| JPMORGAN CHASE & CO | 23,199,512 | $4,037,643 |
| VANGUARD GROUP INC | 21,076,344 | $3,668,127 |
| Darwin Global Management, Ltd. | 20,933,277 | $3,644,274 |
| BlackRock, Inc. | 15,065,052 | $2,621,922 |
| FMR LLC | 9,927,936 | $1,727,858 |
| BAKER BROS. ADVISORS LP | 6,592,746 | $1,147,402 |
| STATE STREET CORP | 5,201,744 | $905,312 |
| Capital International Investors | 5,151,671 | $896,597 |
| Artisan Partners Limited Partnership | 4,843,749 | $843,006 |
| RTW INVESTMENTS, LP | 4,842,879 | $842,855 |
| D. E. Shaw & Co., Inc. | 4,350,995 | $757,247 |
| GEODE CAPITAL MANAGEMENT, LLC | 4,299,052 | $751,936 |
| Orbis Allan Gray Ltd | 4,179,957 | $727,480 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,039,466 | $703 |
| NORGES BANK | 2,910,971 | $506,625 |
| FRANKLIN RESOURCES INC | 2,755,536 | $479,573 |
| Invesco Ltd. | 2,726,857 | $474,582 |
| AMERIPRISE FINANCIAL INC | 1,968,857 | $342,661 |
| UBS Group AG | 1,867,635 | $325,043 |
| BANK OF AMERICA CORP /DE/ | 1,725,681 | $300,338 |
| MORGAN STANLEY | 1,631,906 | $284,017 |
| Duquesne Family Office LLC | 1,481,752 | $258 |
| Bank of New York Mellon Corp | 1,390,042 | $241,923 |
| MILLENNIUM MANAGEMENT LLC | 1,311,654 | $228,280 |
| Castle Hook Partners LP | 1,253,568 | $218,171 |
| Integral Health Asset Management, LLC | 1,250,000 | $217,550 |
| GOLDMAN SACHS GROUP INC | 1,244,913 | $216,665 |
| NORTHERN TRUST CORP | 1,238,438 | $215,538 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,221,096 | $212,520 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 1,183,029 | $205,894 |
| CITADEL ADVISORS LLC | 1,157,295 | $201,416 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,027,355 | $178,801 |
| Fiera Capital Corp | 992,892 | $172,803 |
| NWI MANAGEMENT LP | 988,460 | $172 |
| TWO SIGMA INVESTMENTS, LP | 962,156 | $167,454 |
| Pictet Asset Management Holding SA | 958,963 | $167,257 |
| UBS ASSET MANAGEMENT AMERICAS INC | 943,306 | $164,173 |
| Jefferies Financial Group Inc. | 926,339 | $161,220 |
| Amundi | 916,998 | $159,594 |
| BNP PARIBAS ARBITRAGE, SA | 915,419 | $159,320 |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 909,080 | $158,216 |
| SEI INVESTMENTS CO | 890,170 | $154,925 |
| FIL Ltd | 838,509 | $145,934 |
| Clearbridge Investments, LLC | 819,011 | $142,541 |
| Holocene Advisors, LP | 801,165 | $139,435 |
| JANUS HENDERSON GROUP PLC | 800,555 | $139,334 |
| RAYMOND JAMES FINANCIAL INC | 779,254 | $135,650 |
| PRINCIPAL FINANCIAL GROUP INC | 771,358 | $134,247 |
| LORD, ABBETT & CO. LLC | 720,898 | $125 |
| Artia Global Partners LP | 682,212 | $118,732 |
| Nuveen, LLC | 650,404 | $113,196 |
| VICTORY CAPITAL MANAGEMENT INC | 646,714 | $112,554 |
| ALLIANCEBERNSTEIN L.P. | 642,719 | $111,859 |
| Hood River Capital Management LLC | 637,577 | $110,964 |
| FEDERATED HERMES, INC. | 632,298 | $110,045 |
| DEUTSCHE BANK AG\ | 590,030 | $102,689 |
| WELLS FARGO & COMPANY/MN | 586,651 | $102,101 |
| Swiss National Bank | 579,112 | $100,789 |
| JENNISON ASSOCIATES LLC | 562,296 | $97,862 |
| Legal & General Group Plc | 540,313 | $94,036 |
| ROYAL BANK OF CANADA | 506,811 | $88,205 |
| Nearwater Capital Markets, Ltd | 500,000 | $87,020 |
| TimesSquare Capital Management, LLC | 490,506 | $85,368 |
| Palo Alto Investors LP | 489,482 | $85,189 |
| WELLINGTON MANAGEMENT GROUP LLP | 486,138 | $84,607 |
| EVENTIDE ASSET MANAGEMENT, LLC | 483,589 | $84,164 |
| GW&K Investment Management, LLC | 482,670 | $84 |
| AQR CAPITAL MANAGEMENT LLC | 468,260 | $81,496 |
| Affinity Asset Advisors, LLC | 450,000 | $78,318 |
| BARCLAYS PLC | 444,706 | $77,397 |
| Sumitomo Mitsui Trust Holdings, Inc. | 435,442 | $75,784 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 432,521 | $75,276 |
| Candriam S.C.A. | 401,042 | $69,800 |
| DIMENSIONAL FUND ADVISORS LP | 399,073 | $69,455 |
| TWO SIGMA ADVISERS, LP | 395,000 | $68,746 |
| MARSHALL WACE, LLP | 389,881 | $67,855 |
| Ensign Peak Advisors, Inc | 382,202 | $66,518 |
| BALYASNY ASSET MANAGEMENT L.P. | 380,561 | $66,233 |
| SAMLYN CAPITAL, LLC | 369,575 | $64,321 |
| GATEWAY INVESTMENT ADVISERS LLC | 365,000 | $63,525 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 354,909 | $61,768 |
| Polar Capital Holdings Plc | 344,228 | $59,909 |
| ProShare Advisors LLC | 340,740 | $59,302 |
| BNP Paribas Investment Partners S.A. | 328,328 | $57 |
| Rock Springs Capital Management LP | 319,250 | $55,562 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 310,330 | $54,010 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | $52,212 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 284,844 | $49,574 |
| Zurich Insurance Group Ltd/FI | 281,098 | $48,922 |
| National Pension Service | 280,442 | $48,808 |
| NEW YORK STATE COMMON RETIREMENT FUND | 276,284 | $48,084 |
| ENVESTNET ASSET MANAGEMENT INC | 276,105 | $48,053 |
| Cormorant Asset Management, LP | 275,000 | $47,861 |
| RHUMBLINE ADVISERS | 268,326 | $46,699 |
| Patient Square Capital LP | 267,000 | $46,469 |
| First Turn Management, LLC | 264,293 | $45,998 |
| TD Asset Management Inc | 262,478 | $45,682 |
| AXIOM INVESTORS LLC /DE | 255,849 | $44,528 |
| abrdn plc | 253,112 | $44,052 |
| FIRST TRUST ADVISORS LP | 247,940 | $43,152 |
| 569 other institutions | 13,175,783 | $2,139,163 |