CIK: 0001778253 · Show all filings
Period: Q4 2020 (← Previous) (Next →)
Filing Date: Feb 12, 2021
Total Value ($000): $2,268,048 (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value ($000) | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| MRNA | MODERNA INC | 1,450,000 | $151,482 | 6.7% | $101.17 | 0.0% | Put | 60770K107 |
| SRPT | SAREPTA THERAPEUTICS INC | 870,900 | $148,481 | 6.5% | — | — | Put | 803607100 |
| XBI | SPDR SER TR | 908,100 | $127,843 | 5.6% | — | — | Put | 78464A870 |
| BIIB | BIOGEN INC | 470,400 | $115,181 | 5.1% | $272.94 | -5.1% | Call | 09062X103 |
| SPY | SPDR S&P 500 ETF TR | 240,000 | $89,731 | 4.0% | — | — | Put | 78462F103 |
| BIIB | BIOGEN INC | 360,000 | $88,148 | 3.9% | $272.94 | -5.1% | Put | 09062X103 |
| SRPT | SAREPTA THERAPEUTICS INC | 501,000 | $85,416 | 3.8% | — | — | Call | 803607100 |
| — | HORIZON THERAPEUTICS PUB L | 977,200 | $71,485 | 3.2% | $77.62 | — | Call | G46188101 |
| ARGX | ARGENX SE | 201,500 | $59,260 | 2.6% | — | — | Put | 04016X101 |
| ARKG | ARK ETF TR | 440,100 | $41,044 | 1.8% | — | — | Put | 00214Q302 |
| NVAX | NOVAVAX INC | 323,700 | $36,097 | 1.6% | $121.82 | -12.7% | Put | 670002401 |
| — | TRACON PHARMACEUTICALS INC | 2,716,840 | $31,787 | 1.4% | $6.50 | — | COM NEW | 89237H209 |
| — | CHEMOCENTRYX INC | 451,700 | $27,969 | 1.2% | $27.03 | — | Put | 16383L106 |
| — | ZYMEWORKS INC | 580,200 | $27,422 | 1.2% | $46.92 | — | Put | 98985W102 |
| BNTX | BIONTECH SE | 319,900 | $26,080 | 1.1% | — | — | Put | 09075V102 |
| ONC | BEIGENE LTD | 97,300 | $25,141 | 1.1% | — | — | Put | 07725L102 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 1,364,990 | $23,915 | 1.1% | $4.43 | +306.1% | COM NEW | 15117B202 |
| — | IGM BIOSCIENCES INC | 250,000 | $22,073 | 1.0% | $90.00 | — | Put | 449585108 |
| — | CUREVAC N V | 261,200 | $21,175 | 0.9% | — | — | Put | N2451R105 |
| — | REATA PHARMACEUTICALS INC | 166,600 | $20,596 | 0.9% | — | — | Put | 75615P103 |
| KALV | KALVISTA PHARMACEUTICALS INC | 1,063,961 | $20,204 | 0.9% | $12.93 | +32.6% | COM | 483497103 |
| ARVN | ARVINAS INC | 232,700 | $19,763 | 0.9% | $34.48 | 0.0% | Call | 04335A105 |
| — | HORIZON THERAPEUTICS PUB L | 265,000 | $19,385 | 0.9% | $77.62 | — | Put | G46188101 |
| BEAM | BEAM THERAPEUTICS INC | 231,000 | $18,858 | 0.8% | — | — | Put | 07373V105 |
| BMY | BRISTOL-MYERS SQUIBB CO | 288,400 | $17,890 | 0.8% | $49.53 | +1.0% | COM | 110122108 |
| — | ZYMEWORKS INC | 375,200 | $17,732 | 0.8% | $46.92 | — | Call | 98985W102 |
| CRSP | CRISPR THERAPEUTICS AG | 115,300 | $17,654 | 0.8% | — | — | Put | H17182108 |
