Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q3 2022 (← Previous) (Next →)

Filing Date: Nov 14, 2022

Total Value: $1.265B (100.0% shares, 0.0% debt)

Holdings (32)

BMRN BIOMARIN PHARMACEUTICAL INC 13.2%

Value $168M Shares 1,976,265 Share Price $84.77 * Est. Cost/Share $83.16 Unrealized @ Report Date +7.1%

UTHR UNITED THERAPEUTICS CORP 10.5%

Value $133M Shares 633,534 Share Price $209.38 * Est. Cost/Share $89.23 Unrealized @ Report Date +150.5%

INSM INSMED INC 9.9%

Value $126M Shares 5,840,398 Share Price $21.54 * Est. Cost/Share $17.79 Unrealized @ Report Date +34.8%

— ABIOMED INC 9.5%

Value $121M Shares 490,754 Share Price $245.66 Est. Cost/Share $81.43 Unrealized @ Report Date —

— REVANCE THERAPEUTICS INC 9.4%

Value $119M Shares 4,405,039 Share Price $27.00 Est. Cost/Share $21.99 Unrealized @ Report Date —

FOLD AMICUS THERAPEUTICS INC 8.1%

Value $103M Shares 9,847,774 Share Price $10.44 * Est. Cost/Share $9.52 Unrealized @ Report Date +17.1%

PRTA PROTHENA CORP PLC 7.9%

Value $100M Shares 1,649,777 Share Price $60.63 * Est. Cost/Share $21.46 Unrealized @ Report Date +47.3%

BIIB BIOGEN INC 7.6%

Value $96.38M Shares 360,981 Share Price $267.00 * Est. Cost/Share $264.06 Unrealized @ Report Date -19.6%

STAA STAAR SURGICAL CO 6.1%

Value $77.39M Shares 1,096,882 Share Price $70.55 * Est. Cost/Share $14.28 Unrealized @ Report Date +499.5%

— SAGE THERAPEUTICS INC 2.6%

Value $33.34M Shares 851,409 Share Price $39.16 Est. Cost/Share $46.62 Unrealized @ Report Date —

— KARYOPHARM THERAPEUTICS INC 2.4%

Value $30.69M Shares 5,621,533 Share Price $5.46 Est. Cost/Share $16.36 Unrealized @ Report Date —

ACAD ACADIA PHARMACEUTICALS INC 2.2%

Value $27.45M Shares 1,678,196 Share Price $16.36 Est. Cost/Share $33.89 Unrealized @ Report Date -52.2%

VNDA VANDA PHARMACEUTICALS INC 1.7%

Value $21.4M Shares 2,166,156 Share Price $9.88 * Est. Cost/Share $11.21 Unrealized @ Report Date -5.8%

GOSS GOSSAMER BIO INC 1.7%

Value $20.97M Shares 1,750,651 Share Price $11.98 * Est. Cost/Share $11.85 Unrealized @ Report Date +4.8%

SNDX SYNDAX PHARMACEUTICALS INC 1.2%

Value $14.72M Shares 612,600 Share Price $24.03 * Est. Cost/Share $16.84 Unrealized @ Report Date +33.3%

ALKS ALKERMES PLC 1.1%

Value $13.47M Shares 603,400 Share Price $22.33 * Est. Cost/Share $22.36 Unrealized @ Report Date +16.3%

ANAB ANAPTYSBIO INC 0.9%

Value $10.99M Shares 431,024 Share Price $25.51 * Est. Cost/Share $19.06 Unrealized @ Report Date +23.0%

ALGN ALIGN TECHNOLOGY INC 0.7%

Value $9.176M Shares 44,305 Share Price $207.11 * Est. Cost/Share $114.31 Unrealized @ Report Date +125.2%

EHTH EHEALTH INC 0.6%

Value $7.734M Shares 1,977,993 Share Price $3.91 * Est. Cost/Share $50.83 Unrealized @ Report Date -86.3%

— GRITSTONE ONCOLOGY INC 0.5%

Value $5.989M Shares 2,330,504 Share Price $2.57 Est. Cost/Share $9.42 Unrealized @ Report Date —

— KEZAR LIFE SCIENCES INC 0.4%

Value $5.65M Shares 656,200 Share Price $8.61 Est. Cost/Share $5.16 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.4%

Value $5.413M Shares 111,717 Share Price $48.45 Est. Cost/Share $6.71 Unrealized @ Report Date +616.9%

— CLOVIS ONCOLOGY INC 0.4%

Value $5.324M Shares 4,473,967 Share Price $1.19 Est. Cost/Share $42.71 Unrealized @ Report Date —

TVTX TRAVERE THERAPEUTICS INC 0.3%

Value $4.092M Shares 166,069 Share Price $24.64 * Est. Cost/Share $23.56 Unrealized @ Report Date +9.7%

— PROVENTION BIO INC 0.1%

Value $1.759M Shares 390,800 Share Price $4.50 Est. Cost/Share $4.50 Unrealized @ Report Date —

MIRM MIRUM PHARMACEUTICALS INC 0.1%

Value $1.359M Shares 64,700 Share Price $21.00 * Est. Cost/Share $15.56 Unrealized @ Report Date +54.8%

— ALIMERA SCIENCES INC 0.1%

Value $1.021M Shares 200,919 Share Price $5.08 Est. Cost/Share $6.30 Unrealized @ Report Date —

