Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q4 2024 (← Previous) (Next →)

Filing Date: Feb 14, 2025

Total Value: $645M (100.0% shares, 0.0% debt)

Holdings (43)

INSM INSMED INC 17.2%
Value $111M Shares 1,603,465 Share Price $69.04 * Est. Cost/Share $17.79 Unrealized @ Report Date +304.8%
FOLD AMICUS THERAPEUTICS INC 11.2%
Value $72.18M Shares 7,662,479 Share Price $9.42 * Est. Cost/Share $9.63 Unrealized @ Report Date +8.0%
BMRN BIOMARIN PHARMACEUTICAL INC 10.9%
Value $70.15M Shares 1,067,266 Share Price $65.73 Est. Cost/Share $83.16 Unrealized @ Report Date -19.4%
UTHR UNITED THERAPEUTICS CORP 8.5%
Value $54.94M Shares 155,714 Share Price $352.84 * Est. Cost/Share $89.23 Unrealized @ Report Date +311.9%
ACAD ACADIA PHARMACEUTICALS INC 7.8%
Value $50.44M Shares 2,748,599 Share Price $18.35 * Est. Cost/Share $26.96 Unrealized @ Report Date -40.1%
ALNY ALNYLAM PHARMACEUTICALS INC 5.1%
Value $33.1M Shares 140,681 Share Price $235.31 * Est. Cost/Share $260.36 Unrealized @ Report Date +1.0%
BIIB BIOGEN INC 4.5%
Value $29.08M Shares 190,148 Share Price $152.92 * Est. Cost/Share $264.98 Unrealized @ Report Date -36.3%
SRPT SAREPTA THERAPEUTICS INC 4.0%
Value $25.57M Shares 210,258 Share Price $121.59 Est. Cost/Share $112.41 Unrealized @ Report Date +9.0%
NVCR NOVOCURE LTD 3.8%
Value $24.26M Shares 814,191 Share Price $29.80 * Est. Cost/Share $47.05 Unrealized @ Report Date -55.0%
PRTA PROTHENA CORP PLC 3.7%
Value $24.07M Shares 1,737,964 Share Price $13.85 * Est. Cost/Share $21.46 Unrealized @ Report Date -26.5%
IOVA IOVANCE BIOTHERAPEUTICS INC 3.5%
Value $22.51M Shares 3,041,685 Share Price $7.40 * Est. Cost/Share $6.52 Unrealized @ Report Date +42.1%
EHTH EHEALTH INC 2.7%
Value $17.65M Shares 1,878,127 Share Price $9.40 * Est. Cost/Share $38.13 Unrealized @ Report Date -85.4%
PTCT PTC THERAPEUTICS INC 2.7%
Value $17.44M Shares 386,413 Share Price $45.14 * Est. Cost/Share $36.42 Unrealized @ Report Date +17.5%
STAA STAAR SURGICAL CO 1.9%
Value $12.16M Shares 500,775 Share Price $24.29 * Est. Cost/Share $24.23 Unrealized @ Report Date +17.8%
ANAB ANAPTYSBIO INC 1.7%
Value $11.17M Shares 843,971 Share Price $13.24 * Est. Cost/Share $19.85 Unrealized @ Report Date +22.0%
ALKS ALKERMES PLC 1.3%
Value $8.32M Shares 289,308 Share Price $28.76 Est. Cost/Share $22.36 Unrealized @ Report Date +28.6%
ALGN ALIGN TECHNOLOGY INC 1.2%
Value $7.876M Shares 37,772 Share Price $208.51 * Est. Cost/Share $149.18 Unrealized @ Report Date +49.7%
GOSS GOSSAMER BIO INC 0.9%
Value $5.678M Shares 6,277,093 Share Price $0.90 Est. Cost/Share $1.58 Unrealized @ Report Date -45.7%
— ACELYRIN INC 0.9%
Value $5.63M Shares 1,792,895 Share Price $3.14 Est. Cost/Share $6.67 Unrealized @ Report Date —
SNDX SYNDAX PHARMACEUTICALS INC 0.8%
Value $5.357M Shares 405,193 Share Price $13.22 * Est. Cost/Share $16.84 Unrealized @ Report Date +1.6%
BCYC BICYCLE THERAPEUTICS PLC-ADR 0.5%
Value $3.485M Shares 248,934 Share Price $14.00 Est. Cost/Share $16.07 Unrealized @ Report Date —
