Paradigm Biocapital Advisors LP Quant / Systematic

Location: New York, NY

CIK: 0001855655 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 14, 2025

Total Value: $3.516B (100.0% shares, 0.0% debt)

Holdings (36)

NUVL NUVALENT INC 13.0%

Value $456M Shares 5,269,433 Est. Cost $60.72 Unrealized +30.2%

— MERUS N V 11.7%

Value $412M Shares 4,373,770 Est. Cost $51.34 Unrealized —

ACLX ARCELLX INC 10.9%

Value $382M Shares 4,649,016 Est. Cost $41.59 Unrealized +73.1%

RVMD REVOLUTION MEDICINES INC 8.3%

Value $291M Shares 6,223,291 Est. Cost $36.52 Unrealized +7.2%

TARS TARSUS PHARMACEUTICALS INC 4.5%

Value $158M Shares 2,665,698 Est. Cost $28.61 Unrealized +72.1%

PCVX VAXCYTE INC 3.9%

Value $136M Shares 3,784,755 Est. Cost $56.25 Unrealized -41.1%

ABVX ABIVAX SA 3.8%

Value $133M Shares 1,564,196 Est. Cost $84.90 Unrealized —

GMAB GENMAB A/S 3.3%

Value $117M Shares 3,816,851 Est. Cost $30.67 Unrealized —

AGIO AGIOS PHARMACEUTICALS INC 3.1%

Value $107M Shares 2,673,555 Est. Cost $34.49 Unrealized +9.0%

CRNX CRINETICS PHARMACEUTICALS IN 3.0%

Value $106M Shares 2,550,774 Est. Cost $26.84 Unrealized +19.1%

XBI SPDR SERIES TRUST 2.8%

Value $100M Shares 1,000,000 Est. Cost — Unrealized —

EWTX EDGEWISE THERAPEUTICS INC 2.8%

Value $100M Shares 6,170,131 Est. Cost $20.10 Unrealized -29.4%

— CIDARA THERAPEUTICS INC 2.6%

Value $92.04M Shares 961,164 Est. Cost $95.76 Unrealized —

URGN UROGEN PHARMA LTD 2.4%

Value $84.11M Shares 4,216,084 Est. Cost $17.96 Unrealized 0.0%

SRRK SCHOLAR ROCK HLDG CORP 2.1%

Value $74.84M Shares 2,009,745 Est. Cost $32.12 Unrealized +8.9%

JANX JANUX THERAPEUTICS INC 2.0%

Value $71.37M Shares 2,920,258 Est. Cost $48.02 Unrealized -49.3%

OLMA OLEMA PHARMACEUTICALS INC 1.9%

Value $66.51M Shares 6,794,172 Est. Cost $8.25 Unrealized -27.2%

APGE APOGEE THERAPEUTICS INC 1.7%

Value $60.46M Shares 1,521,757 Est. Cost $44.51 Unrealized -14.2%

VRDN VIRIDIAN THERAPEUTICS INC 1.6%

Value $56.31M Shares 2,609,353 Est. Cost $17.86 Unrealized +1.0%

ALKS ALKERMES PLC 1.5%

Value $51.58M Shares 1,719,334 Est. Cost $29.45 Unrealized -4.2%

LENZ LENZ THERAPEUTICS INC 1.4%

Value $50M Shares 1,073,461 Est. Cost $27.56 Unrealized +33.4%

PHVS PHARVARIS N V 1.3%

Value $45.8M Shares 1,835,494 Est. Cost $18.67 Unrealized +18.8%

COGT COGENT BIOSCIENCES INC 1.3%

Value $45.33M Shares 3,156,398 Est. Cost $7.69 Unrealized +54.1%

OCUL OCULAR THERAPEUTIX INC 1.2%

Value $40.88M Shares 3,497,307 Est. Cost $7.86 Unrealized +52.0%

BBIO BRIDGEBIO PHARMA INC 1.0%

Value $35.54M Shares 684,277 Est. Cost $36.37 Unrealized +34.1%

ERAS ERASCA INC 0.8%

Value $29.56M Shares 13,560,017 Est. Cost $2.19 Unrealized -27.4%

EYPT EYEPOINT PHARMACEUTICALS INC 0.8%

Value $28.56M Shares 2,005,365 Est. Cost $11.51 Unrealized 0.0%

— MERUS N V 0.8%

Value $28.25M Shares 300,000 Est. Cost $51.34 Unrealized —

TNGX TANGO THERAPEUTICS INC 0.7%

Value $25.92M Shares 3,086,184 Est. Cost $6.77 Unrealized 0.0%

AMLX AMYLYX PHARMACEUTICALS INC 0.7%

Value $25.82M Shares 1,900,000 Est. Cost $9.41 Unrealized 0.0%

SYRE SPYRE THERAPEUTICS INC 0.7%

Value $24.59M Shares 1,467,266 Est. Cost $26.04 Unrealized -37.4%

DYN DYNE THERAPEUTICS INC 0.7%

