Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q2 2023 (← Previous) (Next →)

Filing Date: Aug 14, 2023

Total Value: $1.238B (100.0% shares, 0.0% debt)

Holdings (30)

BMRN BIOMARIN PHARMACEUTICAL INC 12.8%

Value $159M Shares 1,831,035 Share Price $86.68 * Est. Cost/Share $83.16 Unrealized @ Report Date +13.2%

UTHR UNITED THERAPEUTICS CORP 11.2%

Value $139M Shares 627,514 Share Price $220.75 Est. Cost/Share $89.23 Unrealized @ Report Date +148.2%

— REVANCE THERAPEUTICS INC 10.7%

Value $132M Shares 5,228,609 Share Price $25.31 Est. Cost/Share $21.40 Unrealized @ Report Date —

FOLD AMICUS THERAPEUTICS INC 10.7%

Value $132M Shares 10,524,022 Share Price $12.56 * Est. Cost/Share $9.63 Unrealized @ Report Date +23.3%

INSM INSMED INC 10.0%

Value $124M Shares 5,889,491 Share Price $21.10 * Est. Cost/Share $17.79 Unrealized @ Report Date +6.6%

PRTA PROTHENA CORP PLC 9.1%

Value $113M Shares 1,657,458 Share Price $68.28 * Est. Cost/Share $21.46 Unrealized @ Report Date +200.6%

BIIB BIOGEN INC 8.8%

Value $109M Shares 381,282 Share Price $284.85 * Est. Cost/Share $264.98 Unrealized @ Report Date +12.4%

STAA STAAR SURGICAL CO 5.8%

Value $72.27M Shares 1,374,822 Share Price $52.57 * Est. Cost/Share $24.23 Unrealized @ Report Date +151.3%

ACAD ACADIA PHARMACEUTICALS INC 4.7%

Value $57.62M Shares 2,405,793 Share Price $23.95 * Est. Cost/Share $28.41 Unrealized @ Report Date -21.8%

— SAGE THERAPEUTICS INC 3.3%

Value $40.41M Shares 859,517 Share Price $47.02 Est. Cost/Share $46.62 Unrealized @ Report Date —

ALGN ALIGN TECHNOLOGY INC 2.1%

Value $26.38M Shares 74,605 Share Price $353.64 * Est. Cost/Share $149.18 Unrealized @ Report Date +113.5%

NVCR NOVOCURE LTD 1.9%

Value $23.99M Shares 578,118 Share Price $41.50 * Est. Cost/Share $63.11 Unrealized @ Report Date -1.6%

EHTH EHEALTH INC 1.8%

Value $22.02M Shares 2,739,379 Share Price $8.04 Est. Cost/Share $38.13 Unrealized @ Report Date -79.0%

ALKS ALKERMES PLC 1.5%

Value $18.89M Shares 603,400 Share Price $31.30 * Est. Cost/Share $22.36 Unrealized @ Report Date +35.4%

SNDX SYNDAX PHARMACEUTICALS INC 1.0%

Value $12.82M Shares 612,600 Share Price $20.93 Est. Cost/Share $16.84 Unrealized @ Report Date +23.7%

SRPT SAREPTA THERAPEUTICS INC 0.9%

Value $10.77M Shares 94,030 Share Price $114.52 * Est. Cost/Share $128.81 Unrealized @ Report Date 0.0%

— KARYOPHARM THERAPEUTICS INC 0.8%

Value $10.16M Shares 5,675,876 Share Price $1.79 Est. Cost/Share $16.36 Unrealized @ Report Date —

ANAB ANAPTYSBIO INC 0.7%

Value $8.771M Shares 431,224 Share Price $20.34 Est. Cost/Share $19.06 Unrealized @ Report Date +6.4%

— NEVRO CORP 0.4%

Value $4.735M Shares 186,259 Share Price $25.42 Est. Cost/Share $25.42 Unrealized @ Report Date —

GOSS GOSSAMER BIO INC 0.3%

Value $4.158M Shares 3,465,152 Share Price $1.20 Est. Cost/Share $2.02 Unrealized @ Report Date -38.4%

CYTK CYTOKINETICS INC 0.3%

Value $3.644M Shares 111,717 Share Price $32.62 * Est. Cost/Share $6.71 Unrealized @ Report Date +451.1%

TVTX TRAVERE THERAPEUTICS INC 0.2%

Value $2.551M Shares 166,069 Share Price $15.36 * Est. Cost/Share $23.56 Unrealized @ Report Date -22.8%

VNDA VANDA PHARMACEUTICALS INC 0.2%

Value $2.136M Shares 324,073 Share Price $6.59 * Est. Cost/Share $11.21 Unrealized @ Report Date -42.8%

RLMD RELMADA THERAPEUTICS INC 0.1%

Value $1.802M Shares 732,400 Share Price $2.46 * Est. Cost/Share $3.27 Unrealized @ Report Date -15.5%

MIRM MIRUM PHARMACEUTICALS INC 0.1%

Value $1.674M Shares 64,700 Share Price $25.87 * Est. Cost/Share $15.56 Unrealized @ Report Date +71.0%