| AZN | ASTRAZENECA PLC | 350,000 | $17,498 | 0.8% | — | — | Call | 046353108 |
| GILD | GILEAD SCIENCES INC | 300,000 | $17,478 | 0.8% | — | — | Call | 375558103 |
| — | ZOGENIX INC | 867,400 | $17,342 | 0.8% | $24.73 | — | Call | 98978L204 |
| — | MORPHIC HLDG INC | 516,763 | $17,338 | 0.8% | $33.55 | — | COM | 61775R105 |
| LLY | LILLY ELI & CO | 100,000 | $16,884 | 0.7% | — | — | Call | 532457108 |
| IONS | IONIS PHARMACEUTICALS INC | 290,000 | $16,397 | 0.7% | — | — | Call | 462222100 |
| TARA | PROTARA THERAPEUTICS INC | 649,542 | $15,725 | 0.7% | $28.87 | -25.3% | COM STK | 74365U107 |
| ARWR | ARROWHEAD PHARMACEUTICALS IN | 200,000 | $15,346 | 0.7% | — | — | Put | 04280A100 |
| ASND | ASCENDIS PHARMA A/S | 87,090 | $14,526 | 0.6% | $166.79 | — | SPONSORED ADR | 04351P101 |
| PRTA | PROTHENA CORP PLC | 1,186,700 | $14,252 | 0.6% | $11.83 | 0.0% | SHS | G72800108 |
| OCUL | OCULAR THERAPEUTIX INC | 684,573 | $14,171 | 0.6% | $4.95 | +200.0% | COM | 67576A100 |
| — | BLUEPRINT MEDICINES CORP | 120,000 | $13,457 | 0.6% | — | — | Put | 09627Y109 |
| — | SUTRO BIOPHARMA INC | 615,360 | $13,360 | 0.6% | $12.46 | — | COM | 869367102 |
| — | CURIS INC | 1,575,000 | $12,899 | 0.6% | $8.19 | — | COM NEW | 231269200 |
| — | ACCELERON PHARMA INC | 100,000 | $12,793 | 0.6% | — | — | Put | 00434H108 |
| MIST | MILESTONE PHARMACEUTICALS IN | 1,836,545 | $12,305 | 0.5% | $7.14 | -6.3% | COM | 59935V107 |
| — | KARUNA THERAPEUTICS INC | 120,000 | $12,192 | 0.5% | — | — | Call | 48576A100 |
| — | VINCERA PHARMA INC | 538,684 | $11,265 | 0.5% | $20.91 | — | COM | 92731L106 |
| — | FIBROGEN INC | 300,000 | $11,126 | 0.5% | — | — | Call | 31572Q808 |
| — | MIRATI THERAPEUTICS INC | 50,000 | $10,981 | 0.5% | $166.04 | — | Call | 60468T105 |
| CYRX | CRYOPORT INC | 250,000 | $10,970 | 0.5% | $47.63 | 0.0% | Call | 229050307 |
| IMVT | IMMUNOVANT INC | 235,587 | $10,882 | 0.5% | $14.87 | +211.0% | COM | 45258J102 |
| UTHR | UNITED THERAPEUTICS CORP DEL | 69,300 | $10,520 | 0.5% | — | — | Call | 91307C102 |
| — | BIOHAVEN PHARMACTL HLDG CO L | 119,100 | $10,208 | 0.5% | — | — | Call | G11196105 |
| GOSS | GOSSAMER BIO INC | 1,048,383 | $10,138 | 0.4% | $11.36 | -13.3% | COM | 38341P102 |
| XBI | SPDR SER TR | 70,000 | $9,855 | 0.4% | — | — | Call | 78464A870 |
| BDTX | BLACK DIAMOND THERAPEUTICS I | 293,941 | $9,421 | 0.4% | $33.59 | -2.2% | COM | 09203E105 |
| — | MERUS N V | 536,921 | $9,411 | 0.4% | $17.53 | — | COM | N5749R100 |
| — | FIBROGEN INC | 251,900 | $9,343 | 0.4% | — | — | Put | 31572Q808 |