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value $859K Shares 160,800 Share Price $5.34 * Est. Cost/Share $7.10 Unrealized @ Report Date -15.5%

— MAGENTA THERAPEUTICS INC 0.0%

Value $610K Shares 432,300 Share Price $1.41 Est. Cost/Share $7.38 Unrealized @ Report Date —

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.0%

Value $211K Shares 27,100 Share Price $7.79 * Est. Cost/Share $39.74 Unrealized @ Report Date -79.0%

— MARINUS PHARMACEUTICALS INC 0.0%

Value $208K Shares 31,330 Share Price $6.64 Est. Cost/Share $15.48 Unrealized @ Report Date —

URGN UROGEN PHARMA LTD 0.0%

Value $204K Shares 24,500 Share Price $8.33 Est. Cost/Share $27.01 Unrealized @ Report Date -69.4%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	1,976,265	$168M	13.2%	$84.77 *	$83.16	+7.1%	COM	09061G101
UTHR	UNITED THERAPEUTICS CORP	633,534	$133M	10.5%	$209.38 *	$89.23	+150.5%	COM	91307C102
INSM	INSMED INC	5,840,398	$126M	9.9%	$21.54 *	$17.79	+34.8%	COM	457669307
—	ABIOMED INC	490,754	$121M	9.5%	$245.66	$81.43	—	COM	003654100
—	REVANCE THERAPEUTICS INC	4,405,039	$119M	9.4%	$27.00	$21.99	—	COM	761330109
FOLD	AMICUS THERAPEUTICS INC	9,847,774	$103M	8.1%	$10.44 *	$9.52	+17.1%	COM	03152W109
PRTA	PROTHENA CORP PLC	1,649,777	$100M	7.9%	$60.63 *	$21.46	+47.3%	COM	G72800108
BIIB	BIOGEN INC	360,981	$96.38M	7.6%	$267.00 *	$264.06	-19.6%	COM	09062X103
STAA	STAAR SURGICAL CO	1,096,882	$77.39M	6.1%	$70.55 *	$14.28	+499.5%	COM	852312305
—	SAGE THERAPEUTICS INC	851,409	$33.34M	2.6%	$39.16	$46.62	—	COM	78667J108
—	KARYOPHARM THERAPEUTICS INC	5,621,533	$30.69M	2.4%	$5.46	$16.36	—	COM	48576U106
ACAD	ACADIA PHARMACEUTICALS INC	1,678,196	$27.45M	2.2%	$16.36	$33.89	-52.2%	COM	004225108
VNDA	VANDA PHARMACEUTICALS INC	2,166,156	$21.4M	1.7%	$9.88 *	$11.21	-5.8%	COM	921659108
GOSS	GOSSAMER BIO INC	1,750,651	$20.97M	1.7%	$11.98 *	$11.85	+4.8%	COM	38341P102
SNDX	SYNDAX PHARMACEUTICALS INC	612,600	$14.72M	1.2%	$24.03 *	$16.84	+33.3%	COM	87164F105
ALKS	ALKERMES PLC	603,400	$13.47M	1.1%	$22.33 *	$22.36	+16.3%	COM	G01767105
ANAB	ANAPTYSBIO INC	431,024	$10.99M	0.9%	$25.51 *	$19.06	+23.0%	COM	032724106
ALGN	ALIGN TECHNOLOGY INC	44,305	$9.176M	0.7%	$207.11 *	$114.31	+125.2%	COM	016255101
EHTH	EHEALTH INC	1,977,993	$7.734M	0.6%	$3.91 *	$50.83	-86.3%	COM	28238P109
—	GRITSTONE ONCOLOGY INC	2,330,504	$5.989M	0.5%	$2.57	$9.42	—	COM	39868T105
—	KEZAR LIFE SCIENCES INC	656,200	$5.65M	0.4%	$8.61	$5.16	—	COM	49372L100
CYTK	CYTOKINETICS INC	111,717	$5.413M	0.4%	$48.45	$6.71	+616.9%	COM	23282W605
—	CLOVIS ONCOLOGY INC	4,473,967	$5.324M	0.4%	$1.19	$42.71	—	COM	189464100
TVTX	TRAVERE THERAPEUTICS INC	166,069	$4.092M	0.3%	$24.64 *	$23.56	+9.7%	COM	89422G107
—	PROVENTION BIO INC	390,800	$1.759M	0.1%	$4.50	$4.50	—	COM	74374N102
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$1.359M	0.1%	$21.00 *	$15.56	+54.8%	COM	604749101
—	ALIMERA SCIENCES INC	200,919	$1.021M	0.1%	$5.08	$6.30	—	COM	016259202
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$859K	0.1%	$5.34 *	$7.10	-15.5%	COM	01438T106
—	MAGENTA THERAPEUTICS INC	432,300	$610K	0.0%	$1.41	$7.38	—	COM	55910K108
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$211K	0.0%	$7.79 *	$39.74	-79.0%	COM	87357P100
—	MARINUS PHARMACEUTICALS INC	31,330	$208K	0.0%	$6.64	$15.48	—	COM	56854Q200
URGN	UROGEN PHARMA LTD	24,500	$204K	0.0%	$8.33	$27.01	-69.4%	COM	M96088105