Frazier Life Sciences Management, L.P. Diversified Active

CIK: 0001892134 · Show all filings

Period: Q3 2022 (← Previous) (Next →)

Filing Date: Nov 14, 2022

Total Value ($000): $1,298,702 (100.0% shares, 0.0% debt)

Holdings (43)

— HILLEVAX INC 12.8%

Value ($000) $166,770 Shares 9,758,359 Est. Cost $11.23 Unrealized —

ARQT ARCUTIS BIOTHERAPEUTICS INC 12.8%

Value ($000) $165,956 Shares 8,684,232 Est. Cost $17.08 Unrealized +32.6%

PHAT PHATHOM PHARMACEUTICALS INC 7.2%

Value ($000) $93,151 Shares 8,407,152 Est. Cost $14.12 Unrealized -32.5%

— CHINOOK THERAPEUTICS INC 6.5%

Value ($000) $83,861 Shares 4,265,559 Est. Cost $17.11 Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC 6.3%

Value ($000) $82,010 Shares 3,412,838 Est. Cost $17.19 Unrealized +30.5%

MIRM MIRUM PHARMACEUTICALS INC 6.2%

Value ($000) $80,422 Shares 3,827,781 Est. Cost $20.65 Unrealized +16.6%

KRYS KRYSTAL BIOTECH INC 5.5%

Value ($000) $70,982 Shares 1,018,388 Est. Cost $62.37 Unrealized +15.8%

RYTM RHYTHM PHARMACEUTICALS INC 3.6%

Value ($000) $46,403 Shares 1,894,000 Est. Cost $18.60 Unrealized 0.0%

— IMAGO BIOSCIENCES INC 3.4%

Value ($000) $44,718 Shares 2,971,274 Est. Cost $19.27 Unrealized —

PCVX VAXCYTE INC 2.9%

Value ($000) $37,138 Shares 1,547,405 Est. Cost $21.85 Unrealized +16.0%

COGT COGENT BIOSCIENCES INC 2.4%

Value ($000) $30,946 Shares 2,074,154 Est. Cost $6.96 Unrealized +96.8%

TARS TARSUS PHARMACEUTICALS INC 2.4%

Value ($000) $30,602 Shares 1,787,527 Est. Cost $17.82 Unrealized -10.9%

— ALLAKOS INC 2.3%

Value ($000) $29,327 Shares 4,792,000 Est. Cost $6.12 Unrealized —

CRNX CRINETICS PHARMACEUTICALS IN 2.1%

Value ($000) $27,787 Shares 1,414,823 Est. Cost $20.24 Unrealized +0.8%

— TRICIDA INC 2.1%

Value ($000) $26,721 Shares 2,549,671 Est. Cost $8.63 Unrealized —

ANAB ANAPTYSBIO INC 1.8%

Value ($000) $22,951 Shares 899,700 Est. Cost $30.26 Unrealized -22.5%

KALV KALVISTA PHARMACEUTICALS INC 1.8%

Value ($000) $22,813 Shares 1,572,192 Est. Cost $14.37 Unrealized -2.7%

— ALPINE IMMUNE SCIENCES INC 1.7%

Value ($000) $21,497 Shares 2,985,757 Est. Cost $8.97 Unrealized —

— VERONA PHARMA PLC 1.7%

Value ($000) $21,457 Shares 2,099,541 Est. Cost $10.22 Unrealized —

— FRAZIER LIFESCIENCES ACQU CO 1.2%

Value ($000) $15,235 Shares 1,501,000 Est. Cost $9.99 Unrealized —

— MERUS N V 1.2%

Value ($000) $14,952 Shares 746,479 Est. Cost $25.59 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 1.1%