| KURA | KURA ONCOLOGY INC | 285,000 | $9,309 | 0.4% | $22.02 | +59.6% | Call | 50127T109 |
| — | LYRA THERAPEUTICS INC | 815,364 | $9,295 | 0.4% | $11.30 | — | COM | 55234L105 |
| CMPS | COMPASS PATHWAYS PLC | 187,800 | $8,947 | 0.4% | $34.90 | — | Call | 20451W101 |
| — | INTRA CELLULAR THERAPIES INC | 280,989 | $8,934 | 0.4% | $26.27 | — | COM | 46116X101 |
| — | BIOHAVEN PHARMACTL HLDG CO L | 104,100 | $8,923 | 0.4% | — | — | Put | G11196105 |
| — | VISTAGEN THERAPEUTICS INC | 4,485,952 | $8,703 | 0.4% | $1.94 | — | COM NEW | 92840H202 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 200,000 | $8,663 | 0.4% | — | — | Call | 37890U108 |
| ARVN | ARVINAS INC | 100,000 | $8,493 | 0.4% | $34.48 | 0.0% | Put | 04335A105 |
| ASND | ASCENDIS PHARMA A/S | 50,700 | $8,456 | 0.4% | $166.79 | — | Call | 04351P101 |
| — | SERES THERAPEUTICS INC | 341,100 | $8,357 | 0.4% | $28.30 | — | Call | 81750R102 |
| — | ALLAKOS INC | 58,700 | $8,218 | 0.4% | — | — | Call | 01671P100 |
| — | DECIPHERA PHARMACEUTICALS IN | 140,000 | $7,989 | 0.4% | — | — | Call | 24344T101 |
| — | SCPHARMACEUTICALS INC | 1,466,147 | $7,756 | 0.3% | $7.39 | — | COM | 810648105 |
| CRDF | CARDIFF ONCOLOGY INC | 417,900 | $7,517 | 0.3% | — | — | Put | 14147L108 |
| ARDX | ARDELYX INC | 1,155,436 | $7,476 | 0.3% | $6.44 | -7.8% | COM | 039697107 |
| PCVX | VAXCYTE INC | 276,110 | $7,336 | 0.3% | $36.88 | +0.8% | COM | 92243G108 |
| VIR | VIR BIOTECHNOLOGY INC | 268,000 | $7,176 | 0.3% | — | — | Put | 92764N102 |
| NBP | I MAB | 150,000 | $7,073 | 0.3% | $47.03 | — | SPONSORED ADS | 44975P103 |
| — | SAGE THERAPEUTICS INC | 81,700 | $7,069 | 0.3% | $58.62 | — | Call | 78667J108 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 400,000 | $7,008 | 0.3% | $4.43 | +306.1% | Call | 15117B202 |
| — | BIOXCEL THERAPEUTICS INC | 150,000 | $6,930 | 0.3% | $20.58 | — | Call | 09075P105 |
| IMTX | IMMATICS N.V | 638,094 | $6,885 | 0.3% | $10.53 | +0.1% | SHS | N44445109 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 50,000 | $6,499 | 0.3% | — | — | Put | 02043Q107 |
| MRNA | MODERNA INC | 62,059 | $6,483 | 0.3% | $101.17 | 0.0% | COM | 60770K107 |
| OCUL | OCULAR THERAPEUTIX INC | 312,100 | $6,461 | 0.3% | $4.95 | +200.0% | Call | 67576A100 |
| — | TRICIDA INC | 858,908 | $6,055 | 0.3% | $7.45 | — | COM | 89610F101 |
| — | SOLID BIOSCIENCES INC | 788,008 | $5,973 | 0.3% | $2.56 | — | COM | 83422E105 |
| — | CHIMERIX INC | 1,232,513 | $5,953 | 0.3% | $2.49 | — | COM | 16934W106 |
| — | STRONGBRIDGE BIOPHARMA PLC | 2,440,028 | $5,929 | 0.3% | $1.90 | — | SHS USD | G85347105 |
