Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q2 2024 (← Previous) (Next →)

Filing Date: Aug 14, 2024

Total Value: $863M (100.0% shares, 0.0% debt)

Holdings (39)

INSM INSMED INC 16.6%

Value $143M Shares 2,138,963 Share Price $67.00 * Est. Cost/Share $17.79 Unrealized @ Report Date +118.0%

BMRN BIOMARIN PHARMACEUTICAL INC 10.8%

Value $93.05M Shares 1,130,167 Share Price $82.33 Est. Cost/Share $83.16 Unrealized @ Report Date +0.1%

FOLD AMICUS THERAPEUTICS INC 10.4%

Value $89.58M Shares 9,029,843 Share Price $9.92 * Est. Cost/Share $9.63 Unrealized @ Report Date +6.6%

UTHR UNITED THERAPEUTICS CORP 9.9%

Value $85.03M Shares 266,914 Share Price $318.55 * Est. Cost/Share $89.23 Unrealized @ Report Date +196.6%

BIIB BIOGEN INC 7.8%

Value $67.01M Shares 289,050 Share Price $231.82 * Est. Cost/Share $264.98 Unrealized @ Report Date -18.0%

STAA STAAR SURGICAL CO 7.6%

Value $65.78M Shares 1,381,619 Share Price $47.61 * Est. Cost/Share $24.23 Unrealized @ Report Date +80.8%

— ALNYLAM PHARMACEUTICALS INC 5.2%

Value $44.5M Shares 183,123 Share Price $243.00 Est. Cost/Share $243.00 Unrealized @ Report Date —

ACAD ACADIA PHARMACEUTICALS INC 4.6%

Value $39.31M Shares 2,418,841 Share Price $16.25 Est. Cost/Share $28.41 Unrealized @ Report Date -43.2%

PRTA PROTHENA CORP PLC 4.0%

Value $34.39M Shares 1,666,378 Share Price $20.64 * Est. Cost/Share $21.46 Unrealized @ Report Date +0.9%

SRPT SAREPTA THERAPEUTICS INC 3.7%

Value $31.87M Shares 201,683 Share Price $158.00 * Est. Cost/Share $111.32 Unrealized @ Report Date +15.4%

ANAB ANAPTYSBIO INC 2.3%

Value $20.14M Shares 803,641 Share Price $25.06 * Est. Cost/Share $19.13 Unrealized @ Report Date +21.7%

IOVA IOVANCE BIOTHERAPEUTICS INC 2.0%

Value $16.97M Shares 2,116,403 Share Price $8.02 * Est. Cost/Share $5.23 Unrealized @ Report Date +104.8%

— REVANCE THERAPEUTICS INC 1.6%

Value $13.51M Shares 5,257,086 Share Price $2.57 Est. Cost/Share $21.40 Unrealized @ Report Date —

ALKS ALKERMES PLC 1.4%

Value $11.94M Shares 495,592 Share Price $24.10 Est. Cost/Share $22.36 Unrealized @ Report Date +9.7%

— SAGE THERAPEUTICS INC 1.3%

Value $10.98M Shares 1,010,833 Share Price $10.86 Est. Cost/Share $42.50 Unrealized @ Report Date —

EHTH EHEALTH INC 1.2%

Value $10.65M Shares 2,350,190 Share Price $4.53 * Est. Cost/Share $38.13 Unrealized @ Report Date -86.8%

NVCR NOVOCURE LTD 1.1%

Value $9.625M Shares 561,908 Share Price $17.13 * Est. Cost/Share $58.84 Unrealized @ Report Date -70.1%

ALGN ALIGN TECHNOLOGY INC 1.1%

Value $9.119M Shares 37,772 Share Price $241.43 * Est. Cost/Share $149.18 Unrealized @ Report Date +86.6%

SNDX SYNDAX PHARMACEUTICALS INC 1.0%

Value $8.319M Shares 405,193 Share Price $20.53 Est. Cost/Share $16.84 Unrealized @ Report Date +24.3%

— ACELYRIN INC 0.9%

Value $7.564M Shares 1,715,180 Share Price $4.41 Est. Cost/Share $6.75 Unrealized @ Report Date —

— NEVRO CORP 0.7%

Value $6.318M Shares 750,371 Share Price $8.42 Est. Cost/Share $21.87 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.7%

Value $6.053M Shares 111,717 Share Price $54.18 * Est. Cost/Share $6.71 Unrealized @ Report Date +799.1%

