Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q1 2024 (← Previous) (Next →)

Filing Date: May 15, 2024

Total Value: $887M (100.0% shares, 0.0% debt)

Holdings (38)

INSM INSMED INC 13.5%

Value $120M Shares 4,423,369 Share Price $27.13 * Est. Cost/Share $17.79 Unrealized @ Report Date +57.3%

FOLD AMICUS THERAPEUTICS INC 12.4%

Value $110M Shares 9,344,102 Share Price $11.78 * Est. Cost/Share $9.63 Unrealized @ Report Date +32.9%

BMRN BIOMARIN PHARMACEUTICAL INC 11.2%

Value $99.09M Shares 1,134,569 Share Price $87.34 * Est. Cost/Share $83.16 Unrealized @ Report Date +7.7%

BIIB BIOGEN INC 7.1%

Value $62.52M Shares 289,958 Share Price $215.63 * Est. Cost/Share $264.98 Unrealized @ Report Date -11.6%

UTHR UNITED THERAPEUTICS CORP 6.9%

Value $61.51M Shares 267,759 Share Price $229.72 Est. Cost/Share $89.23 Unrealized @ Report Date +152.9%

STAA STAAR SURGICAL CO 6.0%

Value $52.81M Shares 1,379,590 Share Price $38.28 * Est. Cost/Share $24.23 Unrealized @ Report Date +34.2%

ACAD ACADIA PHARMACEUTICALS INC 5.0%

Value $44.65M Shares 2,414,943 Share Price $18.49 * Est. Cost/Share $28.41 Unrealized @ Report Date -12.8%

PRTA PROTHENA CORP PLC 4.6%

Value $41.2M Shares 1,663,448 Share Price $24.77 * Est. Cost/Share $21.46 Unrealized @ Report Date +38.7%

IOVA IOVANCE BIOTHERAPEUTICS INC 3.5%

Value $31.31M Shares 2,112,811 Share Price $14.82 * Est. Cost/Share $5.23 Unrealized @ Report Date +122.4%

ALNY ALNYLAM PHARMACEUTICALS INC 3.1%

Value $27.31M Shares 182,766 Share Price $149.45 * Est. Cost/Share $169.79 Unrealized @ Report Date -1.8%

SRPT SAREPTA THERAPEUTICS INC 2.9%

Value $26.06M Shares 201,265 Share Price $129.46 * Est. Cost/Share $111.32 Unrealized @ Report Date +10.0%

— REVANCE THERAPEUTICS INC 2.9%

Value $25.82M Shares 5,248,004 Share Price $4.92 Est. Cost/Share $21.40 Unrealized @ Report Date —

— SAGE THERAPEUTICS INC 2.1%

Value $18.85M Shares 1,005,776 Share Price $18.74 Est. Cost/Share $42.50 Unrealized @ Report Date —

ANAB ANAPTYSBIO INC 2.0%

Value $18.01M Shares 799,906 Share Price $22.52 * Est. Cost/Share $19.13 Unrealized @ Report Date +23.8%

EHTH EHEALTH INC 1.8%

Value $16.38M Shares 2,715,681 Share Price $6.03 * Est. Cost/Share $38.13 Unrealized @ Report Date -82.6%

ALGN ALIGN TECHNOLOGY INC 1.8%

Value $16.1M Shares 49,105 Share Price $327.92 * Est. Cost/Share $149.18 Unrealized @ Report Date +96.7%

ALKS ALKERMES PLC 1.5%

Value $13.42M Shares 495,592 Share Price $27.07 * Est. Cost/Share $22.36 Unrealized @ Report Date +27.0%

— ACELYRIN INC 1.3%

Value $11.58M Shares 1,715,180 Share Price $6.75 Est. Cost/Share $6.75 Unrealized @ Report Date —

— NEVRO CORP 1.2%

Value $10.84M Shares 750,371 Share Price $14.44 Est. Cost/Share $21.87 Unrealized @ Report Date —

SNDX SYNDAX PHARMACEUTICALS INC 1.1%

Value $9.644M Shares 405,193 Share Price $23.80 * Est. Cost/Share $16.84 Unrealized @ Report Date +32.5%

NVCR NOVOCURE LTD 1.0%

Value $8.783M Shares 561,908 Share Price $15.63 * Est. Cost/Share $58.84 Unrealized @ Report Date -75.0%

CYTK CYTOKINETICS INC 0.9%

Value $7.832M Shares 111,717 Share Price $70.11 * Est. Cost/Share $6.71 Unrealized @ Report Date +1052.1%

