Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q3 2022 (← Previous) (Next →)

Filing Date: Nov 14, 2022

Total Value: $1.265B (100.0% shares, 0.0% debt)

Holdings (32)

BMRN BIOMARIN PHARMACEUTICAL INC 13.2%

Value $168M Shares 1,976,265 Est. Cost $83.16 Unrealized +7.1%

UTHR UNITED THERAPEUTICS CORP 10.5%

Value $133M Shares 633,534 Est. Cost $89.23 Unrealized +150.5%

INSM INSMED INC 9.9%

Value $126M Shares 5,840,398 Est. Cost $17.79 Unrealized +34.8%

— ABIOMED INC 9.5%

Value $121M Shares 490,754 Est. Cost $81.43 Unrealized —

— REVANCE THERAPEUTICS INC 9.4%

Value $119M Shares 4,405,039 Est. Cost $21.99 Unrealized —

FOLD AMICUS THERAPEUTICS INC 8.1%

Value $103M Shares 9,847,774 Est. Cost $9.52 Unrealized +17.1%

PRTA PROTHENA CORP PLC 7.9%

Value $100M Shares 1,649,777 Est. Cost $21.46 Unrealized +47.3%

BIIB BIOGEN INC 7.6%

Value $96.38M Shares 360,981 Est. Cost $264.06 Unrealized -19.6%

STAA STAAR SURGICAL CO 6.1%

Value $77.39M Shares 1,096,882 Est. Cost $14.28 Unrealized +499.5%

— SAGE THERAPEUTICS INC 2.6%

Value $33.34M Shares 851,409 Est. Cost $46.62 Unrealized —

— KARYOPHARM THERAPEUTICS INC 2.4%

Value $30.69M Shares 5,621,533 Est. Cost $16.36 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 2.2%

Value $27.45M Shares 1,678,196 Est. Cost $33.89 Unrealized -52.2%

VNDA VANDA PHARMACEUTICALS INC 1.7%

Value $21.4M Shares 2,166,156 Est. Cost $11.21 Unrealized -5.8%

GOSS GOSSAMER BIO INC 1.7%

Value $20.97M Shares 1,750,651 Est. Cost $11.85 Unrealized +4.8%

SNDX SYNDAX PHARMACEUTICALS INC 1.2%

Value $14.72M Shares 612,600 Est. Cost $16.84 Unrealized +33.3%

ALKS ALKERMES PLC 1.1%

Value $13.47M Shares 603,400 Est. Cost $22.36 Unrealized +16.3%

ANAB ANAPTYSBIO INC 0.9%

Value $10.99M Shares 431,024 Est. Cost $19.06 Unrealized +23.0%

ALGN ALIGN TECHNOLOGY INC 0.7%

Value $9.176M Shares 44,305 Est. Cost $114.31 Unrealized +125.2%

EHTH EHEALTH INC 0.6%

Value $7.734M Shares 1,977,993 Est. Cost $50.83 Unrealized -86.3%

— GRITSTONE ONCOLOGY INC 0.5%

Value $5.989M Shares 2,330,504 Est. Cost $9.42 Unrealized —

— KEZAR LIFE SCIENCES INC 0.4%

Value $5.65M Shares 656,200 Est. Cost $5.16 Unrealized —

CYTK CYTOKINETICS INC 0.4%

Value $5.413M Shares 111,717 Est. Cost $6.71 Unrealized +616.9%

— CLOVIS ONCOLOGY INC 0.4%

Value $5.324M Shares 4,473,967 Est. Cost $42.71 Unrealized —

TVTX TRAVERE THERAPEUTICS INC 0.3%

Value $4.092M Shares 166,069 Est. Cost $23.56 Unrealized +9.7%

— PROVENTION BIO INC 0.1%

Value $1.759M Shares 390,800 Est. Cost $4.50 Unrealized —

MIRM MIRUM PHARMACEUTICALS INC 0.1%

Value $1.359M Shares 64,700 Est. Cost $15.56 Unrealized +54.8%

— ALIMERA SCIENCES INC 0.1%

Value $1.021M Shares 200,919 Est. Cost $6.30 Unrealized —

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value $859K Shares 160,800 Est. Cost $7.10 Unrealized -15.5%

