Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q3 2023 (← Previous) (Next →)

Filing Date: Nov 14, 2023

Total Value: $1.057B (100.0% shares, 0.0% debt)

Holdings (29)

BMRN BIOMARIN PHARMACEUTICAL INC 15.3%

Value $162M Shares 1,831,035 Share Price $88.48 Est. Cost/Share $83.16 Unrealized @ Report Date +7.0%

INSM INSMED INC 14.1%

Value $149M Shares 5,889,491 Share Price $25.25 * Est. Cost/Share $17.79 Unrealized @ Report Date +28.5%

UTHR UNITED THERAPEUTICS CORP 12.3%

Value $130M Shares 575,907 Share Price $225.87 Est. Cost/Share $89.23 Unrealized @ Report Date +158.1%

FOLD AMICUS THERAPEUTICS INC 12.1%

Value $128M Shares 10,524,022 Share Price $12.16 * Est. Cost/Share $9.63 Unrealized @ Report Date +34.0%

BIIB BIOGEN INC 9.3%

Value $97.99M Shares 381,282 Share Price $257.01 * Est. Cost/Share $264.98 Unrealized @ Report Date +0.9%

PRTA PROTHENA CORP PLC 7.6%

Value $79.97M Shares 1,657,458 Share Price $48.25 * Est. Cost/Share $21.46 Unrealized @ Report Date +176.9%

— REVANCE THERAPEUTICS INC 5.7%

Value $59.97M Shares 5,228,609 Share Price $11.47 Est. Cost/Share $21.40 Unrealized @ Report Date —

STAA STAAR SURGICAL CO 5.2%

Value $55.24M Shares 1,374,822 Share Price $40.18 * Est. Cost/Share $24.23 Unrealized @ Report Date +93.3%

ACAD ACADIA PHARMACEUTICALS INC 4.7%

Value $50.14M Shares 2,405,793 Share Price $20.84 * Est. Cost/Share $28.41 Unrealized @ Report Date -4.4%

— SAGE THERAPEUTICS INC 2.0%

Value $20.7M Shares 1,005,776 Share Price $20.58 Est. Cost/Share $42.84 Unrealized @ Report Date —

EHTH EHEALTH INC 1.9%

Value $20.27M Shares 2,739,379 Share Price $7.40 * Est. Cost/Share $38.13 Unrealized @ Report Date -79.4%

ALGN ALIGN TECHNOLOGY INC 1.6%

Value $17.01M Shares 55,705 Share Price $305.32 * Est. Cost/Share $149.18 Unrealized @ Report Date +131.6%

ALKS ALKERMES PLC 1.6%

Value $16.9M Shares 603,400 Share Price $28.01 * Est. Cost/Share $22.36 Unrealized @ Report Date +31.1%

SRPT SAREPTA THERAPEUTICS INC 1.1%

Value $11.4M Shares 94,030 Share Price $121.22 * Est. Cost/Share $128.81 Unrealized @ Report Date -12.3%

NVCR NOVOCURE LTD 1.0%

Value $10.66M Shares 660,275 Share Price $16.15 * Est. Cost/Share $58.84 Unrealized @ Report Date -51.0%

ANAB ANAPTYSBIO INC 0.7%

Value $7.745M Shares 431,224 Share Price $17.96 * Est. Cost/Share $19.06 Unrealized @ Report Date +0.1%

— KARYOPHARM THERAPEUTICS INC 0.7%

Value $7.606M Shares 5,675,876 Share Price $1.34 Est. Cost/Share $16.36 Unrealized @ Report Date —

— NEVRO CORP 0.7%

Value $7.435M Shares 386,832 Share Price $19.22 Est. Cost/Share $22.21 Unrealized @ Report Date —

SNDX SYNDAX PHARMACEUTICALS INC 0.6%

Value $6.862M Shares 472,600 Share Price $14.52 * Est. Cost/Share $16.84 Unrealized @ Report Date +12.3%

GOSS GOSSAMER BIO INC 0.5%

Value $5.438M Shares 6,530,288 Share Price $0.83 * Est. Cost/Share $1.61 Unrealized @ Report Date -28.6%

CYTK CYTOKINETICS INC 0.3%

Value $3.291M Shares 111,717 Share Price $29.46 * Est. Cost/Share $6.71 Unrealized @ Report Date +396.1%

RLMD RELMADA THERAPEUTICS INC 0.2%

Value $2.197M Shares 732,400 Share Price $3.00 Est. Cost/Share $3.27 Unrealized @ Report Date -9.2%

MIRM MIRUM PHARMACEUTICALS INC 0.2%

Value $2.045M Shares 64,700 Share Price $31.60 * Est. Cost/Share $15.56 Unrealized @ Report Date +76.0%

TVTX TRAVERE THERAPEUTICS INC 0.1%

Value $1.485M Shares 166,069 Share Price $8.94 * Est. Cost/Share $23.56 Unrealized @ Report Date -40.1%

VNDA VANDA PHARMACEUTICALS INC 0.1%

Value $1.205M Shares 278,985 Share Price $4.32 * Est. Cost/Share $11.21 Unrealized @ Report Date -50.5%