— KARYOPHARM THERAPEUTICS INC 0.9%

Value $7.704M Shares 5,102,193 Share Price $1.51 Est. Cost/Share $16.36 Unrealized @ Report Date —

— VERVE THERAPEUTICS INC 0.9%

Value $7.647M Shares 575,817 Share Price $13.28 Est. Cost/Share $13.94 Unrealized @ Report Date —

GOSS GOSSAMER BIO INC 0.9%

Value $7.542M Shares 6,391,775 Share Price $1.18 * Est. Cost/Share $1.58 Unrealized @ Report Date -30.3%

— ELEVATION ONCOLOGY INC 0.8%

Value $6.908M Shares 1,346,666 Share Price $5.13 Est. Cost/Share $5.13 Unrealized @ Report Date —

— BLUEBIRD BIO INC 0.7%

Value $5.837M Shares 4,560,171 Share Price $1.28 Est. Cost/Share $1.35 Unrealized @ Report Date —

RLMD RELMADA THERAPEUTICS INC 0.4%

Value $3.406M Shares 732,400 Share Price $4.65 * Est. Cost/Share $3.27 Unrealized @ Report Date +47.3%

NUVB NUVATION BIO INC 0.3%

Value $2.812M Shares 772,652 Share Price $3.64 * Est. Cost/Share $1.92 Unrealized @ Report Date 0.0%

TSHA TAYSHA GENE THERAPIES INC 0.3%

Value $2.328M Shares 811,268 Share Price $2.87 * Est. Cost/Share $2.02 Unrealized @ Report Date +2.9%

STOK STOKE THERAPEUTICS INC 0.2%

Value $1.699M Shares 125,861 Share Price $13.50 * Est. Cost/Share $6.06 Unrealized @ Report Date 0.0%

MIRM MIRUM PHARMACEUTICALS INC 0.2%

Value $1.625M Shares 64,700 Share Price $25.12 * Est. Cost/Share $15.56 Unrealized @ Report Date +76.7%

HUM HUMANA INC 0.2%

Value $1.382M Shares 3,985 Share Price $346.72 * Est. Cost/Share $369.63 Unrealized @ Report Date 0.0%

VYNE VYNE THERAPEUTICS INC 0.2%

Value $1.367M Shares 445,434 Share Price $3.07 * Est. Cost/Share $3.12 Unrealized @ Report Date -30.9%

TVTX TRAVERE THERAPEUTICS INC 0.1%

Value $854K Shares 110,719 Share Price $7.71 * Est. Cost/Share $23.56 Unrealized @ Report Date -64.2%

ALDX ALDEYRA THERAPEUTICS INC 0.1%

Value $737K Shares 225,465 Share Price $3.27 Est. Cost/Share $5.95 Unrealized @ Report Date -44.7%

ACRS ACLARIS THERAPEUTICS INC 0.1%

Value $707K Shares 569,832 Share Price $1.24 Est. Cost/Share $1.19 Unrealized @ Report Date 0.0%