Value $24.02M Shares 1,898,950 Est. Cost $11.41 Unrealized 0.0%

BBOT BRIDGEBIO ONCOLOGY THERAPEUT 0.6%

Value $21.61M Shares 1,866,141 Est. Cost $11.58 Unrealized —

IRON DISC MEDICINE INC 0.5%

Value $16.37M Shares 247,716 Est. Cost $48.64 Unrealized +22.3%

GPCR STRUCTURE THERAPEUTICS INC 0.3%

Value $10.44M Shares 372,869 Est. Cost $28.00 Unrealized —

AGIO AGIOS PHARMACEUTICALS INC 0.2%

Value $8.028M Shares 200,000 Est. Cost $34.49 Unrealized +9.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
NUVL	NUVALENT INC	5,269,433	$456M	13.0%	$60.72	+30.2%	COM	670703107
—	MERUS N V	4,373,770	$412M	11.7%	$51.34	—	COM	N5749R100
ACLX	ARCELLX INC	4,649,016	$382M	10.9%	$41.59	+73.1%	COMMON STOCK	03940C100
RVMD	REVOLUTION MEDICINES INC	6,223,291	$291M	8.3%	$36.52	+7.2%	COM	76155X100
TARS	TARSUS PHARMACEUTICALS INC	2,665,698	$158M	4.5%	$28.61	+72.1%	COM	87650L103
PCVX	VAXCYTE INC	3,784,755	$136M	3.9%	$56.25	-41.1%	COM	92243G108
ABVX	ABIVAX SA	1,564,196	$133M	3.8%	$84.90	—	SPONSORED ADS	00370M103
GMAB	GENMAB A/S	3,816,851	$117M	3.3%	$30.67	—	SPONSORED ADS	372303206
AGIO	AGIOS PHARMACEUTICALS INC	2,673,555	$107M	3.1%	$34.49	+9.0%	COM	00847X104
CRNX	CRINETICS PHARMACEUTICALS IN	2,550,774	$106M	3.0%	$26.84	+19.1%	COM	22663K107
XBI	SPDR SERIES TRUST	1,000,000	$100M	2.8%	—	—	Put	78464A870
EWTX	EDGEWISE THERAPEUTICS INC	6,170,131	$100M	2.8%	$20.10	-29.4%	COM	28036F105
—	CIDARA THERAPEUTICS INC	961,164	$92.04M	2.6%	$95.76	—	COM NEW	171757206
URGN	UROGEN PHARMA LTD	4,216,084	$84.11M	2.4%	$17.96	0.0%	COM	M96088105
SRRK	SCHOLAR ROCK HLDG CORP	2,009,745	$74.84M	2.1%	$32.12	+8.9%	COM	80706P103
JANX	JANUX THERAPEUTICS INC	2,920,258	$71.37M	2.0%	$48.02	-49.3%	COM	47103J105
OLMA	OLEMA PHARMACEUTICALS INC	6,794,172	$66.51M	1.9%	$8.25	-27.2%	COM	68062P106
APGE	APOGEE THERAPEUTICS INC	1,521,757	$60.46M	1.7%	$44.51	-14.2%	COM	03770N101
VRDN	VIRIDIAN THERAPEUTICS INC	2,609,353	$56.31M	1.6%	$17.86	+1.0%	COM	92790C104
ALKS	ALKERMES PLC	1,719,334	$51.58M	1.5%	$29.45	-4.2%	SHS	G01767105
LENZ	LENZ THERAPEUTICS INC	1,073,461	$50M	1.4%	$27.56	+33.4%	COM	52635N103
PHVS	PHARVARIS N V	1,835,494	$45.8M	1.3%	$18.67	+18.8%	COM	N69605108
COGT	COGENT BIOSCIENCES INC	3,156,398	$45.33M	1.3%	$7.69	+54.1%	COM	19240Q201
OCUL	OCULAR THERAPEUTIX INC	3,497,307	$40.88M	1.2%	$7.86	+52.0%	COM	67576A100
BBIO	BRIDGEBIO PHARMA INC	684,277	$35.54M	1.0%	$36.37	+34.1%	COM	10806X102
ERAS	ERASCA INC	13,560,017	$29.56M	0.8%	$2.19	-27.4%	COM	29479A108
EYPT	EYEPOINT PHARMACEUTICALS INC	2,005,365	$28.56M	0.8%	$11.51	0.0%	COM NEW	30233G209
—	MERUS N V	300,000	$28.25M	0.8%	$51.34	—	Call	N5749R100
TNGX	TANGO THERAPEUTICS INC	3,086,184	$25.92M	0.7%	$6.77	0.0%	COM	87583X109
AMLX	AMYLYX PHARMACEUTICALS INC	1,900,000	$25.82M	0.7%	$9.41	0.0%	COM	03237H101
SYRE	SPYRE THERAPEUTICS INC	1,467,266	$24.59M	0.7%	$26.04	-37.4%	COM NEW	00773J202
DYN	DYNE THERAPEUTICS INC	1,898,950	$24.02M	0.7%	$11.41	0.0%	COM	26818M108
BBOT	BRIDGEBIO ONCOLOGY THERAPEUT	1,866,141	$21.61M	0.6%	$11.58	—	COM NEW	107924102
IRON	DISC MEDICINE INC	247,716	$16.37M	0.5%	$48.64	+22.3%	COM	254604101
GPCR	STRUCTURE THERAPEUTICS INC	372,869	$10.44M	0.3%	$28.00	—	SPONSORED ADS	86366E106
AGIO	AGIOS PHARMACEUTICALS INC	200,000	$8.028M	0.2%	$34.49	+9.0%	Call	00847X104