| — | SAGE THERAPEUTICS INC | 66,151 | $5,723 | 0.3% | $58.62 | — | COM | 78667J108 |
| SRRK | SCHOLAR ROCK HLDG CORP | 117,059 | $5,680 | 0.3% | $36.31 | 0.0% | COM | 80706P103 |
| AGIO | AGIOS PHARMACEUTICALS INC | 125,000 | $5,416 | 0.2% | — | — | Call | 00847X104 |
| — | LIFESCI ACQUISITION II CORP | 505,000 | $5,363 | 0.2% | $10.62 | — | COM | 53229E103 |
| — | X4 PHARMACEUTICALS INC | 826,424 | $5,314 | 0.2% | $6.75 | — | COM | 98420X103 |
| TGTX | TG THERAPEUTICS INC | 100,000 | $5,202 | 0.2% | — | — | Put | 88322Q108 |
| FULC | FULCRUM THERAPEUTICS INC | 437,700 | $5,125 | 0.2% | $11.31 | 0.0% | COM | 359616109 |
| — | SIERRA ONCOLOGY INC | 318,890 | $5,111 | 0.2% | $10.80 | — | COM NEW | 82640U404 |
| — | ONCTERNAL THERAPEUTICS INC | 1,030,323 | $5,048 | 0.2% | $4.90 | — | COM | 68236P107 |
| CCCC | C4 THERAPEUTICS INC | 151,500 | $5,019 | 0.2% | $29.00 | 0.0% | COM STK | 12529R107 |
| — | VERASTEM INC | 2,254,591 | $4,802 | 0.2% | $2.45 | — | COM | 92337C104 |
| QNCX | CORTEXYME INC | 170,000 | $4,722 | 0.2% | $45.47 | -2.6% | Put | 22053A107 |
| CYTK | CYTOKINETICS INC | 227,000 | $4,718 | 0.2% | $19.52 | -6.4% | COM NEW | 23282W605 |
| — | BLUEBIRD BIO INC | 106,200 | $4,595 | 0.2% | $60.11 | — | Call | 09609G100 |
| — | CARA THERAPEUTICS INC | 301,700 | $4,565 | 0.2% | $13.21 | — | Call | 140755109 |
| — | QUIDEL CORP | 25,300 | $4,545 | 0.2% | — | — | Call | 74838J101 |
| — | APPLIED THERAPEUTICS INC | 200,000 | $4,402 | 0.2% | $22.00 | — | Put | 03828A101 |
| ARCT | ARCTURUS THERAPEUTICS HLDGS | 100,000 | $4,338 | 0.2% | — | — | Put | 03969T109 |
| — | CHARDAN HEALTHCR ACQSTN 2 CO | 400,000 | $4,236 | 0.2% | $10.50 | — | UNIT 99/99/9999 | 15957T206 |
| DMAC | DIAMEDICA THERAPEUTICS INC | 415,000 | $4,208 | 0.2% | $5.29 | +3.4% | COM NEW | 25253X207 |
| — | CURIS INC | 512,500 | $4,198 | 0.2% | $8.19 | — | Call | 231269200 |
| — | CARA THERAPEUTICS INC | 273,524 | $4,137 | 0.2% | $13.21 | — | COM | 140755109 |
| ANAB | ANAPTYSBIO INC | 182,100 | $3,915 | 0.2% | $21.17 | +14.7% | Call | 032724106 |
| — | KADMON HLDGS INC | 936,615 | $3,887 | 0.2% | $4.19 | — | COM | 48283N106 |
| — | FS DEV CORP | 350,000 | $3,850 | 0.2% | $11.00 | — | COM CL A | 303020101 |
| — | TCR2 THERAPEUTICS INC | 121,486 | $3,757 | 0.2% | $30.93 | — | COM | 87808K106 |
| INMB | INMUNE BIO INC | 217,568 | $3,747 | 0.2% | $9.42 | 0.0% | COM | 45782T105 |
| — | CASI PHARMACEUTICALS INC | 1,268,154 | $3,741 | 0.2% | $1.87 | — | COM | 14757U109 |
| GOSS | GOSSAMER BIO INC | 381,300 | $3,688 | 0.2% | $11.36 | -13.3% | Call | 38341P102 |
