Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q1 2023 (← Previous) (Next →)

Filing Date: May 15, 2023

Total Value: $1.207B (100.0% shares, 0.0% debt)

Holdings (30)

BMRN BIOMARIN PHARMACEUTICAL INC 14.8%

Value $178M Shares 1,831,035 Share Price $97.24 * Est. Cost/Share $83.16 Unrealized @ Report Date +24.7%

— REVANCE THERAPEUTICS INC 14.1%

Value $170M Shares 5,270,209 Share Price $32.21 Est. Cost/Share $21.40 Unrealized @ Report Date —

UTHR UNITED THERAPEUTICS CORP 11.6%

Value $141M Shares 627,514 Share Price $223.96 * Est. Cost/Share $89.23 Unrealized @ Report Date +176.3%

FOLD AMICUS THERAPEUTICS INC 9.7%

Value $117M Shares 10,524,022 Share Price $11.09 * Est. Cost/Share $9.63 Unrealized @ Report Date +28.1%

BIIB BIOGEN INC 8.8%

Value $106M Shares 381,282 Share Price $278.03 Est. Cost/Share $264.98 Unrealized @ Report Date +4.4%

INSM INSMED INC 8.3%

Value $100M Shares 5,889,491 Share Price $17.05 * Est. Cost/Share $17.79 Unrealized @ Report Date +9.2%

STAA STAAR SURGICAL CO 7.1%

Value $86.16M Shares 1,347,322 Share Price $63.95 * Est. Cost/Share $23.48 Unrealized @ Report Date +177.9%

PRTA PROTHENA CORP PLC 6.7%

Value $80.64M Shares 1,663,777 Share Price $48.47 * Est. Cost/Share $21.46 Unrealized @ Report Date +146.2%

ACAD ACADIA PHARMACEUTICALS INC 3.8%

Value $45.28M Shares 2,405,793 Share Price $18.82 Est. Cost/Share $28.41 Unrealized @ Report Date -33.0%

— SAGE THERAPEUTICS INC 3.0%

Value $36.07M Shares 859,517 Share Price $41.96 Est. Cost/Share $46.62 Unrealized @ Report Date —

EHTH EHEALTH INC 2.1%

Value $25.17M Shares 2,689,379 Share Price $9.36 * Est. Cost/Share $38.69 Unrealized @ Report Date -79.7%

ALGN ALIGN TECHNOLOGY INC 2.1%

Value $24.93M Shares 74,605 Share Price $334.14 * Est. Cost/Share $149.18 Unrealized @ Report Date +97.8%

— KARYOPHARM THERAPEUTICS INC 1.8%

Value $22.08M Shares 5,675,876 Share Price $3.89 Est. Cost/Share $16.36 Unrealized @ Report Date —

ALKS ALKERMES PLC 1.4%

Value $17.01M Shares 603,400 Share Price $28.19 * Est. Cost/Share $22.36 Unrealized @ Report Date +21.8%

SNDX SYNDAX PHARMACEUTICALS INC 1.1%

Value $12.94M Shares 612,600 Share Price $21.12 * Est. Cost/Share $16.84 Unrealized @ Report Date +47.7%

— PROVENTION BIO INC 0.8%

Value $9.418M Shares 390,800 Share Price $24.10 Est. Cost/Share $4.50 Unrealized @ Report Date —

ANAB ANAPTYSBIO INC 0.8%

Value $9.383M Shares 431,224 Share Price $21.76 * Est. Cost/Share $19.06 Unrealized @ Report Date +27.5%

GOSS GOSSAMER BIO INC 0.4%

Value $4.366M Shares 3,465,152 Share Price $1.26 * Est. Cost/Share $2.02 Unrealized @ Report Date -5.4%

CYTK CYTOKINETICS INC 0.3%

Value $3.931M Shares 111,717 Share Price $35.19 * Est. Cost/Share $6.71 Unrealized @ Report Date +507.7%

TVTX TRAVERE THERAPEUTICS INC 0.3%

Value $3.735M Shares 166,069 Share Price $22.49 * Est. Cost/Share $23.56 Unrealized @ Report Date -9.8%

VNDA VANDA PHARMACEUTICALS INC 0.3%

Value $3.278M Shares 482,697 Share Price $6.79 * Est. Cost/Share $11.21 Unrealized @ Report Date -37.3%

— KEZAR LIFE SCIENCES INC 0.2%

Value $2.054M Shares 656,200 Share Price $3.13 Est. Cost/Share $5.16 Unrealized @ Report Date —

NVCR NOVOCURE LTD 0.2%

Value $1.972M Shares 32,790 Share Price $60.14 * Est. Cost/Share $79.91 Unrealized @ Report Date 0.0%

— GRITSTONE ONCOLOGY INC 0.2%

Value $1.852M Shares 666,127 Share Price $2.78 Est. Cost/Share $9.42 Unrealized @ Report Date —

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value $1.597M Shares 160,800 Share Price $9.93 * Est. Cost/Share $7.10 Unrealized @ Report Date -0.4%

