Opaleye Management Inc. Quant / Systematic

CIK: 0001595855 · Show all filings

Period: Q4 2024 (← Previous) (Next →)

Filing Date: Feb 14, 2025

Total Value ($000): $571,423 (98.1% shares, 1.9% debt)

Holdings (39)

HROW HARROW HEALTH INC 23.4%

Value ($000) $133,865 Shares 3,990,000 Est. Cost $6.33 Unrealized +598.7%

TGTX TG THERAPEUTICS INC 11.9%

Value ($000) $68,026 Shares 2,260,000 Est. Cost $13.67 Unrealized +110.0%

CDXS CODEXIS INC 7.4%

Value ($000) $42,167 Shares 8,840,000 Est. Cost $2.89 Unrealized +42.3%

ETON ETON PHARMACEUTICALS INC 6.6%

Value ($000) $37,990 Shares 2,852,070 Est. Cost $5.71 Unrealized +77.6%

OCUL OCULAR THERAPEUTIX INC 6.5%

Value ($000) $37,085 Shares 4,342,500 Est. Cost $5.10 Unrealized +91.5%

ARVN ARVINAS INC 5.9%

Value ($000) $33,643 Shares 1,625,000 Est. Cost $26.77 Unrealized -9.2%

RYTM RHYTHM PHARMACEUTICALS INC 4.9%

Value ($000) $27,990 Shares 500,000 Est. Cost $12.73 Unrealized +333.9%

IMNM IMMUNOME INC 3.8%

Value ($000) $21,665 Shares 2,040,000 Est. Cost $14.15 Unrealized -14.6%

LQDA LIQUIDIA CORPORATION 3.5%

Value ($000) $19,970 Shares 1,698,142 Est. Cost $9.89 Unrealized +10.5%

EWTX EDGEWISE THERAPEUTICS INC 2.2%

Value ($000) $12,816 Shares 480,000 Est. Cost $10.13 Unrealized +214.4%

DNA GINKGO BIOWORKS HOLDINGS 2.1%

Value ($000) $11,784 Shares 1,200,000 Est. Cost $9.56 Unrealized -10.4%

— CARGO THERAPEUTICS INC 1.9%

Value ($000) $10,815 Shares 750,000 Est. Cost $15.86 Unrealized —

TARA PROTARA THERAPEUTICS INC 1.7%

Value ($000) $9,636 Shares 1,825,000 Est. Cost $27.06 Unrealized -88.1%

TRVI TREVI THERAPEUTICS INC 1.7%

Value ($000) $9,548 Shares 2,317,500 Est. Cost $2.06 Unrealized +55.6%

JSPR JASPER THERAPEUTICS INC 1.5%

Value ($000) $8,552 Shares 400,000 Est. Cost $18.12 Unrealized +14.9%

NAMS NEWAMSTERDAM PHARMA COMPANY 1.5%

Value ($000) $8,353 Shares 325,000 Est. Cost $11.31 Unrealized +87.9%

— ACELYRIN INC 1.3%

Value ($000) $7,175 Shares 2,235,000 Est. Cost $15.96 Unrealized —

NRIX NURIX THERAPEUTICS INC 1.2%

Value ($000) $7,131 Shares 378,500 Est. Cost $12.50 Unrealized +83.4%

XOMA XOMA CORP DEL 1.1%

Value ($000) $6,570 Shares 250,000 Est. Cost $11.26 Unrealized +159.4%

PCVX VAXCYTE INC 1.1%

Value ($000) $6,140 Shares 75,000 Est. Cost $38.73 Unrealized +156.4%

— GOSSAMER BIO INC 1.1%

Value ($000) $6,090 Shares 11,500,000 Est. Cost $0.43 Unrealized —