GOSS GOSSAMER BIO INC 0.7%

Value $5.655M Shares 6,277,093 Share Price $0.90 * Est. Cost/Share $1.58 Unrealized @ Report Date -52.6%

— ELEVATION ONCOLOGY INC 0.6%

Value $4.86M Shares 1,800,106 Share Price $2.70 Est. Cost/Share $4.52 Unrealized @ Report Date —

— BLUEBIRD BIO INC 0.5%

Value $4.56M Shares 4,633,351 Share Price $0.98 Est. Cost/Share $1.35 Unrealized @ Report Date —

— KARYOPHARM THERAPEUTICS INC 0.5%

Value $4.427M Shares 5,102,193 Share Price $0.87 Est. Cost/Share $16.36 Unrealized @ Report Date —

— VERVE THERAPEUTICS INC 0.3%

Value $2.81M Shares 575,817 Share Price $4.88 Est. Cost/Share $13.94 Unrealized @ Report Date —

NUVB NUVATION BIO INC 0.3%

Value $2.256M Shares 772,652 Share Price $2.92 * Est. Cost/Share $1.92 Unrealized @ Report Date +58.9%

MIRM MIRUM PHARMACEUTICALS INC 0.3%

Value $2.212M Shares 64,700 Share Price $34.19 * Est. Cost/Share $15.56 Unrealized @ Report Date +68.5%

RLMD RELMADA THERAPEUTICS INC 0.3%

Value $2.197M Shares 732,400 Share Price $3.00 * Est. Cost/Share $3.27 Unrealized @ Report Date +10.6%

TSHA TAYSHA GENE THERAPIES INC 0.2%

Value $1.817M Shares 811,268 Share Price $2.24 * Est. Cost/Share $2.02 Unrealized @ Report Date +43.7%

STOK STOKE THERAPEUTICS INC 0.2%

Value $1.7M Shares 125,861 Share Price $13.51 Est. Cost/Share $6.06 Unrealized @ Report Date +122.9%

HUM HUMANA INC 0.2%

Value $1.489M Shares 3,985 Share Price $373.65 * Est. Cost/Share $369.63 Unrealized @ Report Date -10.7%

TVTX TRAVERE THERAPEUTICS INC 0.1%

Value $910K Shares 110,719 Share Price $8.22 * Est. Cost/Share $23.56 Unrealized @ Report Date -71.4%

VYNE VYNE THERAPEUTICS INC PIPE 0.1%

Value $878K Shares 445,434 Share Price $1.97 * Est. Cost/Share $3.12 Unrealized @ Report Date -20.0%

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value $746K Shares 225,465 Share Price $3.31 * Est. Cost/Share $5.95 Unrealized @ Report Date -34.1%

ACRS ACLARIS THERAPEUTICS INC 0.1%

Value $627K Shares 569,832 Share Price $1.10 * Est. Cost/Share $1.19 Unrealized @ Report Date -1.5%

— GENERATION BIO CO 0.0%

Value $424K Shares 150,475 Share Price $2.82 Est. Cost/Share $2.82 Unrealized @ Report Date —

