Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q4 2022 (← Previous) (Next →)

Filing Date: Feb 14, 2023

Total Value: $1.173B (100.0% shares, 0.0% debt)

Holdings (29)

BMRN BIOMARIN PHARMACEUTICAL INC 16.6%

Value $195M Shares 1,885,811 Share Price $103.49 * Est. Cost/Share $83.16 Unrealized @ Report Date +12.9%

UTHR UNITED THERAPEUTICS CORP 14.8%

Value $174M Shares 625,414 Share Price $278.09 * Est. Cost/Share $89.23 Unrealized @ Report Date +182.9%

FOLD AMICUS THERAPEUTICS INC 10.9%

Value $128M Shares 10,493,722 Share Price $12.21 * Est. Cost/Share $9.63 Unrealized @ Report Date +17.0%

INSM INSMED INC 10.0%

Value $117M Shares 5,871,291 Share Price $19.98 * Est. Cost/Share $17.79 Unrealized @ Report Date +8.6%

BIIB BIOGEN INC 9.0%

Value $105M Shares 380,082 Share Price $276.92 Est. Cost/Share $264.98 Unrealized @ Report Date +6.6%

PRTA PROTHENA CORP PLC 8.5%

Value $99.93M Shares 1,658,577 Share Price $60.25 * Est. Cost/Share $21.46 Unrealized @ Report Date +172.9%

— REVANCE THERAPEUTICS INC 8.3%

Value $97.54M Shares 5,283,609 Share Price $18.46 Est. Cost/Share $21.40 Unrealized @ Report Date —

STAA STAAR SURGICAL CO 5.1%

Value $60.19M Shares 1,240,077 Share Price $48.54 * Est. Cost/Share $19.87 Unrealized @ Report Date +215.7%

ACAD ACADIA PHARMACEUTICALS INC 3.2%

Value $37.83M Shares 2,376,369 Share Price $15.92 Est. Cost/Share $28.53 Unrealized @ Report Date -45.2%

— SAGE THERAPEUTICS INC 2.8%

Value $32.67M Shares 856,517 Share Price $38.14 Est. Cost/Share $46.62 Unrealized @ Report Date —

— KARYOPHARM THERAPEUTICS INC 1.6%

Value $19.23M Shares 5,655,676 Share Price $3.40 Est. Cost/Share $16.36 Unrealized @ Report Date —

ALKS ALKERMES PLC 1.3%

Value $15.77M Shares 603,400 Share Price $26.13 * Est. Cost/Share $22.36 Unrealized @ Report Date +7.0%

ALGN ALIGN TECHNOLOGY INC 1.3%

Value $15.73M Shares 74,605 Share Price $210.90 * Est. Cost/Share $149.18 Unrealized @ Report Date +34.2%

SNDX SYNDAX PHARMACEUTICALS INC 1.3%

Value $15.59M Shares 612,600 Share Price $25.45 * Est. Cost/Share $16.84 Unrealized @ Report Date +38.5%

ANAB ANAPTYSBIO INC 1.1%

Value $13.36M Shares 431,024 Share Price $30.99 * Est. Cost/Share $19.06 Unrealized @ Report Date +48.2%

EHTH EHEALTH INC 1.0%

Value $12.02M Shares 2,484,479 Share Price $4.84 * Est. Cost/Share $41.23 Unrealized @ Report Date -91.0%

VNDA VANDA PHARMACEUTICALS INC 0.7%

Value $8.037M Shares 1,087,607 Share Price $7.39 * Est. Cost/Share $11.21 Unrealized @ Report Date -13.2%

CYTK CYTOKINETICS INC 0.4%

Value $5.119M Shares 111,717 Share Price $45.82 * Est. Cost/Share $6.71 Unrealized @ Report Date +539.8%

— KEZAR LIFE SCIENCES INC 0.4%

Value $4.62M Shares 656,200 Share Price $7.04 Est. Cost/Share $5.16 Unrealized @ Report Date —

— PROVENTION BIO INC 0.4%

Value $4.131M Shares 390,800 Share Price $10.57 Est. Cost/Share $4.50 Unrealized @ Report Date —

TVTX TRAVERE THERAPEUTICS INC 0.3%

Value $3.492M Shares 166,069 Share Price $21.03 Est. Cost/Share $23.56 Unrealized @ Report Date -10.0%

— GRITSTONE ONCOLOGY INC 0.2%

Value $2.298M Shares 666,127 Share Price $3.45 Est. Cost/Share $9.42 Unrealized @ Report Date —

— PEAK BIO INC 0.2%

Value $2.022M Shares 497,528 Share Price $4.06 Est. Cost/Share $4.06 Unrealized @ Report Date —

MIRM MIRUM PHARMACEUTICALS INC 0.1%

Value $1.262M Shares 64,700 Share Price $19.50 Est. Cost/Share $15.56 Unrealized @ Report Date +27.1%

