Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q2 2023 (← Previous) (Next →)

Filing Date: Aug 14, 2023

Total Value ($000): $1,237,802 (100.0% shares, 0.0% debt)

Holdings (30)

BMRN BIOMARIN PHARMACEUTICAL INC 12.8%

Value ($000) $158,714 Shares 1,831,035 Est. Cost $83.16 Unrealized +13.2%

UTHR UNITED THERAPEUTICS CORP 11.2%

Value ($000) $138,524 Shares 627,514 Est. Cost $89.23 Unrealized +148.2%

— REVANCE THERAPEUTICS INC 10.7%

Value ($000) $132,336 Shares 5,228,609 Est. Cost $21.40 Unrealized —

FOLD AMICUS THERAPEUTICS INC 10.7%

Value ($000) $132,182 Shares 10,524,022 Est. Cost $9.63 Unrealized +23.3%

INSM INSMED INC 10.0%

Value ($000) $124,268 Shares 5,889,491 Est. Cost $17.79 Unrealized +6.6%

PRTA PROTHENA CORP PLC 9.1%

Value ($000) $113,171 Shares 1,657,458 Est. Cost $21.46 Unrealized +200.6%

BIIB BIOGEN INC 8.8%

Value ($000) $108,608 Shares 381,282 Est. Cost $264.98 Unrealized +12.4%

STAA STAAR SURGICAL CO 5.8%

Value ($000) $72,274 Shares 1,374,822 Est. Cost $24.23 Unrealized +151.3%

ACAD ACADIA PHARMACEUTICALS INC 4.7%

Value ($000) $57,619 Shares 2,405,793 Est. Cost $28.41 Unrealized -21.8%

— SAGE THERAPEUTICS INC 3.3%

Value ($000) $40,414 Shares 859,517 Est. Cost $46.62 Unrealized —

ALGN ALIGN TECHNOLOGY INC 2.1%

Value ($000) $26,383 Shares 74,605 Est. Cost $149.18 Unrealized +113.5%

NVCR NOVOCURE LTD 1.9%

Value ($000) $23,992 Shares 578,118 Est. Cost $63.11 Unrealized -1.6%

EHTH EHEALTH INC 1.8%

Value ($000) $22,025 Shares 2,739,379 Est. Cost $38.13 Unrealized -79.0%

ALKS ALKERMES PLC 1.5%

Value ($000) $18,886 Shares 603,400 Est. Cost $22.36 Unrealized +35.4%

SNDX SYNDAX PHARMACEUTICALS INC 1.0%

Value ($000) $12,822 Shares 612,600 Est. Cost $16.84 Unrealized +23.7%

SRPT SAREPTA THERAPEUTICS INC 0.9%

Value ($000) $10,768 Shares 94,030 Est. Cost $128.81 Unrealized 0.0%

— KARYOPHARM THERAPEUTICS INC 0.8%

Value ($000) $10,160 Shares 5,675,876 Est. Cost $16.36 Unrealized —

ANAB ANAPTYSBIO INC 0.7%

Value ($000) $8,771 Shares 431,224 Est. Cost $19.06 Unrealized +6.4%

— NEVRO CORP 0.4%

Value ($000) $4,735 Shares 186,259 Est. Cost $25.42 Unrealized —

GOSS GOSSAMER BIO INC 0.3%

Value ($000) $4,158 Shares 3,465,152 Est. Cost $2.02 Unrealized -38.4%

CYTK CYTOKINETICS INC 0.3%

Value ($000) $3,644 Shares 111,717 Est. Cost $6.71 Unrealized +451.1%

TVTX TRAVERE THERAPEUTICS INC 0.2%

Value ($000) $2,551 Shares 166,069 Est. Cost $23.56 Unrealized -22.8%

VNDA VANDA PHARMACEUTICALS INC 0.2%

Value ($000) $2,136 Shares 324,073 Est. Cost $11.21 Unrealized -42.8%

RLMD RELMADA THERAPEUTICS INC 0.1%

Value ($000) $1,802 Shares 732,400 Est. Cost $3.27 Unrealized -15.5%

MIRM MIRUM PHARMACEUTICALS INC 0.1%

Value ($000) $1,674 Shares 64,700 Est. Cost $15.56 Unrealized +71.0%

— KEZAR LIFE SCIENCES INC 0.1%

Value ($000) $1,608 Shares 656,200 Est. Cost $5.16 Unrealized —

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value ($000) $1,349 Shares 160,800 Est. Cost $7.10 Unrealized +38.8%