— KEZAR LIFE SCIENCES INC 0.1%

Value $1.608M Shares 656,200 Share Price $2.45 Est. Cost/Share $5.16 Unrealized @ Report Date —

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value $1.349M Shares 160,800 Share Price $8.39 * Est. Cost/Share $7.10 Unrealized @ Report Date +38.8%

— GRITSTONE ONCOLOGY INC 0.1%

Value $1.299M Shares 666,127 Share Price $1.95 Est. Cost/Share $9.42 Unrealized @ Report Date —

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.1%

Value $676K Shares 27,100 Share Price $24.93 * Est. Cost/Share $39.74 Unrealized @ Report Date -47.7%

URGN UROGEN PHARMA LTD 0.0%

Value $254K Shares 24,500 Share Price $10.35 * Est. Cost/Share $27.01 Unrealized @ Report Date -59.2%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	1,831,035	$159M	12.8%	$86.68 *	$83.16	+13.2%	COM	09061G101
UTHR	UNITED THERAPEUTICS CORP	627,514	$139M	11.2%	$220.75	$89.23	+148.2%	COM	91307C102
—	REVANCE THERAPEUTICS INC	5,228,609	$132M	10.7%	$25.31	$21.40	—	COM	761330109
FOLD	AMICUS THERAPEUTICS INC	10,524,022	$132M	10.7%	$12.56 *	$9.63	+23.3%	COM	03152W109
INSM	INSMED INC	5,889,491	$124M	10.0%	$21.10 *	$17.79	+6.6%	COM	457669307
PRTA	PROTHENA CORP PLC	1,657,458	$113M	9.1%	$68.28 *	$21.46	+200.6%	COM	G72800108
BIIB	BIOGEN INC	381,282	$109M	8.8%	$284.85 *	$264.98	+12.4%	COM	09062X103
STAA	STAAR SURGICAL CO	1,374,822	$72.27M	5.8%	$52.57 *	$24.23	+151.3%	COM	852312305
ACAD	ACADIA PHARMACEUTICALS INC	2,405,793	$57.62M	4.7%	$23.95 *	$28.41	-21.8%	COM	004225108
—	SAGE THERAPEUTICS INC	859,517	$40.41M	3.3%	$47.02	$46.62	—	COM	78667J108
ALGN	ALIGN TECHNOLOGY INC	74,605	$26.38M	2.1%	$353.64 *	$149.18	+113.5%	COM	016255101
NVCR	NOVOCURE LTD	578,118	$23.99M	1.9%	$41.50 *	$63.11	-1.6%	COM	G6674U108
EHTH	EHEALTH INC	2,739,379	$22.02M	1.8%	$8.04	$38.13	-79.0%	COM	28238P109
ALKS	ALKERMES PLC	603,400	$18.89M	1.5%	$31.30 *	$22.36	+35.4%	COM	G01767105
SNDX	SYNDAX PHARMACEUTICALS INC	612,600	$12.82M	1.0%	$20.93	$16.84	+23.7%	COM	87164F105
SRPT	SAREPTA THERAPEUTICS INC	94,030	$10.77M	0.9%	$114.52 *	$128.81	0.0%	COM	803607100
—	KARYOPHARM THERAPEUTICS INC	5,675,876	$10.16M	0.8%	$1.79	$16.36	—	COM	48576U106
ANAB	ANAPTYSBIO INC	431,224	$8.771M	0.7%	$20.34	$19.06	+6.4%	COM	032724106
—	NEVRO CORP	186,259	$4.735M	0.4%	$25.42	$25.42	—	COM	64157F103
GOSS	GOSSAMER BIO INC	3,465,152	$4.158M	0.3%	$1.20	$2.02	-38.4%	COM	38341P102
CYTK	CYTOKINETICS INC	111,717	$3.644M	0.3%	$32.62 *	$6.71	+451.1%	COM	23282W605
TVTX	TRAVERE THERAPEUTICS INC	166,069	$2.551M	0.2%	$15.36 *	$23.56	-22.8%	COM	89422G107
VNDA	VANDA PHARMACEUTICALS INC	324,073	$2.136M	0.2%	$6.59 *	$11.21	-42.8%	COM	921659108
RLMD	RELMADA THERAPEUTICS INC	732,400	$1.802M	0.1%	$2.46 *	$3.27	-15.5%	COM	75955J402
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$1.674M	0.1%	$25.87 *	$15.56	+71.0%	COM	604749101
—	KEZAR LIFE SCIENCES INC	656,200	$1.608M	0.1%	$2.45	$5.16	—	COM	49372L100
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$1.349M	0.1%	$8.39 *	$7.10	+38.8%	COM	01438T106
—	GRITSTONE ONCOLOGY INC	666,127	$1.299M	0.1%	$1.95	$9.42	—	COM	39868T105
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$676K	0.1%	$24.93 *	$39.74	-47.7%	COM	87357P100
URGN	UROGEN PHARMA LTD	24,500	$254K	0.0%	$10.35 *	$27.01	-59.2%	COM	M96088105