AMYLYX PHARMACEUTICALS INC

Ticker: AMLX CUSIP: 03237H101 Class: Common Stock

Holders for Q4 2025 Position Changes for Q4 2025

Note: Option positions (PUT/CALL) are excluded.

New Positions (37)

HighVista Strategies LLC
Value ($000) $2,885 Shares 238,812
Sofinnova Investments, Inc.
Value ($000) $6,367 Shares 527,099
Atom Investors LP
Value ($000) $1,684 Shares 139,422
XTX Topco Ltd
Value ($000) $2,291 Shares 189,673
ACT CAPITAL MANAGEMENT, LLC
Value ($000) $109 Shares 9,000
Integrated Quantitative Investments LLC
Value ($000) $329 Shares 27,234
FOX RUN MANAGEMENT, L.L.C.
Value ($000) $428 Shares 35,409
Virtus Investment Advisers, LLC
Value ($000) $245 Shares 20,307
Headlands Technologies LLC
Value ($000) $369 Shares 30,543
FRANKLIN RESOURCES INC
Value ($000) $14,497 Shares 1,200,096
VOLORIDGE INVESTMENT MANAGEMENT, LLC
Value ($000) $1,853 Shares 153,363
ALPS ADVISORS INC
Value ($000) $1,089 Shares 90,172
Aquatic Capital Management LLC
Value ($000) $294 Shares 24,352
JANE STREET GROUP, LLC
Value ($000) $3,180 Shares 263,235
Swiss National Bank
Value ($000) $1,953 Shares 161,700
Squarepoint Ops LLC
Value ($000) $925 Shares 76,562
UBS ASSET MANAGEMENT AMERICAS INC
Value ($000) $1,194 Shares 98,838
Engineers Gate Manager LP
Value ($000) $222 Shares 18,358
SEI INVESTMENTS CO
Value ($000) $639 Shares 52,856
SUSQUEHANNA INTERNATIONAL GROUP, LLP
Value ($000) $832 Shares 68,892

Increased Positions (68)

Commodore Capital LP
Value ($000) $68,252 (+23.2%) Shares 5,650,000 (+38.6%)
GREAT POINT PARTNERS LLC
Value ($000) $21,140 (-8.5%) Shares 1,750,000 (+2.9%)
STEMPOINT CAPITAL LP
Value ($000) $6,827 (+81.5%) Shares 565,140 (+104.1%)
Patient Square Capital LP
Value ($000) $4,228 (-1.6%) Shares 350,000 (+10.7%)
ADAR1 Capital Management, LLC
Value ($000) $10,756 (-8.6%) Shares 890,356 (+2.8%)
DRIEHAUS CAPITAL MANAGEMENT LLC
Value ($000) $37,563 (+14.2%) Shares 3,109,503 (+28.5%)
Numerai GP LLC
Value ($000) $1,361 (+49.1%) Shares 112,648 (+67.7%)
Tetragon Partners GP Ltd
Value ($000) $3,296 (-6.1%) Shares 272,828 (+5.6%)
Persistent Asset Partners Ltd
Value ($000) $376 (+20.8%) Shares 31,147 (+35.9%)
Campbell & CO Investment Adviser LLC
Value ($000) $951 (+186.0%) Shares 78,763 (+221.7%)
SummitTX Capital, L.P.
Value ($000) $2,638 (+15.6%) Shares 218,399 (+30.0%)
JANUS HENDERSON GROUP PLC
Value ($000) $53,992 (+56.7%) Shares 4,465,872 (+76.1%)
FMR LLC
Value ($000) $199,543 (+29.0%) Shares 16,518,419 (+45.2%)
FEDERATED HERMES, INC.
Value ($000) $5,526 (+91.4%) Shares 457,412 (+115.4%)
Caitong International Asset Management Co., Ltd
Value ($000) $47 (+837.2%) Shares 3,859 (+954.4%)
TWO SIGMA INVESTMENTS, LP
Value ($000) $4,160 (+211.1%) Shares 344,401 (+249.9%)
TWO SIGMA ADVISERS, LP
Value ($000) $3,967 (+104.1%) Shares 328,401 (+129.7%)
BlackRock, Inc.
Value ($000) $109,378 (+12.7%) Shares 9,054,431 (+26.8%)
Qube Research & Technologies Ltd
Value ($000) $4,988 (+119.6%) Shares 412,873 (+147.1%)
BANK OF AMERICA CORP /DE/
Value ($000) $16,139 (+176.5%) Shares 1,336,010 (+211.1%)