— KARYOPHARM THERAPEUTICS INC 0.5%
Value $3.319M Shares 4,907,001 Share Price $0.68 Est. Cost/Share $16.36 Unrealized @ Report Date —
— VERVE THERAPEUTICS INC 0.5%
Value $3.248M Shares 575,817 Share Price $5.64 Est. Cost/Share $13.94 Unrealized @ Report Date —
EW EDWARDS LIFESCIENCES CORP 0.5%
Value $2.922M Shares 39,473 Share Price $74.03 * Est. Cost/Share $72.66 Unrealized @ Report Date -3.7%
BNTX BIONTECH SE-ADR 0.4%
Value $2.872M Shares 25,206 Share Price $113.95 Est. Cost/Share $118.77 Unrealized @ Report Date —
— NEVRO CORP 0.4%
Value $2.791M Shares 750,371 Share Price $3.72 Est. Cost/Share $21.87 Unrealized @ Report Date —
MIRM MIRUM PHARMACEUTICALS INC 0.4%
Value $2.675M Shares 64,700 Share Price $41.35 Est. Cost/Share $15.56 Unrealized @ Report Date +167.9%
NUVB NUVATION BIO INC 0.3%
Value $2.055M Shares 772,652 Share Price $2.66 * Est. Cost/Share $1.92 Unrealized @ Report Date +34.1%
TVTX TRAVERE THERAPEUTICS INC 0.3%
Value $1.929M Shares 110,719 Share Price $17.42 Est. Cost/Share $23.56 Unrealized @ Report Date -24.9%
PYXS PYXIS ONCOLOGY INC 0.3%
Value $1.618M Shares 1,037,421 Share Price $1.56 * Est. Cost/Share $2.98 Unrealized @ Report Date -3.4%
VYNE VYNE THERAPEUTICS INC PIPE 0.2%
Value $1.492M Shares 445,434 Share Price $3.35 * Est. Cost/Share $3.12 Unrealized @ Report Date -16.0%
ACRS ACLARIS THERAPEUTICS INC 0.2%
Value $1.413M Shares 569,832 Share Price $2.48 Est. Cost/Share $1.19 Unrealized @ Report Date +108.7%
TSHA TAYSHA GENE THERAPIES INC 0.2%
Value $1.403M Shares 811,268 Share Price $1.73 * Est. Cost/Share $2.02 Unrealized @ Report Date +2.5%
STOK STOKE THERAPEUTICS INC 0.2%
Value $1.388M Shares 125,861 Share Price $11.03 * Est. Cost/Share $6.06 Unrealized @ Report Date +102.8%
ALDX ALDEYRA THERAPEUTICS INC 0.2%
Value $1.125M Shares 225,465 Share Price $4.99 * Est. Cost/Share $5.95 Unrealized @ Report Date -13.7%
HUM HUMANA INC 0.2%
Value $1.011M Shares 3,985 Share Price $253.71 * Est. Cost/Share $369.63 Unrealized @ Report Date -28.7%
JSPR JASPER THERAPEUTICS INC 0.1%
Value $655K Shares 30,651 Share Price $21.38 * Est. Cost/Share $20.82 Unrealized @ Report Date 0.0%
ABEO ABEONA THERAPEUTICS INC 0.1%
Value $606K Shares 108,865 Share Price $5.57 * Est. Cost/Share $6.04 Unrealized @ Report Date +1.8%
URGN UROGEN PHARMA LTD 0.0%
Value $261K Shares 24,500 Share Price $10.65 * Est. Cost/Share $27.01 Unrealized @ Report Date -55.7%
RLMD RELMADA THERAPEUTICS INC 0.0%
Value $257K Shares 495,146 Share Price $0.52 * Est. Cost/Share $3.27 Unrealized @ Report Date -25.4%
TIL INSTIL BIO INC 0.0%
Value $213K Shares 11,165 Share Price $19.09 * Est. Cost/Share $23.54 Unrealized @ Report Date +29.5%
AKTX AKARI THERAPEUTICS PLC-ADR 0.0%
Value $178K Shares 146,024 Share Price $1.22 Est. Cost/Share $1.22 Unrealized @ Report Date —
— GENERATION BIO CO 0.0%
Value $160K Shares 150,475 Share Price $1.06 Est. Cost/Share $2.82 Unrealized @ Report Date —