Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q4 2023 (← Previous) (Next →)

Filing Date: Feb 15, 2024

Total Value: $1.11B (100.0% shares, 0.0% debt)

Holdings (34)

INSM INSMED INC 15.4%

Value $171M Shares 5,511,721 Share Price $30.99 * Est. Cost/Share $17.79 Unrealized @ Report Date +45.8%

FOLD AMICUS THERAPEUTICS INC 13.3%

Value $147M Shares 10,373,715 Share Price $14.19 * Est. Cost/Share $9.63 Unrealized @ Report Date +18.0%

BMRN BIOMARIN PHARMACEUTICAL INC 13.0%

Value $145M Shares 1,500,749 Share Price $96.42 * Est. Cost/Share $83.16 Unrealized @ Report Date +6.4%

BIIB BIOGEN INC 8.9%

Value $98.44M Shares 380,417 Share Price $258.77 * Est. Cost/Share $264.98 Unrealized @ Report Date -7.3%

UTHR UNITED THERAPEUTICS CORP 7.8%

Value $87.03M Shares 395,784 Share Price $219.89 * Est. Cost/Share $89.23 Unrealized @ Report Date +158.3%

ACAD ACADIA PHARMACEUTICALS INC 6.8%

Value $75.44M Shares 2,409,556 Share Price $31.31 * Est. Cost/Share $28.41 Unrealized @ Report Date -15.9%

PRTA PROTHENA CORP PLC 5.4%

Value $60.33M Shares 1,660,057 Share Price $36.34 * Est. Cost/Share $21.46 Unrealized @ Report Date +79.4%

— REVANCE THERAPEUTICS INC 4.1%

Value $46.04M Shares 5,237,284 Share Price $8.79 Est. Cost/Share $21.40 Unrealized @ Report Date —

STAA STAAR SURGICAL CO 3.9%

Value $42.97M Shares 1,376,950 Share Price $31.21 * Est. Cost/Share $24.23 Unrealized @ Report Date +48.3%

ALNY ALNYLAM PHARMACEUTICALS INC 2.7%

Value $29.56M Shares 154,437 Share Price $191.41 * Est. Cost/Share $170.34 Unrealized @ Report Date 0.0%

EHTH EHEALTH INC 2.2%

Value $23.89M Shares 2,739,379 Share Price $8.72 * Est. Cost/Share $38.13 Unrealized @ Report Date -78.6%

— SAGE THERAPEUTICS INC 1.9%

Value $21.49M Shares 991,525 Share Price $21.67 Est. Cost/Share $42.84 Unrealized @ Report Date —

SRPT SAREPTA THERAPEUTICS INC 1.7%

Value $19.37M Shares 200,905 Share Price $96.43 Est. Cost/Share $111.32 Unrealized @ Report Date -13.8%

IOVA IOVANCE BIOTHERAPEUTICS INC 1.5%

Value $17.13M Shares 2,106,792 Share Price $8.13 * Est. Cost/Share $5.23 Unrealized @ Report Date 0.0%

ALKS ALKERMES PLC 1.5%

Value $16.74M Shares 603,400 Share Price $27.74 * Est. Cost/Share $22.36 Unrealized @ Report Date +16.2%

— NEVRO CORP 1.5%

Value $16.15M Shares 750,371 Share Price $21.52 Est. Cost/Share $21.87 Unrealized @ Report Date —

ALGN ALIGN TECHNOLOGY INC 1.4%

Value $15.26M Shares 55,705 Share Price $274.00 * Est. Cost/Share $149.18 Unrealized @ Report Date +58.9%

ANAB ANAPTYSBIO INC 1.3%

Value $14.71M Shares 686,882 Share Price $21.42 * Est. Cost/Share $18.38 Unrealized @ Report Date -6.2%

SNDX SYNDAX PHARMACEUTICALS INC 0.9%

Value $10.21M Shares 472,600 Share Price $21.61 * Est. Cost/Share $16.84 Unrealized @ Report Date -8.7%