| FATE | FATE THERAPEUTICS INC | 38,800 | $3,529 | 0.2% | — | — | Put | 31189P102 |
| FATE | FATE THERAPEUTICS INC | 38,500 | $3,500 | 0.2% | — | — | Call | 31189P102 |
| — | PASSAGE BIO INC | 136,697 | $3,495 | 0.2% | $25.57 | — | COM | 702712100 |
| — | ZOGENIX INC | 174,091 | $3,480 | 0.2% | $24.73 | — | COM NEW | 98978L204 |
| XENE | XENON PHARMACEUTICALS INC | 223,173 | $3,432 | 0.2% | $12.20 | -4.1% | COM | 98420N105 |
| STTK | SHATTUCK LABS INC | 65,000 | $3,406 | 0.2% | $32.14 | 0.0% | COM | 82024L103 |
| PHAT | PHATHOM PHARMACEUTICALS INC | 100,000 | $3,321 | 0.1% | $40.51 | 0.0% | COM | 71722W107 |
| — | ARENA PHARMACEUTICALS INC | 42,500 | $3,265 | 0.1% | $63.00 | — | Call | 040047607 |
| — | INTRA CELLULAR THERAPIES INC | 100,000 | $3,180 | 0.1% | $26.27 | — | Put | 46116X101 |
| — | CHIASMA INC | 730,299 | $3,177 | 0.1% | $4.34 | — | COM | 16706W102 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 140,913 | $3,134 | 0.1% | $20.74 | 0.0% | COM | 87164F105 |
| — | CLOVIS ONCOLOGY INC | 650,000 | $3,121 | 0.1% | $5.84 | — | Call | 189464100 |
| CYTK | CYTOKINETICS INC | 150,000 | $3,116 | 0.1% | $19.52 | -6.4% | Call | 23282W605 |
| — | CLOVIS ONCOLOGY INC | 642,108 | $3,082 | 0.1% | $5.84 | — | COM | 189464100 |
| — | CYCLACEL PHARMACEUTICALS INC | 391,450 | $3,057 | 0.1% | $7.81 | — | COM | 23254L603 |
| — | FREQUENCY THERAPEUTICS INC | 85,900 | $3,028 | 0.1% | — | — | Put | 35803L108 |
| — | AGENUS INC | 950,000 | $3,020 | 0.1% | $4.00 | — | COM NEW | 00847G705 |
| ACAD | ACADIA PHARMACEUTICALS INC | 56,008 | $2,995 | 0.1% | $47.14 | +5.3% | COM | 004225108 |
| — | TRILLIUM THERAPEUTICS INC | 200,000 | $2,942 | 0.1% | — | — | Call | 89620X506 |
| — | MERSANA THERAPEUTICS INC | 106,000 | $2,820 | 0.1% | $26.60 | — | COM | 59045L106 |
| LQDA | LIQUIDIA CORPORATION | 951,400 | $2,807 | 0.1% | $3.67 | 0.0% | COM NEW | 53635D202 |
| — | ADVERUM BIOTECHNOLOGIES INC | 258,700 | $2,804 | 0.1% | — | — | Call | 00773U108 |
| KALV | KALVISTA PHARMACEUTICALS INC | 145,500 | $2,761 | 0.1% | $12.93 | +32.6% | Call | 483497103 |
| — | POSEIDA THERAPEUTICS INC | 250,837 | $2,752 | 0.1% | $9.06 | — | COM | 73730P108 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 23,654 | $2,630 | 0.1% | $97.05 | +25.9% | COM | 558868105 |
| — | ICAD INC | 195,137 | $2,576 | 0.1% | $9.37 | — | COM NEW | 44934S206 |
| — | NEKTAR THERAPEUTICS | 150,000 | $2,550 | 0.1% | — | — | Call | 640268108 |
| — | SOCIAL CAP HEDSPIA HLDG CO I | 150,000 | $2,516 | 0.1% | $16.77 | — | Call | G8251K107 |
