NKARTA INC

Institution	Shares	Value ($000)
Rangeley Capital, LLC	32,078	$59
GSA CAPITAL PARTNERS LLP	206,682	$0
Abel Hall, LLC	14,578	$27
Dynamic Technology Lab Private Ltd	19,970	$37
D. E. Shaw & Co., Inc.	183,369	$339
BOURGEON CAPITAL MANAGEMENT LLC	10,400	$19
Point72 Asset Management, L.P.	55,168	$102
CANADA PENSION PLAN INVESTMENT BOARD	14,200	$26
RAYMOND JAMES FINANCIAL INC	10,994	$20
NEUBERGER BERMAN GROUP LLC	10,279	$19
GAMMA Investing LLC	192	$0
Caitong International Asset Management Co., Ltd	6	$0
ROTHSCHILD INVESTMENT LLC	6	$0

Increased Positions (32)

Monaco Asset Management SAM

Value ($000) $4,712 (+15.5%) Shares 2,546,932 (+29.2%)

AWM Investment Company, Inc.

Value ($000) $1,676 (+1.2%) Shares 906,000 (+13.3%)

XTX Topco Ltd

Value ($000) $249 (+613.6%) Shares 134,730 (+698.4%)

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $3,149 (+32.8%) Shares 1,702,022 (+48.6%)

Samalin Investment Counsel, LLC

Value ($000) $278 (-4.2%) Shares 150,235 (+7.2%)

TWO SIGMA ADVISERS, LP

Value ($000) $1,197 (+199.9%) Shares 647,200 (+235.5%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $1,798 (+67.0%) Shares 971,982 (+86.9%)

PRELUDE CAPITAL MANAGEMENT, LLC

Value ($000) $136 (+51.3%) Shares 73,300 (+69.3%)

BlackRock, Inc.

Value ($000) $7,613 (-0.6%) Shares 4,115,138 (+11.3%)

PANAGORA ASSET MANAGEMENT INC

Value ($000) $526 (+39.9%) Shares 284,210 (+56.5%)

VANGUARD GROUP INC

Value ($000) $4,805 (-6.8%) Shares 2,597,370 (+4.2%)

BAILARD, INC.

Value ($000) $117 (+91.4%) Shares 63,400 (+114.2%)

Nuveen, LLC

Value ($000) $353 (+78.3%) Shares 190,683 (+99.5%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $2,136 (-3.4%) Shares 1,154,323 (+8.1%)

JANE STREET GROUP, LLC

Value ($000) $451 (+34.6%) Shares 243,704 (+50.6%)

MARSHALL WACE, LLP

Value ($000) $287 (+63.2%) Shares 155,036 (+82.6%)

HSBC HOLDINGS PLC

Value ($000) $299 (+53.1%) Shares 161,434 (+70.0%)

GOLDMAN SACHS GROUP INC

Value ($000) $629 (+8.3%) Shares 340,241 (+21.2%)

UBS Group AG

Value ($000) $148 (+245.2%) Shares 79,862 (+286.3%)

Man Group plc

Value ($000) $164 (+81.2%) Shares 88,438 (+102.7%)

Institution	Prev Shares	Curr Shares	Change
Monaco Asset Management SAM	1,970,910	2,546,932	+576,022 (+29.2%)
AWM Investment Company, Inc.	800,000	906,000	+106,000 (+13.3%)
XTX Topco Ltd	16,874	134,730	+117,856 (+698.4%)
RENAISSANCE TECHNOLOGIES LLC	1,145,077	1,702,022	+556,945 (+48.6%)
Samalin Investment Counsel, LLC	140,165	150,235	+10,070 (+7.2%)
TWO SIGMA ADVISERS, LP	192,900	647,200	+454,300 (+235.5%)
TWO SIGMA INVESTMENTS, LP	520,172	971,982	+451,810 (+86.9%)
PRELUDE CAPITAL MANAGEMENT, LLC	43,300	73,300	+30,000 (+69.3%)
BlackRock, Inc.	3,698,537	4,115,138	+416,601 (+11.3%)
PANAGORA ASSET MANAGEMENT INC	181,600	284,210	+102,610 (+56.5%)
VANGUARD GROUP INC	2,491,717	2,597,370	+105,653 (+4.2%)
BAILARD, INC.	29,600	63,400	+33,800 (+114.2%)
Nuveen, LLC	95,563	190,683	+95,120 (+99.5%)
GEODE CAPITAL MANAGEMENT, LLC	1,068,105	1,154,323	+86,218 (+8.1%)
JANE STREET GROUP, LLC	161,778	243,704	+81,926 (+50.6%)
MARSHALL WACE, LLP	84,914	155,036	+70,122 (+82.6%)
HSBC HOLDINGS PLC	94,955	161,434	+66,479 (+70.0%)
GOLDMAN SACHS GROUP INC	280,783	340,241	+59,458 (+21.2%)
UBS Group AG	20,675	79,862	+59,187 (+286.3%)
Man Group plc	43,628	88,438	+44,810 (+102.7%)

Decreased Positions (39)

TANG CAPITAL MANAGEMENT LLC

Value ($000) $2,740 (-81.2%) Shares 1,480,823 (-79.0%)

Samsara BioCapital, LLC

Value ($000) $6,489 (-16.8%) Shares 3,507,666 (-6.9%)

CITADEL ADVISORS LLC

Value ($000) $2,489 (-58.5%) Shares 1,345,233 (-53.6%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $194 (-87.5%) Shares 104,652 (-86.0%)