CYTK CYTOKINETICS INC 0.8%

Value $9.327M Shares 111,717 Share Price $83.49 * Est. Cost/Share $6.71 Unrealized @ Report Date +439.4%

NVCR NOVOCURE LTD 0.8%

Value $8.389M Shares 561,908 Share Price $14.93 * Est. Cost/Share $58.84 Unrealized @ Report Date -77.3%

— VERVE THERAPEUTICS INC 0.7%

Value $8.027M Shares 575,817 Share Price $13.94 Est. Cost/Share $13.94 Unrealized @ Report Date —

GOSS GOSSAMER BIO INC 0.6%

Value $6.53M Shares 5,958,888 Share Price $1.10 * Est. Cost/Share $1.61 Unrealized @ Report Date -54.2%

— BLUEBIRD BIO INC 0.4%

Value $4.6M Shares 3,333,333 Share Price $1.38 Est. Cost/Share $1.38 Unrealized @ Report Date —

— KARYOPHARM THERAPEUTICS INC 0.4%

Value $4.413M Shares 5,102,193 Share Price $0.87 Est. Cost/Share $16.36 Unrealized @ Report Date —

RLMD RELMADA THERAPEUTICS INC 0.3%

Value $3.032M Shares 732,400 Share Price $4.14 * Est. Cost/Share $3.27 Unrealized @ Report Date -9.5%

MIRM MIRUM PHARMACEUTICALS INC 0.2%

Value $1.91M Shares 64,700 Share Price $29.52 * Est. Cost/Share $15.56 Unrealized @ Report Date +94.5%

VNDA VANDA PHARMACEUTICALS INC 0.1%

Value $1.177M Shares 278,985 Share Price $4.22 * Est. Cost/Share $11.21 Unrealized @ Report Date -64.0%

VYNE VYNE THERAPEUTICS INC PIPE 0.1%

Value $1.038M Shares 445,434 Share Price $2.33 * Est. Cost/Share $3.12 Unrealized @ Report Date 0.0%

TVTX TRAVERE THERAPEUTICS INC 0.1%

Value $995K Shares 110,719 Share Price $8.99 * Est. Cost/Share $23.56 Unrealized @ Report Date -69.1%

TSHA TAYSHA GENE THERAPIES INC 0.1%

Value $938K Shares 529,861 Share Price $1.77 * Est. Cost/Share $1.99 Unrealized @ Report Date 0.0%

SGHT SIGHT SCIENCES INC 0.1%

Value $897K Shares 173,790 Share Price $5.16 * Est. Cost/Share $3.09 Unrealized @ Report Date 0.0%

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value $791K Shares 225,465 Share Price $3.51 * Est. Cost/Share $5.95 Unrealized @ Report Date -48.1%