Value ($000) $14,026 Shares 857,338 Est. Cost $16.19 Unrealized 0.0%

REPL REPLIMUNE GROUP INC 1.1%

Value ($000) $13,924 Shares 806,267 Est. Cost $18.60 Unrealized +2.5%

— GRITSTONE BIO INC 1.0%

Value ($000) $13,460 Shares 5,237,348 Est. Cost $4.12 Unrealized —

ARVN ARVINAS INC 1.0%

Value ($000) $12,694 Shares 285,331 Est. Cost $67.21 Unrealized -27.8%

TYRA TYRA BIOSCIENCES INC 0.9%

Value ($000) $11,670 Shares 1,327,665 Est. Cost $11.74 Unrealized -22.1%

NTLA INTELLIA THERAPEUTICS INC 0.9%

Value ($000) $11,398 Shares 203,684 Est. Cost $84.72 Unrealized -26.8%

— CEREVEL THERAPEUTICS HLDNG I 0.9%

Value ($000) $11,106 Shares 393,000 Est. Cost $28.54 Unrealized —

— SUTRO BIOPHARMA INC 0.8%

Value ($000) $9,859 Shares 1,776,479 Est. Cost $8.22 Unrealized —

— GRACELL BIOTECHNOLOGIES INC 0.7%

Value ($000) $9,306 Shares 2,890,102 Est. Cost $2.33 Unrealized —

— BLUEBIRD BIO INC 0.7%

Value ($000) $9,120 Shares 1,440,757 Est. Cost $6.33 Unrealized —

SLN SILENCE THERAPEUTICS PLC 0.7%

Value ($000) $8,697 Shares 881,173 Est. Cost $19.00 Unrealized —

TRVI TREVI THERAPEUTICS INC 0.6%

Value ($000) $8,322 Shares 5,403,590 Est. Cost $3.10 Unrealized +5.7%

AUTL AUTOLUS THERAPEUTICS PLC 0.6%

Value ($000) $8,018 Shares 3,746,857 Est. Cost $4.17 Unrealized —

ACRS ACLARIS THERAPEUTICS INC 0.5%

Value ($000) $6,427 Shares 408,329 Est. Cost $13.64 Unrealized +15.5%

— PASSAGE BIO INC 0.4%

Value ($000) $4,696 Shares 3,756,915 Est. Cost $3.10 Unrealized —

IMVT IMMUNOVANT INC 0.3%

Value ($000) $3,269 Shares 585,759 Est. Cost $6.23 Unrealized -21.5%

MGNX MACROGENICS INC 0.2%

Value ($000) $2,428 Shares 701,631 Est. Cost $3.83 Unrealized 0.0%

— PARDES BIOSCIENCES INC 0.1%

Value ($000) $1,564 Shares 845,636 Est. Cost $7.22 Unrealized —

— ESSA PHARMA INC 0.1%

Value ($000) $1,261 Shares 692,910 Est. Cost $6.18 Unrealized —

— MOLECULAR TEMPLATES INC 0.1%

Value ($000) $1,030 Shares 1,374,047 Est. Cost $3.45 Unrealized —

— APTINYX INC 0.1%

Value ($000) $693 Shares 1,883,244 Est. Cost $2.27 Unrealized —

NBRVF NABRIVA THERAPEUTICS PLC 0.0%

Value ($000) $35 Shares 17,025 Est. Cost $4.21 Unrealized 0.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	HILLEVAX INC	9,758,359	$166,770	12.8%	$11.23	—	COM	43157M102
ARQT	ARCUTIS BIOTHERAPEUTICS INC	8,684,232	$165,956	12.8%	$17.08	+32.6%	COM	03969K108
PHAT	PHATHOM PHARMACEUTICALS INC	8,407,152	$93,151	7.2%	$14.12	-32.5%	COM	71722W107
—	CHINOOK THERAPEUTICS INC	4,265,559	$83,861	6.5%	$17.11	—	COM	16961L106
SNDX	SYNDAX PHARMACEUTICALS INC	3,412,838	$82,010	6.3%	$17.19	+30.5%	COM	87164F105
MIRM	MIRUM PHARMACEUTICALS INC	3,827,781	$80,422	6.2%	$20.65	+16.6%	COM	604749101