ROYAL BANK OF CANADA

Value ($000) $7 (-99.2%) Shares 4,033 (-99.0%)

BANK OF AMERICA CORP /DE/

Value ($000) $204 (-77.8%) Shares 110,019 (-75.1%)

Woodline Partners LP

Value ($000) $464 (-40.2%) Shares 250,848 (-33.1%)

MORGAN STANLEY

Value ($000) $576 (-41.2%) Shares 311,116 (-34.3%)

WASATCH ADVISORS LP

Value ($000) $2,916 (-14.0%) Shares 1,576,282 (-3.8%)

BARCLAYS PLC

Value ($000) $340 (-67.6%) Shares 183,923 (-20.9%)

AQR CAPITAL MANAGEMENT LLC

Value ($000) $590 (-27.4%) Shares 318,992 (-18.7%)

CITIGROUP INC

Value ($000) $69 (-69.0%) Shares 37,275 (-65.3%)

DIMENSIONAL FUND ADVISORS LP

Value ($000) $368 (-24.4%) Shares 198,699 (-15.4%)

DEUTSCHE BANK AG\

Value ($000) $4 (-92.7%) Shares 2,115 (-91.8%)

Quadrature Capital Ltd

Value ($000) $41 (-47.1%) Shares 22,111 (-40.7%)

Bank of New York Mellon Corp

Value ($000) $204 (-23.2%) Shares 110,033 (-14.1%)

NORTHERN TRUST CORP

Value ($000) $665 (-14.7%) Shares 359,626 (-4.6%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $74 (-34.2%) Shares 40,017 (-26.4%)

STIFEL FINANCIAL CORP

Value ($000) $217 (-18.4%) Shares 117,228 (-8.7%)

Vanguard Personalized Indexing Management, LLC

Value ($000) $39 (-38.4%) Shares 20,895 (-31.1%)

Institution	Prev Shares	Curr Shares	Change
TANG CAPITAL MANAGEMENT LLC	7,055,576	1,480,823	-5,574,753 (-79.0%)
Samsara BioCapital, LLC	3,768,035	3,507,666	-260,369 (-6.9%)
CITADEL ADVISORS LLC	2,899,758	1,345,233	-1,554,525 (-53.6%)
MILLENNIUM MANAGEMENT LLC	748,494	104,652	-643,842 (-86.0%)
ROYAL BANK OF CANADA	406,634	4,033	-402,601 (-99.0%)
BANK OF AMERICA CORP /DE/	442,493	110,019	-332,474 (-75.1%)
Woodline Partners LP	375,166	250,848	-124,318 (-33.1%)
MORGAN STANLEY	473,217	311,116	-162,101 (-34.3%)
WASATCH ADVISORS LP	1,637,737	1,576,282	-61,455 (-3.8%)
BARCLAYS PLC	232,566	183,923	-48,643 (-20.9%)
AQR CAPITAL MANAGEMENT LLC	392,565	318,992	-73,573 (-18.7%)
CITIGROUP INC	107,320	37,275	-70,045 (-65.3%)
DIMENSIONAL FUND ADVISORS LP	234,740	198,699	-36,041 (-15.4%)
DEUTSCHE BANK AG\	25,736	2,115	-23,621 (-91.8%)
Quadrature Capital Ltd	37,289	22,111	-15,178 (-40.7%)
Bank of New York Mellon Corp	128,041	110,033	-18,008 (-14.1%)
NORTHERN TRUST CORP	376,916	359,626	-17,290 (-4.6%)
BNP PARIBAS ARBITRAGE, SA	54,335	40,017	-14,318 (-26.4%)
STIFEL FINANCIAL CORP	128,419	117,228	-11,191 (-8.7%)
Vanguard Personalized Indexing Management, LLC	30,338	20,895	-9,443 (-31.1%)

Exited Positions (12)

Forefront Wealth Partners, LLC

Value ($000) $82 Shares 39,452

OXFORD ASSET MANAGEMENT LLP

Value ($000) $54 Shares 26,290

Atom Investors LP

Value ($000) $74 Shares 35,701

Founders Capital Management

Value ($000) $10 Shares 5,000

China Universal Asset Management Co., Ltd.

Value ($000) $26 Shares 12,450

Pallas Capital Advisors LLC

Value ($000) $22 Shares 10,738

Merit Financial Group, LLC

Value ($000) $21 Shares 10,085

Mirae Asset Global Investments Co., Ltd.

Value ($000) $6 Shares 2,746

GF FUND MANAGEMENT CO. LTD.

Value ($000) $3 Shares 1,463

Virtu Financial LLC

Value ($000) $0 Shares 49,274

MAI Capital Management

Value ($000) $0 Shares 100

Allworth Financial LP

Value ($000) $0 Shares 18

Institution	Prev Shares	Prev Value ($000)
Forefront Wealth Partners, LLC	39,452	$82
OXFORD ASSET MANAGEMENT LLP	26,290	$54
Atom Investors LP	35,701	$74
Founders Capital Management	5,000	$10
China Universal Asset Management Co., Ltd.	12,450	$26
Pallas Capital Advisors LLC	10,738	$22
Merit Financial Group, LLC	10,085	$21
Mirae Asset Global Investments Co., Ltd.	2,746	$6
GF FUND MANAGEMENT CO. LTD.	1,463	$3
Virtu Financial LLC	49,274	$0
MAI Capital Management	100	$0
Allworth Financial LP	18	$0