URGN UROGEN PHARMA LTD 0.0%

Value $368K Shares 24,500 Share Price $15.00 * Est. Cost/Share $27.01 Unrealized @ Report Date -51.9%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
INSM	INSMED INC	5,511,721	$171M	15.4%	$30.99 *	$17.79	+45.8%	COM PAR $.01	457669307
FOLD	AMICUS THERAPEUTICS INC	10,373,715	$147M	13.3%	$14.19 *	$9.63	+18.0%	COM	03152W109
BMRN	BIOMARIN PHARMACEUTICAL INC	1,500,749	$145M	13.0%	$96.42 *	$83.16	+6.4%	COM	09061G101
BIIB	BIOGEN INC	380,417	$98.44M	8.9%	$258.77 *	$264.98	-7.3%	COM	09062X103
UTHR	UNITED THERAPEUTICS CORP	395,784	$87.03M	7.8%	$219.89 *	$89.23	+158.3%	COM	91307C102
ACAD	ACADIA PHARMACEUTICALS INC	2,409,556	$75.44M	6.8%	$31.31 *	$28.41	-15.9%	COM	004225108
PRTA	PROTHENA CORP PLC	1,660,057	$60.33M	5.4%	$36.34 *	$21.46	+79.4%	SHS	G72800108
—	REVANCE THERAPEUTICS INC	5,237,284	$46.04M	4.1%	$8.79	$21.40	—	COM	761330109
STAA	STAAR SURGICAL CO	1,376,950	$42.97M	3.9%	$31.21 *	$24.23	+48.3%	COM PAR $0.01	852312305
ALNY	ALNYLAM PHARMACEUTICALS INC	154,437	$29.56M	2.7%	$191.41 *	$170.34	0.0%	COM	02043Q107
EHTH	EHEALTH INC	2,739,379	$23.89M	2.2%	$8.72 *	$38.13	-78.6%	COM	28238P109
—	SAGE THERAPEUTICS INC	991,525	$21.49M	1.9%	$21.67	$42.84	—	COM	78667J108
SRPT	SAREPTA THERAPEUTICS INC	200,905	$19.37M	1.7%	$96.43	$111.32	-13.8%	COM	803607100
IOVA	IOVANCE BIOTHERAPEUTICS INC	2,106,792	$17.13M	1.5%	$8.13 *	$5.23	0.0%	COM	462260100
ALKS	ALKERMES PLC	603,400	$16.74M	1.5%	$27.74 *	$22.36	+16.2%	SHS	G01767105
—	NEVRO CORP	750,371	$16.15M	1.5%	$21.52	$21.87	—	COM	64157F103
ALGN	ALIGN TECHNOLOGY INC	55,705	$15.26M	1.4%	$274.00 *	$149.18	+58.9%	COM	016255101
ANAB	ANAPTYSBIO INC	686,882	$14.71M	1.3%	$21.42 *	$18.38	-6.2%	COM	032724106
SNDX	SYNDAX PHARMACEUTICALS INC	472,600	$10.21M	0.9%	$21.61 *	$16.84	-8.7%	COM	87164F105
CYTK	CYTOKINETICS INC	111,717	$9.327M	0.8%	$83.49 *	$6.71	+439.4%	COM NEW	23282W605
NVCR	NOVOCURE LTD	561,908	$8.389M	0.8%	$14.93 *	$58.84	-77.3%	ORD SHS	G6674U108
—	VERVE THERAPEUTICS INC	575,817	$8.027M	0.7%	$13.94	$13.94	—	COM	92539P101
GOSS	GOSSAMER BIO INC	5,958,888	$6.53M	0.6%	$1.10 *	$1.61	-54.2%	COM	38341P102
—	BLUEBIRD BIO INC	3,333,333	$4.6M	0.4%	$1.38	$1.38	—	COM	09609G100
—	KARYOPHARM THERAPEUTICS INC	5,102,193	$4.413M	0.4%	$0.87	$16.36	—	COM	48576U106
RLMD	RELMADA THERAPEUTICS INC	732,400	$3.032M	0.3%	$4.14 *	$3.27	-9.5%	COM	75955J402
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$1.91M	0.2%	$29.52 *	$15.56	+94.5%	COM	604749101
VNDA	VANDA PHARMACEUTICALS INC	278,985	$1.177M	0.1%	$4.22 *	$11.21	-64.0%	COM	921659108
VYNE	VYNE THERAPEUTICS INC PIPE	445,434	$1.038M	0.1%	$2.33 *	$3.12	0.0%	COM	92941V308
TVTX	TRAVERE THERAPEUTICS INC	110,719	$995K	0.1%	$8.99 *	$23.56	-69.1%	COM	89422G107
TSHA	TAYSHA GENE THERAPIES INC	529,861	$938K	0.1%	$1.77 *	$1.99	0.0%	COM SHS	877619106
SGHT	SIGHT SCIENCES INC	173,790	$897K	0.1%	$5.16 *	$3.09	0.0%	COM	82657M105
ALDX	ALDEYRA THERAPEUTICS INC	225,465	$791K	0.1%	$3.51 *	$5.95	-48.1%	COM	01438T106
URGN	UROGEN PHARMA LTD	24,500	$368K	0.0%	$15.00 *	$27.01	-51.9%	COM	M96088105