Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q4 2024 (← Previous) (Next →)

Filing Date: Feb 14, 2025

Total Value: $645M (100.0% shares, 0.0% debt)

Holdings (43)

INSM INSMED INC 17.2%

Value $111M Shares 1,603,465 Est. Cost $17.79 Unrealized +304.8%

FOLD AMICUS THERAPEUTICS INC 11.2%

Value $72.18M Shares 7,662,479 Est. Cost $9.63 Unrealized +8.0%

BMRN BIOMARIN PHARMACEUTICAL INC 10.9%

Value $70.15M Shares 1,067,266 Est. Cost $83.16 Unrealized -19.4%

UTHR UNITED THERAPEUTICS CORP 8.5%

Value $54.94M Shares 155,714 Est. Cost $89.23 Unrealized +311.9%

ACAD ACADIA PHARMACEUTICALS INC 7.8%

Value $50.44M Shares 2,748,599 Est. Cost $26.96 Unrealized -40.1%

ALNY ALNYLAM PHARMACEUTICALS INC 5.1%

Value $33.1M Shares 140,681 Est. Cost $260.36 Unrealized +1.0%

BIIB BIOGEN INC 4.5%

Value $29.08M Shares 190,148 Est. Cost $264.98 Unrealized -36.3%

SRPT SAREPTA THERAPEUTICS INC 4.0%

Value $25.57M Shares 210,258 Est. Cost $112.41 Unrealized +9.0%

NVCR NOVOCURE LTD 3.8%

Value $24.26M Shares 814,191 Est. Cost $47.05 Unrealized -55.0%

PRTA PROTHENA CORP PLC 3.7%

Value $24.07M Shares 1,737,964 Est. Cost $21.46 Unrealized -26.5%

IOVA IOVANCE BIOTHERAPEUTICS INC 3.5%

Value $22.51M Shares 3,041,685 Est. Cost $6.52 Unrealized +42.1%

EHTH EHEALTH INC 2.7%

Value $17.65M Shares 1,878,127 Est. Cost $38.13 Unrealized -85.4%

PTCT PTC THERAPEUTICS INC 2.7%

Value $17.44M Shares 386,413 Est. Cost $36.42 Unrealized +17.5%

STAA STAAR SURGICAL CO 1.9%

Value $12.16M Shares 500,775 Est. Cost $24.23 Unrealized +17.8%

ANAB ANAPTYSBIO INC 1.7%

Value $11.17M Shares 843,971 Est. Cost $19.85 Unrealized +22.0%

ALKS ALKERMES PLC 1.3%

Value $8.32M Shares 289,308 Est. Cost $22.36 Unrealized +28.6%

ALGN ALIGN TECHNOLOGY INC 1.2%

Value $7.876M Shares 37,772 Est. Cost $149.18 Unrealized +49.7%

GOSS GOSSAMER BIO INC 0.9%

Value $5.678M Shares 6,277,093 Est. Cost $1.58 Unrealized -45.7%

— ACELYRIN INC 0.9%

Value $5.63M Shares 1,792,895 Est. Cost $6.67 Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC 0.8%

