Paradigm Biocapital Advisors LP Quant / Systematic

Location: New York, NY

CIK: 0001855655 · Show all filings

Period: Q4 2025 (← Previous) (Next →)

Filing Date: Feb 17, 2026

Total Value: $3.918B (100.0% shares, 0.0% debt)

Holdings (30)

NUVL NUVALENT INC 13.5%

Value $530M Shares 5,269,433 Est. Cost $60.72 Unrealized +62.4%

RVMD REVOLUTION MEDICINES INC 13.5%

Value $529M Shares 6,644,403 Est. Cost $38.36 Unrealized +70.9%

ACLX ARCELLX INC 9.5%

Value $373M Shares 5,724,016 Est. Cost $48.76 Unrealized +63.6%

GMAB GENMAB A/S 5.5%

Value $217M Shares 7,039,834 Est. Cost $30.73 Unrealized —

TARS TARSUS PHARMACEUTICALS INC 5.4%

Value $210M Shares 2,562,154 Est. Cost $28.61 Unrealized +161.0%

ABVX ABIVAX SA 4.9%

Value $191M Shares 1,417,473 Est. Cost $84.90 Unrealized —

OLMA OLEMA PHARMACEUTICALS INC 4.8%

Value $189M Shares 7,544,172 Est. Cost $9.20 Unrealized +93.4%

PCVX VAXCYTE INC 4.8%

Value $188M Shares 4,068,020 Est. Cost $55.45 Unrealized -19.3%

XBI SPDR SERIES TRUST 4.7%

Value $183M Shares 1,500,000 Est. Cost — Unrealized —

— CIDARA THERAPEUTICS INC 4.3%

Value $168M Shares 759,565 Est. Cost $95.76 Unrealized —

EWTX EDGEWISE THERAPEUTICS INC 4.1%

Value $162M Shares 6,541,210 Est. Cost $20.10 Unrealized -0.1%

SRRK SCHOLAR ROCK HLDG CORP 3.4%

Value $135M Shares 3,062,157 Est. Cost $33.97 Unrealized +10.4%

URGN UROGEN PHARMA LTD 2.7%

Value $105M Shares 4,473,648 Est. Cost $18.17 Unrealized +19.4%

CRNX CRINETICS PHARMACEUTICALS IN 2.6%

Value $103M Shares 2,210,774 Est. Cost $26.84 Unrealized +65.9%

APGE APOGEE THERAPEUTICS INC 2.2%

Value $84.78M Shares 1,123,243 Est. Cost $44.51 Unrealized +41.5%

EYPT EYEPOINT INC 1.7%

Value $67.44M Shares 3,691,475 Est. Cost $12.73 Unrealized +11.4%

ERAS ERASCA INC 1.3%

Value $52.67M Shares 14,159,095 Est. Cost $2.22 Unrealized +26.9%

BBIO BRIDGEBIO PHARMA INC 1.3%

Value $52.34M Shares 684,277 Est. Cost $36.37 Unrealized +80.5%

ORKA ORUKA THERAPEUTICS INC 1.3%

Value $51.84M Shares 1,710,316 Est. Cost $27.86 Unrealized 0.0%

SYRE SPYRE THERAPEUTICS INC 1.2%

Value $48.07M Shares 1,467,266 Est. Cost $26.04 Unrealized +0.3%

LXEO LEXEO THERAPEUTICS INC 1.2%

Value $47.3M Shares 4,763,198 Est. Cost $9.13 Unrealized 0.0%

VRDN VIRIDIAN THERAPEUTICS INC 1.1%

Value $44.91M Shares 1,443,102 Est. Cost $17.86 Unrealized +53.5%

OCUL OCULAR THERAPEUTIX INC 0.9%

Value $35.63M Shares 2,935,284 Est. Cost $7.86 Unrealized +54.4%

TERN TERNS PHARMACEUTICALS INC 0.8%

Value $32.74M Shares 810,286 Est. Cost $23.11 Unrealized 0.0%

BBOT BRIDGEBIO ONCOLOGY THERAPEUT 0.7%

Value $28.32M Shares 2,261,749 Est. Cost $11.74 Unrealized —

VOR VOR BIOPHARMA INC 0.6%

Value $22.89M Shares 1,750,000 Est. Cost $18.62 Unrealized 0.0%

