Opaleye Management Inc. Quant / Systematic

Location: Boston, MA

CIK: 0001595855 · Show all filings

Period: Q3 2024 (← Previous) (Next →)

Filing Date: Nov 14, 2024

Total Value: $600M (98.6% shares, 1.4% debt)

Holdings (44)

HROW HARROW HEALTH INC 29.9%

Value $179M Shares 3,990,000 Est. Cost $6.33 Unrealized +433.8%

TGTX TG THERAPEUTICS INC 8.9%

Value $53.33M Shares 2,280,000 Est. Cost $13.67 Unrealized +59.8%

OCUL OCULAR THERAPEUTIX INC 7.3%

Value $43.72M Shares 5,025,000 Est. Cost $5.10 Unrealized +61.8%

ARVN ARVINAS INC 5.2%

Value $30.91M Shares 1,255,000 Est. Cost $27.50 Unrealized -5.0%

CDXS CODEXIS INC 4.5%

Value $27.01M Shares 8,770,000 Est. Cost $2.89 Unrealized +6.9%

RYTM RHYTHM PHARMACEUTICALS INC 4.4%

Value $26.2M Shares 500,000 Est. Cost $12.73 Unrealized +276.4%

KROS KEROS THERAPEUTICS INC 3.8%

Value $22.95M Shares 395,276 Est. Cost $47.79 Unrealized +3.3%

IMNM IMMUNOME INC 3.0%

Value $18.09M Shares 1,237,500 Est. Cost $15.49 Unrealized -8.2%

LQDA LIQUIDIA CORPORATION 2.8%

Value $16.98M Shares 1,698,142 Est. Cost $9.89 Unrealized +10.5%

ETON ETON PHARMACEUTICALS INC 2.8%

Value $16.68M Shares 2,780,000 Est. Cost $5.60 Unrealized -24.5%

EWTX EDGEWISE THERAPEUTICS INC 2.3%

Value $13.95M Shares 522,500 Est. Cost $10.13 Unrealized +96.4%

— CARGO THERAPEUTICS INC 2.0%

Value $11.83M Shares 541,437 Est. Cost $16.42 Unrealized —

— APPLIED THERAPEUTICS INC' 1.9%

Value $11.22M Shares 1,320,000 Est. Cost $4.24 Unrealized —

PCVX VAXCYTE INC 1.6%

Value $9.713M Shares 85,000 Est. Cost $38.73 Unrealized +132.7%

NRIX NURIX THERAPEUTICS INC 1.6%

Value $9.437M Shares 420,000 Est. Cost $12.50 Unrealized +81.2%

— ACELYRIN INC 1.6%

Value $9.336M Shares 1,893,660 Est. Cost $18.25 Unrealized —

TRVI TREVI THERAPEUTICS INC 1.4%

Value $8.577M Shares 2,567,990 Est. Cost $2.06 Unrealized +44.5%

— BIODESIX INC 1.2%

Value $6.971M Shares 3,815,000 Est. Cost $2.17 Unrealized —

DNA GINKGO BIOWORKS HOLDINGS 1.1%

Value $6.685M Shares 820,202 Est. Cost $10.02 Unrealized 0.0%

JSPR JASPER THERAPEUTICS INC 1.1%

Value $6.649M Shares 353,500 Est. Cost $17.76 Unrealized +12.1%

XOMA XOMA CORP DEL 1.1%

Value $6.62M Shares 250,000 Est. Cost $11.26 Unrealized +140.5%

NUVL NUVALENT INC 1.1%

Value $6.547M Shares 64,000 Est. Cost $72.00 Unrealized +15.2%

NAMS NEWAMSTERDAM PHARMA COMPANY 0.9%

Value $5.561M Shares 335,000 Est. Cost $11.31 Unrealized +53.0%

URGN UROGEN PHARMA LTD 0.9%

Value $5.132M Shares 404,100 Est. Cost $10.29 Unrealized +44.3%

PTGX PROTAGONIST THERAPEUTICS INC 0.8%

