Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q1 2023 (← Previous) (Next →)

Filing Date: May 15, 2023

Total Value ($000): $1,207,102 (100.0% shares, 0.0% debt)

Holdings (30)

BMRN BIOMARIN PHARMACEUTICAL INC 14.8%

Value ($000) $178,050 Shares 1,831,035 Est. Cost $83.16 Unrealized +24.7%

— REVANCE THERAPEUTICS INC 14.1%

Value ($000) $169,753 Shares 5,270,209 Est. Cost $21.40 Unrealized —

UTHR UNITED THERAPEUTICS CORP 11.6%

Value ($000) $140,538 Shares 627,514 Est. Cost $89.23 Unrealized +176.3%

FOLD AMICUS THERAPEUTICS INC 9.7%

Value ($000) $116,711 Shares 10,524,022 Est. Cost $9.63 Unrealized +28.1%

BIIB BIOGEN INC 8.8%

Value ($000) $106,008 Shares 381,282 Est. Cost $264.98 Unrealized +4.4%

INSM INSMED INC 8.3%

Value ($000) $100,416 Shares 5,889,491 Est. Cost $17.79 Unrealized +9.2%

STAA STAAR SURGICAL CO 7.1%

Value ($000) $86,161 Shares 1,347,322 Est. Cost $23.48 Unrealized +177.9%

PRTA PROTHENA CORP PLC 6.7%

Value ($000) $80,643 Shares 1,663,777 Est. Cost $21.46 Unrealized +146.2%

ACAD ACADIA PHARMACEUTICALS INC 3.8%

Value ($000) $45,277 Shares 2,405,793 Est. Cost $28.41 Unrealized -33.0%

— SAGE THERAPEUTICS INC 3.0%

Value ($000) $36,065 Shares 859,517 Est. Cost $46.62 Unrealized —

EHTH EHEALTH INC 2.1%

Value ($000) $25,173 Shares 2,689,379 Est. Cost $38.69 Unrealized -79.7%

ALGN ALIGN TECHNOLOGY INC 2.1%

Value ($000) $24,929 Shares 74,605 Est. Cost $149.18 Unrealized +97.8%

— KARYOPHARM THERAPEUTICS INC 1.8%

Value ($000) $22,079 Shares 5,675,876 Est. Cost $16.36 Unrealized —

ALKS ALKERMES PLC 1.4%

Value ($000) $17,010 Shares 603,400 Est. Cost $22.36 Unrealized +21.8%

SNDX SYNDAX PHARMACEUTICALS INC 1.1%

Value ($000) $12,938 Shares 612,600 Est. Cost $16.84 Unrealized +47.7%

— PROVENTION BIO INC 0.8%

Value ($000) $9,418 Shares 390,800 Est. Cost $4.50 Unrealized —

ANAB ANAPTYSBIO INC 0.8%

Value ($000) $9,383 Shares 431,224 Est. Cost $19.06 Unrealized +27.5%

GOSS GOSSAMER BIO INC 0.4%

Value ($000) $4,366 Shares 3,465,152 Est. Cost $2.02 Unrealized -5.4%

CYTK CYTOKINETICS INC 0.3%

Value ($000) $3,931 Shares 111,717 Est. Cost $6.71 Unrealized +507.7%

TVTX TRAVERE THERAPEUTICS INC 0.3%

Value ($000) $3,735 Shares 166,069 Est. Cost $23.56 Unrealized -9.8%

VNDA VANDA PHARMACEUTICALS INC 0.3%

Value ($000) $3,278 Shares 482,697 Est. Cost $11.21 Unrealized -37.3%

— KEZAR LIFE SCIENCES INC 0.2%

Value ($000) $2,054 Shares 656,200 Est. Cost $5.16 Unrealized —

NVCR NOVOCURE LTD 0.2%

Value ($000) $1,972 Shares 32,790 Est. Cost $79.91 Unrealized 0.0%

— GRITSTONE ONCOLOGY INC 0.2%

Value ($000) $1,852 Shares 666,127 Est. Cost $9.42 Unrealized —

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value ($000) $1,597 Shares 160,800 Est. Cost $7.10 Unrealized -0.4%

