| RA CAPITAL MANAGEMENT, L.P. | 10,805,129 | $19,989 |
| BlackRock, Inc. | 4,115,138 | $7,613 |
| NEA Management Company, LLC | 3,568,781 | $6,602 |
| Samsara BioCapital, LLC | 3,507,666 | $6,489 |
| SR ONE CAPITAL MANAGEMENT, LP | 3,333,333 | $6,167 |
| GSK plc | 3,150,732 | $5,829 |
| VANGUARD GROUP INC | 2,597,370 | $4,805 |
| Monaco Asset Management SAM | 2,546,932 | $4,712 |
| Alyeska Investment Group, L.P. | 2,084,840 | $3,857 |
| RENAISSANCE TECHNOLOGIES LLC | 1,702,022 | $3,149 |
| WASATCH ADVISORS LP | 1,576,282 | $2,916 |
| TANG CAPITAL MANAGEMENT LLC | 1,480,823 | $2,740 |
| CITADEL ADVISORS LLC | 1,345,233 | $2,489 |
| STATE STREET CORP | 1,169,356 | $2,163 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,154,323 | $2,136 |
| TWO SIGMA INVESTMENTS, LP | 971,982 | $1,798 |
| AWM Investment Company, Inc. | 906,000 | $1,676 |
| Blackstone Inc. | 747,044 | $1,382 |
| ACADIAN ASSET MANAGEMENT LLC | 692,087 | $1 |
| Peapod Lane Capital LLC | 676,199 | $1,251 |
| TWO SIGMA ADVISERS, LP | 647,200 | $1,197 |
| JPMORGAN CHASE & CO | 598,985 | $1,108 |
| NORTHERN TRUST CORP | 359,626 | $665 |
| GOLDMAN SACHS GROUP INC | 340,241 | $629 |
| AQR CAPITAL MANAGEMENT LLC | 318,992 | $590 |
| MORGAN STANLEY | 311,116 | $576 |
| PANAGORA ASSET MANAGEMENT INC | 284,210 | $526 |
| Woodline Partners LP | 250,848 | $464 |
| JANE STREET GROUP, LLC | 243,704 | $451 |
| GSA CAPITAL PARTNERS LLP | 206,682 | $0 |
| DIMENSIONAL FUND ADVISORS LP | 198,699 | $368 |
| Nuveen, LLC | 190,683 | $353 |
| BARCLAYS PLC | 183,923 | $340 |
| D. E. Shaw & Co., Inc. | 183,369 | $339 |
| HSBC HOLDINGS PLC | 161,434 | $299 |
| MARSHALL WACE, LLP | 155,036 | $287 |
| Invesco Ltd. | 150,476 | $278 |
| Samalin Investment Counsel, LLC | 150,235 | $278 |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 150,000 | $278 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 142,835 | $297 |
| XTX Topco Ltd | 134,730 | $249 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 129,175 | $239 |
| FMR LLC | 119,618 | $221 |
| STIFEL FINANCIAL CORP | 117,228 | $217 |
| Bank of New York Mellon Corp | 110,033 | $204 |
| BANK OF AMERICA CORP /DE/ | 110,019 | $204 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 107,800 | $199 |
| MILLENNIUM MANAGEMENT LLC | 104,652 | $194 |
| AMERICAN CENTURY COMPANIES INC | 95,205 | $176 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 94,746 | $175 |
| ALLIANCEBERNSTEIN L.P. | 89,870 | $166 |
| Man Group plc | 88,438 | $164 |
| UBS Group AG | 79,862 | $148 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 73,300 | $136 |
| RHUMBLINE ADVISERS | 66,988 | $124 |
| BAILARD, INC. | 63,400 | $117 |
| IEQ CAPITAL, LLC | 59,821 | $111 |
| Point72 Asset Management, L.P. | 55,168 | $102 |
| WELLS FARGO & COMPANY/MN | 47,997 | $89 |
| Forefront Analytics, LLC | 40,702 | $75 |
| BNP PARIBAS ARBITRAGE, SA | 40,017 | $74 |
| CITIGROUP INC | 37,275 | $69 |
| Rangeley Capital, LLC | 32,078 | $59 |
| Graham Capital Management, L.P. | 31,751 | $59 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 28,922 | $0 |
| BANK OF MONTREAL /CAN/ | 27,843 | $52 |
| Cerity Partners LLC | 23,394 | $43 |
| CWM, LLC | 23,274 | $0 |
| SEI INVESTMENTS CO | 22,898 | $42 |
| Quadrature Capital Ltd | 22,111 | $41 |
| SG Americas Securities, LLC | 21,218 | $0 |
| Vanguard Personalized Indexing Management, LLC | 20,895 | $39 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,379 | $38 |
| Dynamic Technology Lab Private Ltd | 19,970 | $37 |
| INTECH INVESTMENT MANAGEMENT LLC | 19,232 | $36 |
| HRT FINANCIAL LP | 17,562 | $0 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 14,998 | $29 |
| Abel Hall, LLC | 14,578 | $27 |
| CANADA PENSION PLAN INVESTMENT BOARD | 14,200 | $26 |
| Mariner, LLC | 13,151 | $24 |
| DLK Investment Management, LLC | 11,320 | $21 |
| RAYMOND JAMES FINANCIAL INC | 10,994 | $20 |
| Police & Firemen's Retirement System of New Jersey | 10,638 | $20 |
| BOURGEON CAPITAL MANAGEMENT LLC | 10,400 | $19 |
| NEUBERGER BERMAN GROUP LLC | 10,279 | $19 |
| SIMPLEX TRADING, LLC | 9,761 | $18 |
| Tower Research Capital LLC (TRC) | 9,458 | $17 |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,455 | $16 |
| FEDERATED HERMES, INC. | 5,615 | $10 |
| Ameritas Investment Partners, Inc. | 5,184 | $10 |
| Russell Investments Group, Ltd. | 4,885 | $9 |
| Legal & General Group Plc | 4,567 | $8 |
| GROUP ONE TRADING, L.P. | 4,420 | $8 |
| Rockefeller Capital Management L.P. | 4,166 | $8 |
| ROYAL BANK OF CANADA | 4,033 | $7 |
| Sterling Capital Management LLC | 2,935 | $5 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,614 | $5 |
| DEUTSCHE BANK AG\ | 2,115 | $4 |
| EverSource Wealth Advisors, LLC | 1,462 | $3 |
| AMALGAMATED BANK | 1,336 | $0 |
| 18 other institutions | 4,298 | $8 |