Value $4.725M Shares 105,000 Est. Cost $17.50 Unrealized +130.9%

— GOSSAMER BIO INC 0.7%

Value $4.189M Shares 8,000,000 Est. Cost $0.39 Unrealized —

CYTK CYTOKINETICS INC 0.7%

Value $3.976M Shares 75,300 Est. Cost $60.36 Unrealized -7.7%

— KARYOPHARM THERAPEUTICS INC 0.7%

Value $3.961M Shares 6,000,000 Est. Cost $0.62 Unrealized —

GOSS GOSSAMER BIO INC 0.6%

Value $3.706M Shares 3,665,010 Est. Cost $1.04 Unrealized -7.6%

ZNTL ZENTALIS PHARMACEUTICALS INC 0.6%

Value $3.559M Shares 967,000 Est. Cost $3.63 Unrealized 0.0%

TARA PROTARA THERAPEUTICS INC 0.5%

Value $3.077M Shares 1,681,154 Est. Cost $29.10 Unrealized -92.9%

RZLT REZOLUTE INC 0.4%

Value $2.263M Shares 466,563 Est. Cost $4.59 Unrealized 0.0%

CPRX CATALYST PHARMACEUTICALS INC 0.4%

Value $2.236M Shares 112,500 Est. Cost $13.39 Unrealized +38.5%

ABCL ABCELLERA BIOLOGICS INC 0.3%

Value $2.08M Shares 800,000 Est. Cost $3.02 Unrealized -8.4%

— LYELL IMMUNOPHARMA INC 0.3%

Value $1.925M Shares 1,395,000 Est. Cost $2.23 Unrealized —

— ALLAKOS INC 0.3%

Value $1.573M Shares 2,407,600 Est. Cost $1.23 Unrealized —

RLMD RELMADA THERAPEUTICS INC 0.3%

Value $1.555M Shares 480,000 Est. Cost $2.96 Unrealized +9.4%

PEPG PEPGEN INC 0.3%

Value $1.532M Shares 179,200 Est. Cost $11.83 Unrealized 0.0%

— REVANCE THERAPEUTICS INC 0.2%

Value $1.427M Shares 275,000 Est. Cost $5.19 Unrealized —

SYRS SYROS PHARMACEUTICALS INC 0.2%

Value $1.408M Shares 654,943 Est. Cost $5.32 Unrealized -32.4%

— AEROVATE THERAPEUTICS INC 0.2%

Value $920K Shares 440,000 Est. Cost $1.66 Unrealized —

— REGULUS THERAPEUTICS INC 0.1%

Value $840K Shares 535,000 Est. Cost $1.91 Unrealized —

IBIO IBIO INC 0.1%

Value $833K Shares 375,000 Est. Cost $1.26 Unrealized +57.1%

ADGM ADAGIO MED HLDGS INC 0.0%

Value $285K Shares 110,571 Est. Cost $4.76 Unrealized 0.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
HROW	HARROW HEALTH INC	3,990,000	$179M	29.9%	$6.33	+433.8%	COM	415858109
TGTX	TG THERAPEUTICS INC	2,280,000	$53.33M	8.9%	$13.67	+59.8%	COM	88322Q108
OCUL	OCULAR THERAPEUTIX INC	5,025,000	$43.72M	7.3%	$5.10	+61.8%	COM	67576A100
ARVN	ARVINAS INC	1,255,000	$30.91M	5.2%	$27.50	-5.0%	COM	04335A105
CDXS	CODEXIS INC	8,770,000	$27.01M	4.5%	$2.89	+6.9%	COM	192005106
RYTM	RHYTHM PHARMACEUTICALS INC	500,000	$26.2M	4.4%	$12.73	+276.4%	COM	76243J105
KROS	KEROS THERAPEUTICS INC	395,276	$22.95M	3.8%	$47.79	+3.3%	COM	492327101
IMNM	IMMUNOME INC	1,237,500	$18.09M	3.0%	$15.49	-8.2%	COM	45257U108
LQDA	LIQUIDIA CORPORATION	1,698,142	$16.98M	2.8%	$9.89	+10.5%	COM NEW	53635D202