ASMB ASSEMBLY BIOSCIENCES INC 0.6%

Value $22.63M Shares 665,251 Est. Cost $32.21 Unrealized 0.0%

ORIC ORIC PHARMACEUTICALS INC 0.5%

Value $19.64M Shares 2,401,217 Est. Cost $11.51 Unrealized 0.0%

IVA INVENTIVA SA 0.5%

Value $18.6M Shares 4,000,000 Est. Cost $4.65 Unrealized —

KLRS KALARIS THERAPEUTICS INC 0.2%

Value $5.908M Shares 700,000 Est. Cost $6.39 Unrealized 0.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
NUVL	NUVALENT INC	5,269,433	$530M	13.5%	$60.72	+62.4%	COM	670703107
RVMD	REVOLUTION MEDICINES INC	6,644,403	$529M	13.5%	$38.36	+70.9%	COM	76155X100
ACLX	ARCELLX INC	5,724,016	$373M	9.5%	$48.76	+63.6%	COMMON STOCK	03940C100
GMAB	GENMAB A/S	7,039,834	$217M	5.5%	$30.73	—	SPONSORED ADS	372303206
TARS	TARSUS PHARMACEUTICALS INC	2,562,154	$210M	5.4%	$28.61	+161.0%	COM	87650L103
ABVX	ABIVAX SA	1,417,473	$191M	4.9%	$84.90	—	SPONSORED ADS	00370M103
OLMA	OLEMA PHARMACEUTICALS INC	7,544,172	$189M	4.8%	$9.20	+93.4%	COM	68062P106
PCVX	VAXCYTE INC	4,068,020	$188M	4.8%	$55.45	-19.3%	COM	92243G108
XBI	SPDR SERIES TRUST	1,500,000	$183M	4.7%	—	—	Put	78464A870
—	CIDARA THERAPEUTICS INC	759,565	$168M	4.3%	$95.76	—	COM NEW	171757206
EWTX	EDGEWISE THERAPEUTICS INC	6,541,210	$162M	4.1%	$20.10	-0.1%	COM	28036F105
SRRK	SCHOLAR ROCK HLDG CORP	3,062,157	$135M	3.4%	$33.97	+10.4%	COM	80706P103
URGN	UROGEN PHARMA LTD	4,473,648	$105M	2.7%	$18.17	+19.4%	COM	M96088105
CRNX	CRINETICS PHARMACEUTICALS IN	2,210,774	$103M	2.6%	$26.84	+65.9%	COM	22663K107
APGE	APOGEE THERAPEUTICS INC	1,123,243	$84.78M	2.2%	$44.51	+41.5%	COM	03770N101
EYPT	EYEPOINT INC	3,691,475	$67.44M	1.7%	$12.73	+11.4%	COM NEW	30233G209
ERAS	ERASCA INC	14,159,095	$52.67M	1.3%	$2.22	+26.9%	COM	29479A108
BBIO	BRIDGEBIO PHARMA INC	684,277	$52.34M	1.3%	$36.37	+80.5%	COM	10806X102
ORKA	ORUKA THERAPEUTICS INC	1,710,316	$51.84M	1.3%	$27.86	0.0%	COM	687604108
SYRE	SPYRE THERAPEUTICS INC	1,467,266	$48.07M	1.2%	$26.04	+0.3%	COM NEW	00773J202
LXEO	LEXEO THERAPEUTICS INC	4,763,198	$47.3M	1.2%	$9.13	0.0%	COM	52886X107
VRDN	VIRIDIAN THERAPEUTICS INC	1,443,102	$44.91M	1.1%	$17.86	+53.5%	COM	92790C104
OCUL	OCULAR THERAPEUTIX INC	2,935,284	$35.63M	0.9%	$7.86	+54.4%	COM	67576A100
TERN	TERNS PHARMACEUTICALS INC	810,286	$32.74M	0.8%	$23.11	0.0%	COM	880881107
BBOT	BRIDGEBIO ONCOLOGY THERAPEUT	2,261,749	$28.32M	0.7%	$11.74	—	COM NEW	107924102
VOR	VOR BIOPHARMA INC	1,750,000	$22.89M	0.6%	$18.62	0.0%	COM NEW	929033207
ASMB	ASSEMBLY BIOSCIENCES INC	665,251	$22.63M	0.6%	$32.21	0.0%	COM NEW	045396207
ORIC	ORIC PHARMACEUTICALS INC	2,401,217	$19.64M	0.5%	$11.51	0.0%	COM	68622P109
IVA	INVENTIVA SA	4,000,000	$18.6M	0.5%	$4.65	—	ADS	46124U107
KLRS	KALARIS THERAPEUTICS INC	700,000	$5.908M	0.2%	$6.39	0.0%	COM	482929106