MIRM MIRUM PHARMACEUTICALS INC 0.1%

Value $1.554M Shares 64,700 Share Price $24.02 * Est. Cost/Share $15.56 Unrealized @ Report Date +46.5%

RLMD RELMADA THERAPEUTICS INC 0.1%

Value $1.225M Shares 542,100 Share Price $2.26 * Est. Cost/Share $3.45 Unrealized @ Report Date 0.0%

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.0%

Value $445K Shares 27,100 Share Price $16.42 * Est. Cost/Share $39.74 Unrealized @ Report Date -65.0%

— PEAK BIO INC 0.0%

Value $314K Shares 497,528 Share Price $0.63 Est. Cost/Share $4.06 Unrealized @ Report Date —

URGN UROGEN PHARMA LTD 0.0%

Value $226K Shares 24,500 Share Price $9.24 Est. Cost/Share $27.01 Unrealized @ Report Date -65.9%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	1,831,035	$178M	14.8%	$97.24 *	$83.16	+24.7%	COM	09061G101
—	REVANCE THERAPEUTICS INC	5,270,209	$170M	14.1%	$32.21	$21.40	—	COM	761330109
UTHR	UNITED THERAPEUTICS CORP	627,514	$141M	11.6%	$223.96 *	$89.23	+176.3%	COM	91307C102
FOLD	AMICUS THERAPEUTICS INC	10,524,022	$117M	9.7%	$11.09 *	$9.63	+28.1%	COM	03152W109
BIIB	BIOGEN INC	381,282	$106M	8.8%	$278.03	$264.98	+4.4%	COM	09062X103
INSM	INSMED INC	5,889,491	$100M	8.3%	$17.05 *	$17.79	+9.2%	COM	457669307
STAA	STAAR SURGICAL CO	1,347,322	$86.16M	7.1%	$63.95 *	$23.48	+177.9%	COM	852312305
PRTA	PROTHENA CORP PLC	1,663,777	$80.64M	6.7%	$48.47 *	$21.46	+146.2%	COM	G72800108
ACAD	ACADIA PHARMACEUTICALS INC	2,405,793	$45.28M	3.8%	$18.82	$28.41	-33.0%	COM	004225108
—	SAGE THERAPEUTICS INC	859,517	$36.07M	3.0%	$41.96	$46.62	—	COM	78667J108
EHTH	EHEALTH INC	2,689,379	$25.17M	2.1%	$9.36 *	$38.69	-79.7%	COM	28238P109
ALGN	ALIGN TECHNOLOGY INC	74,605	$24.93M	2.1%	$334.14 *	$149.18	+97.8%	COM	016255101
—	KARYOPHARM THERAPEUTICS INC	5,675,876	$22.08M	1.8%	$3.89	$16.36	—	COM	48576U106
ALKS	ALKERMES PLC	603,400	$17.01M	1.4%	$28.19 *	$22.36	+21.8%	COM	G01767105
SNDX	SYNDAX PHARMACEUTICALS INC	612,600	$12.94M	1.1%	$21.12 *	$16.84	+47.7%	COM	87164F105
—	PROVENTION BIO INC	390,800	$9.418M	0.8%	$24.10	$4.50	—	COM	74374N102
ANAB	ANAPTYSBIO INC	431,224	$9.383M	0.8%	$21.76 *	$19.06	+27.5%	COM	032724106
GOSS	GOSSAMER BIO INC	3,465,152	$4.366M	0.4%	$1.26 *	$2.02	-5.4%	COM	38341P102
CYTK	CYTOKINETICS INC	111,717	$3.931M	0.3%	$35.19 *	$6.71	+507.7%	COM	23282W605
TVTX	TRAVERE THERAPEUTICS INC	166,069	$3.735M	0.3%	$22.49 *	$23.56	-9.8%	COM	89422G107
VNDA	VANDA PHARMACEUTICALS INC	482,697	$3.278M	0.3%	$6.79 *	$11.21	-37.3%	COM	921659108
—	KEZAR LIFE SCIENCES INC	656,200	$2.054M	0.2%	$3.13	$5.16	—	COM	49372L100
NVCR	NOVOCURE LTD	32,790	$1.972M	0.2%	$60.14 *	$79.91	0.0%	COM	G6674U108
—	GRITSTONE ONCOLOGY INC	666,127	$1.852M	0.2%	$2.78	$9.42	—	COM	39868T105
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$1.597M	0.1%	$9.93 *	$7.10	-0.4%	COM	01438T106
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$1.554M	0.1%	$24.02 *	$15.56	+46.5%	COM	604749101
RLMD	RELMADA THERAPEUTICS INC	542,100	$1.225M	0.1%	$2.26 *	$3.45	0.0%	COM	75955J402
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$445K	0.0%	$16.42 *	$39.74	-65.0%	COM	87357P100
—	PEAK BIO INC	497,528	$314K	0.0%	$0.63	$4.06	—	COM	70470P108
URGN	UROGEN PHARMA LTD	24,500	$226K	0.0%	$9.24	$27.01	-65.9%	COM	M96088105