Location: Palo Alto, CA
CIK: 0001306923 · Show all filings
Period: Q1 2025 (← Previous) (Next →)
Filing Date: May 15, 2025
Total Value: $525M (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| INSM | INSMED INC | 987,153 | $75.31M | 14.3% | $17.79 | +330.0% | COM PAR $.01 | 457669307 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 991,207 | $70.07M | 13.3% | $83.16 | -19.1% | COM | 09061G101 |
| FOLD | AMICUS THERAPEUTICS INC | 7,345,002 | $59.94M | 11.4% | $9.63 | -3.9% | COM | 03152W109 |
| ACAD | ACADIA PHARMACEUTICALS INC | 2,663,925 | $44.25M | 8.4% | $26.96 | -32.6% | COM | 004225108 |
| UTHR | UNITED THERAPEUTICS CORP | 105,228 | $32.44M | 6.2% | $89.23 | +284.0% | COM | 91307C102 |
| BIIB | BIOGEN INC | 204,923 | $28.04M | 5.3% | $256.18 | -44.2% | COM | 09062X103 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 83,488 | $22.54M | 4.3% | $260.36 | -1.3% | COM | 02043Q107 |
| PTCT | PTC THERAPEUTICS INC | 404,196 | $20.6M | 3.9% | $37.01 | +34.8% | COM | 69366J200 |
| PRTA | PROTHENA CORP PLC | 1,659,734 | $20.54M | 3.9% | $21.46 | -34.1% | SHS | G72800108 |
| ANAB | ANAPTYSBIO INC | 1,020,713 | $18.98M | 3.6% | $19.30 | -13.6% | COM | 032724106 |
| NVCR | NOVOCURE LTD | 1,002,061 | $17.86M | 3.4% | $42.49 | -46.5% | ORD SHS | G6674U108 |
| SRPT | SAREPTA THERAPEUTICS INC | 210,258 | $13.42M | 2.6% | $112.41 | -6.4% | COM | 803607100 |
| EHTH | EHEALTH INC | 1,684,336 | $11.25M | 2.1% | $38.13 | -76.1% | COM | 28238P109 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 3,211,314 | $10.69M | 2.0% | $6.45 | -20.1% | COM | 462260100 |
| STAA | STAAR SURGICAL CO | 525,017 | $9.256M | 1.8% | $24.04 | -16.6% | COM PAR $0.01 | 852312305 |
| AGIO | AGIOS PHARMACEUTICALS INC | 276,578 | $8.104M | 1.5% | $33.17 | 0.0% | COM | 00847X104 |
| ALKS | ALKERMES PLC | 221,513 | $7.314M | 1.4% | $22.36 | +45.9% | SHS | G01767105 |
| GOSS | GOSSAMER BIO INC | 6,276,893 | $6.905M | 1.3% | $1.58 | -26.8% | COM | 38341P102 |
| ALGN | ALIGN TECHNOLOGY INC | 37,772 | $6M | 1.1% | $149.18 | +31.6% | COM | 016255101 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 444,367 | $5.459M | 1.0% | $16.60 | -15.0% | COM | 87164F105 |
| — | ACELYRIN INC | 1,792,895 | $4.428M | 0.8% | $6.67 | — | COM | 00445A100 |
| DYN | DYNE THERAPEUTICS INC | 333,391 | $3.487M | 0.7% | $14.30 | 0.0% | COM | 26818M108 |
| MIRM | MIRUM PHARMACEUTICALS INC | 64,700 | $2.915M | 0.6% | $15.56 | +203.0% | COM | 604749101 |
| EW | EDWARDS LIFESCIENCES CORP | 39,473 | $2.861M | 0.5% | $72.66 | -1.5% | COM | 28176E108 |
| — | VERVE THERAPEUTICS INC | 575,817 | $2.631M | 0.5% | $13.94 | — | COM | 92539P101 |
| BNTX | BIONTECH SE-ADR | 25,206 | $2.295M | 0.4% | $118.77 | — | SPONSORED ADS | 09075V102 |
| BCYC | BICYCLE THERAPEUTICS PLC-ADR | 248,934 | $2.113M | 0.4% | $16.07 | — | SPONSORED ADS | 088786108 |
| TVTX | TRAVERE THERAPEUTICS INC | 110,719 | $1.984M | 0.4% | $23.56 | -13.8% | COM | 89422G107 |
| TSHA | TAYSHA GENE THERAPIES INC | 1,419,468 | $1.973M | 0.4% | $1.87 | -10.7% | COM SHS | 877619106 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 13,334 | $1.475M | 0.3% | $126.68 | 0.0% | COM | 64125C109 |
| NUVB | NUVATION BIO INC | 772,652 | $1.36M | 0.3% | $1.92 | +18.5% | COM CL A | 67080N101 |
| ALDX | ALDEYRA THERAPEUTICS INC | 225,465 | $1.296M | 0.2% | $5.95 | -0.6% | COM | 01438T106 |
| — | KARYOPHARM THERAPEUTICS INC | 324,032 | $1.212M | 0.2% | $16.36 | — | COM | 48576U106 |
| ACRS | ACLARIS THERAPEUTICS INC | 776,028 | $1.187M | 0.2% | $1.44 | +47.9% | COM | 00461U105 |
| HUM | HUMANA INC | 3,985 | $1.054M | 0.2% | $369.63 | -27.8% | COM | 444859102 |
| PYXS | PYXIS ONCOLOGY INC | 1,037,421 | $1.017M | 0.2% | $2.98 | -55.3% | COMMON STOCK | 747324101 |
| STOK | STOKE THERAPEUTICS INC | 125,861 | $837K | 0.2% | $6.06 | +53.9% | COM | 86150R107 |
| VYNE | VYNE THERAPEUTICS INC PIPE | 445,434 | $704K | 0.1% | $3.12 | -21.0% | COM | 92941V308 |
| ABEO | ABEONA THERAPEUTICS INC | 108,865 | $518K | 0.1% | $6.04 | -10.0% | COM NEW | 00289Y206 |
| URGN | UROGEN PHARMA LTD | 24,500 | $271K | 0.1% | $27.01 | -60.5% | COM | M96088105 |
| TIL | INSTIL BIO INC | 11,165 | $194K | 0.0% | $23.54 | -11.9% | COM NEW | 45783C200 |
| AKTX | AKARI THERAPEUTICS PLC-ADR | 146,024 | $181K | 0.0% | $1.22 | — | SPONSORED ADR | 00972G207 |
| RLMD | RELMADA THERAPEUTICS INC | 495,146 | $134K | 0.0% | $3.27 | -89.9% | COM | 75955J402 |
| — | GENERATION BIO CO | 150,475 | $60,942 | 0.0% | $2.82 | — | COM | 37148K100 |