$42.71	—	COM	189464100
—	GRITSTONE ONCOLOGY INC	2,330,504	$5,640	0.5%	$9.42	—	COM	39868T105
—	KEZAR LIFE SCIENCES INC	656,200	$5,427	0.5%	$5.16	—	COM	49372L100
CYTK	CYTOKINETICS INC	111,717	$4,389	0.4%	$6.71	+499.7%	COM	23282W605
TVTX	TRAVERE THERAPEUTICS INC	166,069	$4,024	0.4%	$23.56	+6.8%	COM	89422G107
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$1,259	0.1%	$15.56	+51.6%	COM	604749101
—	ALIMERA SCIENCES INC	200,919	$1,099	0.1%	$6.30	—	COM	016259202
NVAX	NOVAVAX INC	12,500	$643	0.1%	$171.82	-69.9%	COM	670002401
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$642	0.1%	$7.10	-51.5%	COM	01438T106
—	MAGENTA THERAPEUTICS INC	432,300	$519	0.0%	$7.38	—	COM	55910K108
URGN	UROGEN PHARMA LTD	24,500	$201	0.0%	$27.01	-74.6%	COM	M96088105
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$198	0.0%	$39.74	-68.1%	COM	87357P100
—	MARINUS PHARMACEUTICALS INC	31,330	$152	0.0%	$15.48	—	COM	56854Q200