Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q1 2025 (← Previous) (Next →)

Filing Date: May 15, 2025

Total Value ($000): $525,145 (100.0% shares, 0.0% debt)

Holdings (44)

INSM INSMED INC 14.3%
Value ($000) $75,310 Shares 987,153 Est. Cost $17.79 Unrealized +330.0%
BMRN BIOMARIN PHARMACEUTICAL INC 13.3%
Value ($000) $70,068 Shares 991,207 Est. Cost $83.16 Unrealized -19.1%
FOLD AMICUS THERAPEUTICS INC 11.4%
Value ($000) $59,935 Shares 7,345,002 Est. Cost $9.63 Unrealized -3.9%
ACAD ACADIA PHARMACEUTICALS INC 8.4%
Value ($000) $44,248 Shares 2,663,925 Est. Cost $26.96 Unrealized -32.6%
UTHR UNITED THERAPEUTICS CORP 6.2%
Value ($000) $32,439 Shares 105,228 Est. Cost $89.23 Unrealized +284.0%
BIIB BIOGEN INC 5.3%
Value ($000) $28,042 Shares 204,923 Est. Cost $256.18 Unrealized -44.2%
ALNY ALNYLAM PHARMACEUTICALS INC 4.3%
Value ($000) $22,543 Shares 83,488 Est. Cost $260.36 Unrealized -1.3%
PTCT PTC THERAPEUTICS INC 3.9%
Value ($000) $20,598 Shares 404,196 Est. Cost $37.01 Unrealized +34.8%
PRTA PROTHENA CORP PLC 3.9%
Value ($000) $20,539 Shares 1,659,734 Est. Cost $21.46 Unrealized -34.1%
ANAB ANAPTYSBIO INC 3.6%
Value ($000) $18,975 Shares 1,020,713 Est. Cost $19.30 Unrealized -13.6%
NVCR NOVOCURE LTD 3.4%
Value ($000) $17,857 Shares 1,002,061 Est. Cost $42.49 Unrealized -46.5%
SRPT SAREPTA THERAPEUTICS INC 2.6%
Value ($000) $13,419 Shares 210,258 Est. Cost $112.41 Unrealized -6.4%
EHTH EHEALTH INC 2.1%
Value ($000) $11,251 Shares 1,684,336 Est. Cost $38.13 Unrealized -76.1%
IOVA IOVANCE BIOTHERAPEUTICS INC 2.0%
Value ($000) $10,694 Shares 3,211,314 Est. Cost $6.45 Unrealized -20.1%
STAA STAAR SURGICAL CO 1.8%
Value ($000) $9,256 Shares 525,017 Est. Cost $24.04 Unrealized -16.6%
AGIO AGIOS PHARMACEUTICALS INC 1.5%
Value ($000) $8,104 Shares 276,578 Est. Cost $33.17 Unrealized 0.0%
ALKS ALKERMES PLC 1.4%
Value ($000) $7,314 Shares 221,513 Est. Cost $22.36 Unrealized +45.9%
GOSS GOSSAMER BIO INC 1.3%
Value ($000) $6,905 Shares 6,276,893 Est. Cost $1.58 Unrealized -26.8%
ALGN ALIGN TECHNOLOGY INC 1.1%
Value ($000) $6,000 Shares 37,772 Est. Cost $149.18 Unrealized +31.6%
SNDX SYNDAX PHARMACEUTICALS INC 1.0%
Value ($000) $5,459 Shares 444,367 Est. Cost $16.60 Unrealized -15.0%
ACELYRIN INC 0.8%
Value ($000) $4,428 Shares 1,792,895 Est. Cost $6.67 Unrealized
DYN DYNE THERAPEUTICS INC 0.7%
Value ($000) $3,487 Shares 333,391 Est. Cost $14.30 Unrealized 0.0%
MIRM MIRUM PHARMACEUTICALS INC 0.6%
Value ($000) $2,915 Shares 64,700 Est. Cost $15.56 Unrealized +203.0%
EW EDWARDS LIFESCIENCES CORP 0.5%
Value ($000) $2,861 Shares 39,473 Est. Cost $72.66 Unrealized -1.5%
VERVE THERAPEUTICS INC 0.5%
Value ($000) $2,631 Shares 575,817 Est. Cost $13.94 Unrealized
BNTX BIONTECH SE-ADR 0.4%
Value ($000) $2,295 Shares 25,206 Est. Cost $118.77 Unrealized
BCYC BICYCLE THERAPEUTICS PLC-ADR 0.4%
Value ($000) $2,113 Shares 248,934 Est. Cost $16.07 Unrealized
TVTX TRAVERE THERAPEUTICS INC 0.4%
Value ($000) $1,984 Shares 110,719 Est. Cost $23.56 Unrealized -13.8%
TSHA TAYSHA GENE THERAPIES INC 0.4%
Value ($000) $1,973 Shares 1,419,468 Est. Cost $1.87 Unrealized -10.7%
NBIX NEUROCRINE BIOSCIENCES INC 0.3%
Value ($000) $1,475 Shares 13,334 Est. Cost $126.68 Unrealized 0.0%
NUVB NUVATION BIO INC 0.3%
Value ($000) $1,360 Shares 772,652 Est. Cost $1.92 Unrealized +18.5%
ALDX ALDEYRA THERAPEUTICS INC 0.2%
Value ($000) $1,296 Shares 225,465 Est. Cost $5.95 Unrealized -0.6%
KARYOPHARM THERAPEUTICS INC 0.2%
Value ($000) $1,212 Shares 324,032 Est. Cost $16.36 Unrealized
ACRS ACLARIS THERAPEUTICS INC 0.2%
Value ($000) $1,187 Shares 776,028 Est. Cost $1.44 Unrealized +47.9%
HUM HUMANA INC 0.2%
Value ($000) $1,054 Shares 3,985 Est. Cost $369.63 Unrealized -27.8%
PYXS PYXIS ONCOLOGY INC 0.2%
Value ($000) $1,017 Shares 1,037,421 Est. Cost $2.98 Unrealized -55.3%
STOK STOKE THERAPEUTICS INC 0.2%
Value ($000) $837 Shares 125,861 Est. Cost $6.06 Unrealized +53.9%
VYNE VYNE THERAPEUTICS INC PIPE 0.1%
Value ($000) $704 Shares 445,434 Est. Cost $3.12 Unrealized -21.0%
ABEO ABEONA THERAPEUTICS INC 0.1%
Value ($000) $518 Shares 108,865 Est. Cost $6.04 Unrealized -10.0%
URGN UROGEN PHARMA LTD 0.1%
Value ($000) $271 Shares 24,500 Est. Cost $27.01 Unrealized -60.5%
TIL INSTIL BIO INC 0.0%
Value ($000) $194 Shares 11,165 Est. Cost $23.54 Unrealized -11.9%
AKTX AKARI THERAPEUTICS PLC-ADR 0.0%
Value ($000) $181 Shares 146,024 Est. Cost $1.22 Unrealized
RLMD RELMADA THERAPEUTICS INC 0.0%
Value ($000) $134 Shares 495,146 Est. Cost $3.27 Unrealized -89.9%
GENERATION BIO CO 0.0%
Value ($000) $61 Shares 150,475 Est. Cost $2.82 Unrealized