— MAGENTA THERAPEUTICS INC 0.0%

Value $610K Shares 432,300 Est. Cost $7.38 Unrealized —

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.0%

Value $211K Shares 27,100 Est. Cost $39.74 Unrealized -79.0%

— MARINUS PHARMACEUTICALS INC 0.0%

Value $208K Shares 31,330 Est. Cost $15.48 Unrealized —

URGN UROGEN PHARMA LTD 0.0%

Value $204K Shares 24,500 Est. Cost $27.01 Unrealized -69.4%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	1,976,265	$168M	13.2%	$83.16	+7.1%	COM	09061G101
UTHR	UNITED THERAPEUTICS CORP	633,534	$133M	10.5%	$89.23	+150.5%	COM	91307C102
INSM	INSMED INC	5,840,398	$126M	9.9%	$17.79	+34.8%	COM	457669307
—	ABIOMED INC	490,754	$121M	9.5%	$81.43	—	COM	003654100
—	REVANCE THERAPEUTICS INC	4,405,039	$119M	9.4%	$21.99	—	COM	761330109
FOLD	AMICUS THERAPEUTICS INC	9,847,774	$103M	8.1%	$9.52	+17.1%	COM	03152W109
PRTA	PROTHENA CORP PLC	1,649,777	$100M	7.9%	$21.46	+47.3%	COM	G72800108
BIIB	BIOGEN INC	360,981	$96.38M	7.6%	$264.06	-19.6%	COM	09062X103
STAA	STAAR SURGICAL CO	1,096,882	$77.39M	6.1%	$14.28	+499.5%	COM	852312305
—	SAGE THERAPEUTICS INC	851,409	$33.34M	2.6%	$46.62	—	COM	78667J108
—	KARYOPHARM THERAPEUTICS INC	5,621,533	$30.69M	2.4%	$16.36	—	COM	48576U106
ACAD	ACADIA PHARMACEUTICALS INC	1,678,196	$27.45M	2.2%	$33.89	-52.2%	COM	004225108
VNDA	VANDA PHARMACEUTICALS INC	2,166,156	$21.4M	1.7%	$11.21	-5.8%	COM	921659108
GOSS	GOSSAMER BIO INC	1,750,651	$20.97M	1.7%	$11.85	+4.8%	COM	38341P102
SNDX	SYNDAX PHARMACEUTICALS INC	612,600	$14.72M	1.2%	$16.84	+33.3%	COM	87164F105
ALKS	ALKERMES PLC	603,400	$13.47M	1.1%	$22.36	+16.3%	COM	G01767105
ANAB	ANAPTYSBIO INC	431,024	$10.99M	0.9%	$19.06	+23.0%	COM	032724106
ALGN	ALIGN TECHNOLOGY INC	44,305	$9.176M	0.7%	$114.31	+125.2%	COM	016255101
EHTH	EHEALTH INC	1,977,993	$7.734M	0.6%	$50.83	-86.3%	COM	28238P109
—	GRITSTONE ONCOLOGY INC	2,330,504	$5.989M	0.5%	$9.42	—	COM	39868T105
—	KEZAR LIFE SCIENCES INC	656,200	$5.65M	0.4%	$5.16	—	COM	49372L100
CYTK	CYTOKINETICS INC	111,717	$5.413M	0.4%	$6.71	+616.9%	COM	23282W605
—	CLOVIS ONCOLOGY INC	4,473,967	$5.324M	0.4%	$42.71	—	COM	189464100
TVTX	TRAVERE THERAPEUTICS INC	166,069	$4.092M	0.3%	$23.56	+9.7%	COM	89422G107
—	PROVENTION BIO INC	390,800	$1.759M	0.1%	$4.50	—	COM	74374N102
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$1.359M	0.1%	$15.56	+54.8%	COM	604749101
—	ALIMERA SCIENCES INC	200,919	$1.021M	0.1%	$6.30	—	COM	016259202
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$859K	0.1%	$7.10	-15.5%	COM	01438T106
—	MAGENTA THERAPEUTICS INC	432,300	$610K	0.0%	$7.38	—	COM	55910K108
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$211K	0.0%	$39.74	-79.0%	COM	87357P100
—	MARINUS PHARMACEUTICALS INC	31,330	$208K	0.0%	$15.48	—	COM	56854Q200
URGN	UROGEN PHARMA LTD	24,500	$204K	0.0%	$27.01	-69.4%	COM	M96088105