Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q3 2023 (← Previous) (Next →)

Filing Date: Nov 14, 2023

Total Value: $1.057B (100.0% shares, 0.0% debt)

Holdings (29)

BMRN BIOMARIN PHARMACEUTICAL INC 15.3%

Value $162M Shares 1,831,035 Est. Cost $83.16 Unrealized +7.0%

INSM INSMED INC 14.1%

Value $149M Shares 5,889,491 Est. Cost $17.79 Unrealized +28.5%

UTHR UNITED THERAPEUTICS CORP 12.3%

Value $130M Shares 575,907 Est. Cost $89.23 Unrealized +158.1%

FOLD AMICUS THERAPEUTICS INC 12.1%

Value $128M Shares 10,524,022 Est. Cost $9.63 Unrealized +34.0%

BIIB BIOGEN INC 9.3%

Value $97.99M Shares 381,282 Est. Cost $264.98 Unrealized +0.9%

PRTA PROTHENA CORP PLC 7.6%

Value $79.97M Shares 1,657,458 Est. Cost $21.46 Unrealized +176.9%

— REVANCE THERAPEUTICS INC 5.7%

Value $59.97M Shares 5,228,609 Est. Cost $21.40 Unrealized —

STAA STAAR SURGICAL CO 5.2%

Value $55.24M Shares 1,374,822 Est. Cost $24.23 Unrealized +93.3%

ACAD ACADIA PHARMACEUTICALS INC 4.7%

Value $50.14M Shares 2,405,793 Est. Cost $28.41 Unrealized -4.4%

— SAGE THERAPEUTICS INC 2.0%

Value $20.7M Shares 1,005,776 Est. Cost $42.84 Unrealized —

EHTH EHEALTH INC 1.9%

Value $20.27M Shares 2,739,379 Est. Cost $38.13 Unrealized -79.4%

ALGN ALIGN TECHNOLOGY INC 1.6%

Value $17.01M Shares 55,705 Est. Cost $149.18 Unrealized +131.6%

ALKS ALKERMES PLC 1.6%

Value $16.9M Shares 603,400 Est. Cost $22.36 Unrealized +31.1%

SRPT SAREPTA THERAPEUTICS INC 1.1%

Value $11.4M Shares 94,030 Est. Cost $128.81 Unrealized -12.3%

NVCR NOVOCURE LTD 1.0%

Value $10.66M Shares 660,275 Est. Cost $58.84 Unrealized -51.0%

ANAB ANAPTYSBIO INC 0.7%

Value $7.745M Shares 431,224 Est. Cost $19.06 Unrealized +0.1%

— KARYOPHARM THERAPEUTICS INC 0.7%

Value $7.606M Shares 5,675,876 Est. Cost $16.36 Unrealized —

— NEVRO CORP 0.7%

Value $7.435M Shares 386,832 Est. Cost $22.21 Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC 0.6%

Value $6.862M Shares 472,600 Est. Cost $16.84 Unrealized +12.3%

GOSS GOSSAMER BIO INC 0.5%

Value $5.438M Shares 6,530,288 Est. Cost $1.61 Unrealized -28.6%

CYTK CYTOKINETICS INC 0.3%

Value $3.291M Shares 111,717 Est. Cost $6.71 Unrealized +396.1%

RLMD RELMADA THERAPEUTICS INC 0.2%

Value $2.197M Shares 732,400 Est. Cost $3.27 Unrealized -9.2%

MIRM MIRUM PHARMACEUTICALS INC 0.2%

Value $2.045M Shares 64,700 Est. Cost $15.56 Unrealized +76.0%

TVTX TRAVERE THERAPEUTICS INC 0.1%

Value $1.485M Shares 166,069 Est. Cost $23.56 Unrealized -40.1%

VNDA VANDA PHARMACEUTICALS INC 0.1%

Value $1.205M Shares 278,985 Est. Cost $11.21 Unrealized -50.5%

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value $1.074M Shares 160,800 Est. Cost $7.10 Unrealized +4.6%