URGN UROGEN PHARMA LTD 0.0%

Value $368K Shares 24,500 Share Price $15.00 * Est. Cost/Share $27.01 Unrealized @ Report Date -39.5%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
INSM	INSMED INC	4,423,369	$120M	13.5%	$27.13 *	$17.79	+57.3%	COM PAR $.01	457669307
FOLD	AMICUS THERAPEUTICS INC	9,344,102	$110M	12.4%	$11.78 *	$9.63	+32.9%	COM	03152W109
BMRN	BIOMARIN PHARMACEUTICAL INC	1,134,569	$99.09M	11.2%	$87.34 *	$83.16	+7.7%	COM	09061G101
BIIB	BIOGEN INC	289,958	$62.52M	7.1%	$215.63 *	$264.98	-11.6%	COM	09062X103
UTHR	UNITED THERAPEUTICS CORP	267,759	$61.51M	6.9%	$229.72	$89.23	+152.9%	COM	91307C102
STAA	STAAR SURGICAL CO	1,379,590	$52.81M	6.0%	$38.28 *	$24.23	+34.2%	COM PAR $0.01	852312305
ACAD	ACADIA PHARMACEUTICALS INC	2,414,943	$44.65M	5.0%	$18.49 *	$28.41	-12.8%	COM	004225108
PRTA	PROTHENA CORP PLC	1,663,448	$41.2M	4.6%	$24.77 *	$21.46	+38.7%	SHS	G72800108
IOVA	IOVANCE BIOTHERAPEUTICS INC	2,112,811	$31.31M	3.5%	$14.82 *	$5.23	+122.4%	COM	462260100
ALNY	ALNYLAM PHARMACEUTICALS INC	182,766	$27.31M	3.1%	$149.45 *	$169.79	-1.8%	COM	02043Q107
SRPT	SAREPTA THERAPEUTICS INC	201,265	$26.06M	2.9%	$129.46 *	$111.32	+10.0%	COM	803607100
—	REVANCE THERAPEUTICS INC	5,248,004	$25.82M	2.9%	$4.92	$21.40	—	COM	761330109
—	SAGE THERAPEUTICS INC	1,005,776	$18.85M	2.1%	$18.74	$42.50	—	COM	78667J108
ANAB	ANAPTYSBIO INC	799,906	$18.01M	2.0%	$22.52 *	$19.13	+23.8%	COM	032724106
EHTH	EHEALTH INC	2,715,681	$16.38M	1.8%	$6.03 *	$38.13	-82.6%	COM	28238P109
ALGN	ALIGN TECHNOLOGY INC	49,105	$16.1M	1.8%	$327.92 *	$149.18	+96.7%	COM	016255101
ALKS	ALKERMES PLC	495,592	$13.42M	1.5%	$27.07 *	$22.36	+27.0%	SHS	G01767105
—	ACELYRIN INC	1,715,180	$11.58M	1.3%	$6.75	$6.75	—	COM	00445A100
—	NEVRO CORP	750,371	$10.84M	1.2%	$14.44	$21.87	—	COM	64157F103
SNDX	SYNDAX PHARMACEUTICALS INC	405,193	$9.644M	1.1%	$23.80 *	$16.84	+32.5%	COM	87164F105
NVCR	NOVOCURE LTD	561,908	$8.783M	1.0%	$15.63 *	$58.84	-75.0%	ORD SHS	G6674U108
CYTK	CYTOKINETICS INC	111,717	$7.832M	0.9%	$70.11 *	$6.71	+1052.1%	COM NEW	23282W605
—	KARYOPHARM THERAPEUTICS INC	5,102,193	$7.704M	0.9%	$1.51	$16.36	—	COM	48576U106
—	VERVE THERAPEUTICS INC	575,817	$7.647M	0.9%	$13.28	$13.94	—	COM	92539P101
GOSS	GOSSAMER BIO INC	6,391,775	$7.542M	0.9%	$1.18 *	$1.58	-30.3%	COM	38341P102
—	ELEVATION ONCOLOGY INC	1,346,666	$6.908M	0.8%	$5.13	$5.13	—	COM	28623U101
—	BLUEBIRD BIO INC	4,560,171	$5.837M	0.7%	$1.28	$1.35	—	COM	09609G100
RLMD	RELMADA THERAPEUTICS INC	732,400	$3.406M	0.4%	$4.65 *	$3.27	+47.3%	COM	75955J402
NUVB	NUVATION BIO INC	772,652	$2.812M	0.3%	$3.64 *	$1.92	0.0%	COM	67080N101
TSHA	TAYSHA GENE THERAPIES INC	811,268	$2.328M	0.3%	$2.87 *	$2.02	+2.9%	COM SHS	877619106
STOK	STOKE THERAPEUTICS INC	125,861	$1.699M	0.2%	$13.50 *	$6.06	0.0%	COM	86150R107
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$1.625M	0.2%	$25.12 *	$15.56	+76.7%	COM	604749101
HUM	HUMANA INC	3,985	$1.382M	0.2%	$346.72 *	$369.63	0.0%	COM	444859102
VYNE	VYNE THERAPEUTICS INC	445,434	$1.367M	0.2%	$3.07 *	$3.12	-30.9%	COM	92941V308
TVTX	TRAVERE THERAPEUTICS INC	110,719	$854K	0.1%	$7.71 *	$23.56	-64.2%	COM	89422G107
ALDX	ALDEYRA THERAPEUTICS INC	225,465	$737K	0.1%	$3.27	$5.95	-44.7%	COM	01438T106
ACRS	ACLARIS THERAPEUTICS INC	569,832	$707K	0.1%	$1.24	$1.19	0.0%	COM	00461U105
URGN	UROGEN PHARMA LTD	24,500	$368K	0.0%	$15.00 *	$27.01	-39.5%	COM	M96088105