KRYS	KRYSTAL BIOTECH INC	1,018,388	$70,982	5.5%	$62.37	+15.8%	COM	501147102
RYTM	RHYTHM PHARMACEUTICALS INC	1,894,000	$46,403	3.6%	$18.60	0.0%	COM	76243J105
—	IMAGO BIOSCIENCES INC	2,971,274	$44,718	3.4%	$19.27	—	COM	45250K107
PCVX	VAXCYTE INC	1,547,405	$37,138	2.9%	$21.85	+16.0%	COM	92243G108
COGT	COGENT BIOSCIENCES INC	2,074,154	$30,946	2.4%	$6.96	+96.8%	COM	19240Q201
TARS	TARSUS PHARMACEUTICALS INC	1,787,527	$30,602	2.4%	$17.82	-10.9%	COM	87650L103
—	ALLAKOS INC	4,792,000	$29,327	2.3%	$6.12	—	COM	01671P100
CRNX	CRINETICS PHARMACEUTICALS IN	1,414,823	$27,787	2.1%	$20.24	+0.8%	COM	22663K107
—	TRICIDA INC	2,549,671	$26,721	2.1%	$8.63	—	COM	89610F101
ANAB	ANAPTYSBIO INC	899,700	$22,951	1.8%	$30.26	-22.5%	COM	032724106
KALV	KALVISTA PHARMACEUTICALS INC	1,572,192	$22,813	1.8%	$14.37	-2.7%	COM	483497103
—	ALPINE IMMUNE SCIENCES INC	2,985,757	$21,497	1.7%	$8.97	—	COM	02083G100
—	VERONA PHARMA PLC	2,099,541	$21,457	1.7%	$10.22	—	SPONSORED ADS	925050106
—	FRAZIER LIFESCIENCES ACQU CO	1,501,000	$15,235	1.2%	$9.99	—	UNIT 12/09/2025	G3710A121
—	MERUS N V	746,479	$14,952	1.2%	$25.59	—	COM	N5749R100
ACAD	ACADIA PHARMACEUTICALS INC	857,338	$14,026	1.1%	$16.19	0.0%	COM	004225108
REPL	REPLIMUNE GROUP INC	806,267	$13,924	1.1%	$18.60	+2.5%	COM	76029N106
—	GRITSTONE BIO INC	5,237,348	$13,460	1.0%	$4.12	—	COM	39868T105
ARVN	ARVINAS INC	285,331	$12,694	1.0%	$67.21	-27.8%	COM	04335A105
TYRA	TYRA BIOSCIENCES INC	1,327,665	$11,670	0.9%	$11.74	-22.1%	COM	90240B106
NTLA	INTELLIA THERAPEUTICS INC	203,684	$11,398	0.9%	$84.72	-26.8%	COM	45826J105
—	CEREVEL THERAPEUTICS HLDNG I	393,000	$11,106	0.9%	$28.54	—	COM	15678U128
—	SUTRO BIOPHARMA INC	1,776,479	$9,859	0.8%	$8.22	—	COM	869367102
—	GRACELL BIOTECHNOLOGIES INC	2,890,102	$9,306	0.7%	$2.33	—	SPONSORED ADS	38406L103
—	BLUEBIRD BIO INC	1,440,757	$9,120	0.7%	$6.33	—	COM	09609G100
SLN	SILENCE THERAPEUTICS PLC	881,173	$8,697	0.7%	$19.00	—	ADS	82686Q101
TRVI	TREVI THERAPEUTICS INC	5,403,590	$8,322	0.6%	$3.10	+5.7%	COM	89532M101
AUTL	AUTOLUS THERAPEUTICS PLC	3,746,857	$8,018	0.6%	$4.17	—	SPON ADS	05280R100
ACRS	ACLARIS THERAPEUTICS INC	408,329	$6,427	0.5%	$13.64	+15.5%	COM	00461U105
—	PASSAGE BIO INC	3,756,915	$4,696	0.4%	$3.10	—	COM	702712100
IMVT	IMMUNOVANT INC	585,759	$3,269	0.3%	$6.23	-21.5%	COM	45258J102
MGNX	MACROGENICS INC	701,631	$2,428	0.2%	$3.83	0.0%	COM	556099109
—	PARDES BIOSCIENCES INC	845,636	$1,564	0.1%	$7.22	—	COM	69945Q105
—	ESSA PHARMA INC	692,910	$1,261	0.1%	$6.18	—	COM NEW	29668H708
—	MOLECULAR TEMPLATES INC	1,374,047	$1,030	0.1%	$3.45	—	COM	608550109
—	APTINYX INC	1,883,244	$693	0.1%	$2.27	—	COM	03836N103
NBRVF	NABRIVA THERAPEUTICS PLC	17,025	$35	0.0%	$4.21	0.0%	SHS NEW 2022	G63637139