| — | ADICET BIO INC | 174,277 | $2,449 | 0.1% | $11.89 | — | COM | 007002108 |
| — | PANACEA ACQUISITION CORP | 201,808 | $2,361 | 0.1% | $11.70 | — | CL A | 698102100 |
| ACHV | ACHIEVE LIFE SCIENCES INC | 284,151 | $2,302 | 0.1% | $9.17 | -7.7% | COM | 004468500 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 23,700 | $2,272 | 0.1% | — | — | Call | 64125C109 |
| — | YUMANITY THERAPEUTICS INC | 132,514 | $2,253 | 0.1% | $17.00 | — | COM | 98872L102 |
| — | APPLIED GENETIC TECHNOLOGIES | 545,884 | $2,232 | 0.1% | $3.74 | — | COM | 03820J100 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 100,000 | $2,224 | 0.1% | $20.74 | 0.0% | Call | 87164F105 |
| — | GW PHARMACEUTICALS PLC | 19,100 | $2,204 | 0.1% | — | — | Put | 36197T103 |
| CYRX | CRYOPORT INC | 50,000 | $2,195 | 0.1% | $47.63 | 0.0% | Put | 229050307 |
| — | NEXTCURE INC | 200,000 | $2,179 | 0.1% | $8.80 | — | COM | 65343E108 |
| ANAB | ANAPTYSBIO INC | 100,000 | $2,149 | 0.1% | $21.17 | +14.7% | COM | 032724106 |
| HROW | HARROW HEALTH INC | 308,607 | $2,117 | 0.1% | $6.00 | -6.0% | COM | 415858109 |
| DCTH | DELCATH SYS INC | 112,712 | $2,019 | 0.1% | $10.24 | +33.8% | COM NEW | 24661P807 |
| — | MUSTANG BIO INC | 526,003 | $1,991 | 0.1% | $3.50 | — | COM | 62818Q104 |
| ACRS | ACLARIS THERAPEUTICS INC | 300,000 | $1,941 | 0.1% | $4.22 | 0.0% | COM | 00461U105 |
| — | DBV TECHNOLOGIES S A | 358,330 | $1,897 | 0.1% | $5.68 | — | SPONSORED ADR | 23306J101 |
| — | INTRA CELLULAR THERAPIES INC | 58,000 | $1,846 | 0.1% | $26.27 | — | Call | 46116X101 |
| — | KINIKSA PHARMACEUTICALS LTD | 101,273 | $1,789 | 0.1% | $15.33 | — | COM CL A | G5269C101 |
| — | BELLICUM PHARMACEUTICALS INC | 500,000 | $1,765 | 0.1% | $3.53 | — | COM NEW | 079481404 |
| — | BCTG ACQUISITION CORP | 149,512 | $1,711 | 0.1% | $11.44 | — | COM | 05492W103 |
| — | OTONOMY INC | 259,337 | $1,678 | 0.1% | $3.42 | — | COM | 68906L105 |
| — | SOCIAL CAP HEDSPIA HLDG CO I | 100,000 | $1,677 | 0.1% | $16.77 | — | COM CL A | G8251K107 |
| ATYR | ATYR PHARMA INC | 400,000 | $1,552 | 0.1% | $3.66 | 0.0% | COM NEW | 002120202 |
| ACRS | ACLARIS THERAPEUTICS INC | 235,800 | $1,527 | 0.1% | $4.22 | 0.0% | Call | 00461U105 |
| BIIB | BIOGEN INC | 5,700 | $1,396 | 0.1% | $272.94 | -5.1% | COM | 09062X103 |
| — | CATABASIS PHARMACEUTICALS IN | 650,000 | $1,392 | 0.1% | $2.14 | — | COM NEW | 14875P206 |
| AUPH | AURINIA PHARMACEUTICALS INC | 100,000 | $1,383 | 0.1% | — | — | Call | 05156V102 |
| — | GAMIDA CELL LTD | 160,000 | $1,343 | 0.1% | $8.39 | — | SHS | M47364100 |