— GRITSTONE ONCOLOGY INC 0.1%

Value ($000) $1,299 Shares 666,127 Est. Cost $9.42 Unrealized —

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.1%

Value ($000) $676 Shares 27,100 Est. Cost $39.74 Unrealized -47.7%

URGN UROGEN PHARMA LTD 0.0%

Value ($000) $254 Shares 24,500 Est. Cost $27.01 Unrealized -59.2%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	1,831,035	$158,714	12.8%	$83.16	+13.2%	COM	09061G101
UTHR	UNITED THERAPEUTICS CORP	627,514	$138,524	11.2%	$89.23	+148.2%	COM	91307C102
—	REVANCE THERAPEUTICS INC	5,228,609	$132,336	10.7%	$21.40	—	COM	761330109
FOLD	AMICUS THERAPEUTICS INC	10,524,022	$132,182	10.7%	$9.63	+23.3%	COM	03152W109
INSM	INSMED INC	5,889,491	$124,268	10.0%	$17.79	+6.6%	COM	457669307
PRTA	PROTHENA CORP PLC	1,657,458	$113,171	9.1%	$21.46	+200.6%	COM	G72800108
BIIB	BIOGEN INC	381,282	$108,608	8.8%	$264.98	+12.4%	COM	09062X103
STAA	STAAR SURGICAL CO	1,374,822	$72,274	5.8%	$24.23	+151.3%	COM	852312305
ACAD	ACADIA PHARMACEUTICALS INC	2,405,793	$57,619	4.7%	$28.41	-21.8%	COM	004225108
—	SAGE THERAPEUTICS INC	859,517	$40,414	3.3%	$46.62	—	COM	78667J108
ALGN	ALIGN TECHNOLOGY INC	74,605	$26,383	2.1%	$149.18	+113.5%	COM	016255101
NVCR	NOVOCURE LTD	578,118	$23,992	1.9%	$63.11	-1.6%	COM	G6674U108
EHTH	EHEALTH INC	2,739,379	$22,025	1.8%	$38.13	-79.0%	COM	28238P109
ALKS	ALKERMES PLC	603,400	$18,886	1.5%	$22.36	+35.4%	COM	G01767105
SNDX	SYNDAX PHARMACEUTICALS INC	612,600	$12,822	1.0%	$16.84	+23.7%	COM	87164F105
SRPT	SAREPTA THERAPEUTICS INC	94,030	$10,768	0.9%	$128.81	0.0%	COM	803607100
—	KARYOPHARM THERAPEUTICS INC	5,675,876	$10,160	0.8%	$16.36	—	COM	48576U106
ANAB	ANAPTYSBIO INC	431,224	$8,771	0.7%	$19.06	+6.4%	COM	032724106
—	NEVRO CORP	186,259	$4,735	0.4%	$25.42	—	COM	64157F103
GOSS	GOSSAMER BIO INC	3,465,152	$4,158	0.3%	$2.02	-38.4%	COM	38341P102
CYTK	CYTOKINETICS INC	111,717	$3,644	0.3%	$6.71	+451.1%	COM	23282W605
TVTX	TRAVERE THERAPEUTICS INC	166,069	$2,551	0.2%	$23.56	-22.8%	COM	89422G107
VNDA	VANDA PHARMACEUTICALS INC	324,073	$2,136	0.2%	$11.21	-42.8%	COM	921659108
RLMD	RELMADA THERAPEUTICS INC	732,400	$1,802	0.1%	$3.27	-15.5%	COM	75955J402
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$1,674	0.1%	$15.56	+71.0%	COM	604749101
—	KEZAR LIFE SCIENCES INC	656,200	$1,608	0.1%	$5.16	—	COM	49372L100
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$1,349	0.1%	$7.10	+38.8%	COM	01438T106
—	GRITSTONE ONCOLOGY INC	666,127	$1,299	0.1%	$9.42	—	COM	39868T105
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$676	0.1%	$39.74	-47.7%	COM	87357P100
URGN	UROGEN PHARMA LTD	24,500	$254	0.0%	$27.01	-59.2%	COM	M96088105