MIRM MIRUM PHARMACEUTICALS INC 0.1%

Value ($000) $1,554 Shares 64,700 Est. Cost $15.56 Unrealized +46.5%

RLMD RELMADA THERAPEUTICS INC 0.1%

Value ($000) $1,225 Shares 542,100 Est. Cost $3.45 Unrealized 0.0%

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.0%

Value ($000) $445 Shares 27,100 Est. Cost $39.74 Unrealized -65.0%

— PEAK BIO INC 0.0%

Value ($000) $314 Shares 497,528 Est. Cost $4.06 Unrealized —

URGN UROGEN PHARMA LTD 0.0%

Value ($000) $226 Shares 24,500 Est. Cost $27.01 Unrealized -65.9%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	1,831,035	$178,050	14.8%	$83.16	+24.7%	COM	09061G101
—	REVANCE THERAPEUTICS INC	5,270,209	$169,753	14.1%	$21.40	—	COM	761330109
UTHR	UNITED THERAPEUTICS CORP	627,514	$140,538	11.6%	$89.23	+176.3%	COM	91307C102
FOLD	AMICUS THERAPEUTICS INC	10,524,022	$116,711	9.7%	$9.63	+28.1%	COM	03152W109
BIIB	BIOGEN INC	381,282	$106,008	8.8%	$264.98	+4.4%	COM	09062X103
INSM	INSMED INC	5,889,491	$100,416	8.3%	$17.79	+9.2%	COM	457669307
STAA	STAAR SURGICAL CO	1,347,322	$86,161	7.1%	$23.48	+177.9%	COM	852312305
PRTA	PROTHENA CORP PLC	1,663,777	$80,643	6.7%	$21.46	+146.2%	COM	G72800108
ACAD	ACADIA PHARMACEUTICALS INC	2,405,793	$45,277	3.8%	$28.41	-33.0%	COM	004225108
—	SAGE THERAPEUTICS INC	859,517	$36,065	3.0%	$46.62	—	COM	78667J108
EHTH	EHEALTH INC	2,689,379	$25,173	2.1%	$38.69	-79.7%	COM	28238P109
ALGN	ALIGN TECHNOLOGY INC	74,605	$24,929	2.1%	$149.18	+97.8%	COM	016255101
—	KARYOPHARM THERAPEUTICS INC	5,675,876	$22,079	1.8%	$16.36	—	COM	48576U106
ALKS	ALKERMES PLC	603,400	$17,010	1.4%	$22.36	+21.8%	COM	G01767105
SNDX	SYNDAX PHARMACEUTICALS INC	612,600	$12,938	1.1%	$16.84	+47.7%	COM	87164F105
—	PROVENTION BIO INC	390,800	$9,418	0.8%	$4.50	—	COM	74374N102
ANAB	ANAPTYSBIO INC	431,224	$9,383	0.8%	$19.06	+27.5%	COM	032724106
GOSS	GOSSAMER BIO INC	3,465,152	$4,366	0.4%	$2.02	-5.4%	COM	38341P102
CYTK	CYTOKINETICS INC	111,717	$3,931	0.3%	$6.71	+507.7%	COM	23282W605
TVTX	TRAVERE THERAPEUTICS INC	166,069	$3,735	0.3%	$23.56	-9.8%	COM	89422G107
VNDA	VANDA PHARMACEUTICALS INC	482,697	$3,278	0.3%	$11.21	-37.3%	COM	921659108
—	KEZAR LIFE SCIENCES INC	656,200	$2,054	0.2%	$5.16	—	COM	49372L100
NVCR	NOVOCURE LTD	32,790	$1,972	0.2%	$79.91	0.0%	COM	G6674U108
—	GRITSTONE ONCOLOGY INC	666,127	$1,852	0.2%	$9.42	—	COM	39868T105
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$1,597	0.1%	$7.10	-0.4%	COM	01438T106
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$1,554	0.1%	$15.56	+46.5%	COM	604749101
RLMD	RELMADA THERAPEUTICS INC	542,100	$1,225	0.1%	$3.45	0.0%	COM	75955J402
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$445	0.0%	$39.74	-65.0%	COM	87357P100
—	PEAK BIO INC	497,528	$314	0.0%	$4.06	—	COM	70470P108
URGN	UROGEN PHARMA LTD	24,500	$226	0.0%	$27.01	-65.9%	COM	M96088105