Decreased Positions (41)

Saturn V Capital Management LP
Value ($000) $54,318 (-13.2%) Shares 4,496,487 (-2.4%)
Boxer Capital Management, LLC
Value ($000) $9,664 (-21.0%) Shares 800,000 (-11.1%)
PERCEPTIVE ADVISORS LLC
Value ($000) $100,081 (-17.7%) Shares 8,284,882 (-7.5%)
Logos Global Management LP
Value ($000) $11,476 (-41.8%) Shares 950,000 (-34.5%)
Kennondale Capital Management LLC
Value ($000) $645 (-56.3%) Shares 53,423 (-50.8%)
SILVERARC CAPITAL MANAGEMENT, LLC
Value ($000) $6,115 (-35.7%) Shares 506,242 (-27.7%)
Aldebaran Capital, LLC
Value ($000) $2,398 (-13.7%) Shares 198,508 (-2.9%)
Parkman Healthcare Partners LLC
Value ($000) $4,612 (-41.4%) Shares 381,760 (-34.1%)
PFM Health Sciences, LP
Value ($000) $1,625 (-72.6%) Shares 134,549 (-69.2%)
683 Capital Management, LLC
Value ($000) $19,932 (-16.7%) Shares 1,650,000 (-6.3%)
ADAGE CAPITAL PARTNERS GP, L.L.C.
Value ($000) $33,547 (-63.8%) Shares 2,777,055 (-59.3%)
Cormorant Asset Management, LP
Value ($000) $4,832 (-28.9%) Shares 400,000 (-20.0%)
Nantahala Capital Management, LLC
Value ($000) $10,095 (-20.6%) Shares 835,684 (-10.7%)
Point72 Asset Management, L.P.
Value ($000) $4,047 (-89.3%) Shares 335,000 (-88.0%)
EAM Investors, LLC
Value ($000) $643 (-37.0%) Shares 53,256 (-29.1%)
Trexquant Investment LP
Value ($000) $581 (-80.8%) Shares 48,112 (-78.4%)
EntryPoint Capital, LLC
Value ($000) $127 (-45.7%) Shares 10,487 (-38.9%)
Alpha Wave Global, LP
Value ($000) $3,838 (-13.7%) Shares 317,678 (-2.9%)
BALYASNY ASSET MANAGEMENT L.P.
Value ($000) $10,373 (-48.3%) Shares 858,684 (-41.8%)
UBS Group AG
Value ($000) $6,563 (-65.6%) Shares 543,323 (-61.3%)

Exited Positions (28)

Ally Bridge Group (NY) LLC
Value ($000) $5,944 Shares 437,391
Paradigm Biocapital Advisors LP
Value ($000) $25,821 Shares 1,900,000
Longaeva Partners L.P.
Value ($000) $2,718 Shares 200,000
DIADEMA PARTNERS LP
Value ($000) $1,359 Shares 100,000
BRAIDWELL LP
Value ($000) $8,329 Shares 612,841
ORBIMED ADVISORS LLC
Value ($000) $10,201 Shares 750,600
Monashee Investment Management LLC
Value ($000) $408 Shares 30,000
OXFORD ASSET MANAGEMENT LLP
Value ($000) $260 Shares 19,120
TANG CAPITAL MANAGEMENT LLC
Value ($000) $1,359 Shares 100,000
DARK FOREST CAPITAL MANAGEMENT LP
Value ($000) $1,180 Shares 86,795
READYSTATE ASSET MANAGEMENT LP
Value ($000) $804 Shares 59,132
Maven Securities LTD
Value ($000) $951 Shares 70,000
Hennion & Walsh Asset Management, Inc.
Value ($000) $651 Shares 47,898
Aster Capital Management (DIFC) Ltd
Value ($000) $48 Shares 3,568
FRED ALGER MANAGEMENT, LLC
Value ($000) $2,229 Shares 164,042
JENNISON ASSOCIATES LLC
Value ($000) $7,864 Shares 578,659
Brevan Howard Capital Management LP
Value ($000) $770 Shares 56,667
Quantbot Technologies LP
Value ($000) $226 Shares 16,653
TD Asset Management Inc
Value ($000) $557 Shares 40,966
HSBC HOLDINGS PLC
Value ($000) $278 Shares 19,369