URGN UROGEN PHARMA LTD 0.0%

Value $411K Shares 24,500 Share Price $16.78 * Est. Cost/Share $27.01 Unrealized @ Report Date -47.3%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
INSM	INSMED INC	2,138,963	$143M	16.6%	$67.00 *	$17.79	+118.0%	COM PAR $.01	457669307
BMRN	BIOMARIN PHARMACEUTICAL INC	1,130,167	$93.05M	10.8%	$82.33	$83.16	+0.1%	COM	09061G101
FOLD	AMICUS THERAPEUTICS INC	9,029,843	$89.58M	10.4%	$9.92 *	$9.63	+6.6%	COM	03152W109
UTHR	UNITED THERAPEUTICS CORP	266,914	$85.03M	9.9%	$318.55 *	$89.23	+196.6%	COM	91307C102
BIIB	BIOGEN INC	289,050	$67.01M	7.8%	$231.82 *	$264.98	-18.0%	COM	09062X103
STAA	STAAR SURGICAL CO	1,381,619	$65.78M	7.6%	$47.61 *	$24.23	+80.8%	COM PAR $0.01	852312305
—	ALNYLAM PHARMACEUTICALS INC	183,123	$44.5M	5.2%	$243.00	$243.00	—	COM	02043QAB3
ACAD	ACADIA PHARMACEUTICALS INC	2,418,841	$39.31M	4.6%	$16.25	$28.41	-43.2%	COM	004225108
PRTA	PROTHENA CORP PLC	1,666,378	$34.39M	4.0%	$20.64 *	$21.46	+0.9%	SHS	G72800108
SRPT	SAREPTA THERAPEUTICS INC	201,683	$31.87M	3.7%	$158.00 *	$111.32	+15.4%	COM	803607100
ANAB	ANAPTYSBIO INC	803,641	$20.14M	2.3%	$25.06 *	$19.13	+21.7%	COM	032724106
IOVA	IOVANCE BIOTHERAPEUTICS INC	2,116,403	$16.97M	2.0%	$8.02 *	$5.23	+104.8%	COM	462260100
—	REVANCE THERAPEUTICS INC	5,257,086	$13.51M	1.6%	$2.57	$21.40	—	COM	761330109
ALKS	ALKERMES PLC	495,592	$11.94M	1.4%	$24.10	$22.36	+9.7%	SHS	G01767105
—	SAGE THERAPEUTICS INC	1,010,833	$10.98M	1.3%	$10.86	$42.50	—	COM	78667J108
EHTH	EHEALTH INC	2,350,190	$10.65M	1.2%	$4.53 *	$38.13	-86.8%	COM	28238P109
NVCR	NOVOCURE LTD	561,908	$9.625M	1.1%	$17.13 *	$58.84	-70.1%	ORD SHS	G6674U108
ALGN	ALIGN TECHNOLOGY INC	37,772	$9.119M	1.1%	$241.43 *	$149.18	+86.6%	COM	016255101
SNDX	SYNDAX PHARMACEUTICALS INC	405,193	$8.319M	1.0%	$20.53	$16.84	+24.3%	COM	87164F105
—	ACELYRIN INC	1,715,180	$7.564M	0.9%	$4.41	$6.75	—	COM	00445A100
—	NEVRO CORP	750,371	$6.318M	0.7%	$8.42	$21.87	—	COM	64157F103
CYTK	CYTOKINETICS INC	111,717	$6.053M	0.7%	$54.18 *	$6.71	+799.1%	COM NEW	23282W605
GOSS	GOSSAMER BIO INC	6,277,093	$5.655M	0.7%	$0.90 *	$1.58	-52.6%	COM	38341P102
—	ELEVATION ONCOLOGY INC	1,800,106	$4.86M	0.6%	$2.70	$4.52	—	COM	28623U101
—	BLUEBIRD BIO INC	4,633,351	$4.56M	0.5%	$0.98	$1.35	—	COM	09609G100
—	KARYOPHARM THERAPEUTICS INC	5,102,193	$4.427M	0.5%	$0.87	$16.36	—	COM	48576U106
—	VERVE THERAPEUTICS INC	575,817	$2.81M	0.3%	$4.88	$13.94	—	COM	92539P101
NUVB	NUVATION BIO INC	772,652	$2.256M	0.3%	$2.92 *	$1.92	+58.9%	COM	67080N101
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$2.212M	0.3%	$34.19 *	$15.56	+68.5%	COM	604749101
RLMD	RELMADA THERAPEUTICS INC	732,400	$2.197M	0.3%	$3.00 *	$3.27	+10.6%	COM	75955J402
TSHA	TAYSHA GENE THERAPIES INC	811,268	$1.817M	0.2%	$2.24 *	$2.02	+43.7%	COM SHS	877619106
STOK	STOKE THERAPEUTICS INC	125,861	$1.7M	0.2%	$13.51	$6.06	+122.9%	COM	86150R107
HUM	HUMANA INC	3,985	$1.489M	0.2%	$373.65 *	$369.63	-10.7%	COM	444859102
TVTX	TRAVERE THERAPEUTICS INC	110,719	$910K	0.1%	$8.22 *	$23.56	-71.4%	COM	89422G107
VYNE	VYNE THERAPEUTICS INC PIPE	445,434	$878K	0.1%	$1.97 *	$3.12	-20.0%	COM	92941V308
ALDX	ALDEYRA THERAPEUTICS INC	225,465	$746K	0.1%	$3.31 *	$5.95	-34.1%	COM	01438T106
ACRS	ACLARIS THERAPEUTICS INC	569,832	$627K	0.1%	$1.10 *	$1.19	-1.5%	COM	00461U105
—	GENERATION BIO CO	150,475	$424K	0.0%	$2.82	$2.82	—	COM	37148K100
URGN	UROGEN PHARMA LTD	24,500	$411K	0.0%	$16.78 *	$27.01	-47.3%	COM	M96088105