— KEZAR LIFE SCIENCES INC 0.1%

Value $781K Shares 656,200 Est. Cost $5.16 Unrealized —

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.0%

Value $381K Shares 27,100 Est. Cost $39.74 Unrealized -50.7%

URGN UROGEN PHARMA LTD 0.0%

Value $343K Shares 24,500 Est. Cost $27.01 Unrealized -40.6%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	1,831,035	$162M	15.3%	$83.16	+7.0%	COM	09061G101
INSM	INSMED INC	5,889,491	$149M	14.1%	$17.79	+28.5%	COM	457669307
UTHR	UNITED THERAPEUTICS CORP	575,907	$130M	12.3%	$89.23	+158.1%	COM	91307C102
FOLD	AMICUS THERAPEUTICS INC	10,524,022	$128M	12.1%	$9.63	+34.0%	COM	03152W109
BIIB	BIOGEN INC	381,282	$97.99M	9.3%	$264.98	+0.9%	COM	09062X103
PRTA	PROTHENA CORP PLC	1,657,458	$79.97M	7.6%	$21.46	+176.9%	COM	G72800108
—	REVANCE THERAPEUTICS INC	5,228,609	$59.97M	5.7%	$21.40	—	COM	761330109
STAA	STAAR SURGICAL CO	1,374,822	$55.24M	5.2%	$24.23	+93.3%	COM	852312305
ACAD	ACADIA PHARMACEUTICALS INC	2,405,793	$50.14M	4.7%	$28.41	-4.4%	COM	004225108
—	SAGE THERAPEUTICS INC	1,005,776	$20.7M	2.0%	$42.84	—	COM	78667J108
EHTH	EHEALTH INC	2,739,379	$20.27M	1.9%	$38.13	-79.4%	COM	28238P109
ALGN	ALIGN TECHNOLOGY INC	55,705	$17.01M	1.6%	$149.18	+131.6%	COM	016255101
ALKS	ALKERMES PLC	603,400	$16.9M	1.6%	$22.36	+31.1%	COM	G01767105
SRPT	SAREPTA THERAPEUTICS INC	94,030	$11.4M	1.1%	$128.81	-12.3%	COM	803607100
NVCR	NOVOCURE LTD	660,275	$10.66M	1.0%	$58.84	-51.0%	COM	G6674U108
ANAB	ANAPTYSBIO INC	431,224	$7.745M	0.7%	$19.06	+0.1%	COM	032724106
—	KARYOPHARM THERAPEUTICS INC	5,675,876	$7.606M	0.7%	$16.36	—	COM	48576U106
—	NEVRO CORP	386,832	$7.435M	0.7%	$22.21	—	COM	64157F103
SNDX	SYNDAX PHARMACEUTICALS INC	472,600	$6.862M	0.6%	$16.84	+12.3%	COM	87164F105
GOSS	GOSSAMER BIO INC	6,530,288	$5.438M	0.5%	$1.61	-28.6%	COM	38341P102
CYTK	CYTOKINETICS INC	111,717	$3.291M	0.3%	$6.71	+396.1%	COM	23282W605
RLMD	RELMADA THERAPEUTICS INC	732,400	$2.197M	0.2%	$3.27	-9.2%	COM	75955J402
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$2.045M	0.2%	$15.56	+76.0%	COM	604749101
TVTX	TRAVERE THERAPEUTICS INC	166,069	$1.485M	0.1%	$23.56	-40.1%	COM	89422G107
VNDA	VANDA PHARMACEUTICALS INC	278,985	$1.205M	0.1%	$11.21	-50.5%	COM	921659108
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$1.074M	0.1%	$7.10	+4.6%	COM	01438T106
—	KEZAR LIFE SCIENCES INC	656,200	$781K	0.1%	$5.16	—	COM	49372L100
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$381K	0.0%	$39.74	-50.7%	COM	87357P100
URGN	UROGEN PHARMA LTD	24,500	$343K	0.0%	$27.01	-40.6%	COM	M96088105