ETON	ETON PHARMACEUTICALS INC	2,780,000	$16.68M	2.8%	$5.60	-24.5%	COM	29772L108
EWTX	EDGEWISE THERAPEUTICS INC	522,500	$13.95M	2.3%	$10.13	+96.4%	COM	28036F105
—	CARGO THERAPEUTICS INC	541,437	$11.83M	2.0%	$16.42	—	COM	14179K101
—	APPLIED THERAPEUTICS INC'	1,320,000	$11.22M	1.9%	$4.24	—	COM	03828A101
PCVX	VAXCYTE INC	85,000	$9.713M	1.6%	$38.73	+132.7%	COM	92243G108
NRIX	NURIX THERAPEUTICS INC	420,000	$9.437M	1.6%	$12.50	+81.2%	COM	67080M103
—	ACELYRIN INC	1,893,660	$9.336M	1.6%	$18.25	—	COM	00445A100
TRVI	TREVI THERAPEUTICS INC	2,567,990	$8.577M	1.4%	$2.06	+44.5%	COM	89532M101
—	BIODESIX INC	3,815,000	$6.971M	1.2%	$2.17	—	COM	09075X108
DNA	GINKGO BIOWORKS HOLDINGS	820,202	$6.685M	1.1%	$10.02	0.0%	Class A New	37611X209
JSPR	JASPER THERAPEUTICS INC	353,500	$6.649M	1.1%	$17.76	+12.1%	COM NEW	471871202
XOMA	XOMA CORP DEL	250,000	$6.62M	1.1%	$11.26	+140.5%	COM NEW	98419J206
NUVL	NUVALENT INC	64,000	$6.547M	1.1%	$72.00	+15.2%	COM	670703107
NAMS	NEWAMSTERDAM PHARMA COMPANY	335,000	$5.561M	0.9%	$11.31	+53.0%	ORDINARY SHARES	N62509109
URGN	UROGEN PHARMA LTD	404,100	$5.132M	0.9%	$10.29	+44.3%	COM	M96088105
PTGX	PROTAGONIST THERAPEUTICS INC	105,000	$4.725M	0.8%	$17.50	+130.9%	COM	74366E102
—	GOSSAMER BIO INC	8,000,000	$4.189M	0.7%	$0.39	—	NOTE 5.000% 6/0	38341PAA0
CYTK	CYTOKINETICS INC	75,300	$3.976M	0.7%	$60.36	-7.7%	COM NEW	23282W605
—	KARYOPHARM THERAPEUTICS INC	6,000,000	$3.961M	0.7%	$0.62	—	NOTE 3.000%10/1	48576UAA4
GOSS	GOSSAMER BIO INC	3,665,010	$3.706M	0.6%	$1.04	-7.6%	COM	38341P102
ZNTL	ZENTALIS PHARMACEUTICALS INC	967,000	$3.559M	0.6%	$3.63	0.0%	COM	98943L107
TARA	PROTARA THERAPEUTICS INC	1,681,154	$3.077M	0.5%	$29.10	-92.9%	COM STK	74365U107
RZLT	REZOLUTE INC	466,563	$2.263M	0.4%	$4.59	0.0%	COM NEW	76200L309
CPRX	CATALYST PHARMACEUTICALS INC	112,500	$2.236M	0.4%	$13.39	+38.5%	COM	14888U101
ABCL	ABCELLERA BIOLOGICS INC	800,000	$2.08M	0.3%	$3.02	-8.4%	COM	00288U106
—	LYELL IMMUNOPHARMA INC	1,395,000	$1.925M	0.3%	$2.23	—	COM	55083R104
—	ALLAKOS INC	2,407,600	$1.573M	0.3%	$1.23	—	COM	01671P100
RLMD	RELMADA THERAPEUTICS INC	480,000	$1.555M	0.3%	$2.96	+9.4%	COM	75955J402
PEPG	PEPGEN INC	179,200	$1.532M	0.3%	$11.83	0.0%	COM	713317105
—	REVANCE THERAPEUTICS INC	275,000	$1.427M	0.2%	$5.19	—	COM	761330109
SYRS	SYROS PHARMACEUTICALS INC	654,943	$1.408M	0.2%	$5.32	-32.4%	COM NEW	87184Q206
—	AEROVATE THERAPEUTICS INC	440,000	$920K	0.2%	$1.66	—	COM	008064107
—	REGULUS THERAPEUTICS INC	535,000	$840K	0.1%	$1.91	—	COM	75915K309
IBIO	IBIO INC	375,000	$833K	0.1%	$1.26	+57.1%	COM NEW	451033708
ADGM	ADAGIO MED HLDGS INC	110,571	$285K	0.0%	$4.76	0.0%	COM	00534B100