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value $1.074M Shares 160,800 Share Price $6.68 * Est. Cost/Share $7.10 Unrealized @ Report Date +4.6%

— KEZAR LIFE SCIENCES INC 0.1%

Value $781K Shares 656,200 Share Price $1.19 Est. Cost/Share $5.16 Unrealized @ Report Date —

TCMD TACTILE SYSTEMS TECHNOLOGY I 0.0%

Value $381K Shares 27,100 Share Price $14.05 * Est. Cost/Share $39.74 Unrealized @ Report Date -50.7%

URGN UROGEN PHARMA LTD 0.0%

Value $343K Shares 24,500 Share Price $14.01 * Est. Cost/Share $27.01 Unrealized @ Report Date -40.6%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	1,831,035	$162M	15.3%	$88.48	$83.16	+7.0%	COM	09061G101
INSM	INSMED INC	5,889,491	$149M	14.1%	$25.25 *	$17.79	+28.5%	COM	457669307
UTHR	UNITED THERAPEUTICS CORP	575,907	$130M	12.3%	$225.87	$89.23	+158.1%	COM	91307C102
FOLD	AMICUS THERAPEUTICS INC	10,524,022	$128M	12.1%	$12.16 *	$9.63	+34.0%	COM	03152W109
BIIB	BIOGEN INC	381,282	$97.99M	9.3%	$257.01 *	$264.98	+0.9%	COM	09062X103
PRTA	PROTHENA CORP PLC	1,657,458	$79.97M	7.6%	$48.25 *	$21.46	+176.9%	COM	G72800108
—	REVANCE THERAPEUTICS INC	5,228,609	$59.97M	5.7%	$11.47	$21.40	—	COM	761330109
STAA	STAAR SURGICAL CO	1,374,822	$55.24M	5.2%	$40.18 *	$24.23	+93.3%	COM	852312305
ACAD	ACADIA PHARMACEUTICALS INC	2,405,793	$50.14M	4.7%	$20.84 *	$28.41	-4.4%	COM	004225108
—	SAGE THERAPEUTICS INC	1,005,776	$20.7M	2.0%	$20.58	$42.84	—	COM	78667J108
EHTH	EHEALTH INC	2,739,379	$20.27M	1.9%	$7.40 *	$38.13	-79.4%	COM	28238P109
ALGN	ALIGN TECHNOLOGY INC	55,705	$17.01M	1.6%	$305.32 *	$149.18	+131.6%	COM	016255101
ALKS	ALKERMES PLC	603,400	$16.9M	1.6%	$28.01 *	$22.36	+31.1%	COM	G01767105
SRPT	SAREPTA THERAPEUTICS INC	94,030	$11.4M	1.1%	$121.22 *	$128.81	-12.3%	COM	803607100
NVCR	NOVOCURE LTD	660,275	$10.66M	1.0%	$16.15 *	$58.84	-51.0%	COM	G6674U108
ANAB	ANAPTYSBIO INC	431,224	$7.745M	0.7%	$17.96 *	$19.06	+0.1%	COM	032724106
—	KARYOPHARM THERAPEUTICS INC	5,675,876	$7.606M	0.7%	$1.34	$16.36	—	COM	48576U106
—	NEVRO CORP	386,832	$7.435M	0.7%	$19.22	$22.21	—	COM	64157F103
SNDX	SYNDAX PHARMACEUTICALS INC	472,600	$6.862M	0.6%	$14.52 *	$16.84	+12.3%	COM	87164F105
GOSS	GOSSAMER BIO INC	6,530,288	$5.438M	0.5%	$0.83 *	$1.61	-28.6%	COM	38341P102
CYTK	CYTOKINETICS INC	111,717	$3.291M	0.3%	$29.46 *	$6.71	+396.1%	COM	23282W605
RLMD	RELMADA THERAPEUTICS INC	732,400	$2.197M	0.2%	$3.00	$3.27	-9.2%	COM	75955J402
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$2.045M	0.2%	$31.60 *	$15.56	+76.0%	COM	604749101
TVTX	TRAVERE THERAPEUTICS INC	166,069	$1.485M	0.1%	$8.94 *	$23.56	-40.1%	COM	89422G107
VNDA	VANDA PHARMACEUTICALS INC	278,985	$1.205M	0.1%	$4.32 *	$11.21	-50.5%	COM	921659108
ALDX	ALDEYRA THERAPEUTICS INC	160,800	$1.074M	0.1%	$6.68 *	$7.10	+4.6%	COM	01438T106
—	KEZAR LIFE SCIENCES INC	656,200	$781K	0.1%	$1.19	$5.16	—	COM	49372L100
TCMD	TACTILE SYSTEMS TECHNOLOGY I	27,100	$381K	0.0%	$14.05 *	$39.74	-50.7%	COM	87357P100
URGN	UROGEN PHARMA LTD	24,500	$343K	0.0%	$14.01 *	$27.01	-40.6%	COM	M96088105