| — | LONGVIEW ACQUISITION CORP | 62,796 | $1,243 | 0.1% | $19.79 | — | COM CL A | 543195101 |
| — | RIGEL PHARMACEUTICALS INC | 345,529 | $1,209 | 0.1% | $1.68 | — | COM NEW | 766559603 |
| — | HOMOLOGY MEDICINES INC | 100,000 | $1,129 | 0.0% | — | — | Put | 438083107 |
| CMPS | COMPASS PATHWAYS PLC | 23,648 | $1,127 | 0.0% | $34.90 | — | SPONSORED ADS | 20451W101 |
| — | SYROS PHARMACEUTICALS INC | 100,000 | $1,085 | 0.0% | $10.85 | — | COM | 87184Q107 |
| — | CHEMBIO DIAGNOSTICS INC | 219,109 | $1,041 | 0.0% | $4.75 | — | COM NEW | 163572209 |
| PBYI | PUMA BIOTECHNOLOGY INC | 100,000 | $1,026 | 0.0% | $8.28 | +22.3% | Call | 74587V107 |
| CYRX | CRYOPORT INC | 22,900 | $1,004 | 0.0% | $47.63 | 0.0% | COM PAR $0.001 | 229050307 |
| ALEC | ALECTOR INC | 57,500 | $870 | 0.0% | $12.45 | -0.2% | COM | 014442107 |
| ALT | ALTIMMUNE INC | 75,445 | $851 | 0.0% | $5.49 | +114.5% | COM NEW | 02155H200 |
| — | 89BIO INC | 32,799 | $799 | 0.0% | $25.66 | — | COM | 282559103 |
| — | MIRATI THERAPEUTICS INC | 3,557 | $781 | 0.0% | $166.04 | — | COM | 60468T105 |
| QNCX | CORTEXYME INC | 28,000 | $776 | 0.0% | $45.47 | -2.6% | Call | 22053A107 |
| IFRX | INFLARX NV | 149,750 | $754 | 0.0% | $2.92 | +54.0% | COM | N44821101 |
| — | APPLIED THERAPEUTICS INC | 33,002 | $726 | 0.0% | $22.00 | — | COM | 03828A101 |
| — | ALBIREO PHARMA INC | 16,883 | $633 | 0.0% | $37.49 | — | COM | 01345P106 |
| — | KALA PHARMACEUTICALS INC | 87,813 | $594 | 0.0% | $7.50 | — | COM | 483119103 |
| PBYI | PUMA BIOTECHNOLOGY INC | 54,901 | $563 | 0.0% | $8.28 | +22.3% | COM | 74587V107 |
| — | CERECOR INC | 202,865 | $536 | 0.0% | $5.16 | — | COM | 15671L109 |
| RCUS | ARCUS BIOSCIENCES INC | 20,500 | $532 | 0.0% | — | — | Put | 03969F109 |
| — | ADVERUM BIOTECHNOLOGIES INC | 44,800 | $486 | 0.0% | — | — | Put | 00773U108 |
| COGT | COGENT BIOSCIENCES INC | 41,762 | $469 | 0.0% | $10.99 | 0.0% | COM | 19240Q201 |
| — | AERPIO PHARMACEUTICALS INC | 475,778 | $468 | 0.0% | $1.50 | — | COM | 00810B105 |
| — | BRISTOL-MYERS SQUIBB CO | 644,021 | $444 | 0.0% | $3.18 | — | RIGHT 99/99/9999 | 110122157 |
| — | ASSEMBLY BIOSCIENCES INC | 72,468 | $439 | 0.0% | $20.46 | — | COM | 045396108 |
| MREO | MEREO BIOPHARMA GROUP PLC | 1,146,308 | $416 | 0.0% | $0.58 | — | ADS | 589492107 |
| ABUS | ARBUTUS BIOPHARMA CORP | 115,000 | $408 | 0.0% | $3.04 | +15.1% | COM | 03879J100 |
| — | ASLAN PHARMACEUTICALS LTD | 2,006,451 | $405 | 0.0% | $0.20 | — | ADS | 04522R101 |
| — | SUNESIS PHARMACEUTICALS INC | 200,000 | $398 | 0.0% | $1.99 | — | COM NEW | 867328874 |