ZNTL ZENTALIS PHARMACEUTICALS INC 0.9%

Value ($000) $5,356 Shares 1,767,500 Est. Cost $3.47 Unrealized -5.6%

— BIODESIX INC 0.9%

Value ($000) $5,301 Shares 3,465,000 Est. Cost $2.17 Unrealized —

— KARYOPHARM THERAPEUTICS INC 0.8%

Value ($000) $4,670 Shares 6,000,000 Est. Cost $0.62 Unrealized —

NUVL NUVALENT INC 0.8%

Value ($000) $4,579 Shares 58,500 Est. Cost $72.00 Unrealized +29.7%

GOSS GOSSAMER BIO INC 0.7%

Value ($000) $4,062 Shares 4,490,000 Est. Cost $1.01 Unrealized -14.9%

PTGX PROTAGONIST THERAPEUTICS INC 0.7%

Value ($000) $4,053 Shares 105,000 Est. Cost $17.50 Unrealized +149.2%

— ESSA PHARMA INC 0.7%

Value ($000) $3,956 Shares 2,209,998 Est. Cost $1.79 Unrealized —

ABCL ABCELLERA BIOLOGICS INC 0.5%

Value ($000) $2,827 Shares 965,000 Est. Cost $2.98 Unrealized -6.6%

URGN UROGEN PHARMA LTD 0.4%

Value ($000) $2,343 Shares 220,000 Est. Cost $10.29 Unrealized +16.4%

RZLT REZOLUTE INC 0.4%

Value ($000) $2,279 Shares 465,000 Est. Cost $4.59 Unrealized +9.7%

IMTX IMMATICS NV 0.2%

Value ($000) $1,173 Shares 165,000 Est. Cost $8.59 Unrealized 0.0%

IBIO IBIO INC 0.2%

Value ($000) $919 Shares 375,000 Est. Cost $1.26 Unrealized +104.3%

LXEO LEXEO THERAPEUTICS INC 0.1%

Value ($000) $855 Shares 130,000 Est. Cost $7.88 Unrealized 0.0%

RGNX REGENXBIO Inc 0.1%

Value ($000) $618 Shares 80,000 Est. Cost $9.39 Unrealized 0.0%

VTYX VENTYX BIOSCIENCES 0.1%

Value ($000) $613 Shares 280,000 Est. Cost $2.27 Unrealized 0.0%

PEPG PEPGEN INC 0.1%

Value ($000) $417 Shares 110,000 Est. Cost $11.83 Unrealized -47.3%

STOK STOKE THERAPEUTICS INC 0.0%

Value ($000) $276 Shares 25,000 Est. Cost $12.29 Unrealized 0.0%

ADGM ADAGIO MED HLDGS INC 0.0%

Value ($000) $116 Shares 110,571 Est. Cost $4.76 Unrealized -49.3%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
HROW	HARROW HEALTH INC	3,990,000	$133,865	23.4%	$6.33	+598.7%	COM	415858109
TGTX	TG THERAPEUTICS INC	2,260,000	$68,026	11.9%	$13.67	+110.0%	COM	88322Q108
CDXS	CODEXIS INC	8,840,000	$42,167	7.4%	$2.89	+42.3%	COM	192005106
ETON	ETON PHARMACEUTICALS INC	2,852,070	$37,990	6.6%	$5.71	+77.6%	COM	29772L108
OCUL	OCULAR THERAPEUTIX INC	4,342,500	$37,085	6.5%	$5.10	+91.5%	COM	67576A100
ARVN	ARVINAS INC	1,625,000	$33,643	5.9%	$26.77	-9.2%	COM	04335A105
RYTM	RHYTHM PHARMACEUTICALS INC	500,000	$27,990	4.9%	$12.73	+333.9%	COM	76243J105