Value $5.357M Shares 405,193 Est. Cost $16.84 Unrealized +1.6%

BCYC BICYCLE THERAPEUTICS PLC-ADR 0.5%

Value $3.485M Shares 248,934 Est. Cost $16.07 Unrealized —

— KARYOPHARM THERAPEUTICS INC 0.5%

Value $3.319M Shares 4,907,001 Est. Cost $16.36 Unrealized —

— VERVE THERAPEUTICS INC 0.5%

Value $3.248M Shares 575,817 Est. Cost $13.94 Unrealized —

EW EDWARDS LIFESCIENCES CORP 0.5%

Value $2.922M Shares 39,473 Est. Cost $72.66 Unrealized -3.7%

BNTX BIONTECH SE-ADR 0.4%

Value $2.872M Shares 25,206 Est. Cost $118.77 Unrealized —

— NEVRO CORP 0.4%

Value $2.791M Shares 750,371 Est. Cost $21.87 Unrealized —

MIRM MIRUM PHARMACEUTICALS INC 0.4%

Value $2.675M Shares 64,700 Est. Cost $15.56 Unrealized +167.9%

NUVB NUVATION BIO INC 0.3%

Value $2.055M Shares 772,652 Est. Cost $1.92 Unrealized +34.1%

TVTX TRAVERE THERAPEUTICS INC 0.3%

Value $1.929M Shares 110,719 Est. Cost $23.56 Unrealized -24.9%

PYXS PYXIS ONCOLOGY INC 0.3%

Value $1.618M Shares 1,037,421 Est. Cost $2.98 Unrealized -3.4%

VYNE VYNE THERAPEUTICS INC PIPE 0.2%

Value $1.492M Shares 445,434 Est. Cost $3.12 Unrealized -16.0%

ACRS ACLARIS THERAPEUTICS INC 0.2%

Value $1.413M Shares 569,832 Est. Cost $1.19 Unrealized +108.7%

TSHA TAYSHA GENE THERAPIES INC 0.2%

Value $1.403M Shares 811,268 Est. Cost $2.02 Unrealized +2.5%

STOK STOKE THERAPEUTICS INC 0.2%

Value $1.388M Shares 125,861 Est. Cost $6.06 Unrealized +102.8%

ALDX ALDEYRA THERAPEUTICS INC 0.2%

Value $1.125M Shares 225,465 Est. Cost $5.95 Unrealized -13.7%

HUM HUMANA INC 0.2%

Value $1.011M Shares 3,985 Est. Cost $369.63 Unrealized -28.7%

JSPR JASPER THERAPEUTICS INC 0.1%

Value $655K Shares 30,651 Est. Cost $20.82 Unrealized 0.0%

ABEO ABEONA THERAPEUTICS INC 0.1%

Value $606K Shares 108,865 Est. Cost $6.04 Unrealized +1.8%

URGN UROGEN PHARMA LTD 0.0%

Value $261K Shares 24,500 Est. Cost $27.01 Unrealized -55.7%

RLMD RELMADA THERAPEUTICS INC 0.0%

Value $257K Shares 495,146 Est. Cost $3.27 Unrealized -25.4%

TIL INSTIL BIO INC 0.0%

Value $213K Shares 11,165 Est. Cost $23.54 Unrealized +29.5%

AKTX AKARI THERAPEUTICS PLC-ADR 0.0%

Value $178K Shares 146,024 Est. Cost $1.22 Unrealized —

— GENERATION BIO CO 0.0%

Value $160K Shares 150,475 Est. Cost $2.82 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
INSM	INSMED INC	1,603,465	$111M	17.2%	$17.79	+304.8%	COM PAR $.01	457669307
FOLD	AMICUS THERAPEUTICS INC	7,662,479	$72.18M	11.2%	$9.63	+8.0%	COM	03152W109
BMRN	BIOMARIN PHARMACEUTICAL INC	1,067,266	$70.15M	10.9%	$83.16	-19.4%	COM	09061G101
UTHR	UNITED THERAPEUTICS CORP	155,714	$54.94M	8.5%	$89.23	+311.9%	COM	91307C102
ACAD	ACADIA PHARMACEUTICALS INC	2,748,599	$50.44M	7.8%	$26.96	-40.1%	COM	004225108
ALNY	ALNYLAM PHARMACEUTICALS INC	140,681	$33.1M	5.1%	$260.36	+1.0%	COM	02043Q107