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value $1.119M Shares 160,800 Share Price $6.96 * Est. Cost/Share $7.10 Unrealized @ Report Date -19.4%

— ALIMERA SCIENCES INC 0.0%

Value $544K Shares 200,919 Share Price $2.71 Est. Cost/Share $6.30 Unrealized @ Report Date —

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.0%

Value $311K Shares 27,100 Share Price $11.48 * Est. Cost/Share $39.74 Unrealized @ Report Date -77.9%

URGN UROGEN PHARMA LTD 0.0%

Value $217K Shares 24,500 Share Price $8.87 * Est. Cost/Share $27.01 Unrealized @ Report Date -64.9%

GOSS GOSSAMER BIO INC 0.0%

Value $81,918 Shares 37,750 Share Price $2.17 * Est. Cost/Share $11.85 Unrealized @ Report Date -30.5%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	1,885,811	$195M	16.6%	$103.49 *	$83.16	+12.9%	COM	09061G101
UTHR	UNITED THERAPEUTICS CORP	625,414	$174M	14.8%	$278.09 *	$89.23	+182.9%	COM	91307C102
FOLD	AMICUS THERAPEUTICS INC	10,493,722	$128M	10.9%	$12.21 *	$9.63	+17.0%	COM	03152W109
INSM	INSMED INC	5,871,291	$117M	10.0%	$19.98 *	$17.79	+8.6%	COM	457669307
BIIB	BIOGEN INC	380,082	$105M	9.0%	$276.92	$264.98	+6.6%	COM	09062X103
PRTA	PROTHENA CORP PLC	1,658,577	$99.93M	8.5%	$60.25 *	$21.46	+172.9%	COM	G72800108
—	REVANCE THERAPEUTICS INC	5,283,609	$97.54M	8.3%	$18.46	$21.40	—	COM	761330109
STAA	STAAR SURGICAL CO	1,240,077	$60.19M	5.1%	$48.54 *	$19.87	+215.7%	COM	852312305
ACAD	ACADIA PHARMACEUTICALS INC	2,376,369	$37.83M	3.2%	$15.92	$28.53	-45.2%	COM	004225108
—	SAGE THERAPEUTICS INC	856,517	$32.67M	2.8%	$38.14	$46.62	—	COM	78667J108
—	KARYOPHARM THERAPEUTICS INC	5,655,676	$19.23M	1.6%	$3.40	$16.36	—	COM	48576U106
ALKS	ALKERMES PLC	603,400	$15.77M	1.3%	$26.13 *	$22.36	+7.0%	COM	G01767105
ALGN	ALIGN TECHNOLOGY INC	74,605	$15.73M	1.3%	$210.90 *	$149.18	+34.2%	COM	016255101
SNDX	SYNDAX PHARMACEUTICALS INC	612,600	$15.59M	1.3%	$25.45 *	$16.84	+38.5%	COM	87164F105
ANAB	ANAPTYSBIO INC	431,024	$13.36M	1.1%	$30.99 *	$19.06	+48.2%	COM	032724106
EHTH	EHEALTH INC	2,484,479	$12.02M	1.0%	$4.84 *	$41.23	-91.0%	COM	28238P109
VNDA	VANDA PHARMACEUTICALS INC	1,087,607	$8.037M	0.7%	$7.39 *	$11.21	-13.2%	COM	921659108
CYTK	CYTOKINETICS INC	111,717	$5.119M	0.4%	$45.82 *	$6.71	+539.8%	COM	23282W605
—	KEZAR LIFE SCIENCES INC	656,200	$4.62M	0.4%	$7.04	$5.16	—	COM	49372L100
—	PROVENTION BIO INC	390,800	$4.131M	0.4%	$10.57	$4.50	—	COM	74374N102
TVTX	TRAVERE THERAPEUTICS INC	166,069	$3.492M	0.3%	$21.03	$23.56	-10.0%	COM	89422G107
—	GRITSTONE ONCOLOGY INC	666,127	$2.298M	0.2%	$3.45	$9.42	—	COM	39868T105
—	PEAK BIO INC	497,528	$2.022M	0.2%	$4.06	$4.06	—	COM	70470P108
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$1.262M	0.1%	$19.50	$15.56	+27.1%	COM	604749101
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$1.119M	0.1%	$6.96 *	$7.10	-19.4%	COM	01438T106
—	ALIMERA SCIENCES INC	200,919	$544K	0.0%	$2.71	$6.30	—	COM	016259202
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$311K	0.0%	$11.48 *	$39.74	-77.9%	COM	87357P100
URGN	UROGEN PHARMA LTD	24,500	$217K	0.0%	$8.87 *	$27.01	-64.9%	COM	M96088105
GOSS	GOSSAMER BIO INC	37,750	$81,918	0.0%	$2.17 *	$11.85	-30.5%	COM	38341P102