IMNM	IMMUNOME INC	2,040,000	$21,665	3.8%	$14.15	-14.6%	COM	45257U108
LQDA	LIQUIDIA CORPORATION	1,698,142	$19,970	3.5%	$9.89	+10.5%	COM NEW	53635D202
EWTX	EDGEWISE THERAPEUTICS INC	480,000	$12,816	2.2%	$10.13	+214.4%	COM	28036F105
DNA	GINKGO BIOWORKS HOLDINGS	1,200,000	$11,784	2.1%	$9.56	-10.4%	Class A New	37611X209
—	CARGO THERAPEUTICS INC	750,000	$10,815	1.9%	$15.86	—	COM	14179K101
TARA	PROTARA THERAPEUTICS INC	1,825,000	$9,636	1.7%	$27.06	-88.1%	COM STK	74365U107
TRVI	TREVI THERAPEUTICS INC	2,317,500	$9,548	1.7%	$2.06	+55.6%	COM	89532M101
JSPR	JASPER THERAPEUTICS INC	400,000	$8,552	1.5%	$18.12	+14.9%	COM NEW	471871202
NAMS	NEWAMSTERDAM PHARMA COMPANY	325,000	$8,353	1.5%	$11.31	+87.9%	ORDINARY SHARES	N62509109
—	ACELYRIN INC	2,235,000	$7,175	1.3%	$15.96	—	COM	00445A100
NRIX	NURIX THERAPEUTICS INC	378,500	$7,131	1.2%	$12.50	+83.4%	COM	67080M103
XOMA	XOMA CORP DEL	250,000	$6,570	1.1%	$11.26	+159.4%	COM NEW	98419J206
PCVX	VAXCYTE INC	75,000	$6,140	1.1%	$38.73	+156.4%	COM	92243G108
—	GOSSAMER BIO INC	11,500,000	$6,090	1.1%	$0.43	—	NOTE 5.000% 6/0	38341PAA0
ZNTL	ZENTALIS PHARMACEUTICALS INC	1,767,500	$5,356	0.9%	$3.47	-5.6%	COM	98943L107
—	BIODESIX INC	3,465,000	$5,301	0.9%	$2.17	—	COM	09075X108
—	KARYOPHARM THERAPEUTICS INC	6,000,000	$4,670	0.8%	$0.62	—	NOTE 3.000%10/1	48576UAA4
NUVL	NUVALENT INC	58,500	$4,579	0.8%	$72.00	+29.7%	COM	670703107
GOSS	GOSSAMER BIO INC	4,490,000	$4,062	0.7%	$1.01	-14.9%	COM	38341P102
PTGX	PROTAGONIST THERAPEUTICS INC	105,000	$4,053	0.7%	$17.50	+149.2%	COM	74366E102
—	ESSA PHARMA INC	2,209,998	$3,956	0.7%	$1.79	—	COM NEW	29668H708
ABCL	ABCELLERA BIOLOGICS INC	965,000	$2,827	0.5%	$2.98	-6.6%	COM	00288U106
URGN	UROGEN PHARMA LTD	220,000	$2,343	0.4%	$10.29	+16.4%	COM	M96088105
RZLT	REZOLUTE INC	465,000	$2,279	0.4%	$4.59	+9.7%	COM NEW	76200L309
IMTX	IMMATICS NV	165,000	$1,173	0.2%	$8.59	0.0%	ORDINARY SHARES	N44445109
IBIO	IBIO INC	375,000	$919	0.2%	$1.26	+104.3%	COM NEW	451033708
LXEO	LEXEO THERAPEUTICS INC	130,000	$855	0.1%	$7.88	0.0%	COM	52886X107
RGNX	REGENXBIO Inc	80,000	$618	0.1%	$9.39	0.0%	COM	75901B107
VTYX	VENTYX BIOSCIENCES	280,000	$613	0.1%	$2.27	0.0%	COM	92332V107
PEPG	PEPGEN INC	110,000	$417	0.1%	$11.83	-47.3%	COM	713317105
STOK	STOKE THERAPEUTICS INC	25,000	$276	0.0%	$12.29	0.0%	COM	86150R107
ADGM	ADAGIO MED HLDGS INC	110,571	$116	0.0%	$4.76	-49.3%	COM	00534B100