| — | AVADEL PHARMACEUTICALS PLC | 54,694 | $366 | 0.0% | $8.06 | — | SPONSORED ADR | 05337M104 |
| KURA | KURA ONCOLOGY INC | 11,203 | $366 | 0.0% | $22.02 | +59.6% | COM | 50127T109 |
| QNCX | CORTEXYME INC | 13,000 | $361 | 0.0% | $45.47 | -2.6% | COM | 22053A107 |
| ARVN | ARVINAS INC | 4,216 | $358 | 0.0% | $34.48 | 0.0% | COM | 04335A105 |
| — | RAPT THERAPEUTICS INC | 15,600 | $309 | 0.0% | — | — | Put | 75382E109 |
| — | BELLUS HEALTH INC NEW | 100,000 | $306 | 0.0% | $2.27 | — | COM NEW | 07987C204 |
| NVAX | NOVAVAX INC | 2,636 | $294 | 0.0% | $121.82 | -12.7% | COM NEW | 670002401 |
| — | MILLENDO THERAPEUTICS INC | 135,193 | $289 | 0.0% | $1.76 | — | COM | 60040X103 |
| — | PRAXIS PRECISION MEDICINES I | 5,000 | $275 | 0.0% | $55.00 | — | COM | 74006W108 |
| — | INHIBRX INC | 8,076 | $266 | 0.0% | $32.94 | — | COM | 45720L107 |
| — | SOLENO THERAPEUTICS INC | 122,462 | $236 | 0.0% | $1.93 | — | COM NEW | 834203200 |
| IVA | INVENTIVA SA | 15,000 | $214 | 0.0% | $11.80 | — | ADS | 46124U107 |
| — | CORBUS PHARMACEUTICALS HLDGS | 139,100 | $174 | 0.0% | $1.25 | — | COM | 21833P103 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 17,900 | $119 | 0.0% | — | — | Call | 30233G209 |
| — | BAUDAX BIO INC | 100,000 | $101 | 0.0% | $2.48 | — | COM | 07160F107 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 2,100 | $91 | 0.0% | — | — | Put | 37890U108 |
| — | KINNATE BIOPHARMA INC | 2,000 | $79 | 0.0% | $39.50 | — | COM | 49705R105 |
| RCKT | ROCKET PHARMACEUTICALS INC | 1,400 | $75 | 0.0% | $36.45 | 0.0% | COM | 77313F106 |
| — | ZYMEWORKS INC | 1,556 | $73 | 0.0% | $46.92 | — | COM | 98985W102 |
| — | RAPT THERAPEUTICS INC | 3,500 | $69 | 0.0% | — | — | Call | 75382E109 |
| — | TRANSLATE BIO INC | 3,600 | $67 | 0.0% | — | — | Put | 89374L104 |
| — | ALPINE IMMUNE SCIENCES INC | 4,739 | $60 | 0.0% | $9.71 | — | COM | 02083G100 |
| — | STEALTH BIOTHERAPEUTICS CORP | 37,597 | $57 | 0.0% | $3.27 | — | SPONSORED ADS | 85789A105 |
| — | IGM BIOSCIENCES INC | 300 | $27 | 0.0% | $90.00 | — | COM | 449585108 |
| — | APTOSE BIOSCIENCES INC | 3,904 | $18 | 0.0% | $5.89 | — | COM NEW | 03835T200 |
| — | KARYOPHARM THERAPEUTICS INC | 791 | $12 | 0.0% | $15.17 | — | COM | 48576U106 |
| — | BLUEBIRD BIO INC | 281 | $12 | 0.0% | $60.11 | — | COM | 09609G100 |
| CGEN | COMPUGEN LTD | 500 | $6 | 0.0% | — | — | Put | M25722105 |
| — | CHEMOCENTRYX INC | 37 | $2 | 0.0% | $27.03 | — | COM | 16383L106 |
| — | BCLS ACQUISITION CORP | 100 | $1 | 0.0% | $10.00 | — | COM CL A | G0904B105 |
| — | GW PHARMACEUTICALS PLC | 8 | $0 | 0.0% | — | — | ADS | 36197T103 |