BIIB	BIOGEN INC	190,148	$29.08M	4.5%	$264.98	-36.3%	COM	09062X103
SRPT	SAREPTA THERAPEUTICS INC	210,258	$25.57M	4.0%	$112.41	+9.0%	COM	803607100
NVCR	NOVOCURE LTD	814,191	$24.26M	3.8%	$47.05	-55.0%	ORD SHS	G6674U108
PRTA	PROTHENA CORP PLC	1,737,964	$24.07M	3.7%	$21.46	-26.5%	SHS	G72800108
IOVA	IOVANCE BIOTHERAPEUTICS INC	3,041,685	$22.51M	3.5%	$6.52	+42.1%	COM	462260100
EHTH	EHEALTH INC	1,878,127	$17.65M	2.7%	$38.13	-85.4%	COM	28238P109
PTCT	PTC THERAPEUTICS INC	386,413	$17.44M	2.7%	$36.42	+17.5%	COM	69366J200
STAA	STAAR SURGICAL CO	500,775	$12.16M	1.9%	$24.23	+17.8%	COM PAR $0.01	852312305
ANAB	ANAPTYSBIO INC	843,971	$11.17M	1.7%	$19.85	+22.0%	COM	032724106
ALKS	ALKERMES PLC	289,308	$8.32M	1.3%	$22.36	+28.6%	SHS	G01767105
ALGN	ALIGN TECHNOLOGY INC	37,772	$7.876M	1.2%	$149.18	+49.7%	COM	016255101
GOSS	GOSSAMER BIO INC	6,277,093	$5.678M	0.9%	$1.58	-45.7%	COM	38341P102
—	ACELYRIN INC	1,792,895	$5.63M	0.9%	$6.67	—	COM	00445A100
SNDX	SYNDAX PHARMACEUTICALS INC	405,193	$5.357M	0.8%	$16.84	+1.6%	COM	87164F105
BCYC	BICYCLE THERAPEUTICS PLC-ADR	248,934	$3.485M	0.5%	$16.07	—	SPONSORED ADS	088786108
—	KARYOPHARM THERAPEUTICS INC	4,907,001	$3.319M	0.5%	$16.36	—	COM	48576U106
—	VERVE THERAPEUTICS INC	575,817	$3.248M	0.5%	$13.94	—	COM	92539P101
EW	EDWARDS LIFESCIENCES CORP	39,473	$2.922M	0.5%	$72.66	-3.7%	COM	28176E108
BNTX	BIONTECH SE-ADR	25,206	$2.872M	0.4%	$118.77	—	SPONSORED ADS	09075V102
—	NEVRO CORP	750,371	$2.791M	0.4%	$21.87	—	COM	64157F103
MIRM	MIRUM PHARMACEUTICALS INC	64,700	$2.675M	0.4%	$15.56	+167.9%	COM	604749101
NUVB	NUVATION BIO INC	772,652	$2.055M	0.3%	$1.92	+34.1%	COM CL A	67080N101
TVTX	TRAVERE THERAPEUTICS INC	110,719	$1.929M	0.3%	$23.56	-24.9%	COM	89422G107
PYXS	PYXIS ONCOLOGY INC	1,037,421	$1.618M	0.3%	$2.98	-3.4%	COMMON STOCK	747324101
VYNE	VYNE THERAPEUTICS INC PIPE	445,434	$1.492M	0.2%	$3.12	-16.0%	COM	92941V308
ACRS	ACLARIS THERAPEUTICS INC	569,832	$1.413M	0.2%	$1.19	+108.7%	COM	00461U105
TSHA	TAYSHA GENE THERAPIES INC	811,268	$1.403M	0.2%	$2.02	+2.5%	COM SHS	877619106
STOK	STOKE THERAPEUTICS INC	125,861	$1.388M	0.2%	$6.06	+102.8%	COM	86150R107
ALDX	ALDEYRA THERAPEUTICS INC	225,465	$1.125M	0.2%	$5.95	-13.7%	COM	01438T106
HUM	HUMANA INC	3,985	$1.011M	0.2%	$369.63	-28.7%	COM	444859102
JSPR	JASPER THERAPEUTICS INC	30,651	$655K	0.1%	$20.82	0.0%	COM NEW	471871202
ABEO	ABEONA THERAPEUTICS INC	108,865	$606K	0.1%	$6.04	+1.8%	COM NEW	00289Y206
URGN	UROGEN PHARMA LTD	24,500	$261K	0.0%	$27.01	-55.7%	COM	M96088105
RLMD	RELMADA THERAPEUTICS INC	495,146	$257K	0.0%	$3.27	-25.4%	COM	75955J402
TIL	INSTIL BIO INC	11,165	$213K	0.0%	$23.54	+29.5%	COM NEW	45783C200
AKTX	AKARI THERAPEUTICS PLC-ADR	146,024	$178K	0.0%	$1.22	—	SPONSORED ADR	00972G207
—	GENERATION BIO CO	150,475	$160K	0.0%	$2.82	—	COM	37148K100